TWiV 1275: An amazing sequence and a gutsy therapy
Nov 30, 2025•1 hr 49 min•Ep. 1275
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Episode description
TWiV explains the Nobel Prize-winning discovery of pre-mRNA splicing, and engineering bacteriophage to deliver proteins to the human intestine.
Hosts: Vincent Racaniello, Kathy Spindler, and Brianne BarkerSubscribe (free): Apple Podcasts, RSS, email
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Links for this episode- Support science education at MicrobeTV
- Immune 100 live at the Incubator
- Spliced segments of adenovirus mRNA (PNAS)
- An amazing sequence in adenovirus mRNA (Cell)
- Nobel Prize for mRNA splicing (Nobel)
- A predominant undecanucleotide in adenovirus late mRNAs (Cell)
- Splicing RNA with Phillip A. Sharp (ASM)
- Protein production in the gut by engineered phage (Nat Biotech)
- Engineered phage T4 (Curr Op Virol)
- Timestamps by Jolene Ramsey. Thanks!
Brianne – Can You Identify These Lines from Classic SciFi Novels? Kathy – Saturday Morning Physics, Photograph 51 and JCE article Rich – Wikipedia:Wiki Science Competition 2025 in the United States Jolene – Data visualization workshop Vincent – Transformer: The Deep Chemistry of Life and Death by Nick Lane
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.
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