Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler Guest: Jared Rice The TWiV academia discuss induction of diarrhea by the capsid protein of an astrovirus, and association of a fungal RNA virus with white-nose syndrome of North American bats. Become a patron of TWiV! Links for this episode Register for ASV 2017 ASM-ASV Conference on Interplay of Viral and Bacterial Pathogens Astrovirus capsid protein induces diarrhea (mBio) Fungal virus associated with...
Jan 08, 2017•1 hr 50 min
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler The TWiVestigators wrap up 2016 with a discussion of the year's ten compelling virology stories. Become a patron of TWiV! Should auld infections be forgotAnd never T-cells primed?Will cross-reacting antigensProtect the host next time? Links for this episode Register for ASV 2017 ASM-ASV Conference on Interplay of Viral and Bacterial Pathogens Ten virology stories from 2016 Zika virus (first covered in 2...
Jan 01, 2017•1 hr 57 min
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler Guest: Nathan Letts The TWiVnauts present another example of an infectious but replication incompetent vaccine, an insect specific arborvirus bearing chikungunya virus structural proteins. Become a patron of TWiV! Links for this episode Register for ASV 2017 ASM-ASV Conference on Interplay of Viral and Bacterial Pathogens Chikungunya virus vaccine using insect virus platform (Nat Med) Ebola vaccine resu...
Dec 25, 2016•1 hr 52 min
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler The TWiV gurus describe how to use an orthogonal translation system to produce infectious but replication-incompetent influenza vaccines. Become a patron of TWiV! Links for this episode Register for ASV 2017 Local Zika virus transmission in Texas Texaszika.org Local dengue virus transmission in Texas (EID) No more Zika virus transmission in Florida (FL DOH) Dengue virus antibodies enhance Zika virus inf...
Dec 18, 2016•1 hr 56 min
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler The TWiVrific gang reveal how integration of a virophage into the nuclear genome of a marine protozoan enhances host survival after infection with a giant virus. Become a patron of TWiV! Links for this episode Microcephaly associated with Zika virus infection in Colombia (MMWR) Virophage genome integration and activation by superinfection (Nature) Don Nelson interview (pdf) Page view and h index for pap...
Dec 11, 2016•1 hr 45 min
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler The TWiVsters describe a new animal model for MERS coronavirus-induced acute respiratory distress syndrome, produced by CRISPR/Cas9 editing of the mouse gene encoding an ortholog of the virus receptor. Become a patron of TWiV! Links for this episode New mouse model for MERS (Nat Micro) RNA-guided genome engineering (Science) Photo by Finny Letters read on TWiV 418 This episode is brought to you by Curio...
Dec 04, 2016•1 hr 44 min
Host: Vincent Racaniello Guest: Gary Nabel Vincent speaks with Gary Nabel, Chief Scientific Officer at Sanofi and former Director of the Vaccine Research Institute of NIAID, about his career and his work on HIV vaccines. Become a patron of TWiV! Links for this episode World AIDS Day Video of this interview (YouTube) Send your virology questions and comments to twiv@microbe.tv...
Dec 01, 2016•41 min
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler The Fellowship of the Virus trace the early history of HIV in North America, based on genome sequences obtained from late 1970s archival sera, which also reveal that Gaetan Dugas was not Patient Zero. Become a patron of TWiV! Links for this episode WHO: Zika virus is no longer a PHEIC World AIDS Day Early HIV/AIDS history in North America (Nature) Dugas was not AIDS patient zero (virology blog) Image cr...
Nov 27, 2016•1 hr 51 min
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler The multi-dimensional TWiV-brane bring you the entries in the haiku/limerick contest, and explain how a giant virus infects a host within another host (it has to do with predators!). Become a patron of TWiV! Links for this episode Predators allow virus infection of endosymbiont (PNAS) Image credit Letters read on TWiV 416 This episode is brought to you by CuriosityStream, a subscription streaming servic...
Nov 20, 2016•2 hr 7 min
Hosts: Vincent Racaniello , Alan Dove , Rich Condit , and Kathy Spindler Guests: Jeremy Luban , Aaron Lin , and Ted Diehl Jeremy, Aaron, and Ted join the TWiV team to discuss their work on identifying a single amino acid change in the Ebola virus glycoprotein from the West African outbreak that increases infectivity in human cells. Become a patron of TWiV! Links for this episode Ebola virus glycoprotein with increased infectivity (Cell) Effect in cells of Ebola virus mutations from West African ...
Nov 13, 2016•1 hr 50 min
Host: Vincent Racaniello Guest: Michael Diamond Michael Diamond visits the TWiV studio to talk about chikungunya virus and his laboratory's work on a mouse model of Zika virus, including the recent finding of testicular damage caused by viral replication. Become a patron of TWiV! Links for this episode Chikungunya virus chronic joint disease caused by adaptive response (J Virol) Mouse model of Zika virus pathogenesis (Cell Host Micr) Zika virus infection during mouse pregnancy (Cell) Zika virus ...
Nov 06, 2016•1 hr 23 min
Hosts: Vincent Racaniello, Alan Dove , and Paul Duprex Guests: Ralph Baric , Felix Drexler , Marion Koopmans , and Stacey Schultz-Cherry From the EIDA2Z conference at Boston University, Vincent, Alan and Paul meet up with Ralph Baric, Felix Drexler, Marion Koopmans, Stacey Schultz-Cherry to talk about discovering, understanding, protecting, and collaborating on emerging infectious diseases. Become a patron of TWiV! Links for this episode EIDA2Z meeting MERS-CoV infection of Alpaca (EID) Origins ...
Oct 30, 2016•1 hr 12 min
Hosts: Vincent Racaniello , Alan Dove , Rich Condit , and Kathy Spindler Guest: Mark Fuccio The TWiVome reveal the first eukaryotic genes found in a bacteriophage of Wolbachia , and how DNA tumor virus oncogenes antagonize sensing of cytoplasmic DNA by the cell. Become a patron of TWiV! Links for this episode Zika virus in vaginal secretions (EID) Zika virus in semen (EID) Eukaryotic genes in a bacteriophage (Nat Commun) Seth Bordenstein on TWiV 332 DNA tumor virus oncogenes antagonize cGAS-STIN...
Oct 23, 2016•2 hr 1 min
Hosts: Vincent Racaniello , Alan Dove , Rich Condit , and Kathy Spindler The TWiVeroos examine a reverse spillover of Newcastle disease virus vaccines into wild birds, and identification of a protein cell receptor for murine noroviruses. Become a patron of TWiV! Links for this episode MicrobeTV Store Florida DOH Daily Zika Update Zika virus in new Miami neighborhood ( CNN , NYTimes ) NDV vaccine virus in wild birds (PLoS One) Protein cell receptor for murine norovirus ( Science , PNAS ) Poliovir...
Oct 16, 2016•1 hr 35 min
Hosts: Vincent Racaniello , Alan Dove , Rich Condit , and Kathy Spindler Guests: Sharon Isern and Scott Michael Sharon and Scott join the TWiV team to talk about their work on dengue antibody-dependent enhancement of Zika virus infection, and identifying the virus in mosquitoes from Miami. Become a patron of TWiV! Links for this episode Live at Florida Gulf Coast University ( TWiV #111 ) Florida DOH Daily Zika Update Regional Zika update, Americas (PAHO, WHO) NJ Zika Bill Dengue virus antibodies...
Oct 09, 2016•2 hr 1 min
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler Guest: Jeremy Luban Jeremy joins the TWiVeroids to tell the amazing story of how the function of the HIV-1 protein called Nef was discovered and found to promote infection by excluding the host protein SERINC from virus particles. Become a patron of TWiV! Links for this episode No recovery in PACE trial (virology blog) The real PACE data (virology blog) Contagious Thinking Florida DOH daily Zika update ...
Oct 02, 2016•2 hr 4 min
Hosts: Vincent Racaniello and Alan Dove Guest: David Quammen Four years after filming 'Threading the NEIDL', Vincent and Alan return to the National Emerging Infectious Diseases Laboratory BSL4 facility at Boston University where they speak with science writer David Quammen. Watch this episode at YouTube Become a patron of TWiV! Links for this episode David Quammen's website Spillover by David Quammen Threading the NEIDL (TWiV 200) The NEIDL at Boston University This episode is brought to you by...
Sep 25, 2016•1 hr 9 min
Host: Vincent Racaniello Guests: Ralph Baric , Kristina De Paris , Tal Kafri , Helen Lazear , Mark Heise , and David Margolis In the second of two shows recorded at the University of North Carolina in Chapel Hill, Vincent meets up with faculty members to talk about how they got into science, their research on RNA viruses, and what they would be doing if they were not scientists. View video of this episode at YouTube Become a patron of TWiV! This episode is brought to you by CuriosityStream, a su...
Sep 21, 2016•1 hr 23 min
Host: Vincent Racaniello Guests: Dirk Dittmer , Cary Moody , Nat Moorman , Nancy Raab-Traub , Lishan Su , and Jennifer Webster-Cyriaque In the first of two shows recorded at the University of North Carolina in Chapel Hill, Vincent meets up with faculty members to talk about how they got into science, their research on DNA viruses, and what they would be doing if they were not scientists. View video of this episode at YouTube Become a patron of TWiV! This episode is brought to you by CuriosityStr...
Sep 18, 2016•1 hr 11 min
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler The TWiV team discussed eye infections caused by Zika virus, failure of Culex mosquitoes to transmit the virus, and replication of norovirus in stem cell derived enteroids. Become a patron of TWiV! Links for this episode Florida DOH daily Zika update Congress fails again on Zika (NY Times) Culex pipiens does not support Zika virus replication (EID) Zika virus in the eye (Cell Rep) Norovirus replication ...
Sep 11, 2016•1 hr 38 min
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , and Kathy Spindler The TWiXers discuss a study on vertical transmission of Zika virus by Aedes mosquitoes, and uncovering Earth's virome by mining existing metagenomic sequence data. Become a patron of TWiV! Links for this episode Roger Tsien , 64 (UC San Diego Health) CDC running out of Zika money (NYTimes) Zika virus in Miami mosquitoes (NYTimes) No Zika virus in Rio Olympics (NYTimes) Vertical transmission of Zika virus in Aedes aeg...
Sep 04, 2016•1 hr 57 min
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , and Rich Condit From the twiVivants, follow up on FluMist and Zoster vaccines, Zika virus update, and isolation of a multicomponent animal virus from mosquitoes. Become a patron of TWiV! Links for this episode FluMist problem (FDA) DA Henderson obituary (NY Times) DA Henderson, smallpox eradicator (TWiV Special) Efficacy of VZV vaccine (Ther Adv Vaccines) Zika virus burden, Puerto Rico (JAMA) Zika virus in Miami Beach (STAT) Congenital...
Aug 28, 2016•2 hr 6 min
Donald "D.A." Henderson, a physician, educator, and epidemiologist who led the World Health Organization's campaign to eradicate smallpox, died at 87 years of age on Aug. 19, 2016. Vincent was fortunate to have the opportunity to speak with DA Henderson in 2014 about his career, the smallpox eradication effort, and what it means for the eradication of polio. Become a patron of TWiV! This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documen...
Aug 23, 2016•54 min
Hosts: Vincent Racaniello , Alan Dove , and Rich Condit The TWiV team takes on an experimental plant-based poliovirus vaccine, contradictory findings on the efficacy of Flumist, waning protection conferred by Zostavax, a new adjuvanted subunit zoster vaccine. Become a patron of TWiV! Links for this episode Tribunal orders release of PACE trial data (Valerie Eliot Smith) Our request for PACE trial data (virology blog) GM mosquito release on ballot (NPR) Florida Keys Mosquito Control District on T...
Aug 21, 2016•1 hr 36 min
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , and Rich Condit Polio returns to Nigeria, Zika virus spreads in Miami, and virus infection of plants attracts bumblebees for pollination, from the virus gentlepeople at TWiV. Become a patron of TWiV! Links for this episode Marian Horzinek , 80 (ProMedMail) Polio in Nigeria ( Atlantic , Stat , ProMedMail ) Zika virus spreads in Miami (NYTimes) More Zika virus vaccines (Science) Back to work on Zika, Congress ! (Asbury Park Press) Lack o...
Aug 14, 2016•1 hr 58 min
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , and Kathy Spindler Zika virus spreads in the USA, a Zika virus DNA vaccine goes into phase I trials, and how mosquito bites enhance virus replication and disease, from the friendly TWiFolk Vincent, Dickson, Alan, and Kathy. Become a patron of TWiV! Links for this episode Beverly Griffin, 86 ( 1 2 3 ) Zika virus in the US (CDC) Zika virus spreading in Miami (CDC) Zika virus in Florida (NY Times) NIH begins phase I trial of Zika virus DN...
Aug 07, 2016•1 hr 59 min
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler Guest: Harold Varmus The TWiV team is together in New York City for a conversation with Nobel Laureate Harold Varmus about his remarkable career in science. Become a patron of TWiV! Links for this episode Varmus Laboratory Varmus and Kandel on Charlie Rose (transcript) Rescuing biomedical research Letters read on TWiV 400 Video of this episode at YouTube This episode is sponsored by CuriosityStream. Get...
Jul 31, 2016•2 hr 19 min
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , and Rich Condit The latest Zika virus news from the ConTWiVstadors, including a case of female to male transmission, risk of infection at the 2016 summer Olympics, a DNA vaccine, antibody-dependent enhancement by dengue antibodies, and sites of replication in the placenta. Links for this episode Zika virus disease in the US (CDC) Female to male Zika virus transmission (CDC) Zika virus in female genital tract (Lancet) Zika virus transmi...
Jul 24, 2016•1 hr 43 min
Host: Vincent Racaniello Guest: Sandy Weller Vincent speaks with Sandy Weller about her career and her work on the mechanisms of synthesis, maturation and cleavage and packaging of viral DNA genomes. Become a patron of TWiV! Links for this episode Cell killing by avian leukosis virus (Sandy's first paper, J Virol) ND10 protein and herpes simplex virus replication (J Virol) Recombination promoted by DNA viruses (Ann Rev Micro) HSV-1 and DNA damage response (Fut Virol) Video of this episode at You...
Jul 17, 2016•49 min
Host: Vincent Racaniello Guest: David Tuller Vincent speaks with David Tuller about flaws in the U.K's $8 million PACE trial for chronic fatigue syndrome, and efforts to have the trial data released. Become a patron of TWiV! Links for this episode Science and journalism ( TWiV 111 ) Chronic fatigue syndrome and the CDC (virology blog) PACE trial (Lancet) Trial by error part one , two , three (virology blog) PACE economics analysis (PLoS One) All articles by David Tuller at virology blog Valerie ...
Jul 10, 2016•1 hr 33 min
