The TWiVians present an imported case of yellow fever in New York City, and explain how a dengue virus subgenomic RNA disrupts immunity in mosquito salivary glands to increase virus replication. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler Become a patron of TWiV! Links for this episode ASM Conference on Viral Manipulation of Nuclear Processes Roger W. Hendrix, 74 (Pittsburgh Post-Gazette) Roger Hendrix video on TWiV #135 Yellow fever in traveler ...
Sep 09, 2017•1 hr 59 min•Ep. 458
Brianne returns to the TWiV Gang to discuss the distribution of proteins on the influenza viral genome, and the evolution of myxoma virus that was released in Australia to control the rabbit population. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , and Rich Condit Guest: Brianne Barker Become a patron of TWiV! Links for this episode First genetically engineered salmon sold in Canada Nucleoprotein on influenza virus RNA (Nucl Acids Res) Evolution of released myxoma virus in Austral...
Sep 03, 2017•2 hr 3 min•Ep. 457
Brianne joins the TWiVMasters to explain how mutations in genes encoding RNA polymerase III predispose children to severe varicella, and detection of an RNA virus by a DNA sensor. Hosts: Vincent Racaniello and Rich Condit Guest: Brianne Barker Become a patron of TWiV! Links for this episode RNA pol III mutations underlie severe varicella (J Clin Inves) Dengue virus activates cGAS by release of mitochondrial DNA (Sci Rep) Dengue virus NS2B protein targets cGAS for degradation (Nat Micr) Image cre...
Aug 26, 2017•2 hr 4 min•Ep. 456
Erin joins the TWiVirions to discuss a computer exploit encoded in DNA, creation of pigs free of endogenous retroviruses, and mutations in the gene encoding an innate sensor of RNA in children with severe viral respiratory disease. Hosts: Vincent Racaniello , Alan Dove , Rich Condit , and Kathy Spindler Guest: Erin Garcia Become a patron of TWiV! Links for this episode DNA-based computer exploit (pdf) Inactivation of porcine endogenous retrovirus in pigs (Science) Severe viral respiratory infect...
Aug 20, 2017•1 hr 45 min•Ep. 455
Sharon and Scott return to TWiV for a Zika virus update, including their work on viral evolution and spread, and whether pre-existing immunity to dengue virus enhances pathogenesis. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , and Kathy Spindler Guests: Sharon Isern and Scott Michael Become a patron of TWiV! Links for this episode Hurricane Zika ( TWiV 410 ) 454 Corporation (Wikipedia) Regional Zika update, Americas (PAHO, WHO) Zika virus serum bank (pdf) Zika virus evolution and...
Aug 13, 2017•1 hr 48 min•Ep. 454
From the Vector-Borne Viruses Symposium in Hamilton, Montana, Dickson and Vincent speak with Diane Griffin about her career and her work on understanding viral infections of the central nervous system. Hosts: Vincent Racaniello and Dickson Despommier Guest: Diane Griffin Become a patron of TWiV! Links for this episode Vector-Borne Viruses Symposium Diane Griffin Adoptive immunization of immunosuppressed mice infected with Sindbis virus Role of the immune response in age-dependent resistance of m...
Aug 06, 2017•1 hr 4 min•Ep. 453
Lynda Coughlan joins the weekly virtual bus companions for a discussion of a host defense peptide from frogs that destroys influenza virus, and mouse models for acute and chronic hepacivirus infection. Hosts: Vincent Racaniello , Alan Dove , and Kathy Spindler Guest: Lynda Coughlan Become a patron of TWiV! Links for this episode Linda on Virus Watch and BSGCT Anti-influenza peptide from frogs (Immunity) Magainins (Wikipedia) Urumi Kathy's defensin paper (PLoS Path) World Hepatitis Day Mouse mode...
Jul 29, 2017•1 hr 53 min
The TWiV scientists reveal that mosquitoes transmit different West Nile virus populations with each blood meal, only to have the diversity purged in a bird host. Hosts: Vincent Racaniello , Alan Dove , Rich Condit , and Kathy Spindler Become a patron of TWiV! Links for this episode Driving past a milestone ( TWiP 100 ) Debug Fresno (Verily blog) What could possibly go wrong? ( TWiV 388 ) Chestnut blight (ProMedMail) Hypovirus molecular biology (Adv Virus Res) Mosquitoes transmit unique WNV popul...
Jul 23, 2017•1 hr 44 min
Ben tenOever joins the TWiVoli to discuss the evolution of RNA interference and his lab's finding that RNAse III nucleases, needed for the maturation of cellular RNAs, are an ancient antiviral RNA recognition platform in all domains of life. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler Guest: Ben tenOever Become a patron of TWiV! Links for this episode RNAseIII is an ancient antiviral effector (Nature) Influenza suppression of RNAi (PNAS) Question...
Jul 16, 2017•1 hr 36 min
The TWiV Council explores the finding that facial appearance affects science communication, and evidence that RNA interference confers antiviral immunity in mammalian cells. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , and Kathy Spindler Become a patron of TWiV! Links for this episode JMBE SciComm Issue Facial appearance affects science communication (PNAS) Your face matters to science (virology blog) RNA based antiviral immunity in mammals (Immunity) How mice say nodavirus ( TWi...
Jul 09, 2017•1 hr 42 min
From ASV 2017 in Madison, Wisconsin, the complete TWiV team speaks with Mavis Agbandje-McKenna about her career and her work solving virus structures by x-ray crystallography and cryo-electron microscopy. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler Guest: Mavis Agbandje-McKenna Become a patron of TWiV! This episode of TWiV is sponsored by Promega Corporation. Promega is a leader in providing innovative solutions and technical support to the life ...
Jul 02, 2017•1 hr 7 min
The glorious TWiVerati un-impact their email backlog, anwering questions about viruses, viruses, viruses, viruses, viruses, and more. You should listen - our fans ask great questions! Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler Become a patron of TWiV! Links for this episode JMBE SciComm Issue Female role models in engineering (PNAS) Gender equity at ASM meeting (mBio) Invisible Frontiers Time, Love, Memory The Eighth Day of Creation Predatory jo...
Jun 24, 2017•1 hr 50 min
The TWiV hosts review an analysis of gender parity trends at virology conferences, and the origin and unusual pathogenesis of the 1918 pandemic H1N1 influenza virus. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler Become a patron of TWiV! Links for this episode ASM grant writing online course Gender parity trends at virology meetings (J Virol) Professor gender perpetuates gender gap (NBER) Next generation researchers initiative (NIH) NIH abandons gra...
Jun 17, 2017•1 hr 52 min
From Nido2017 in Kansas City, Vincent meets up with three virologists to talk about their careers and their work on nidoviruses. Host: Vincent Racaniello Guests: Margo Brinton , Luis Enjuanes , and Linda Saif Become a patron of TWiV! Links for this episode Murine flavivirus resistance gene (PNAS) TIA-1/TIAR binding sites in West Nile virus RNA (J Virol) Infectious coronavirus DNA in BAC (PNAS) Norovirus binding to lettuce (Appl Env Micro) This episode is brought to you by Blue Apron. Blue Apron ...
Jun 11, 2017•1 hr 4 min
From ASM Microbe 2017 at New Orleans, Vincent and Rich meet up with astronaut Kate Rubins to talk about becoming an astronaut, space travel, and doing science in space. Hosts: Vincent Racaniello and Rich Condit Guest: Kate Rubins Become a patron of TWiV! Links for this episode Live from the Space Station, NASA Astronaut Kate Rubins Kate Rubins ( NASA , Wikipedia ) Expedition 48-49 launches to the ISS Expedition 48-49 Crew Docks to the Space Station Expedition 48-49 Crew Welcomed to the Space Sta...
Jun 04, 2017•1 hr 11 min
David Tuller returns to discuss the continuing saga of the UK's PACE trial for chronic fatigue syndrome, including the accusation that he is engaging in libelous blogging. Host: Vincent Racaniello Guest: David Tuller Become a patron of TWiV! Links for this episode TWiV 397: Trial by Error All articles by David Tuller at virology blog Getting it wrong on chronic fatigue syndrome (NY Times) Esther Crawley slide (Twitter) David's fundraising page Intro music is by Ronald Jenkees . Send your virolog...
May 31, 2017•50 min
The TWiVsters reveal the puppet master: an RNA virus injected with wasp eggs that paralyzes the ladybug so that she protects the cocoon until the adult emerges. Hosts: Vincent Racaniello , Alan Dove , Rich Condit , and Kathy Spindler Become a patron of TWiV! Links for this episode ASM grant writing online course Who is the puppet master ? (Proc Roy Soc B) Why ladybird ? Ladybird ladybird Dinocampus coccinellae Image credit Letters read on TWiV 443 Weekly Science Picks Kathy - Science Showcase Vi...
May 28, 2017•1 hr 48 min
Freelance science journalist Tim Requarth joins the TWiVers to explain why scientists should stop thinking that explaining science will fix information illiteracy. Hosts: Vincent Racaniello , Alan Dove , Rich Condit , and Kathy Spindler Guest: Tim Requarth Become a patron of TWiV! Links for this episode Neuwrite JMBE science communication issue Smallpox vaccination day The problem with facts (Fin Times) Countering antivaccination attitudes (PNAS) Effective messages in vaccine promotion (Pediatri...
May 21, 2017•1 hr 56 min
The Beacons of Viral Education (aka the TWiVoners) reveal a cost of being a male mouse - the Y chromosome regulates their susceptibility to influenza virus infection. Hosts: Vincent Racaniello , Alan Dove , Rich Condit , and Kathy Spindler Become a patron of TWiV! Links for this episode ASM Grant Writing Online Course Giant viruses not from fourth domain of life (Virology) Nuclear envelope disruption during parvovirus infection (J Virol) Nuclear deformation during SV40 infection (Nucleus) Y chro...
May 14, 2017•1 hr 59 min
No problem being nice to Dickson in this episode, because he's absent for a discussion of a new giant virus that replicates in the cytoplasm yet transiently accesses the nucleus to bootstrap infection. Hosts: Vincent Racaniello , Alan Dove , Rich Condit , and Kathy Spindler Become a patron of TWiV! Links for this episode ASM Microbe Noumeavirus cytoplasmic replication depends on transient nuclear access (Nat Commun) Giants among viruses ( TWiV 261 ) Image credit Letters read on TWiV 440 Weekly S...
May 07, 2017•1 hr 59 min
Paul Bieniasz joins the TWiV team to talk about the co-option, millions of years ago, of an endogenous retrovirus envelope protein by hominid ancestors for host defense against viral infection. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler Guest: Paul Bieniasz Become a patron of TWiV! Links for this episode ASM Grant Writing Online Course Bieniasz Laboratory Julius S. Youngner, 96 Distinguished virology career of Julius S. Youngner ( TWiV 373 ) Rec...
Apr 30, 2017•2 hr 2 min
On the eve of the March for Science, the TWiV team gathers at ASM Headquarters in Washington, DC with guests Stefano and Susie to talk about the state of science communication. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , and Rich Condit Guests: Stefano Bertuzzi and Susan Sharp Become a patron of TWiV! Links for this episode Journal of Microbiology & Biology Education sci comm issue ASM Cultures Stefano Bertuzzi and the scientists' big picture (Washington Post) March for Scie...
Apr 23, 2017•1 hr 43 min
The TWiVsters reveal new giant viruses that argue against a fourth domain of life, and discovery of viruses in the oceanic basement. Hosts: Vincent Racaniello , Dickson Despommier , Rich Condit , and Kathy Spindler Become a patron of TWiV! Links for this episode Journal of Microbiology & Biology Education sci comm issue Mark Wainberg dies Giant viruses with many translation system components (Science) Viruses in the oceanic basement (mBio) 2-back test Photo by Judy Letters read on TWiV 437 T...
Apr 16, 2017•1 hr 44 min
Host: Vincent Racaniello Guests: Susan Daniel , Colin Parrish , and Gary Whittaker At Cornell University in Ithaca, New York, Vincent speaks with Susan, Colin, and Gary about the work of their laboratories on parvoviruses, influenza viruses, and coronaviruses that infect dogs, cats, horses and other mammals. Become a patron of TWiV! Links for this episode Daniel Laboratory Parrish Laboratory Whittaker Laboratory This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient ...
Apr 09, 2017•1 hr 38 min
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler The TWiVome discuss the blood virome of 8,420 humans, and thoroughly geek out on a paper about the number of parental viruses in a plaque. Become a patron of TWiV! Links for this episode ASM Grant Writing Course Screwworm letters Blood DNA virome of 8,240 humans (PLoS Path) Plaque co-infection frequencies (mBio) Ode to a plaque ( TWiV 68 ) Counting viruses (Virus Watch) First animal virus plaque assay (...
Apr 02, 2017•2 hr 1 min
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , and Kathy Spindler The esteemed TWiVumvirate reveal the discovery of a new negative stranded RNA virus of wasps that regulates longevity and sex ratio of its parasitoid host. Become a patron of TWiV! Links for this episode ASM Microbe 2017 Parasitoid wasp virus regulates sex ratio (PLoS Path) What is a contig ? Image credit Letters read on TWiV 434 This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and ...
Mar 26, 2017•1 hr 46 min
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , and Kathy Spindler The lovely TWiV team explore evolution of our fecal virome, and the antiviral RNA interference response in the nematode C. elegans . Become a patron of TWiV! Links for this episode ASM Clinical Virology Symposium Evolution of the human fecal virome (PNAS) Antiviral RNAi response in C. elegans (Curr Biol) Orsay virus ( TWiV 123 ) Broad VSV host range (J Comp Neurol) Image credit Letters read on TWiV 433 This episode i...
Mar 18, 2017•1 hr 47 min
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , and Kathy Spindler The TWiVites discuss Zika virus seroprevalence in wild monkeys, Zika virus mRNA vaccines, and a gamete fusion protein inherited from viruses. Become a patron of TWiV! Links for this episode Nido2017 Meeting ASMCUE Seroprevalence of Zika virus in wild monkeys and baboons (mSphere) Zika virus mRNA vaccines ( paper one , paper two ) Gamete fusion protein is type II viral fusogen ( paper one , paper two ) Image credit Le...
Mar 12, 2017•1 hr 48 min
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler The TWiVirions reveal bacteriophage genes that control eukaryotic reproduction, and the biochemical basis for increased Ebolavirus glycoprotein activity during the recent outbreak. Become a patron of TWiV! Links for this episode Nido2017 Meeting ASM Microbe 2017 Mark Buller obituary RS virus pipeline ( pdf ) Prophage WO genes and cytoplasmic incompatibility (Nature) Vanderbilt Virology ( TWiV 332 ) Basi...
Mar 05, 2017•1 hr 58 min
Hosts: Vincent Racaniello , Dickson Despommier , Rich Condit , and Kathy Spindler The TWiX cabal discuss sexual transmission of Zika virus in mice, and how immune escape enables herpes simplex virus escape from latency. Become a patron of TWiV! Links for this episode Nido2017 Meeting ASM Clinical Virology Symposium Zika virus sexual transmission in mice (Cell Rep) Viral RNA is not infectious virus (virology blog) Methyl-phospho switch (TWiV 369) Immune escape of herpesvirus from latency (Cell Re...
Feb 26, 2017•1 hr 44 min
