TWiV explains the Nobel Prize-winning discovery of pre-mRNA splicing, and engineering bacteriophage to deliver proteins to the human intestine. Hosts: Vincent Racaniello , Kathy Spindler , and Brianne Barker Subscribe (free): Apple Podcasts , RSS , email Become a patron of TWiV! Links for this episode Support science education at MicrobeTV Immune 100 live at the Incubator Spliced segments of adenovirus mRNA (PNAS) An amazing sequence in adenovirus mRNA (Cell) Nobel Prize for mRNA splicing (Nobel...
Nov 30, 2025•1 hr 49 min•Ep. 1275
In his weekly clinical update, Dr. Griffin and Vincent Racaniello wish everyone a Happy Thanksgiving and then decry appointment of the Louisiana State surgeon general as deputy chief of the CDC, the 3 children’s deaths during this fall’s pertussis outbreak, the Marburg virus outbreak in Ethiopia, results of the phase 1 safety trial for the novel poliovirus vaccines nOPV1 and nOPV3, and the first human death from H5N5 influenza virus infection in the US this fall, before Dr. Griffin deep dives in...
Nov 29, 2025•58 min•Ep. 1274
TWiV explains the 1953 paper by Watson & Crick proposing a structure for DNA, and the role of Epstein-Barr virus in triggering the autoimmune disease systemic lupus erythematosus. Hosts: Vincent Racaniello , Kathy Spindler , and Brianne Barker Subscribe (free): Apple Podcasts , RSS , email Become a patron of TWiV! Links for this episode Support science education at MicrobeTV Immune 100 live at the Incubator CDC revives debunked ‘link’ between childhood vaccines and autism (npr) A structure f...
Nov 23, 2025•1 hr 38 min•Ep. 1273
In his weekly clinical update, Dr. Griffin and Vincent Racaniello are dismayed by the changes on CDC vaccine website positively stating the link between autism and vaccination, the finding of wild type poliovirus 1 in Germany, Marburg virus in Ethiopia, decimation of the elephant breeding colony by H5N1 and the first human case of H5N5 influenza virus infection before Dr. Griffin deep dives into recent statistics on the measles epidemic, RSV, influenza and SARS-CoV-2 infections, the Wasterwater ...
Nov 22, 2025•1 hr 3 min•Ep. 1272
Vincent visits Virginia Tech for the CeZAP Symposium and speaks with XJ Meng and Kylene Kehn-Hall about their research on hepatitis E virus and Rift Valley fever virus. Host: Vincent Racaniello Guests: XJ Meng and Kylene Kehn-Hall Subscribe (free): Apple Podcasts , RSS , email Become a patron of TWiV! Links for this episode Support science education at MicrobeTV Immune 100 live at the Incubator Hepatitis E virus (Curr Op Micro) Rift Valley fever virus NSs and autophagy (PLoS Path) Timestamps by ...
Nov 16, 2025•1 hr 19 min•Ep. 1271
In his weekly clinical update, Dr. Griffin and Vincent Racaniello record from the ASTMH meeting in Toronto and discuss continuing avian flu outbreaks, the continued global measles outbreak, the effectiveness of high and low doses of the influenza vaccine before Dr. Griffin deep dives into recent statistics on the measles epidemic, RSV, influenza and SARS-CoV-2 infections, the Wasterwater Scan dashboard, Johns Hopkins measles tracker, children hospitalizations following COVID-19 and influenza vac...
Nov 15, 2025•51 min•Ep. 1270
TWiV reviews the passing of James D. Watson, the research that showed human papillomaviruses to be present in genital and laryngeal papillomas and in some cervical cancers, and influenza virus infection, shedding and symptoms in a human challenge study. Hosts: Vincent Racaniello , Alan Dove , Rich Condit , and Brianne Barker Subscribe (free): Apple Podcasts , RSS , email Become a patron of TWiV! Links for this episode Support science education at MicrobeTV Immune 100 live at the Incubator James ...
Nov 09, 2025•1 hr 52 min•Ep. 1269
In his weekly clinical update, Dr. Griffin with Vincent Racaniello discusses the link between in utero SARS-CoV-2 infection and poor neurodevelopment outcomes, the use of an mRNA vaccine as an anti-cancer therapy, why one should receive the HPV vaccine, asymptomatic H5N1 isolations in humans, and H5N1 on turkey farms, before Dr. Griffin deep dives into recent statistics on the measles epidemic, RSV, influenza and SARS-CoV-2 infections, the Wasterwater Scan dashboard, Johns Hopkins measles tracke...
Nov 08, 2025•52 min•Ep. 1268
TWiV discusses the impact of vaccinating with Gardasil-9 adult women who are human papillomavirus positive or with confirmed squamous intraepithelial lesions, and human monoclonal antibodies that target the monkeypox virus A35 protein which protect against lethal disease. Hosts: Vincent Racaniello , Alan Dove , Rich Condit , Kathy Spindler , and Brianne Barker Subscribe (free): Apple Podcasts , RSS , email Become a patron of TWiV! Links for this episode Support science education at MicrobeTV Imm...
Nov 02, 2025•2 hr 2 min•Ep. 1267
In his weekly clinical update, Dr. Griffin and Vincent Racaniello ponder the nomination of Casey Means for Surgeon General by President Trump, how mRNA vaccines may enhance effectiveness of check point inhibitor cancer therapies, if viral infection associates with cardiac disease, H5N1 isolation from backyard birds and turkey farms, and the effectiveness of the COVID-19, RSV and influenza vaccines before Dr. Griffin deep dives into recent statistics on the measles epidemic, RSV, influenza and SA...
Nov 01, 2025•50 min•Ep. 1266
TWiV explains studies showing that SARS-CoV-2 mRNA vaccines improve life span of cancer patients on checkpoint immunotherapy, and broad immunity conferred by a vaccine central in A(H5) influenza antigenic space. Hosts: Vincent Racaniello , Alan Dove , Rich Condit , and Kathy Spindler Subscribe (free): Apple Podcasts , RSS , email Become a patron of TWiV! Links for this episode Support science education at MicrobeTV Immune 100 live at the Incubator SARS-CoV-2 mRNA vaccines sensitize tumors to che...
Oct 26, 2025•1 hr 51 min•Ep. 1265
In his weekly clinical update, Dr. Griffin with Vincent Racaniello are distressed by the continuing government shutdown, first locally acquired chikungunya virus infection, President Trump’s suggestion for removing aluminum from vaccines, H5N1 isolation from backyard birds and turkey farms, and the suggestion of establishing an alternative to the CDC’s MMWR and asymptomatic measles infections before Dr. Griffin deep dives into recent statistics on the measles epidemic, RSV, influenza and SARS-Co...
Oct 25, 2025•43 min•Ep. 1264
TWiV reviews continuing US measles outbreak, host and genetic variations that regulate antibody responses to hepatitis C virus, and varicella-zoster reactivation and the risk of dementia. Hosts: Vincent Racaniello , Alan Dove , Brianne Barker , and Angela Mingarelli Subscribe (free): Apple Podcasts , RSS , email Become a patron of TWiV! Links for this episode Support science education at MicrobeTV Mass firings at CDC (Time) Measles cases continue to climb in US (NPR) Immune 100 at The Incubator ...
Oct 19, 2025•1 hr 49 min•Ep. 1263
In his weekly clinical update, Dr. Griffin with Vincent Racaniello are dismayed by the government shutdown, the firings at the CDC including EIS agents, H5N1 isolation from backyard birds and its stability in raw milk and cheese, before Dr. Griffin deep dives into recent statistics on the measles epidemic, RSV, influenza and SARS-CoV-2 infections, the Wasterwater Scan dashboard, Johns Hopkins measles tracker, the quarantining of college students in the US due to measles, Japan’s declaration of a...
Oct 18, 2025•44 min•Ep. 1262
TWiV covers a MacArthur Award for Jason McLellan, 2025 Nobel Prizes in Physiology or Medicine, first treatment for Huntington’s Disease, structure of an archael dsDNA virus from head to tail, and discovery of a Legionella phage that explains a determinant of human disease. Hosts: Vincent Racaniello , Alan Dove , and Jolene Ramsey Subscribe (free): Apple Podcasts , RSS , email Become a patron of TWiV! Links for this episode Support science education at MicrobeTV Jason McLellan wins MacArthur Awar...
Oct 12, 2025•1 hr 50 min•Ep. 1261
In his weekly clinical update, Dr. Griffin with Vincent Racaniello chat about Jane Goodall’s death and the Nobel prize in Physiology/Medicine for understanding immune system control before Dr. Griffin deep dives into recent statistics on the measles epidemic, RSV, influenza and SARS-CoV-2 infections, the Wasterwater Scan dashboard, Johns Hopkins measles tracker, if 2 doses of the influenza vaccine are better for protection of first season children, if COVID-19 negatively impacts pregnancy and th...
Oct 11, 2025•49 min•Ep. 1260
TWiV reviews experiments to understand infection, pathogenesis, and transmission of avian H5N1 influenza virus in goats, and identification of a cellular receptor for tick-borne encephalitis virus. Hosts: Vincent Racaniello , Alan Dove , and Brianne Barker Subscribe (free): Apple Podcasts , RSS , email Become a patron of TWiV! Links for this episode Support science education at MicrobeTV Public trust in science (Nature) Culling of H5N1 ostriches in Canada (Science) H5N1 in goats (Cell Rep) Recep...
Oct 05, 2025•1 hr 44 min•Ep. 1259
In his weekly clinical update, Dr. Griffin with Vincent Racaniello chat about the ongoing Ebola outbreak in DRC, increases in screwworm diagnoses, a pertussis death in Mississippi before Dr. Griffin deep dives into recent statistics on the measles epidemic, RSV, influenza and SARS-CoV-2 infections, the Wasterwater Scan dashboard, Johns Hopkins measles tracker, monoclonal antibody therapy against RSV, where to find PEMGARDA, long COVID treatment center, where to go for answers to your long COVID ...
Oct 04, 2025•44 min•Ep. 1258
From ESCV 2025, Vincent speaks with Elke Wollants about a project to identify SARS-CoV-2 and other viruses in toilet waste from airplanes. Host: Vincent Racaniello Guest: Elke Wollants Subscribe (free): Apple Podcasts , RSS , email Become a patron of TWiV! Links for this episode Support science education at MicrobeTV Laboratory for Clinical and Epidemiological Virology (KU Leuven) Virologists in Greece ( TWiV 1255 from ESCV) Airplane wastewater surveillance for pathogens (SSRN) Timestamps by Jol...
Oct 01, 2025•29 min
TWiV explains experiments to create genetically modified chickens that are resistant to avian influenza infection, and discovery of combination antiviral therapy for HTLV-1 infection. Hosts: Vincent Racaniello , Alan Dove , and Rich Condit Subscribe (free): Apple Podcasts , RSS , email Become a patron of TWiV! Links for this episode Support science education at MicrobeTV Creating avian influenza virus resistant chickens (Nat Comm) Antiretroviral therapy and apoptosis inhibition for HTLV-1 (Cell)...
Sep 28, 2025•1 hr 50 min•Ep. 1257
Sep 27, 2025•43 min•Ep. 1256
Vincent travels to Thessaloniki, Greece to attend the 27th meeting of the European Society for Clinical Virology, where he speaks with Pamela Vallely, ESCV President, and Piotr Kramarz, Chief Scientist, European CDC, about the activities of ESCV and ECDC. Host: Vincent Racaniello Guests: Piotr Kramarz and Pamela Vallely Subscribe (free): Apple Podcasts , RSS , email Become a patron of TWiV! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv Content in t...
Sep 21, 2025•33 min•Ep. 1255
In his weekly clinical update, Dr. Griffin with Vincent Racaniello lament the anti-vaccine, anti-science composition of the ACIP, US cases of Chagas disease, the Ebola vaccination campaign in the DRC, the death of an infant in LA due to measles complications (SSPE), before Dr. Griffin deep dives into recent statistics on the measles epidemic, RSV, influenza and SARS-CoV-2 infections, the Wasterwater Scan dashboard, Johns Hopkins measles tracker, use of monoclonal antibodies against influenza, th...
Sep 20, 2025•52 min•Ep. 1254
Vincent travels to Waterville Valley, NH to attend the Harvard virology retreat, where he speaks with Aaron Schmidt, Ben Gewurz, and Tatum Sass about their careers and their research on influenza virus, Epstein-Barr virus, and CAR-T cells. Hosts: Vincent Racaniello Guests: Aaron Schmidt , Ben Gewurz , and Tatum Sass Subscribe (free): Apple Podcasts , RSS , email Become a patron of TWiV! Links for this episode Support science education at MicrobeTV Harvard Program in Virology Conserved sites on H...
Sep 14, 2025•1 hr 10 min•Ep. 1253
In his weekly clinical update, Dr. Griffin with Vincent Racaniello discuss the continued Legionnaire’s outbreak in Harlem, invasive Asia longhorned tick and associated disease, potential Ebola outbreak in the Congo, Florida ending childhood vaccine mandates, before Dr. Griffin deep dives into recent statistics on the measles epidemic, RSV, influenza and SARS-CoV-2 infections, the Wasterwater Scan dashboard, Johns Hopkins measles tracker, SARS-CoV-2 spillover into household/domestic dogs, real da...
Sep 13, 2025•47 min•Ep. 1252
TWiV re-issues our 100th episode which featured a discussion of viruses with David Baltimore, an exemplary scientist and Vincent’s exemplary mentor, who passed on 6 September 2025. Hosts: Vincent Racaniello , Alan Dove , and Rich Condit Guest: David Baltimore Subscribe (free): Apple Podcasts , RSS , email Become a patron of TWiV! Links for this episode Support science education at MicrobeTV David’s early papers on poliovirus and mengovirus RNA synthesis Reverse transcriptase found by Baltimore a...
Sep 09, 2025•1 hr 7 min
TWiV reviews a study showing that the 2009 influenza pandemic virus disrupted biennial respiratory syncytial virus epidemics in northern Stockholm, and development of broad-spectrum synthetic carbohydrate receptors that inhibit viral entry of coronaviruses, filoviruses, and paramyxoviruses. Hosts: Vincent Racaniello , Alan Dove , Rich Condit , Kathy Spindler , and Angela Mingarelli Subscribe (free): Apple Podcasts , RSS , email Become a patron of TWiV! Links for this episode Support science educ...
Sep 07, 2025•1 hr 56 min•Ep. 1251
In his weekly clinical update, Dr. Griffin with Vincent Racaniello is shocked by COVID vaccine restrictions and uncertainties such as pharmacy stock, the ACIP meeting roster and whether it guidance is legal, 3 new ACIP members all anti-vaccine, ending of childhood vaccine mandates in Florida, the continued Legionnaire’s outbreak in Harlem, before Dr. Griffin deep dives into recent statistics on the measles epidemic, RSV, influenza and SARS-CoV-2 infections, the Wasterwater Scan dashboard, Johns ...
Sep 06, 2025•1 hr•Ep. 1250
TWiV reviews the major shakeup in CDC leadership, herpes simplex virus infection doubles the risk of dementia, and the prototypic crAssphage is a linear phage-plasmid. Hosts: Vincent Racaniello , Rich Condit , Brianne Barker , and Jolene Ramsey Subscribe (free): Apple Podcasts , RSS , email Become a patron of TWiV! Links for this episode Support science education at MicrobeTV CDC director ousted? (CNN) Herpes simplex infection doubles risk of dementia (J Alzheimers Res) Fishing for viruses in se...
Aug 31, 2025•1 hr 58 min•Ep. 1249
In his weekly clinical update, Dr. Griffin with Vincent Racaniello are dismayed about the recent attack on public health the firing of the director of the CDC as well as resignation of 3 others members of the agency’s leadership, the continued Legionnaire’s outbreak in Harlem, suspension of Ixchiq the Chikungunya virus attenuated infectious vaccine, the first US case of New World screwworm before Dr. Griffin deep dives into recent statistics on the measles epidemic, RSV, influenza and SARS-CoV-2...
Aug 30, 2025•47 min•Ep. 1248
