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TWiN explains the finding that vaginal microbiota transfer ameliorates cesarean-associated neurodevelopmental deficits in mice via synthesis of a sphingosine derivative on neonatal skin. .Hosts: Vincent Racaniello , Vivianne Morrison, and Tim Cheung Subscribe (free): Apple Podcasts , Google Podcasts , RSS Links for this episode MicrobeTV Discord Server Vaginal microbiota transfer ameliorates cesarean-associated neurodevelopmental deficits (Cell Host Microbe) Timestamps by Jolene Ramsey . Thanks!...
TWiN explains the finding that activation of intracellular, not plasma membrane, serotonin 2A receptors is responsible for the plasticity-promoting and antidepressant-like properties of psychedelic compounds. Hosts: Vincent Racaniello , Vivianne Morrison, and Tim Cheung Subscribe (free): Apple Podcasts , Google Podcasts , RSS Links for this episode MicrobeTV Discord Server Psychedelics rewire the brain from within (Science) Psychedelics elicit their effects by Gi signaling (Nature) History of LS...
TWiN explains the role of a ubiquitin ligase component in regulating the sheathing of multiple axons by Schwann cells. Hosts: Vincent Racaniello , Vivianne Morrison, and Tim Cheung Subscribe (free): Apple Podcasts , Google Podcasts , RSS Links for this episode MicrobeTV Discord Server Gut microbiome promotes pain in fibromyalgia (Neuron) Timestamps by Jolene Ramsey . Thanks! Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv...
TWiN explains a study which showed that transplanting gut microbiota from women with fibromyalgia into mice induces pain, as well as phenotypes commonly observed in patients, such as immune activation, metabolomic changes, and reduced skin innervation. Hosts: Vincent Racaniello , Vivianne Morrison, and Tim Cheung Subscribe (free): Apple Podcasts , Google Podcasts , RSS Links for this episode MicrobeTV Discord Server Gut microbiome promotes pain in fibromyalgia (Neuron) Timestamps by Jolene Ramse...
TWiN explores the use of speech brain-computer interfaces to restore communication to people with paralysis, and reveals strategies for protecting private inner speech. Hosts: Vincent Racaniello , Vivianne Morrison, and Tim Cheung Subscribe (free): Apple Podcasts , Google Podcasts , RSS Links for this episode MicrobeTV Discord Server Keeping private inner speech from brain-computer interfaces (Cell) Mind-reading brain implant with password protection (Nature) Timestamps by Jolene Ramsey . Thanks...
TWiN explores how theta phase shifts mediate contextual perception of facial expressions during everyday social interactions. Hosts: Vincent Racaniello , Vivianne Morrison, and Tim Cheung Subscribe (free): Apple Podcasts , Google Podcasts , RSS Links for this episode MicrobeTV Discord Server Neural computations underlying contextual processing in humans (Cell Rep) Previous experience shapes perception (Front Human Neurosci) Timestamps by Jolene Ramsey . Thanks! Music is by Ronald Jenkees Send yo...
This episode reviews the complex neurobiological mechanisms underlying overeating and obesity. It differentiates between homeostatic eating, driven by metabolic needs, and hedonic eating, fueled by pleasure and reward, detailing the critical roles of the hypothalamus, ghrelin, leptin, and dopamine. The discussion also covers genetic predispositions to overeating, the controversial "food addiction" concept, and how GLP-1 receptor agonists like Ozempic target these systems for weight loss, including potential side effects.
TWiN explains epidemiological data showing that exposure to air pollution was associated with an increased risk of developing Lewy body dementia, and nasal administration of air pollution in mice led to brain atrophy and impaired cognition and motor function. Hosts: Vincent Racaniello , Vivianne Morrison, and Tim Cheung Subscribe (free): Apple Podcasts , Google Podcasts , RSS Links for this episode MicrobeTV Discord Server Links between air pollution and dementias (Science) Letter from Susan Sch...
TWiN explains how visual neurons show functional flexibility by selectively responding to subsets of inputs representing attended objects while ignoring those conveying information about irrelevant objects. Hosts: Vincent Racaniello , Vivianne Morrison, and Tim Cheung Subscribe (free): Apple Podcasts , Google Podcasts , RSS Links for this episode MicrobeTV Discord Server Gamma-band synchronization in visual cortex (Nat Comm) Timestamps by Jolene Ramsey . Thanks! Music is by Ronald Jenkees Send y...
TWiN discusses research showing that Lactobacillus acidophilus promotes cognitive function recovery after cerebral ischemia, by regulating microglial peroxisomal function. Hosts: Vincent Racaniello , Vivianne Morrison, and Tim Cheung Subscribe (free): Apple Podcasts , Google Podcasts , RSS Links for this episode MicrobeTV Discord Server Arc is pdb molecule of the month (PDB) Probiotics after stroke (Cell Host Microbe) Timestamps by Jolene Ramsey . Thanks! Music is by Ronald Jenkees Send your neu...
TWiN explains research which identifies the regions of the brain that register a long-lasting aversion to potentially poisonous food even with meal to illness delays of several days. Hosts: Vincent Racaniello , and Tim Cheung Subscribe (free): Apple Podcasts , Google Podcasts , RSS Links for this episode MicrobeTV Discord Server A neural mechanism for post-ingestion feedback (Nature) Timestamps by Jolene Ramsey . Thanks! Music is by Ronald Jenkees Send your neuroscience questions and comments to...
TWiN reveals that proteins travel from the blood to the brain where they are taken up by microglia, revealing a new mode of communication between the brain and the periphery. Hosts: Vincent Racaniello , Tim Cheung, and Vivianne Morrison Subscribe (free): Apple Podcasts , Google Podcasts , RSS Links for this episode MicrobeTV Discord Server Circulatory proteins taken up by brain microglia (bioRxiv) Timestamps by Jolene Ramsey . Thanks! Music is by Ronald Jenkees Send your neuroscience questions a...
TWiN discusses experiments which show that high-fidelity memories that lose their precision with time depends on reorganization of hippocampal circuitry. Hosts: Vincent Racaniello , Jason Shepherd , and Tim Cheung Subscribe (free): Apple Podcasts , Google Podcasts , RSS Links for this episode MicrobeTV Discord Server Loss of precision memory and the hippocampus (Nature) Changes in hippocampi of cab drivers (PNAS) Timestamps by Jolene Ramsey . Thanks! Music is by Ronald Jenkees Send your neurosci...
Tim explains AI co-scientist, a tool released by Google, which it hopes to help scientists generate hypotheses and research proposals, and to accelerate the speed of scientific and biomedical discoveries. Hosts: Vincent Racaniello , Tim Cheung, and Vivianne Morrison Subscribe (free): Apple Podcasts , Google Podcasts , RSS Links for this episode MicrobeTV Discord Server AI cracks superbug problem (BBC) Accelerating scientific breakthroughs (Google Research) Towards an AI co-scientist (arXiv) Time...
TWiN explains a study showing that when a mouse is confronted with an unconscious conspecific, it engages in behavior including tongue-dragging to resuscitate the animal via a tongue-brain connection. Hosts: Vincent Racaniello , Tim Cheung, and Vivianne Morrison Subscribe (free): Apple Podcasts , Google Podcasts , RSS Links for this episode MicrobeTV Discord Server Tongue-dragging in mice (Sci Adv) Timestamps by Jolene Ramsey . Thanks! Music is by Ronald Jenkees Send your neuroscience questions ...
TWiN discusses a study showing that repetitive injury reactivates HSV-1 in a human brain tissue model and induces phenotypes associated with Alzheimer's disease. Hosts: Vincent Racaniello and Tim Cheung Subscribe (free): Apple Podcasts , Google Podcasts , RSS Links for this episode MicrobeTV Discord Server Repetitive injury, herpes, and Alzheimers (Sci Signal) The tau of herpesvirus ( TWiV 1187 ) Fishing for viruses in senile ( TWiV 519 ) Timestamps by Jolene Ramsey . Thanks! Music is by Ronald ...
TWiN explains a study showing that while groups of neurons, form the basis for memory, astrocytes are key components of the adaptive reponse to learning experiences, and regulate the flow of information during circuit plasticity and memory recall. Hosts: Vincent Racaniello , Jason Shepherd , and Tim Cheung Subscribe (free): Apple Podcasts , Google Podcasts , RSS Links for this episode MicrobeTV Discord Server Write your Senator , oppose RFK Jr nomination Astrocytes and memory (Nature) Timestamps...
TWiN explains the identification of a brain circuit and periodic branch-specific neurotransmitter deployment that regulates organismal adaptation to photoperiod change. Hosts: Vincent Racaniello , Jason Shepherd , and Tim Cheung Subscribe (free): Apple Podcasts , Google Podcasts , RSS Links for this episode MicrobeTV Discord Server Brain circuit for photoperiod adaptation (Nature) Timestamps by Jolene . Thanks! Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@micr...
TWiN explores how pregnancy leads to modifications in brain structure and function that may prepare the mother for parenting. Hosts: Vincent Racaniello , Jason Shepherd , and Vivianne Morrison Subscribe (free): Apple Podcasts , Google Podcasts , RSS Links for this episode MicrobeTV Discord Server Pregnancy transforms the brain (Nature) Hormone-mediated neural remodeling during pregnancy (Science) Effects of pregnancy on brain activity (Nature Comm) Timestamps by Jolene . Thanks! Music is by Rona...
Joseph Paton and Felipe Rodrigues join TWiN to explain how they used temperature manipulation to alter the speed of neuronal dynamics in the dorsal striatum of rats, a manipulation that selectively slowed down or sped up time perception, illuminating the mechanisms of time-based decisions. Hosts: Vincent Racaniello , Jason Shepherd , Timothy Cheung , and Vivianne Morrison Guest: Joseph J. Paton and Felipe Rodrigues Subscribe (free): Apple Podcasts , Google Podcasts , RSS Links for this episode M...
Mauro Costa-Mattioli returns to TWiN to discuss the results of a placebo controlled, double blind clinical trial of a probiotic which improved social behavior but not autism severity in children with ASD. Hosts: Jason Shepherd , Timothy Cheung , and Vivianne Morrison Guest: Mauro Costa-Mattioli Subscribe (free): Apple Podcasts , Google Podcasts , RSS Links for this episode MicrobeTV Discord Server Probiotics for autism spectrum disorder (Cell Host Microbe) Timestamps by Jolene . Thanks! Music is...
TWiN reviews altered somatosensory reactivity, which is frequently observed among individuals with autism spectrum disorders (ASD), and in mouse models the developmental timing of aberrant touch processing can predict the manifestation of ASD-associated behaviors in mouse models. Hosts: Vincent Racaniello , Jason Shepherd , Timothy Cheung , and Vivianne Morrison Subscribe (free): Apple Podcasts , Google Podcasts , RSS Links for this episode MicrobeTV Discord Server Mouse models of autism spectru...
TWiN reviews experiments which show that SARS-CoV-2 triggers the up-regulation of synaptic components and perturbs local electrical field potential in cerebral organoids, organotypic culture of human brain explants and post-mortem brain samples from individuals with COVID-19. Hosts: Vincent Racaniello , Jason Shepherd , Timothy Cheung , and Vivianne Morrison Subscribe (free): Apple Podcasts , Google Podcasts , RSS Links for this episode MicrobeTV Discord Server SARS-CoV-2 perturbs synaptic homeo...
TWiN welcomes mice to the elite club of 'self-aware' animals, with a study demonstrating a mirror-induced self-directed behavior in mice resembling visual self-recognition. Hosts: Vincent Racaniello , Timothy Cheung , and Vivianne Morrison Subscribe (free): Apple Podcasts , Google Podcasts , RSS Links for this episode MicrobeTV Discord Server Mice are self-aware (Neuron) Mirror self-recognition in mice (Neuron) Timestamps by Jolene . Thanks! Music is by Ronald Jenkees Send your neuroscience ques...
TWiN describes a study that reveals activation of endogenous retroviruses in oligodenroglia from patients with traumatic brain injury. Hosts: Vincent Racaniello , Jason Shepherd , and Timothy Cheung Subscribe (free): Apple Podcasts , Google Podcasts , RSS Links for this episode MicrobeTV Discord Server Activation of e ndogenous retroviruses in TBI oligodendroglia (Cell Rep) Timestamps by Jolene . Thanks! Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv...
TWiN explains an amazing study of a man who was paralyzed after a spinal cord injury and regained the ability to walk after implantation of a brain-spinal cord interface. Hosts: Vincent Racaniello , Jason Shepherd , and Timothy Cheung Subscribe (free): Apple Podcasts , Google Podcasts , RSS Links for this episode MicrobeTV Discord Server Walking naturally after spinal cord injury (Nature) The paralyzed rat that walked (YouTube) Mike the headless chicken (Wikipedia) Timestamps by Jolene . Thanks!...
TWiN explains research showing that interaction between glioma cells and neurons in the brain shares mechanistic features with synaptic plasticity that contributes to memory and learning in the healthy brain. Hosts: Vincent Racaniello , Jason Shepherd , and Timothy Cheung Subscribe (free): Apple Podcasts , Google Podcasts , RSS Links for this episode MicrobeTV Discord Server Glioma synapses recruit mechanisms of adaptive plasticity (Nature) Timestamps by Jolene . Thanks! Music is by Ronald Jenke...
TWiN discusses research showing that sciatic nerve activation with electroacupuncture at the sciatic nerve controls systemic inflammation and rescues mice from polymicrobial peritonitis, by inducing vagal activation of aromatic L-amino acid decarboxylase, leading to the production of dopamine in the adrenal medulla. Hosts: Vincent Racaniello , Jason Shepherd , and Timothy Cheung Subscribe (free): Apple Podcasts , Google Podcasts , RSS Links for this episode MicrobeTV Discord Server Electroacupun...
TWiN reviews a mouse model of ADHD to characterize hypersensitivity to pain, and that sensitization is further amplified in a pathological inflammatory state. Hosts: Vincent Racaniello , Jason Shepherd , and Timothy Cheung Subscribe (free): Apple Podcasts , Google Podcasts , RSS Links for this episode MicrobeTV Discord Server Pain hypersensitivity in ADHD model (PNAS) Timestamps by Jolene . Thanks! Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv...
TWiN discusses a study of on the pathways that control opioid analgesic tolerance, a root cause of opioid overdose and misuse, which can develop through an associative learning. Hosts: Vincent Racaniello , Jason Shepherd , and Timothy Cheung Subscribe (free): Apple Podcasts , Google Podcasts , RSS Links for this episode MicrobeTV Discord Server Associative opioid analgesic tolerance (Sci Adv) Pavlovian-conditioned opioid tolerance (Sci Adv) Timestamps by Jolene . Thanks! Music is by Ronald Jenke...
