Daniel Griffin joins Ori and the TWiV team an update on the SARS-CoV-2 pandemic, including gastrointestinal illness associated with infection, use of hydroxychloroquine and other antivirals, his experiences treating many patients in the New York area, and much more. Hosts: Vincent Racaniello, Dickson Despommier , Alan Dove , Rich Condit , Kathy Spindler , and Brianne Barker Guests: Daniel Griffin , Ori Lieberman , and Valeria Cagno Subscribe (free): iTunes , Google Podcasts , RSS , email Become ...
Mar 22, 2020•2 hr 19 min•Ep. 593
Ori joins TWiV for an update on the SARS-CoV-2 pandemic, including scary modeling, clinical trials for antivirals and vaccines, asymptomatic transmission, and much more inspired by listener email. Hosts: Vincent Racaniello, Alan Dove , and Rich Condit Guest: Ori Lieberman Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Scary modeling (Imperial College London) Avigan vs SARS-CoV-2 (NHK) SARS-CoV-2 mRNA vaccine (Clinical Trials) SARS-CoV-2 s...
Mar 19, 2020•1 hr 54 min•Ep. 592
Epidemiologist Stephen Morse joins Vincent to discuss epidemiology of SARS-CoV-2 and preparedness for the COVID-19 pandemic. Hosts: Vincent Racaniello Guest: Stephen Morse Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Intro music is by Ronald Jenkees . Send your virology questions and comments to twiv@microbe.tv...
Mar 18, 2020•1 hr 1 min
Ori Lieberman joins Vincent to discuss COVID-19, the disease caused by SARS-CoV-2, gleaned from his experience during clinical rotations in medical school. Hosts: Vincent Racaniello Guest: Ori Lieberman Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Intro music is by Ronald Jenkees . Send your virology questions and comments to twiv@microbe.tv...
Mar 17, 2020•49 min
Ralph Baric joins TWiV to dissect the coronavirus pandemic caused by SARS-CoV-2, including discussion on community spread, asymptomatic infections, origin of the virus, transmission, vaccine development, and much more. Hosts: Vincent Racaniello, Dickson Despommier , Alan Dove , Rich Condit , and Brianne Barker Guest: Ralph Baric Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Aerosol and surface stability of SARS-CoV-2 (medRxiv) Clinical c...
Mar 15, 2020•2 hr 3 min•Ep. 591
The TWiV trio continues in-depth coverage of COVID-19 and SARS-CoV-2, including discussion on genome mutation and circulating lineages, handwashing, facemasks, cruise ship outbreaks, the South Korean situation, and much more. Hosts: Vincent Racaniello, Rich Condit , and Kathy Spindler Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Stanley Perlman answers CoV questions (Boston Globe) Fist bump (Am J Infect Control) Joint WHO-China report (...
Mar 08, 2020•2 hr 7 min•Ep. 590
Infectious disease physician Daniel Griffin and virologist Valeria Cagno join Vincent to provide updates on the situation with SARS-CoV-2 and COVID-19 in New York and Italy. Host: Vincent Racaniello Guests: Daniel Griffin and Valeria Cagno Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Intro music is by Ronald Jenkees . Send your virology questions and comments to twiv@microbe.tv...
Mar 05, 2020•58 min
Vincent and Rich update the current situation with COVID-19 and SARS-CoV-2, including fatality ratios, virus spreading outside of China, immunity to infection, vaccines, antivirals and much more. Hosts: Vincent Racaniello and Rich Condit Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode WHO CoV sitreps How to Prepare for the Coronavirus (NY Times) Multiple shedding routes of SARS-CoV-2 (Emerg Microbes Inf) Cruise ship a/c could promote virus...
Mar 01, 2020•1 hr 24 min•Ep. 589
The TWiV team returns this week to SARS-CoV-2019 coverage to review the latest epi curves, the fatality rate, furin cleavage site and receptor binding domain in the spike glycoprotein, related CoV recovered from pangolins, evidence that the virus did not escape from a laboratory, and many more questions sent in by listeners. Hosts: Vincent Racaniello , Dickson Despommier , Rich Condit , and Kathy Spindler Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for...
Feb 23, 2020•2 hr 31 min•Ep. 588
Vincent and Rich return to the University of Texas Medical Branch at Galveston to speak with Dennis Bente, Shannan Rossi, Nikos Vasilakis, and Scott Weaver about their work on viruses transmitted by mosquitoes and ticks. Hosts: Vincent Racaniello and Rich Condit Guests: Dennis Bente , Shannan Rossi , Nikos Vasilakis , and Scott Weaver Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Measles virus vectored chikungunya vaccine (J Inf Dis) Wor...
Feb 16, 2020•2 hr 6 min•Ep. 587
In this week's coverage of the coronavirus epidemic, the TWiV team discusses the fatality rate, China's initial reaction to the outbreak, conspiracy theories, how long the virus remains infectious on surfaces, and evidence for virus in the intestinal tract. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Brianne Download TWiV 586 (72 MB .mp3, 119 min) Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode China reac...
Feb 09, 2020•1 hr 59 min•Ep. 586
The TWiVerers continue their coverage of the new coronavirus outbreak in China, as the number of cases increase dramatically and the virus begins person-to-person transmission in other countries. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , Kathy Spindler , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode ASV 2020 Real time tracking of 2019-nCoV (JHU) Estimation of 2019-nCoV R0 (Int J Inf Dis...
Feb 02, 2020•1 hr 58 min•Ep. 585
Coronavirus expert Ralph Baric joins TWiV to explain the virology and epidemiology of the recent zoonotic outbreak spreading across China and overseas. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , Kathy Spindler Guest: Ralph Baric Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode ASV 2020 WHO coronavirus sitreps CIDRAP article on coronavirus vaccines Phylogenetic analysis of 2019-nCoV ACE2 is 2019-nCoV receptor ...
Jan 26, 2020•1 hr 46 min•Ep. 584
Vincent and Rich travel to Galveston National Laboratory to speak with Jim LeDuc, Tom Ksiazek, and Bob Tesch about their long careers as virus hunters. Hosts: Vincent Racaniello and Rich Condit Guests: Jim LeDuc , Tom Ksiazek , and Bob Tesh Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Intro music is by Ronald Jenkees . Send your virology questions and comments to twiv@microbe.tv...
Jan 19, 2020•1 hr 24 min•Ep. 583
TWiV provides updates on the new coronavirus causing respiratory disease in China, the current influenza season, and the epidemic of African swine fever, including determination of the three-dimensional structure of the virus particle. Hosts: Vincent Racaniello , Dickson Despommier , Rich Condit , Kathy Spindler , and Brianne Barker Download TWiV 582 (71 MB .mp3, 118 min) Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode ASV 2020 NJ ready to...
Jan 12, 2020•1 hr 58 min•Ep. 582
For the first TWiV of 2020 we reveal that microbiome depletion with antibiotics alters the immune response to influenza vaccine, and how successive blood meals facilitate virus dissemination in mosquitoes and transmission potential. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Kathy Spindler , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode ASV 2020 Vaccines are safe and effective (Science) Microbiome per...
Jan 05, 2020•1 hr 31 min•Ep. 581
From the University of Texas at Austin, Vincent and Rich speak with Chris Sullivan about his work on miRNAs encoded in the genomes of polyomaviruses and papillomaviruses, and how an RNA triphosphatase restricts hepatitis C virus replication. Hosts: Vincent Racaniello and Rich Condit Guest: Chris Sullivan Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Sullivan lab Virus-encoded miRNAs in papillomaviruses (PLoS Path) Murine polyomavirus miR...
Dec 29, 2019•1 hr 36 min•Ep. 580
Vincent speaks with virologists at the University of Nevada at Reno about their careers and their work on herpesviruses, arboviruses, and the development of diagnostics for infectious diseases. Host: Vincent Racaniello Guests: Dave AuCoin , Cyprian Rossetto , Claudia Rückert , and Subhash Verma Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode PAN's labyrinth (Viruses) KSHV SOX protein DNAse activity (J Virol) Vertical flow immunoassay for p...
Dec 22, 2019•1 hr 41 min•Ep. 579
Vincent speaks with members of Prometheus, a team of academic and industrial scientists assembled to develop antibody-based therapeutics against infections caused by tick-borne Crimean-Congo hemorrhagic fever virus and rodent-borne hantaviruses, for which no approved vaccines or specific drugs are available. Host: Vincent Racaniello Guests: Kartik Chandran , Zachary Bornholdt , Steven Bradfute , John Dye , Matthias Forsell , Jason McLellan , Laura Walker , and Cecelia Vial . Subscribe (free): iT...
Dec 15, 2019•1 hr 31 min•Ep. 578
Vincent speaks with Félix Rey about his career and his work on solving structures of a variety of viruses and the insights learned about viral membrane fusion and antibody-mediated neutralization. Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Unité de Virologie Structurale Tick-borne encephalitis glycoprotein structure (Nature) HCV RNA polymerase structure (PNAS) Flavivirus structural heterogeneity (Curr Op Viral) Antibody responses to f...
Dec 08, 2019•1 hr 15 min•Ep. 577
From the 22nd meeting of the European Society for Clinical Virology in Copenhagen, Vincent speaks with Thea, Heli, Kim, Caroline and Irma about big data and its increasing use in virology diagnostics, epidemiology, and public health. Host: Vincent Racaniello Guests: Thea Kølsen Fischer , Kim Benschop , Caroline Brown , Heli Harvala , and Irma Salimovic-Besic Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode 22nd ESCV meeting Timestamps by Jo...
Dec 01, 2019•55 min•Ep. 576
From the Fourth Symposium on Giant Virus Biology in Germany, Vincent, Rich, and Nels speak with Assaf, Stephen, and Alexandra about their careers and their work on giant viruses that infect ocean hosts: Emiliana huxleyi , Aureococcus anophagefferans , and a choanoflagellate. Hosts: Vincent Racaniello , Rich Condit , and Nels Elde Guests: Assaf Vardi , Stephen Wilhelm , and Alexandra Worden Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode 4t...
Nov 24, 2019•2 hr 1 min•Ep. 575
From Georgia State, Vincent speaks with economics professor Paula Stephan about the ways science is supported in the US, how universities offload risks, the absence of risk-taking, and much more. Hosts: Vincent Racaniello Guest: Paula Stephan Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode How Economics Shapes Science Coalition for Next Generation Life Science Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees . Send your viro...
Nov 17, 2019•1 hr 11 min•Ep. 574
William Summers joins the TWiV team to discuss some virology history, including the ever-changing concept of 'virus' and the contribution of phage research to the study of animal viruses. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , and Rich Condit Guest: William Summers Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Bill's ASV 2019 talk ( PPT download ) Inventing viruses (Ann Rev Virol) Timestamps by Jolene . Thanks! Week...
Nov 10, 2019•1 hr 53 min•Ep. 573
Amy joins the TWiV team to review evidence that enterovirus D68 is an etiologic agent of childhood paralysis, and her finding that the ability of the virus to infect cells of the nervous system is not a recently acquired property. Hosts: Vincent Racaniello , Dickson Despommier , Rich Condit , and Kathy Spindler Guest: Amy Rosenfeld Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode EV-D68 antibodies in humans before 2014 outbreak (Emerg Inf D...
Nov 03, 2019•2 hr 1 min•Ep. 572
The League of Extraordinary Virologists celebrate the eradication of wild poliovirus type 3, and consider the effectiveness of an influenza vaccine produced in insect cells, and how small RNAs are protecting the Koala germline from retroviral invasion. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Kathy Spindler , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Flublok (CDC) Adjuvant study of flu vaccines ...
Oct 27, 2019•1 hr 45 min•Ep. 571
At Aarhus University in Denmark, Vincent speaks with Trine Mogensen, Søren Paludan, Ole Søgaard, and Madalina Carter-Timofte about their careers and their work on sensing herpesviral DNA, immunodeficiencies that predispose to severe viral infections, and the path to a cure for HIV/AIDS. Hosts: Vincent Racaniello Guests: Trine Mogensen , Søren Paludan , Ole Søgaard , and Madalina Carter-Timofte Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episod...
Oct 20, 2019•1 hr 41 min•Ep. 570
The TWiV pro-vaxxers reveal viruses that infect endangered wild salmon, and how iron in host serum modulates dengue virus acquisition by mosquitoes. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode New viruses that infect endangered wild salmon (eLife) Host serum iron modulates dengue virus acquisition by mosquitoes (Nat Micro) Image credit Letters read on TWiV ...
Oct 13, 2019•1 hr 50 min•Ep. 569
In the second episode from the Karolinska Institute in Stockholm, Vincent speaks with Jan Albert, Petter Brodin, and Anna Smed-Sörensen about their work on enterovirus D68, systems immunology, and human pulmonary viral infection and inflammation. Hosts: Vincent Racaniello Guests: Jan Albert , Petter Brodin , and Anna Smed-Sörensen Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Karolinska Huddinge Evolution of enterovirus D68 (Virus Evol) ...
Oct 06, 2019•1 hr 35 min•Ep. 568
The TWiV team covers outbreaks of eastern equine encephalitis virus in the US and poliovirus in the Philippines, and explain how a chemokine induced by HIV-1 infection helps release more virus particles from cells. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , Kathy Spindler , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Poliomyelitis returns to the Philippines ( Mashable , virology blog )...
Sep 29, 2019•1 hr 52 min•Ep. 567
