The TWiPlicates solve the case of the Child With Retinal Granuloma, and discuss an association of the complement protein collectin-11 with the pathophysiology of Chagas disease. Hosts: Vincent Racaniello , Dickson Despommier , and Daniel Griffin Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiP. Links for this episode: Chagas disease pathophysiology and collectin-11 (PLoS NTD) Hero: Theobald Smith Image credit: Toxocara canis by Ben Liffner Letters read on TWiP 170...
May 08, 2019•1 hr 31 min•Ep. 170
The TriTWiPomonads solve the case of the Child Who Passed a Worm, and reveal recombination between bovine and human schistosome species. Hosts: Vincent Racaniello , Dickson Despommier , and Daniel Griffin Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiP. Links for this episode: S. bovis and S. haematobium hybrids (PLoS Path) Hero: Ann Bishop Letters read on TWiP 169 Case Study for TWiP 169 9 yo boy brought into mobile clinic set up in small village Bocas del Toro ...
Apr 11, 2019•1 hr 21 min•Ep. 169
The Giardians of the Galaxy solve the case of the Woman With a Colonic Stowaway from Hispaniola, and discuss activation of intestinal tuft cells by Trichinella spiralis . Hosts: Vincent Racaniello , Dickson Despommier , and Daniel Griffin Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiP. Links for this episode: T. spiralis and intestinal tuft cells (PNAS) Hero: Carl Theodore Ernst Van Siebold Letters read on TWiP 168 Case Study for TWiP 168 18 month old child, on ...
Mar 27, 2019•1 hr 33 min•Ep. 168
The Tremendous Trio solve the case of the Woman With Foul Steatorrhea, and reveal breakdown of the glycocalyx associated with severe and fatal malaria. Hosts: Vincent Racaniello , Dickson Despommier , and Daniel Griffin Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiP. Links for this episode: Glycocalyx and severe malaria (Clin Inf Dis) Hero: Bridget Ogilvie Letters read on TWiP 167 Case Study for TWiP 167 Woman 30 yo, traveled to DR, went to tourist part. On retu...
Feb 27, 2019•1 hr 32 min•Ep. 167
The Podfessors solve the case of the Teenager With Swollen Scrotum, and continue the story arc of Daniel's favorite cells, B-1 cells, and their association with protective immune responses in human Chagas disease. Hosts: Vincent Racaniello , Dickson Despommier , and Daniel Griffin Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiP. Links for this episode: B1 cells and Chagas disease (Front Immunol) Daniel discovers B1 cells (J Exp Med) Hero: Bridget Ogilvie Image cr...
Feb 16, 2019•1 hr 23 min•Ep. 166
The TWiP team solves the case of the Four Year Old with Fever, Headache, and Cough, and discuss the release of extracellular vesicles from Leishmania amazonensis that manipulate the host immune response. Hosts: Vincent Racaniello , Dickson Despommier , and Daniel Griffin Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiP. Links for this episode: Crackles (Wikipedia) Extracellular vesicles released by L. amazonensis (Front Microbiol) Hero: Marietta Voge Image credit ...
Jan 26, 2019•1 hr 23 min•Ep. 165
The TWiP legends solve the case of Surfer Sans Septum, and discuss how two symbiotic bacteria in the tsetse fly allow colonization with Trypanosoma brucei . Hosts: Vincent Racaniello , Dickson Despommier , and Daniel Griffin Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiP. Links for this episode: A Tale of Three Species (mBio) V.B. Wigglesworth (Wikipedia) VB Nimble, VB Quick Hero: James Paget Letters read on TWiP 164 Case Study for TWiP 164 Welcome to Uganda. Mo...
Jan 12, 2019•1 hr 41 min•Ep. 164
The doctors of awesome solve the case of the Woman Who Visited Lebanon, and reveal that immunoglobulins protect the olfactory organ of trout against infection with the Ich parasite. Hosts: Vincent Racaniello , Dickson Despommier , and Daniel Griffin Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiP. Links for this episode: Mucosal Ig protect trout from Ich (PLoS Path) Hero: Sir Patrick Manson Letters read on TWiP 163 Case Study for TWiP 163 From here in US before l...
Dec 29, 2018•1 hr 45 min•Ep. 163
The TWiP professors solve the case of the Baby With Pericardial Effusion, and discuss whether the flagellate without a flagella, Dientamoeba fragilis , causes human illness. Hosts: Vincent Racaniello , Dickson Despommier , and Daniel Griffin Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiP. Links for this episode: Patients with Dientamoeba fragilis infection (Am J Trop Med Hyg) Hero: D r. Eloise B. Cram Image credit Letters read on TWiP 162 Case Study for TWiP 162...
Nov 21, 2018•1 hr 28 min•Ep. 162
The TWiPsters solve the case of the Brazilian Immigrant With Heart Problems, and describe how genome organization controls trypanosome antigenic variation. Hosts: Vincent Racaniello , Dickson Despommier , and Daniel Griffin Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiP. Links for this episode: Trypanosome genome organization and antigenic variation (Nature) Hero: Arthur Looss Letters read on TWiP 161 Case Study for TWiP 161 Daniel was asked to see 30 yo female ...
Nov 10, 2018•1 hr 31 min•Ep. 161
The TWiPlets solve the case of the Electrician from Tamil Nadu with a Liver Mass, and reveal that dogs and humans share a common Chadian Guinea worm. Hosts: Vincent Racaniello , Dickson Despommier , and Daniel Griffin Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiP. Links for this episode: Chadian Guinea worms in humans and dogs (PLoS NTD) Hero: Karl George Friedrich Rudolf Leuckart Image credit Letters read on TWiP 160 Case Study for TWiP 160 Referred to Daniel ...
Oct 10, 2018•1 hr 36 min•Ep. 160
The TWiP triptych solve the case of the 9/11 Survivor infested with parasites, and discuss the effect of community ivermectin treatment for onchocerciasis on Loa loa infections. Hosts: Vincent Racaniello , Dickson Despommier , and Daniel Griffin Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiP. Links for this episode: Ivermectin for onchocerciasis and loiasis (PLoS NTD) Hero: William Boog Leishman Thanks to Caitlin for the image Letters read on TWiP 159 Case Study...
Sep 28, 2018•1 hr 35 min•Ep. 159
The TWiP hosts solve the case of the Thai Woman With Red Bumps, and reveal that a master manipulator contacts ant brain tissue to control its behavior. Hosts: Vincent Racaniello , Dickson Despommier , and Daniel Griffin Become a patron of TWiP. Links for this episode: Imaging parasites in ant brain (Nat Rep) Brain worm turns ants into zombies (Nat Hist Museum) Hero: Giovanni Battista Grassi Image credit Letters read on TWiP 158 Case Study for TWiP 158 Male in 50s comes to see Daniel, concerned t...
Sep 14, 2018•1 hr 22 min•Ep. 158
The TWiP professors solve the case of the Woman With Intracellular Ring Forms, and explore the role of Coxiella and Rickettsia endosymbionts in acquisition of Babesia by ticks. Hosts: Vincent Racaniello , Dickson Despommier , and Daniel Griffin Become a patron of TWiP. Links for this episode: Endosymbionts and Babesia in ticks (Front Microbiol) Q fever with Robert Heintzen (TWiM Special) Hero: Percy Garnham Image credit Letters read on TWiP 157 Case Study for TWiP 157 Back to Thailand. Housewife...
Aug 29, 2018•1 hr 46 min•Ep. 157
The TWiP crew solves the case of the Ecuadorian with Immunodeficiency and Chronic Diarrhea, and discuss oral transmission of Chagas disease in mice. Hosts: Vincent Racaniello , Dickson Despommier , and Daniel Griffin Become a patron of TWiP. Links for this episode: Imaging Chagas after oral transmission (Sci Rep) NJ invasive species strike team and app Red Mother Hero: Angelo Dubini Image credit Letters read on TWiP 156 Case Study for TWiP 156 While on ID consultant service on LI during July, as...
Aug 08, 2018•1 hr 28 min•Ep. 156
Justin joins the TWiP team to solve the case of the Gentleman with B cell Lymphoma, and consider the finding of Dracunculus species in river otters from Arkansas. Hosts: Vincent Racaniello , Dickson Despommier , and Daniel Griffin Guest: Justin Aaron Become a patron of TWiP. Links for this episode: Dracunculus in river otters (J Parasitol) Image credit Letters read on TWiP 155 Case Study for TWiP 155 Another challenging one. 60 yo man with poorly defined immunodeficiency: low Ig, low T cells, on...
Jul 24, 2018•1 hr 32 min•Ep. 155
Vincent and Daniel solve the case of the Man in the City with Groin Rash, catch up on the long backlog of email, and present a new case, possibly the most complex one yet on the show. Hosts: Vincent Racaniello and Daniel Griffin Become a patron of TWiP. Links for this episode: Bloodless malaria diagnostic (BBC) Image credit Letters read on TWiP 154 Case Study for TWiP 154 Daniel's colleague will solve this case, in two weeks. 79 year old man history of chronic lymphocytic leukemia that became B ...
Jun 27, 2018•1 hr 38 min•Ep. 154
Vincent and Daniel solve the case of the Panamanian Farmer with Three Weeks of Diarrhea, and discuss how microbes egested during bites of sand flies exacerbate the severity of leishmaniasis. Hosts: Vincent Racaniello and Daniel Griffin Become a patron of TWiP. Links for this episode: Sand fly microbes and leishmaniasis severity (Cell Host Micr) Letters read on TWiP 153 Case Study for TWiP 153 Man in clinic, in city recently, developed rash in groin area, concerned about this. Lives in open relat...
Jun 13, 2018•1 hr 20 min•Ep. 153
The TWiP peeps solve the case of the Panamanian Mother with Steatorrhea, and reveal new monoclonal antibodies that effectively block malarial infection. Hosts: Vincent Racaniello , Dickson Despommier , and Daniel Griffin Become a patron of TWiP. Links for this episode: Plasmodium immunity from injected sporozoites (Nature) New monoclonal prevents malaria infection (Nat Med) Parasite Hero: Carlos Chagas Image credit Letters read on TWiP 152 Case Study for TWiP 152 40 yo man in same Panamanian vil...
May 26, 2018•1 hr 48 min•Ep. 152
The Podfessors solve the case of the Itchy Child from Panama, and discuss competition for blood in human malaria-helminth co-infections. Hosts: Vincent Racaniello , Dickson Despommier , and Daniel Griffin Become a patron of TWiP. Links for this episode: Competing for Blood (Ecol Letters) Parasite Hero: William C. Campbell Image credit Letters read on TWiP 151 Case Study for TWiP 151 Woman in 30s, mother of last two boys we saw, same locale. Concerned about abdominal pain for 3 years. Fullness, b...
May 02, 2018•1 hr 27 min•Ep. 151
The TWiPers solve the case of the Panamanian Man With Leg Ulcer, and describe how a crab predator preferentially feeds on parasite infected prey - even though the parasite makes them faster! Hosts: Vincent Racaniello , Dickson Despommier , and Daniel Griffin Become a patron of TWiP. Links for this episode: Parasite enhances susceptibility to predators (Oecologia) Parasite Hero: Miriam Rothschild Image credit Letters read on TWiP 150 Case Study for TWiP 150 Up to Costa Rican border, travel by boa...
Apr 19, 2018•1 hr 26 min•Ep. 150
Shivang joins the TWiP triumvirate to solve the case of the New Yorker With Rash and Pins and Needles, and reveal how agrochemicals increase risk of human schistosomiasis by causing high snail density. Hosts: Vincent Racaniello , Dickson Despommier , and Daniel Griffin Guest: Shivang Shah Become a patron of TWiP. Links for this episode: Even dinosaurs had parasites (Cosmos Mag) Why some people are wormier than others (RSTMH) Angiostrongylus species in badger lungs (thanks, Rachel!) Spread of rat...
Mar 22, 2018•1 hr 29 min•Ep. 149
The TWiP-tologists solve the case of the South American Child With Belly Pain, and reveal how B1 cell IgE blocks parasite clearance by inhibiting mast cell activation by B2 cell IgE. Hosts: Vincent Racaniello , Dickson Despommier , and Daniel Griffin Become a patron of TWiP. Links for this episode: Do not eat raw earthworms ! (Pediatrics) Would you let worms in your veins? (Science) Guinea Pig Doctors by Jon Franklin and John Sutherland Parasite Hero: David Bruce Letters read on TWiP 148 Case St...
Mar 07, 2018•1 hr 51 min•Ep. 148
The three amigos of parasitology solve the case of the New York Lawyer With A Foot Ulcer, and discuss a survey of rodents for the raccoon roundworm in California. Hosts: Vincent Racaniello , Dickson Despommier , and Daniel Griffin Become a patron of TWiP. Links for this episode: Monthly case studies (CDC) The Parasite on the Playground (NYTimes) Introduced rats and raccoon roundworm (J Parasitol) Parasite Hero: Theodor Bilharz Letters read on TWiP 147 Case Study for TWiP 147 Three year old boy, ...
Feb 24, 2018•1 hr 32 min•Ep. 147
The TWIPniks solve the case of the Man With Diarrhea and 100 Micron Objects In Stool, and discuss the reticulocyte receptor for Plasmodium vivax . Hosts: Vincent Racaniello , Dickson Despommier , and Daniel Griffin Become a patron of TWiP. Links for this episode: Reticulocyte receptor for Plasmodium vivax (Science) Image credit: Parasitic Diseases, 6th Ed. Parasite Heroine: Marietta Voge Letters read on TWiP 146 Case Study for TWiP 146 27 yo male lawyer comes NY area to be seen, has 4 cm ulcer o...
Jan 31, 2018•1 hr 27 min•Ep. 146
The Estimados Profesores of TWIP solve the case of the Man With Motile Objects, and reveal the secreted and excreted proteins of Giardia parasites. Hosts: Vincent Racaniello , Dickson Despommier , and Daniel Griffin Become a patron of TWiP. Links for this episode: Excretory and secretory products of Giardia intestinalis (PLoS NTD) Image credit Letters read on TWiP 145 Case Study for TWiP 145 Male 40s, visiting NYC on business. Lives in Thailand, seeks medical attention for diarrhea and abdominal...
Jan 17, 2018•1 hr 36 min•Ep. 145
The TWiPtomaniacs solve the case of the Boy With Visual Disturbances and Itching, and discuss identifying secreted and excreted proteins of Trichinella parasites. Hosts: Vincent Racaniello , Dickson Despommier , and Daniel Griffin Become a patron of TWiP. Links for this episode: Malaria plasmepsins involved in invasion and egress (Science) Image credit Letters read on TWiP 144 Case Study for TWiP 144 Individual in 30s, male, presented to physician with stomach upset, uncomfortable feeling in leg...
Dec 14, 2017•1 hr 42 min•Ep. 144
The TWiPians solve the case of the Woman With Anemia, Eosinophila, and a Worm in Her Intestine, and discuss a study on the function and druggability of two malarial aspartate proteases. Hosts: Vincent Racaniello , Dickson Despommier , and Daniel Griffin Become a patron of TWiP. Links for this episode: Malaria plasmepsins involved in invasion and egress (Science) Letters read on TWiP 143 Case Study for TWiP 143 From 1990s seen by a colleague, boy late teens, initially presented to ER in US chief ...
Nov 28, 2017•1 hr 39 min•Ep. 143
The TWiPsids solve the case of the Guatemalan Positive for Rhinovirus, and reveal how to kill all African trypanosomes with a primate apolipoprotein. Hosts: Vincent Racaniello , Dickson Despommier , and Daniel Griffin Become a patron of TWiP. Links for this episode: APOLs kill all African trypanosomes (Nat Micro) Trypanocidal properties of APOL1 on TWiP 85: Channeling tryps Letters read on TWiP 142 Case Study for TWiP 142 Woman in 50s, immigrant from rural area with limited resources. Admitted t...
Nov 17, 2017•1 hr 33 min•Ep. 142
The TWiP Wataalamu solve the case of the One Year Old From Kenya With Moving Skin Lesions, and describe how to make mosquitoes refractory to Plasmodium with engineered symbiotic bacteria. Hosts: Vincent Racaniello , Dickson Despommier , and Daniel Griffin Become a patron of TWiP. Links for this episode: Engineered Serratia make mosquitoes refractory to Plasmodium (Science) Operation Sea Spray (Wikipedia) Photo credit Letters read on TWiP 141 Case Study for TWiP 141 A 59 yo Spanish speaking femal...
Oct 31, 2017•1 hr 29 min•Ep. 141
