The TWiP team solves the case of the Gentleman from New York with Intestinal Issues, and review a 20 year study of butterflies, their associated parasitoid wasp and Wolbachia introduced into an island community. Hosts: Vincent Racaniello , Dickson Despommier , Daniel Griffin , and Christina Naula Download TWiP #200 (41 MB .mp3, 68 minutes) Subscribe (free): iTunes , Google Podcasts , RSS , email Links for this episode Accidental parasitoid introduction (Mol Ecol) Hero: Gerald Keusch Support Micr...
Nov 04, 2021•1 hr 22 min•Ep. 200
The TWiP team solves the case of the Traveler to Tanzania with a Purple Lesion, and discuss Mosquirix, the first vaccine approved for Plasmodium parasites. Hosts: Vincent Racaniello , Dickson Despommier , Daniel Griffin , and Christina Naula Subscribe (free): iTunes , Google Podcasts , RSS , email Links for this episode PWB on Facebook , Instagram , Twitter Historic malaria vaccine (Nature) Efficacy and safety of RTS,S/AS01 (Lancet) Letters read on TWiP 199 Become a patron of TWiP Case Study for...
Oct 12, 2021•1 hr 8 min•Ep. 199
The TWiP quadfecta solves the case of the Traveler With Watery Diarrhea, and reveals that a heat-shock response regulated by a transcription factor protects human malaria parasites from the high temperatures of fever. Hosts: Vincent Racaniello , Dickson Despommier , Daniel Griffin , and Christina Naula Subscribe (free): iTunes , Google Podcasts , RSS , email Links for this episode PWB on Facebook , Instagram , Twitter Malaria parasite resists fever due to heat shock response (Nat Micro) Malaria ...
Sep 14, 2021•1 hr 15 min•Ep. 198
TWiP solves the case of the Adventurous Eater with Areas of Swelling, and discusses an experimental Trypanosoma vivax vaccine comprising an invariant flagellum antigen. Hosts: Vincent Racaniello , Dickson Despommier , Daniel Griffin , and Christina Naula Download TWiP #197 (39 MB .mp3, 64 minutes) Subscribe (free): iTunes , Google Podcasts , RSS , email Links for this episode PWB on Facebook , Instagram , Twitter Experimental T. vivax vaccine (Nature) Letters read on TWiP 197 Become a patron of ...
Aug 16, 2021•1 hr 4 min•Ep. 197
TWiP solves the case of the Homeless Man With Skin Issues, and discusses an experimental mRNA based malaria vaccine. Hosts: Vincent Racaniello and Daniel Griffin Download TWiP #196 (49 MB .mp3, 81 minutes) Subscribe (free): iTunes , Google Podcasts , RSS , email Links for this episode PWB on Facebook , Instagram , Twitter Entomophagy ( TWiP 131 ) Malaria mRNA vaccine (NPJ vaccines) Letters read on TWiP 196 Become a patron of TWiP Case Study for TWiP 196 30 yo woman having areas of swelling in di...
Jul 12, 2021•56 min•Ep. 196
Christina returns to the TWiP trifecta to solve the case of the Beachgoer with Red Lines on Her foot, and an experimental malaria vaccine based on the junctional region of the circumsporozoite protein displayed on a virus-like particle. Hosts: Vincent Racaniello , Dickson Despommier , and Daniel Griffin Guest: Christina Naula Download TWiP #195 (46 MB .mp3, 76 minutes) Subscribe (free): iTunes , Google Podcasts , RSS , email Links for this episode PWB on Facebook , Instagram , Twitter VLP-based ...
May 31, 2021•1 hr 21 min•Ep. 195
TWiP solves the case of the Long Island Man with Unilateral Eye Pain, followed by a discussion of how enteric helminth coinfection enhances host susceptibility to West Nile virus by a tuft cell-IL-4 receptor signaling axis. Hosts: Vincent Racaniello , Dickson Despommier , and Daniel Griffin Guest: Christina Naula Subscribe (free): iTunes , Google Podcasts , RSS , email Links for this episode PWB on Facebook , Instagram , Twitter Helminth infection enhances West Nile viruses pathogenesis (Cell) H...
Apr 24, 2021•1 hr 13 min•Ep. 194
Audun returns to help solve the case of the Ecuadorean Gentleman Treated for COVID-19, followed by a discussion of the interaction of Blastocystis with the intestinal microbiota and the immune system, and of course a new clinical case from Daniel. Hosts: Vincent Racaniello , Dickson Despommier , and Daniel Griffin Guest: Audun Lier Download TWiP #192 (46 MB .mp3, 76 minutes) Subscribe (free): iTunes , Google Podcasts , RSS , email Links for this episode PWB on Facebook , Instagram , Twitter Blas...
Mar 29, 2021•1 hr 16 min•Ep. 193
The TWiPers solve the case of the Teenager in Malawi with Red Urine, then Audun joins to present our clinical case for this episode. Hosts: Vincent Racaniello , Dickson Despommier , and Daniel Griffin Guest: Audun Lier Subscribe (free): iTunes , Google Podcasts , RSS , email Links for this episode PWB on Facebook , Instagram , Twitter Hero: George B. Craig Letters read on TWiP 192 Become a patron of TWiP Case Study for TWiP 192 Older gentlemen with chills, muscle aches, headaches, shortness of b...
Feb 15, 2021•1 hr 1 min•Ep. 192
The TWiPers solve the case of the Rural Man from North Carolina with Blurred Vision, and discuss the results of single-cell RNA sequencing of Schistosoma mansoni. Hosts: Vincent Racaniello , Dickson Despommier , and Daniel Griffin Subscribe (free): iTunes , Google Podcasts , RSS , email Links for this episode PWB on Facebook , Instagram , Twitter RNAseq atlas of S. mansoni (Science) Hero: Kathleen Hussey Letters read on TWiP 191 Become a patron of TWiP Case Study for TWiP 191 Visit in Malawi, ca...
Jan 11, 2021•1 hr 20 min•Ep. 191
Christina from Glasgow returns to help the TWiPlets solve the case of the Ghanian Woman with Abdominal Mass, followed by discussion of the impact of COVID-19 on malaria morbidity and mortality in Africa. Hosts: Vincent Racaniello , Dickson Despommier , and Daniel Griffin Guest: Christina Naula Download TWiP #190 (57 MB .mp3, 94 minutes) Subscribe (free): iTunes , Google Podcasts , RSS , email Links for this episode PWB on Facebook , Instagram , Twitter COVID-19 effects on malaria in Africa (Lanc...
Dec 08, 2020•1 hr 34 min•Ep. 190
Christina from Glasgow joins the TWiPlets to solve the case of the Elderly Gentlemen with Full Body Rash, and to present a new clinical case for listeners to solve. Hosts: Vincent Racaniello , Dickson Despommier , and Daniel Griffin Guest: Christina Naula Subscribe (free): iTunes , Google Podcasts , RSS , email Links for this episode PWB on Facebook , Instagram , Twitter Support MicrobeTV through Parasites Without Borders Hero: Tony Fauci Tony Fauci on TWiV 219 and 641 Letters read on TWiP 189 B...
Nov 07, 2020•1 hr 45 min•Ep. 189
Dickson, Daniel and Vincent solve the case of the Baby with Hydrocephalus, and present a new clinical case for listeners to solve. Hosts: Vincent Racaniello , Dickson Despommier , and Daniel Griffin Subscribe (free): iTunes , Google Podcasts , RSS , email Links for this episode PWB on Facebook , Instagram , Twitter Letters read on TWiP 188 Become a patron of TWiP Case Study for TWiP 188 Man in 90s, suffering for months, healthy, hypertension, diabetes, large man, over 6 ft, 200 lb, rash. Full bo...
Sep 26, 2020•1 hr 30 min•Ep. 188
Dickson, Daniel and Vincent solve the case of the Middle Aged Woman with Loss of Vision in One Eye, and discuss the role of heme oxygenase in the various protozoan infections. Hosts: Vincent Racaniello , Dickson Despommier , and Daniel Griffin Subscribe (free): iTunes , Google Podcasts , RSS , email Links for this episode Heme oxygenase-1 in protozoan infections (PLoS Path) Support Floating Doctors at PWB Letters read on TWiP 187 Become a patron of TWiP Case Study for TWiP 187 Pregnant newly mar...
Aug 29, 2020•1 hr 17 min•Ep. 187
Dickson, Daniel and Vincent solve the case of the Elder Gardener Feeling Poorly, and discuss the three-dimensional ultrastructure of Plasmodium falciparum during cytokinesis. Hosts: Vincent Racaniello , Dickson Despommier , and Daniel Griffin Subscribe (free): iTunes , Google Podcasts , RSS , email Links for this episode Three-dimensional structure of malaria parasite (PLoS Path) Support Floating Doctors at PWB Letters read on TWiP 186 Become a patron of TWiP Case Study for TWiP 186 Middle aged ...
Aug 01, 2020•1 hr 21 min•Ep. 186
Dickson, Daniel and Vincent solve the case of the Wife of a Guy with Cyclospora Diarrhea, and discuss the discovery of an intrinsic oscillator that drives the bloodstream stage cycle of the malaria parasite. Hosts: Vincent Racaniello , Dickson Despommier , and Daniel Griffin Subscribe (free): iTunes , Google Podcasts , RSS , email Links for this episode Intrinsic oscillator in malaria parasite (Science) Malaria parasite has intrinsic clock (Science) Letters read on TWiP 185 Become a patron of TW...
Jul 03, 2020•1 hr 4 min•Ep. 185
Dickson, Daniel and Vincent solve the case of the Safari Goer With Watery Diarrhea, and explain how a microsporidian endosymbiont of Anopheles mosquitoes might impair the transmission of malaria. Hosts: Vincent Racaniello , Dickson Despommier , and Daniel Griffin Subscribe (free): iTunes , Google Podcasts , RSS , email Links for this episode Contribute to Parasites Without Borders Microsporidian impairs Plasmodium transmission (Nat Comm) Hero: Eugene T. Lyons ( obituary ) Image credit: Josh Lett...
Jun 06, 2020•1 hr 4 min•Ep. 184
Dickson, Daniel and Vincent solve the case of the Female with Itchy Anus, and reveal the structure of a roundworm membrane protein involved in digestion of nutrients. Hosts: Vincent Racaniello , Dickson Despommier , and Daniel Griffin Subscribe (free): iTunes , Google Podcasts , RSS , email Links for this episode Structure of roundworm digestive complex (PLoS Path) Hero: Dr. Anthony Fauci Fauci Pharmacy ( TWiV 219 ) Letters read on TWiP 183 Become a patron of TWiP. Case Study for TWiP 183 70 yo ...
May 08, 2020•1 hr 12 min•Ep. 183
Dickson, Daniel and Vincent solve the case of the Ugandan Volunteer With Morning Bites and discuss integration of HIV-1 into the Schistosome genome, with a sprinkling of COVID-19 throughout. Hosts: Vincent Racaniello , Dickson Despommier , and Daniel Griffin Subscribe (free): iTunes , Google Podcasts , RSS , email Links for this episode PWB social media: Facebook , Instagram , Twitter Daniel on TWiV HIV-1 integration into Schistosome genome (PLoS Path) Image from John Southall's Treatise of Bugg...
Apr 11, 2020•1 hr 15 min•Ep. 182
Dickson, Daniel and Vincent solve the case of the Two Volunteers With Watery Diarrhea, discuss diagnosis of SARS-CoV-2 in the New York area, and reveal an approach to preventing honeybee colony collapse by imbuing their gut bacteria with the ability to produce antiviral and antiparasite double-stranded RNAs. Hosts: Vincent Racaniello , Dickson Despommier , and Daniel Griffin Subscribe (free): iTunes , Google Podcasts , RSS , email Links for this episode PWB social media: Facebook , Instagram , T...
Mar 14, 2020•1 hr 21 min•Ep. 181
The TWiP professors solve the case of the Ugandan Child with Splenomegaly, and reveal that mutations in the P. falciparum genome that confer artemisinin resistance interfere with endocytic uptake of hemoglobin. Hosts: Vincent Racaniello , Dickson Despommier , and Daniel Griffin Subscribe (free): iTunes , Google Podcasts , RSS , email Links for this episode PWB social media: Facebook , Instagram , Twitter Endocytosis pathway mediates artemisinin resistance in malaria parasites (Science) Letters r...
Feb 08, 2020•1 hr 22 min•Ep. 180
The TWiP DVD solve the case of the Child Who Passed Worms, and discuss a non-human primate model for severe malarial anemia. Hosts: Vincent Racaniello , Dickson Despommier , and Daniel Griffin Subscribe (free): iTunes , Google Podcasts , RSS , email Links for this episode PWB social media: Facebook , Instagram , Twitter Primate model of severe malarial anemia (Sci Rep) Ascaris skirt (and more!) Hero: Harold W. Brown Letters read on TWiP 179 Become a patron of TWiP. Case Study for TWiP 179 From U...
Jan 11, 2020•1 hr 43 min•Ep. 179
The Knights of the TWiP solve the case of the Man Who Lost Weight, and discuss a Plasmodium protein kinase that is a malarial drug target. Hosts: Vincent Racaniello , Dickson Despommier , and Daniel Griffin Subscribe (free): iTunes , Google Podcasts , RSS , email Links for this episode PWB social media: Facebook , Instagram , Twitter Protein kinase as malaria drug target (Science) Hero: Myron Schultz Letters read on TWiP 178 Become a patron of TWiP. Case Study for TWiP 178 Eastern border of Ugan...
Dec 04, 2019•1 hr 52 min•Ep. 178
The TWiPsters solve the case of the Rashy Schoolteacher, and reveal a drug from rotifers that live on the snail intermediate host which paralyzes schistosome cercariae and prevents infection of mice. Hosts: Vincent Racaniello , Dand Daniel Griffin Subscribe (free): iTunes , Google Podcasts , RSS , email Links for this episode Progress towards global eradication of dracunculiasis (MMWR) Rotifer compound that paralyzes schistosome cercariae (PLoS Biol) Image credit Letters read on TWiP 177 Become ...
Nov 06, 2019•1 hr 30 min•Ep. 177
The TWiPpers of the bite fantastic solve the case of the Indian Man Who Hiked, and discuss the effects of schistosome soluble egg antigen on infection of lymphocytes with HIV-1. Hosts: Vincent Racaniello , Dickson Despommier , and Daniel Griffin Subscribe (free): iTunes , Google Podcasts , RSS , email Links for this episode Effect of schistosome soluble egg antigen on HIV-1 infection (PLoS P) Hero: Lawson Soulsby Letters read on TWiP 176 Become a patron of TWiP. Case Study for TWiP 176 Recent ca...
Oct 09, 2019•1 hr 33 min•Ep. 176
The TWiP'ers solve the case of the Sudanese Boy With Fever, and reveal antibodies against that slow invasion of red blood cells potentiate other malaria-blocking antibodies. Hosts: Vincent Racaniello , Dickson Despommier , and Daniel Griffin Subscribe (free): iTunes , Google Podcasts , RSS , email Links for this episode Antibodies that slow malaria invasion (Cell) Hero: Sir Leonard Rogers ( pdf ) Letters read on TWiP 175 Become a patron of TWiP. Case Study for TWiP 175 70 yo man born in India, c...
Sep 04, 2019•1 hr 48 min•Ep. 175
Hosts: Vincent Racaniello , Dickson Despommier , and Daniel Griffin The TWiPloid organisms solve the case of the Doctor with Chronic Epigastric Pain, and reveal how levels of linoleic acid in the intestine enable the sexual cycle of Toxoplasma gondii in cats. Subscribe (free): iTunes , Google Podcasts , RSS , email Links for this episode: Determinant of T. gondii sexual cycle (bioRxiv) A Year's Worth of TWiP by Kevin Carney Hero: William Trager Letters read on TWiP 174 Become a patron of TWiP. C...
Aug 01, 2019•1 hr 14 min•Ep. 174
Hosts: Vincent Racaniello , Dickson Despommier , and Daniel Griffin The podcastellani hosts solve the case of the Sailor With Dysentery, and reveal the first virus discovered in Plasmodium species. Subscribe (free): iTunes , Google Podcasts , RSS , email Links for this episode: Matryoshka RNA virus of Plasmodium (bioRxiv) Hero: Rose Gana Fomban Leke Letters read on TWiP 173 Become a patron of TWiP. Case Study for TWiP 173 Successful individual in NY area with 9 months of epigastric pain. Did upp...
Jul 13, 2019•1 hr 51 min•Ep. 173
Hosts: Vincent Racaniello , Dickson Despommier , and Daniel Griffin The metacyclic TWiPomastigotes solve the case of the Child With a Painless Leg Lesion, and reveal how to kill mosquitoes with a genetically modified fungus. Subscribe (free): iTunes , Google Podcasts , RSS , email Transgenic Metarhizium kills mosquitoes (Science) Hero: Veena Tandon Letters read on TWiP 172 Links for this episode: Become a patron of TWiP. Case Study for TWiP 172 Retired US Navy physician, lives aboard his sailboa...
Jun 14, 2019•1 hr 44 min•Ep. 172
The Leishmaniacs solve the case of the Child With Band Keratopathy, and reveal a eukaryotic parasite with functional mitochondria but without mitochondrial genomes. Hosts: Vincent Racaniello , Dickson Despommier , and Daniel Griffin Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiP. Links for this episode: Elmer Pfefferkorn, 87 Eukaryotic parasite without mitochondrial genomes (Sci Adv) Hero: Charles Wardell Stiles Letters read on TWiP 171 Case Study for TWiP 171 B...
May 23, 2019•1 hr 35 min•Ep. 171
