The TWiV team reveals the protein corona that surrounds virus particles and influences infectivity and amyloid aggregation, and a proofreading-impaired herpesvirus that produces quasispecies-like populations. Hosts: Vincent Racaniello , Alan Dove , and Rich Condit Guest: Kiki Warren Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Human fetal tissue research restrictions (The Scientist) Viral protein corona (Nat Commun) Proofreading-impaire...
Sep 22, 2019•1 hr 51 min•Ep. 566
From the Karolinska Institute in Stockholm, Vincent speaks with Niklas Björkström, Ali Mirazimi, and Matti Sällberg about their work on the impact of chronic hepatitis C virus infection on NK cells, Crimean-Congo hemorrhagic fever virus vaccines, and immunotherapy to block entry of hepatitis B and D viruses. Hosts: Vincent Racaniello Guests: Niklas Björkström , Ali Mirazimi , and Matti Sällberg Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episo...
Sep 15, 2019•1 hr 26 min•Ep. 565
From the 16th Smögen Summer Symposium on Virology, Vincent speaks with Erling Norrby about how he has used archival material to provide insight into early Nobel Prizes for research on viruses. Hosts: Vincent Racaniello Guest: Erling Norrby Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Swedish Society for Virology Nobel Prizes and Life Sciences by Erling Norrby Nobel Prizes and Nature's Surprises by Erling Norrby Nobel Prizes and Notable ...
Sep 08, 2019•1 hr 14 min•Ep. 564
David Tuller returns to talk about his efforts of the past year to expose the methodological and ethical problems with the PACE and Lightning trials for therapy of ME/CFS. Host: Vincent Racaniello Guest: David Tuller Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Intro music is by Ronald Jenkees . Send your virology questions and comments to twiv@microbe.tv...
Sep 03, 2019•1 hr 13 min
The TWiVologists consider whether to receive an influenza vaccine in August (in the northern hemisphere), and mice implanted with human lung fragments for studying microbial pathogens. Hosts: Vincent Racaniello , Alan Dove , Kathy Spindler , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Waning of influenza vaccine protection (Clin Inf Dis) Precision mouse models for microbial pathogenesis (Nat Biotech) Letters read on ...
Sep 01, 2019•1 hr 31 min•Ep. 563
TWiV travels to Rutgers University to speak with Brad, Kay, Siobain, and Kim about their careers and their work on viruses of plants, fungi, bacteria, diatoms, and coccolithophores. Hosts: Vincent Racaniello , Dickson Despommier , and Brianne Barker Guests: Brad Hillman , Kay Bidle , Siobain Duffy , and Kim Thamatrakoln Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Viruses of plant-interacting fungi (Adv Virus Res) W hy are RNA virus mut...
Aug 25, 2019•2 hr 7 min•Ep. 562
The Autonomous CollecTWiVe reveal two effective treatments for Ebolavirus infection, how a virus in a fungus confers heat tolerance to a plant, and dampened inflammation as a mechanism for bat tolerance to viral infection. Hosts: Vincent Racaniello , Alan Dove , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Two new and effective Ebolavirus treatments ( NIH , Nature ) A virus in a fungus in a plant (Science) Dampened NL...
Aug 18, 2019•1 hr 33 min•Ep. 561
From the meeting of the Centers of Excellence for Influenza Research and Surveillance, Vincent speaks with Alan, Florian and Jennifer about their careers, the purpose of CEIRS, universal influenza vaccines, and cellular responses to infection in pediatric populations. Host: Vincent Racaniello Guests: Alan Embry , Florian Krammer , and Jennifer Nayak Become a patron of TWiV! Links for this episode NIAID CEIRS 12th CEIRS meeting summary ( pdf ) Antibody response to influenza virus (Nat Rev Micro) ...
Aug 11, 2019•1 hr 1 min•Ep. 560
The complete TWiV team give a report on the Ebola virus outbreak in DRC, and reveal that cell surface nectin proteins cause the transfer of cytoplasmic cargo, including measles virus, between cells. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , Kathy Spindler , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Fire Alarm at ASV Ebola outbreak sitrep (WHO) Ebola outbreak dashboard (WHO) Ebola ou...
Aug 04, 2019•1 hr 48 min•Ep. 559
From ASV 2019 at the University of Minnesota, TWiV explores the origins of the American Society for Virology with Sid Grossberg and Pat Spear. Hosts: Vincent Racaniello , Rich Condit , Kathy Spindler , and Brianne Barker Guests: Sid Grossberg and Pat Spear Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode American Society for Virology Bill Joklik, 92 How ASV was founded (Virology) Signatures at the Chicago meeting ( page one , page two ) Tim...
Jul 28, 2019•1 hr 1 min•Ep. 558
From the European Congress of Virology in Rotterdam, Vincent and local co-host Ben Berkhout speak with Ron Fouchier, Rosina Girones, and Marie-Paule Kieny about their careers and their work on influenza virus, environmental virology, and developing an Ebola virus vaccine during an epidemic. Hosts: Vincent Racaniello and Ben Berkhout Guests: Ron Fouchier , Rosina Girones , and Marie-Paule Kieny Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episod...
Jul 21, 2019•1 hr 7 min•Ep. 557
TWiV minus one reveals delayed neurological deficits in children without microcephaly born to Zika virus infected mothers, and N-glycolyl-neuraminic acid as a receptor for influenza A viruses. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Kathy Spindler , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Deficits in children born to Zika virus infected mothers (Nat Med) Zika virus is still a threat (NY Times...
Jul 14, 2019•1 hr 43 min•Ep. 556
From ASM Microbe 2019, Vincent, Brianne and Calvin meet up with Craig Cameron to discuss his career and his work exploring RNA-dependent RNA synthesis and single cell virology. Hosts: Vincent Racaniello , Brianne Barker , and Calvin Yeager Guest: Craig Cameron Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Cameron laboratory Curioscity podcast Ribavirin is an RNA virus mutagen (Nat Med) RNA virus error catastrophe: test using ribavirin (P...
Jul 07, 2019•1 hr 16 min•Ep. 555
A trio TWiVers reports on influenza in Australia, how a host protein impacts bird to human movement of influenza virus, and marine DNA viral diversity in the oceans from pole to pole. Hosts: Vincent Racaniello , Kathy Spindler , and Alan Dove Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Australian Influenza Surveillance Real-time tracking of influenza H3N2 ANP32B , or not to be (eLife) ANP32B on TWiV 377 Species specific differences in ...
Jun 30, 2019•1 hr 19 min•Ep. 554
Vincent speaks with David Oshinsky, the Pulitzer Prize-winning author of Polio: An American Story , about the history of poliovirus vaccines. Host: Vincent Racaniello Guest: David Oshinsky Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Intro music is by Ronald Jenkees . Send your virology questions and comments to twiv@microbe.tv...
Jun 23, 2019•1 hr 6 min•Ep. 553
Team TWiV reveals DNA polymerases that do not require a primer, and packaging of hepatitis delta virus by the envelope glycoproteins of diverse viruses. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Brianne Barker Guest: Kiki Warren Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Bacteriophage DNA polymerase is primer-independent (PNAS) Primer-independent DNA polymerase from mobile elements (Cell Rep) Non-H...
Jun 16, 2019•1 hr 56 min•Ep. 552
At Retroviruses 2019 in Cold Spring Harbor, Vincent speaks with virologist Bryan Cullen about his work and his career, together with former associates Ann Skalka, Paul Bieniasz, and Michael Malim. Host: Vincent Racaniello Guests: Bryan Cullen , Paul Bieniasz , Michael Malim , and Ann Skalka Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Intro music is by Ronald Jenkees . Send your virology questions and comments to twiv@microbe.tv...
Jun 09, 2019•1 hr
TWiV explains the use of a neuronal cell line to study herpes simplex virus latency and reactivation, and a strategy for creating vaccines that induce antibodies against specific epitopes. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Neuronal cell line supports herpes simplex virus latency (J Virol) Protect, modify, deprotect (PNAS) Timestamps ...
Jun 02, 2019•1 hr 45 min•Ep. 550
Kartik and Rohit join the TWiV team to present their identification of protocadherin-1 as a cell receptor for New World hantaviruses. Hosts: Vincent Racaniello , Alan Dove , Rich Condit , and Kathy Spindler Guests: Kartik Chandran and Rohit Jangra Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Einstein goes viral ( TWiV 314 ) Michael Rossmann , 88 (virology blog) Protocadherin-1 essential for New World hantavirus entry (Nature) Image cred...
May 26, 2019•1 hr 43 min•Ep. 549
Vincent travels to the European Congress of Virology in Rotterdam and with local co-host Marion Koopmans speak with Martin Beer, Stephan Gunther, and Vera Ross about their careers and their work on Lassa virus, Borna virus, and insect viruses. Hosts: Vincent Racaniello and Marion Koopmans Guests: Martin Beer , Stephan Gunther , and Vera Ros Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode ECV2019 Partnerships not parachutes ( TWiV 413 ) Fat...
May 19, 2019•1 hr 12 min•Ep. 548
Vincent travels to the University at Albany to speak with Cara, Rachel, and Alex about their careers and their work on stress granules, epitranscriptomics, and arboviruses. Host: Vincent Racaniello Guests: Cara Pager , Rachel Netzband , and Alex Ciota Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Five postdocs in North America ( TWiV 194 ) Zika virus subverts stress granules (J Virol) DDX68 modulates miR-122 interaction with HCV RNA (Vir...
May 12, 2019•1 hr 36 min•Ep. 547
The un-encapsidated TWiV Humans discuss finding hepatitis D virus-related sequences in birds and snakes, and fatal swine acute diarrhoea syndrome caused by a coronavirus of bat origin. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode European Virus Archive ASV early bird registration ends 15 May FDA approves Dengvaxia Divergent hepatitis D-like age...
May 05, 2019•2 hr 2 min•Ep. 546
Jens Kuhn returns to TWiV to explain Select Agents, Priority Pathogens, Australia List Pathogens, Risk Group Agents, biosafety, biosecurity, and biosurety. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , and Brianne Barker Guest: Jens Kuhn Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Bioweapon (TWiV 508) Bioterrorism and Biocrimes by W. Seth Carus Select Agents (selectagents.gov) BMBL Manual 5th Edition (pdf) Threading the ...
Apr 28, 2019•1 hr 44 min•Ep. 545
The TWiV team reveals the repertoire of anti-viral antibodies in newborn humans, and a complement protein that binds the adenovirus capsid and prevents release of the viral DNA. Hosts: Vincent Racaniello , Rich Condit , Kathy Spindler , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Maternal anti-viral antibodies in newborns (Nat Med) Complement protein blocks adenovirus uncoating (Cell Host Micr) Antibodies neutralize ...
Apr 21, 2019•1 hr 48 min•Ep. 544
The TWiV team discusses Medusavirus, isolated from a hot spring in Japan, and induction of neurodegeneration by recurrent herpes simplex virus 1 infection of mice. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , Kathy Spindler , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Medusavirus (J Virol) Recurrent herpes simplex virus-1 and Alzheimer's (PLoS Path) Image credit Letters read on TWiV 543...
Apr 14, 2019•1 hr 48 min•Ep. 543
Vincent travels to Microbiotix, Inc, a biopharmaceutical company in Worcester, MA to speak with four members of the company about their discovery and development of small molecule drugs that target serious infectious diseases. Host: Vincent Racaniello Guests: Terry Bowlin, Zach Aron, Grace Lui, and Islam Hussein Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Microbiotix, Inc. MBX-400 Microbiotix pipeline Microbiotix publications Timestamp...
Apr 07, 2019•1 hr 5 min•Ep. 542
The TWiVers present mitoviruses, which infect mitochondria, and how quasi-enveloped hepatitis A virus gets naked again. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , and Kathy Spindler Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Evidence for plant mitoviruses (Virology) Uncoating of quasi-enveloped HAV (eLife) Image credit Letters read on TWiV 541 Timestamps by Jolene . Thanks! Weekly Science Picks Alan- Where and when t...
Mar 31, 2019•1 hr 29 min•Ep. 541
The TWiVstars reveal the diversity of herpes simplex virus type 2 in a neonatal population, and parallel adaptation of rabbits in three countries to myxoma virus. Hosts: Vincent Racaniello , Dickson Despommier , Rich Condit , Alan Dove , and Kathy Spindler Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Diversity of HSV2 in neonates (mSphere) Adaptation of rabbits to myxoma virus (Science) Principal component analysis (YouTube) Image credi...
Mar 24, 2019•1 hr 49 min•Ep. 540
The TWiV hosts present two potentially seminal papers, on long-distance chemoattraction of a host by a chlorovirus, and replication of a nanovirus across multiple cells in a plant. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Kathy Spindler , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Paul Has Measles now in German (virology blog) Chloroviruses lure hosts (J Virol) Multicellular replication in plants...
Mar 17, 2019•1 hr 42 min•Ep. 539
TWiV travels to the University of Iowa to speak with Wendy Maury and Stanley Perlman about their research on Ebolavirus entry and coronavirus pathogenesis. Hosts: Vincent Racaniello , Rich Condit , and Kathy Spindler Guests: Wendy Maury and Stanley Perlman Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode TIM-1 is receptor for Ebolaviruses (Proc Natl Acad Sci) TIM-1 is receptor for Lassa virus (J Virol) SARS coronavirus causes neuronal death...
Mar 10, 2019•1 hr 2 min•Ep. 538
