TWiV 1273: Myocarditis and mimicry

This Week in Virology

Dec 28, 2025•1 hr 58 min•Ep. 1283

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Episode description

TWiV explains studies which reveal that Inhibition of CXCL10 and IFN-γ mitgates myocarditis associated with SARS-CoV-2 mRNA vaccination, and identification of a bacteriophage T7 protein that antagonizes the DNA restriction system of the host by mimicking B form DNA.

Hosts: Vincent Racaniello and Jolene Ramsey

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Links for this episode

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ASV 2026
Understanding mRNA vaccine-associated myocarditis (Sci Transl Med)
T7 protein overcomes DNA restriction of host (J Mol Biol)
Structure of T7 protein that mimics DNA (Mol Cell)
Letters read on TWiV 1283
Timestamps by Jolene Ramsey. Thanks!

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