The TWiV scientists reveal that mosquitoes transmit different West Nile virus populations with each blood meal, only to have the diversity purged in a bird host. Hosts: Vincent Racaniello , Alan Dove , Rich Condit , and Kathy Spindler Become a patron of TWiV! Links for this episode Driving past a milestone ( TWiP 100 ) Debug Fresno (Verily blog) What could possibly go wrong? ( TWiV 388 ) Chestnut blight (ProMedMail) Hypovirus molecular biology (Adv Virus Res) Mosquitoes transmit unique WNV popul...
Jul 23, 2017•1 hr 44 min
Ben tenOever joins the TWiVoli to discuss the evolution of RNA interference and his lab's finding that RNAse III nucleases, needed for the maturation of cellular RNAs, are an ancient antiviral RNA recognition platform in all domains of life. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler Guest: Ben tenOever Become a patron of TWiV! Links for this episode RNAseIII is an ancient antiviral effector (Nature) Influenza suppression of RNAi (PNAS) Question...
Jul 16, 2017•1 hr 36 min
The TWiV Council explores the finding that facial appearance affects science communication, and evidence that RNA interference confers antiviral immunity in mammalian cells. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , and Kathy Spindler Become a patron of TWiV! Links for this episode JMBE SciComm Issue Facial appearance affects science communication (PNAS) Your face matters to science (virology blog) RNA based antiviral immunity in mammals (Immunity) How mice say nodavirus ( TWi...
Jul 09, 2017•1 hr 42 min
From ASV 2017 in Madison, Wisconsin, the complete TWiV team speaks with Mavis Agbandje-McKenna about her career and her work solving virus structures by x-ray crystallography and cryo-electron microscopy. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler Guest: Mavis Agbandje-McKenna Become a patron of TWiV! This episode of TWiV is sponsored by Promega Corporation. Promega is a leader in providing innovative solutions and technical support to the life ...
Jul 02, 2017•1 hr 7 min
The glorious TWiVerati un-impact their email backlog, anwering questions about viruses, viruses, viruses, viruses, viruses, and more. You should listen - our fans ask great questions! Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler Become a patron of TWiV! Links for this episode JMBE SciComm Issue Female role models in engineering (PNAS) Gender equity at ASM meeting (mBio) Invisible Frontiers Time, Love, Memory The Eighth Day of Creation Predatory jo...
Jun 24, 2017•1 hr 50 min
The TWiV hosts review an analysis of gender parity trends at virology conferences, and the origin and unusual pathogenesis of the 1918 pandemic H1N1 influenza virus. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler Become a patron of TWiV! Links for this episode ASM grant writing online course Gender parity trends at virology meetings (J Virol) Professor gender perpetuates gender gap (NBER) Next generation researchers initiative (NIH) NIH abandons gra...
Jun 17, 2017•1 hr 52 min
From Nido2017 in Kansas City, Vincent meets up with three virologists to talk about their careers and their work on nidoviruses. Host: Vincent Racaniello Guests: Margo Brinton , Luis Enjuanes , and Linda Saif Become a patron of TWiV! Links for this episode Murine flavivirus resistance gene (PNAS) TIA-1/TIAR binding sites in West Nile virus RNA (J Virol) Infectious coronavirus DNA in BAC (PNAS) Norovirus binding to lettuce (Appl Env Micro) This episode is brought to you by Blue Apron. Blue Apron ...
Jun 11, 2017•1 hr 4 min
From ASM Microbe 2017 at New Orleans, Vincent and Rich meet up with astronaut Kate Rubins to talk about becoming an astronaut, space travel, and doing science in space. Hosts: Vincent Racaniello and Rich Condit Guest: Kate Rubins Become a patron of TWiV! Links for this episode Live from the Space Station, NASA Astronaut Kate Rubins Kate Rubins ( NASA , Wikipedia ) Expedition 48-49 launches to the ISS Expedition 48-49 Crew Docks to the Space Station Expedition 48-49 Crew Welcomed to the Space Sta...
Jun 04, 2017•1 hr 11 min
David Tuller returns to discuss the continuing saga of the UK's PACE trial for chronic fatigue syndrome, including the accusation that he is engaging in libelous blogging. Host: Vincent Racaniello Guest: David Tuller Become a patron of TWiV! Links for this episode TWiV 397: Trial by Error All articles by David Tuller at virology blog Getting it wrong on chronic fatigue syndrome (NY Times) Esther Crawley slide (Twitter) David's fundraising page Intro music is by Ronald Jenkees . Send your virolog...
May 31, 2017•50 min
The TWiVsters reveal the puppet master: an RNA virus injected with wasp eggs that paralyzes the ladybug so that she protects the cocoon until the adult emerges. Hosts: Vincent Racaniello , Alan Dove , Rich Condit , and Kathy Spindler Become a patron of TWiV! Links for this episode ASM grant writing online course Who is the puppet master ? (Proc Roy Soc B) Why ladybird ? Ladybird ladybird Dinocampus coccinellae Image credit Letters read on TWiV 443 Weekly Science Picks Kathy - Science Showcase Vi...
May 28, 2017•1 hr 48 min
Freelance science journalist Tim Requarth joins the TWiVers to explain why scientists should stop thinking that explaining science will fix information illiteracy. Hosts: Vincent Racaniello , Alan Dove , Rich Condit , and Kathy Spindler Guest: Tim Requarth Become a patron of TWiV! Links for this episode Neuwrite JMBE science communication issue Smallpox vaccination day The problem with facts (Fin Times) Countering antivaccination attitudes (PNAS) Effective messages in vaccine promotion (Pediatri...
May 21, 2017•1 hr 56 min
The Beacons of Viral Education (aka the TWiVoners) reveal a cost of being a male mouse - the Y chromosome regulates their susceptibility to influenza virus infection. Hosts: Vincent Racaniello , Alan Dove , Rich Condit , and Kathy Spindler Become a patron of TWiV! Links for this episode ASM Grant Writing Online Course Giant viruses not from fourth domain of life (Virology) Nuclear envelope disruption during parvovirus infection (J Virol) Nuclear deformation during SV40 infection (Nucleus) Y chro...
May 14, 2017•1 hr 59 min
No problem being nice to Dickson in this episode, because he's absent for a discussion of a new giant virus that replicates in the cytoplasm yet transiently accesses the nucleus to bootstrap infection. Hosts: Vincent Racaniello , Alan Dove , Rich Condit , and Kathy Spindler Become a patron of TWiV! Links for this episode ASM Microbe Noumeavirus cytoplasmic replication depends on transient nuclear access (Nat Commun) Giants among viruses ( TWiV 261 ) Image credit Letters read on TWiV 440 Weekly S...
May 07, 2017•1 hr 59 min
Paul Bieniasz joins the TWiV team to talk about the co-option, millions of years ago, of an endogenous retrovirus envelope protein by hominid ancestors for host defense against viral infection. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler Guest: Paul Bieniasz Become a patron of TWiV! Links for this episode ASM Grant Writing Online Course Bieniasz Laboratory Julius S. Youngner, 96 Distinguished virology career of Julius S. Youngner ( TWiV 373 ) Rec...
Apr 30, 2017•2 hr 2 min
On the eve of the March for Science, the TWiV team gathers at ASM Headquarters in Washington, DC with guests Stefano and Susie to talk about the state of science communication. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , and Rich Condit Guests: Stefano Bertuzzi and Susan Sharp Become a patron of TWiV! Links for this episode Journal of Microbiology & Biology Education sci comm issue ASM Cultures Stefano Bertuzzi and the scientists' big picture (Washington Post) March for Scie...
Apr 23, 2017•1 hr 43 min
The TWiVsters reveal new giant viruses that argue against a fourth domain of life, and discovery of viruses in the oceanic basement. Hosts: Vincent Racaniello , Dickson Despommier , Rich Condit , and Kathy Spindler Become a patron of TWiV! Links for this episode Journal of Microbiology & Biology Education sci comm issue Mark Wainberg dies Giant viruses with many translation system components (Science) Viruses in the oceanic basement (mBio) 2-back test Photo by Judy Letters read on TWiV 437 T...
Apr 16, 2017•1 hr 44 min
Host: Vincent Racaniello Guests: Susan Daniel , Colin Parrish , and Gary Whittaker At Cornell University in Ithaca, New York, Vincent speaks with Susan, Colin, and Gary about the work of their laboratories on parvoviruses, influenza viruses, and coronaviruses that infect dogs, cats, horses and other mammals. Become a patron of TWiV! Links for this episode Daniel Laboratory Parrish Laboratory Whittaker Laboratory This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient ...
Apr 09, 2017•1 hr 38 min
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler The TWiVome discuss the blood virome of 8,420 humans, and thoroughly geek out on a paper about the number of parental viruses in a plaque. Become a patron of TWiV! Links for this episode ASM Grant Writing Course Screwworm letters Blood DNA virome of 8,240 humans (PLoS Path) Plaque co-infection frequencies (mBio) Ode to a plaque ( TWiV 68 ) Counting viruses (Virus Watch) First animal virus plaque assay (...
Apr 02, 2017•2 hr 1 min
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , and Kathy Spindler The esteemed TWiVumvirate reveal the discovery of a new negative stranded RNA virus of wasps that regulates longevity and sex ratio of its parasitoid host. Become a patron of TWiV! Links for this episode ASM Microbe 2017 Parasitoid wasp virus regulates sex ratio (PLoS Path) What is a contig ? Image credit Letters read on TWiV 434 This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and ...
Mar 26, 2017•1 hr 46 min
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , and Kathy Spindler The lovely TWiV team explore evolution of our fecal virome, and the antiviral RNA interference response in the nematode C. elegans . Become a patron of TWiV! Links for this episode ASM Clinical Virology Symposium Evolution of the human fecal virome (PNAS) Antiviral RNAi response in C. elegans (Curr Biol) Orsay virus ( TWiV 123 ) Broad VSV host range (J Comp Neurol) Image credit Letters read on TWiV 433 This episode i...
Mar 18, 2017•1 hr 47 min
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , and Kathy Spindler The TWiVites discuss Zika virus seroprevalence in wild monkeys, Zika virus mRNA vaccines, and a gamete fusion protein inherited from viruses. Become a patron of TWiV! Links for this episode Nido2017 Meeting ASMCUE Seroprevalence of Zika virus in wild monkeys and baboons (mSphere) Zika virus mRNA vaccines ( paper one , paper two ) Gamete fusion protein is type II viral fusogen ( paper one , paper two ) Image credit Le...
Mar 12, 2017•1 hr 48 min
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler The TWiVirions reveal bacteriophage genes that control eukaryotic reproduction, and the biochemical basis for increased Ebolavirus glycoprotein activity during the recent outbreak. Become a patron of TWiV! Links for this episode Nido2017 Meeting ASM Microbe 2017 Mark Buller obituary RS virus pipeline ( pdf ) Prophage WO genes and cytoplasmic incompatibility (Nature) Vanderbilt Virology ( TWiV 332 ) Basi...
Mar 05, 2017•1 hr 58 min
Hosts: Vincent Racaniello , Dickson Despommier , Rich Condit , and Kathy Spindler The TWiX cabal discuss sexual transmission of Zika virus in mice, and how immune escape enables herpes simplex virus escape from latency. Become a patron of TWiV! Links for this episode Nido2017 Meeting ASM Clinical Virology Symposium Zika virus sexual transmission in mice (Cell Rep) Viral RNA is not infectious virus (virology blog) Methyl-phospho switch (TWiV 369) Immune escape of herpesvirus from latency (Cell Re...
Feb 26, 2017•1 hr 44 min
Host: Vincent Racaniello Guests: Katie Antony, Tom Friedrich , Emma Mohr, and David O'Connor Vincent meets with members of team ZEST at the University of Wisconsin Madison to discuss their macaque model for Zika virus pathogenesis. Become a patron of TWiV! Links for this episode Badgers Go Viral ( TWiV 260 ) Rhesus macaque model of Zika virus infection (Nat Commun) Heterologous Zika virus protection in macaques (PLoS NTD) ZEST Data Portal This episode is brought to you by Blue Apron. Blue Apron ...
Feb 19, 2017•1 hr 21 min
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler The TWiVsters explain how superspreader bacteriophages release intact DNA from infected cells, and the role of astrocytes in protecting the cerebellum from virus infection. Become a patron of TWiV! Links for this episode Nido2017 Meeting Superspreader bacteriophages (mBio) Astrocytes , interferon, and viral infection (JCI) Viral disruption of blood brain barrier (Trends Micro) On Warts by Lewis Thomas (...
Feb 12, 2017•1 hr 48 min
Host: Vincent Racaniello Guest: Vincent Munster At the Rocky Mountain Laboratory in Hamilton, Montana, Vincent speaks with Vincent Munster about the work of his laboratory on MERS-coronavirus and Ebolaviruses. Become a patron of TWiV! Links for this episode Rocky Mountain Laboratory Munster Laboratory Small town, big science ( TWiM 140 ) Image credit Send your virology questions and comments to twiv@microbe.tv...
Feb 08, 2017•56 min
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , and Kathy Spindler The TWiVoids discuss the March for Science, the GOF moratorium, and a classic virology paper on mapping the gene order for vesicular stomatitis virus. Become a patron of TWiV! Links for this episode ASM 2017 election is now open - VOTE HERE ASM Election questions: Which positions are we voting for? What is the ASM Board of Directors? Organization Chart What is the Council on Microbial Sciences? Organization Chart FAQ...
Feb 05, 2017•1 hr 38 min
Hosts: Vincent Racaniello , Alan Dove , Rich Condit , and Kathy Spindler The sages of TWiV explain how chronic wasting disease of cervids could be caused by spontaneous misfolding of prion protein, and the role of the membrane protein Axl in Zika virus entry into cells. Become a patron of TWiV! Links for this episode Register for ASV 2017 ASM 2017 election is now open - VOTE HERE ASM Election questions: Which positions are we voting for? What is the ASM Board of Directors? Organization Chart Wha...
Jan 29, 2017•1 hr 50 min
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler The TWiVaniellos discuss a thermostable poliovirus empty capsid vaccine, and two cell genes that act as a switch between entry and clearance of picornavirus infection. Become a patron of TWiV! Links for this episode Register for ASV 2017 ASM-ASV Conference on Interplay of Viral and Bacterial Pathogens XKCD #242 Thermostable poliovirus empty capsid vaccine (PLoS Path) Switch between viral entry and clear...
Jan 22, 2017•1 hr 47 min
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler Guest: Trudy Rey Trudy joins the the TWiVlords to discuss new tests for detecting prions in the blood, and evidence showing that foamy retroviruses originated in the seas with their jawed vertebrate hosts at least 450 million years ago. Become a patron of TWiV! Links for this episode Welcome omega tau to MicrobeTV Register for ASV 2017 Oliver Smithies dies Assays for prions in the blood ( one , two ) Bi...
Jan 15, 2017•1 hr 51 min
