Hosts: Vincent Racaniello , Alan Dove , Rich Condit , Dickson Despommier , Kathy Spindler , Mark Stenglein , and Joseph DeRisi The TWiVites meet with Mark Stenglein and Joseph DeRisi to discuss their discovery of a novel arenavirus in snakes with inclusion body disease. Links for this episode: Highly divergent arenaviruses in snakes (mBio) Taryn's sick snake (NPR) Assemblathon Faculty position in virology , Columbia U. Petridish.org TWiV on Facebook Letters read on TWiV 196 Weekly Science Picks ...
Aug 19, 2012•1 hr 47 min
Hosts: Vincent Racaniello , Alan Dove , Rich Condit , Dickson Despommier , and Ken Stedman The complete TWiV team meets with Ken Stedman to discuss the discovery in Boiling Spring Lake of a DNA virus with the capsid of an RNA virus. Subscribe to TWiV (free) in iTunes , at the Zune Marketplace , by the RSS feed , by email , or listen on your mobile device with the Microbeworld app . Links for this episode: Novel virus from an extreme environment ( Biol Direct , virology blog ) Lassen Volcanic Nat...
Aug 12, 2012•1 hr 47 min
Hosts: Vincent Racaniello , Matthew Daugherty , Jondavid deJong, Helen Lazear, Stefan Oliver, and Cara Pager . Vincent returns to Madison, Wisconsin and meets with postdocs to discuss their science and their careers. Subscribe to TWiV (free) in iTunes , at the Zune Marketplace , by the RSS feed , by email , or listen on your mobile device with the Microbeworld app . Links for this episode: TWiV 189: Five postdocs in Glasgow ASM at the USA Science and Engineering Festival ASV 2012 at Madison, WI ...
Aug 06, 2012•1 hr 34 min
Hosts: Vincent Racaniello , Rich Condit , Carolyn Coyne , and Sara Sawyer Vincent, Rich, Carolyn, and Sara recorded TWiV at the 31st Annual Meeting of the American Society for Virology in Madison, where they discussed genetic conflict between viral and human genes, and how the placenta protects the fetus against viral infection. Subscribe to TWiV (free) in iTunes , at the Zune Marketplace , by the RSS feed , by email , or listen on your mobile device with the Microbeworld app . Links for this ep...
Jul 29, 2012•1 hr 18 min
Hosts: Vincent Racaniello , Alan Dove , and Rich Condit Vincent, Alan, and Rich answer listener email about bioinformatics, insects, influenza, laboratory classes, commensalism, reproducibility of data, and more. Subscribe to TWiV (free) in iTunes , at the Zune Marketplace , by the RSS feed , by email , or listen on your mobile device with the Microbeworld app . Links for this episode: Vaccinia virus sequence from patient with vaccine complication (pdf) The evolution of intellectual freedom (tha...
Jul 22, 2012•1 hr 56 min
Hosts: Vincent Racaniello , Alan Dove , Rich Condit , and Nissin Moussatche Nissin joins the TWiV crew to discuss an outbreak of lethal disease among Cambodian children, and recombination among attenuated herpesvirus vaccines leading to pathogenic viruses. Subscribe to TWiV (free) in iTunes , at the Zune Marketplace , by the RSS feed , by email , or listen on your mobile device with the Microbeworld app . Links for this episode: Outbreak in Cambodia (CNN) Pathogen mix in Cambodian illness (ProMe...
Jul 15, 2012•1 hr 39 min
Hosts: Vincent Racaniello , Alan Dove , and Kathy Spindler Vincent, Alan, and Kathy review selection of influenza H5N1 viruses that can transmit among ferrets by aerosol. Links for this episode: Airborne transmission of H5N1 among ferrets (Science) Potential for H5N1 evolution (Science) H5N1 (Science) The ferrets of fear Jim's podcast list (pdf) TWiV on Facebook Letters read on TWiV 190 Weekly Science Picks Kathy - Wind map Vincent - The A-Z of Epidemiology (YouTube) Listener Pick of the Week Kr...
Jul 01, 2012•1 hr 27 min
Vincent returns to the Centre for Virus Research at the University of Glasgow and meets with postdocs to discuss their science and their careers. Links for this episode: MRC-University of Glasgow Centre for Virus Research Stop CMV Photos of my Glasgow visit ( Facebook and VirusTalk ) TWiV on Facebook...
Jun 24, 2012•1 hr 12 min
Hosts: Vincent Racaniello , Massimo Palmarini , John MacLauchlan , Emma Thomson , and Hande Harmanci . Vincent travels to Scotland to meet with members of the Centre for Virus Research at the University of Glasgow to discuss their work on hepatitis C virus and jaagsiekte sheep retrovirus. Links for this episode: MRC-University of Glasgow Centre for Virus Research Aaron Shatkin, 77 (virology blog) Photos of my Glasgow visit ( Facebook and VirusTalk ) TWiV on Facebook Letters read on TWiV 188 Week...
Jun 15, 2012•1 hr 48 min
Hosts: Vincent Racaniello and Rich Condit Vincent and Rich discuss recovery of a hepatitis B viral genome from a 16th century Korean mummy, and personal omics profiling of an individual over a 14 month period. Links for this episode: Tracing HBV to the 16th century (Hepatology) HBV on TWiV Precautions with ancient DNA (Science) Personal omics profile over 14 months (Cell) A geneticist's research turns personal (NY Times) Mike Snyder on Futures in Biotech The DASH diet TWiV on Facebook Letters re...
Jun 11, 2012•1 hr 28 min
Hosts: Vincent Racaniello , Alan Dove, and Rich Condit The TWiV chiefs tackle reader email about how to pronounce Buda, Texas, grinding tree stumps, and much more. Links for this episode: Detecting antibodies or antigens by ELISA Peter Wildy Prize Biosafety levels Baltimore classification at Viral Zone TWiV on Facebook Letters read on TWiV 186 Weekly Science Picks Alan - World Wide Lightning Location Network Rich - Steve Jobs by Walter IsaacsonVincent - The Ocelloid Listener Pick of the Week laf...
Jun 03, 2012•1 hr 54 min
Vincent visits with members of the Department of Microbiology and Immunology at Northwestern University School of Medicine to discuss their work on herpesviruses and parainfluenzaviruses. Links for this episode: Longnecker laboratory Herpesvirus deubiquitinase is neuroinvasive determinant (PLoS Path) Paramyxovirus HN structure (PNAS) TWiV on Facebook Letters read on TWiV 185 Weekly Science Picks Sarah - Breasts: A Natural and Unnatural History by Florence WilliamsAndrew - The Strangest Man by Gr...
May 27, 2012•1 hr 28 min
Vincent, Rich, and Alan consider how to reform the scientific enterprise to make it more effective and robust. Links for this episode: Reforming science: Methodological and cultural reforms (Infect Immun) Reforming science: Structural reforms (Infect Immun) Sharp rise in retractions (NY Times) Vannevar Bush TWiV on Facebook Letters read on TWiV 184 Weekly Science Picks Alan - PubMed PubReMiner Rich - Intentional Blindness (YouTube)Vincent - Vaccine infographic Listener Pick of the Week Ken - Wat...
May 20, 2012•1 hr 31 min
Connor joins the TWiV team to discuss bats as hosts for major mammalian paramyxoviruses. Links for this episode: NIH response to Osterholm letter (pdf) Who's afraid of the big, bad bioterrorist? Bats host major mammalian paramyxoviruses (Nature Comm) TWiV on Facebook Letters read on TWiV 183 Weekly Science Picks Connor - Microbiology Twitter journal club Alan - Where the Wild Types Are (YouTube)Rich - May 14th: Smallpox vaccination day Dickson - Searching for pore-fection (Science)Vincent - RRRe...
May 13, 2012•1 hr 32 min
Hosts: Vincent Racaniello , Rich Condit , Alan Dove , and Michael J. Imperiale Michael joins the TWiV crew to discuss the recently published influenza H5N1 transmission paper and how it was viewed by the NSABB. Links for this episode: About the NSABB The Kawaoka paper (Nature) Mutant flu paper published (Ed Yong) Osterholm letter (pdf) US policy for dual research of concern (pdf) TWiV on Facebook Letters read on TWiV 182 Weekly Science Picks Alan - 18th century shipping mapped Rich - Brave New W...
May 06, 2012•1 hr 47 min
Hosts: Vincent Racaniello , Rich Condit , and Kathy Spindler Vincent, Rich, and Kathy discuss Cotia virus, a new poxvirus, Orf virus infections associated with handling goats and lamb, and the innate immune response to prions. Links for this episode: Cotia virus (J Virol) Human Orf virus exposures (MMWR) IRF3 protects agains prion infection (J Virol) A mad cow in America (virology blog) Human orf (pdf) Space shuttle flies outside my window (YouTube) TWiV on Facebook Letters read on TWiV 181 Week...
Apr 29, 2012•1 hr 43 min
Hosts: Vincent Racaniello , Alan Dove , and Rich Condit Vincent, Alan, and Rich review association of an interferon-induced protein with severe influenza, and stabilization of HCV RNA by a microRNA. Links for this episode: IFITM3 and severe influenza (Nature) Genetics of flu susceptibiligy (EurekAlert!) Stabilization of HCV RNA by Ago2-miR-122 (PNAS) Clinical trial of anti-mIR-122 TWiV on Facebook Letters read on TWiV 180 Weekly Science Picks Alan - Micro Empire (Vimeo)Rich - Census of marine li...
Apr 22, 2012•1 hr 39 min
Hosts: Vincent Racaniello , Alan Dove, Rich Condit, and G ertrud Radu Gertrud joins the TWiVoners to review how dengue virus infection of mosquitoes alters blood feeding behavior, and gene therapy as practiced by parasitoid wasps. Links for this episode: Renato Dulbecco , 1914-2012 (virology blog) William Jarrett , 83 (thanks, Lynn Enquist) Dengue virus infection of mosquitoes alters their behavior (PLoS Path) Does dengue make mosquitoes thirstier for blood? (NY Times) Polydnaviruses of braconid...
Apr 15, 2012•1 hr 45 min
The TWiValians meet up with Tyler Sharp for a discussion on the Epidemic Intelligence Service and controlling dengue. Links for this episode: 2010 dengue epidemic in Puerto Rico Marshall Islands dengue outbreak ( one and two ) Photo of Tyler by Loren Rodgers TWiV shout-out by NPR and CIDRAP NSABB reverses decision on H5N1 publication TWiV on Facebook Letters read on TWiV 178 Weekly Science Picks Tyler - Co-infection with dengue and Leptospira (Emerging Inf Dis)Alan - The Winged Scourge (YouTube)...
Apr 08, 2012•1 hr 39 min
A discussion of avian influenza H5N1 transmission experiments in ferrets and novel bunyaviruses at the 2012 Spring Conference of the Society for General Microbiology in Dublin, Ireland. Links for this episode: Restricted data on H5N1 transmission (Science) Novel bunyavirus in China ( NEJM and TWiV 127 ) Ten things about Schmallenberg virus (Microbiology Bytes) NSABB reverses decision on H5N1 papers (virology blog) TWiV on Facebook Letters read on TWiV 177 Weekly Science Picks Connor - Wellcome T...
Apr 01, 2012•1 hr 6 min
Vincent, Alan, and Rich answer listener email about MS, CFS, EBV, B cells, virii, influenza B, scientific papers, and more. Links for this episode: More than one way to skin a virus ( comments ) Aerobie aeropress Papers software Vaccinia movies ( one and two ) Lloyd Kozloff dies BSL4 facilities TWiV on Facebook Letters read on TWiV 176 Weekly Science Picks Rich - Alan Alda's Flame Challenge (NY Times article , Science editorial )Alan - ChronoZoom Vincent - Academic Publishing is Broken by Michae...
Mar 24, 2012•1 hr 26 min
Vincent, Alan, and Matt discuss herpes simplex encephalitis in children with innate immune deficiency, and the local response to microneedle-based influenza skin immunization. Links for this episode: Herpes encephalitis in children with TRIF deficiency (J Clin Inv) Toll-like receptor and cytosolic pattern recognition receptors Skin responses to influenza microneedle vaccine (mBio) Microneedles Fluzone intradermal influenza vaccine QDot nanocrystal technology TWiV on Facebook Letters read on TWiV...
Mar 18, 2012•1 hr 20 min
Hosts: Vincent Racaniello , Alan Dove , and Rich Condit Vincent, Alan, and Rich consider whether pet dogs might transmit human noroviruses, and an RNA virus microRNA that might be involved in oncogenesis. Links for this episode: Do pet dogs transmit human norovirus ? (J Clin Virol) RNA virus miRNA that mimics oncomiR (PNAS) MicroRNA expression by an RNA virus (PNAS) Lab safety stickers jpg (thanks, Jon!) Amateur virologists (Zimmer, NY Times) Genome at home (Wired) Barbergators sing national ant...
Mar 11, 2012•1 hr 26 min
The TWiVites discuss seroevidence for human infection with avian influenza H5N1, and the discovery of a new influenza virus in Guatemalan bats. Links for this episode: Seroevidence for human H5N1 infection (Science) Mammalian-transmissible H5N1 (mBio) New information about ferret-adapted H5N1 ( NY Times , virology blog ) New influenza virus from fruit bats (PNAS) Elsevier abandons open access assault (The Scientist) Le virus le plus dangereux ? TWiV on Facebook Letters read on TWiV 173 Weekly Sc...
Mar 04, 2012•1 hr 57 min
Hosts: Vincent Racaniello and Kathy Spindler Vincent and Kathy discuss how a virus may cause disease distant from its replication site, then review a day in the life of a senior microbiology professor. Links for this episode: Celsius vs Centigrade Neuropathogenesis during polymicrobial infection (PLoS Pathogens) Tetramer staining (pdf) One TWiV on Facebook Letters read on TWiV 172...
Feb 27, 2012•1 hr 42 min
Matt joins the TWiVarians to review virus production in single cells and single virion genomics. Links for this episode: H5N1 results will be published (NY Times) Virus production in single cells then and now Single virion genomics (PLoS One) Multiple displacement amplification (Wikipedia) Ranavirus killing turtles, tadpoles in Maryland (Washington Post) Three Dog Night TWiV on Facebook Letters read on TWiV 171...
Feb 19, 2012•1 hr 32 min
Alan, Rich, and Dickson discuss Edward Jenner's paper on cowpox vaccine, then move 200 years later to modern vaccines against norovirus, influenza H5N1, and more. Links for this episode: Norton Zinder , 83 (Reuters) Jenner's cowpox vaccine paper ( Bartleby , Gutenberg ) Norovirus VLP vaccine (NEJM) Plant-grown H5N1 VLP vaccine ( Reuters , PLoS One ) Plant-grown norovirus VLP Hexavalent pediatric vaccine TWiV on Facebook Letters read on TWiV 170...
Feb 12, 2012•1 hr 40 min
Michael and the TWiV team review epidemiology basics, including fatality ratios. Links for this episode: Michael's blog and podcast Epidemiology literature critique (PowerPoint) Seven mistakes in epidemiology (ETE) Snow cholera map TWiV on Facebook Letters read on TWiV 169...
Feb 05, 2012•2 hr 32 min
Welkin joins the TWiV team for a discussion of HIV prophlaxis using vectored antibodies, and the influenza H5N1 virus studies in ferrets that were not redacted. Links for this episode: Vectored HIV immunoprophylaxis (Nature) Vectored immunoprophylaxis - the Movie (YouTube) Adeno-associated virus (Wikipedia) In vitro evolution of H5N1 towards human receptor specificity (Virology) Endogenous viral genes non-essential in chicken (Nature) Rates of HIV transmission per coital act (J Inf Dis) TWiV on ...
Jan 29, 2012•1 hr 38 min
The complete TWiVome deconstructs the movie Contagion .
Jan 22, 2012•1 hr 28 min
