TWiN explains how psychedelic drugs such as LSD, psilocybin, and MDMA, which are being explored for treating a wide range of neuropsychiatric diseases, reopen the social reward period for critical learning. Hosts: Vincent Racaniello , Jason Shepherd , and Timothy Cheung Click arrow to play Download TWiN 042 (34 MB .mp3, 57 min) Subscribe (free): Apple Podcasts , Google Podcasts , RSS Links for this episode MicrobeTV Discord Server Psychedelic drugs open critical period (Nature) Psychedelics reop...
Jul 18, 2023•57 min•Ep. 42
Vivianne explains how early in Alzheimer's disease, the brain attempts to counteract the increased excitatory drive caused by amyloid deposition, and that melanin-concentrating hormone, produced during sleep, is involved in this protective response. Hosts: Vincent Racaniello , Jason Shepherd , Timothy Cheung , and Vivianne Morrison Subscribe (free): Apple Podcasts , Google Podcasts , RSS Links for this episode MicrobeTV Discord Server Melanin-concentrating hormone and Alzheimer's disease (Nat Ne...
Jun 20, 2023•1 hr 19 min•Ep. 41
Tim takes TWiN through two studies on the role of dopamine: that syllables are natural units of spontaneous behavior used by the brain to structure action, and that mesolimbic dopamine release conveys causal associations but not reward prediction errors, thereby challenging the dominant theory of reward learning. Hosts: Vincent Racaniello , Jason Shepherd , Timothy Cheung , and Vivianne Morrison Subscribe (free): Apple Podcasts , Google Podcasts , RSS Links for this episode MicrobeTV Discord Ser...
May 11, 2023•1 hr 4 min•Ep. 40
Junjie from Jason's lab joins TWiN to discuss the observation that the cell gene PNMA2 encodes non-enveloped virus-like capsids that induce autoantibodies which underlie paraneoplastic syndrome. Hosts: Vincent Racaniello , Jason Shepherd , Timothy Cheung , and Junjie Xu Subscribe (free): Apple Podcasts , Google Podcasts , RSS Links for this episode MicrobeTV Discord Server Virus-like capsids in paraneoplastic disease (bioRxiv) Timestamps by Jolene . Thanks! Music is by Ronald Jenkees Send your n...
Apr 28, 2023•53 min•Ep. 39
TWiN explains the finding that immunity to commensal bacteria promotes sensory neuron regeneration via the cytokine interleukin-17A. Hosts: Vincent Racaniello , Ori Lieberman , Timothy Cheung , and Vivianne Morrison Subscribe (free): Apple Podcasts , Google Podcasts , RSS Links for this episode MicrobeTV Discord Server Immunity to the microbiota promotes sensory neuron regeneration (Cell) Timestamps by Jolene . Thanks! Music is by Ronald Jenkees Send your neuroscience questions and comments to t...
Mar 27, 2023•1 hr 5 min•Ep. 38
TWiN reviews the field of microgial research, which has advanced in recent decades but is constrained by nomenclature that is necessary but often implies specific functions. Hosts: Vincent Racaniello , Jason Shepherd , Timothy Cheung , and Vivianne Morrison Subscribe (free): Apple Podcasts , Google Podcasts , RSS Links for this episode Microglia states and nomenclature (Nature) Timestamps by Jolene . Thanks! Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe...
Jan 23, 2023•1 hr 15 min•Ep. 37
TWiN answers listener questions about Alzheimer's disease, glaucoma and the microbiota, Dravet's Syndrome, schizophrenia, brain development, and chips implanted in the human brain. Hosts: Vincent Racaniello , Jason Shepherd , Timothy Cheung , and Vivianne Morrison Subscribe (free): Apple Podcasts , Google Podcasts , RSS Links for this episode Letters read on TWiN 36 Timestamps by Jolene . Thanks! Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv...
Jan 03, 2023•1 hr 30 min•Ep. 36
Jason and Tim review the use of an implanted chronic deep brain sensing and stimulation device to carry out biomarker-driven closed-loop therapy that resulted in a rapid and sustained improvement in depression. Hosts: Jason Shepherd and Timothy Cheung Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Links for this episode Closed-loop neuromodulation for depression (Nat Med) Timestamps by Jolene . Thanks! Music is by Ronald Jenkees Send your neuroscience questions and comments to ...
Dec 06, 2022•1 hr 9 min•Ep. 35
TWiN explains how central nervous system resident macrophages known as microglia coordinate cellular interactions during spinal cord repair in mice. Hosts: Vincent Racaniello , Jason Shepherd , Timothy Cheung , and Vivianne Morrison Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Links for this episode Microglia coordinate spinal cord repair (Nat Commun) Timestamps by Jolene . Thanks! Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv...
Sep 30, 2022•1 hr 9 min•Ep. 34
TWiN describes how neurotropic viruses leave the brain via meningeal lymphatic vessels located dorsally and basally beneath the skull. Hosts: Vincent Racaniello , Ori Lieberman , Jason Shepherd , and Timothy Cheung Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Links for this episode Meningeal lymph vessels and viral exit from brain (Nature Neuroscience) Clearing mouse brain video (YouTube) Timestamps by Jolene . Thanks! Music is by Ronald Jenkees Send your neuroscience questio...
Aug 31, 2022•58 min•Ep. 33
TWiN reviews how, in a mouse stroke model, recovery of movement is associated with the remaining cortex and the striatum coordinating their activity together. Hosts: Ori Lieberman, Timothy Cheung , and Vivianne Morrison Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Links for this episode Recovery after stroke in mice (Cell Rep) Timestamps by Jolene . Thanks! Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv...
Aug 02, 2022•1 hr•Ep. 32
TWiN explains the observation that in mice, the HIV-1 co-receptor CCR5 closes the temporal window for linking different memories. Hosts: Vincent Racaniello , Jason Shepherd , Timothy Cheung , and Vivianne Morrison Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Links for this episode CCR5 and memory linking (Nature) Timestamps by Jolene . Thanks! Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv...
Jun 29, 2022•1 hr 12 min•Ep. 31
TWiN describes experiments demonstrating that gut injection of alpha-synuclein fibrils in mice converts endogenous alpha-synuclein to a pathologic form that spreads to the brain and leads to features of Parkinson's disease. Hosts: Vincent Racaniello , Ori Lieberman , Jason Shepherd , Timothy Cheung , and Vivianne Morrison Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Links for this episode Gut-brain alpha-synuclein transport in PD (Neuron) Gut has a mind of its own (Colbert Re...
May 24, 2022•1 hr 10 min•Ep. 30
TWiN explains the finding that in the mouse visual cortex, astrocytes are key elements in the experience-dependent wiring of brain circuits. Hosts: Vincent Racaniello , Jason Shepherd , Timothy Cheung , and Vivianne Morrison Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiN! Links for this episode Astrocytes close the critical period (Science) Timestamps by Jolene . Thanks! Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@mic...
May 02, 2022•1 hr 2 min•Ep. 29
TWiN reveals how oligodendrocytes enhance axonal energy metabolism by transcellular delivery of a protein, SIRT2, that deacetylates mitochondrial proteins. Hosts: Vincent Racaniello , Timothy Cheung , and Vivianne Morrison Click arrow to play Download TWiN 028 (77 MB .mp3, 64 min) Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiN! Links for this episode Glia 101 ( TWiN 19 ) Oligodendrocytes enhance axonal energy metabolism (Neuron) Timestamps by Jolene . Th...
Apr 04, 2022•1 hr 14 min•Ep. 28
TWiN discusses the finding that rewiring retinal projections to the auditory thalamus in ferrets leads to visually responsive cells that are typical of cells in the visual cortex. Hosts: Ori Lieberman, Jason Shepherd , Timothy Cheung , and Vivianne Morrison Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiN! Links for this episode Remapping retinal projections (Nature) Sweet vs bitter taste (Nature) Timestamps by Jolene . Thanks! Music is by Ronald Jenkees S...
Mar 03, 2022•1 hr 4 min•Ep. 27
TWiN reviews evidence in mice that brain neurons encode and retrieve specific immune responses. Become a patron of TWiN! Links for this episode Memory of immunity (Cell) Timestamps by Jolene . Thanks! Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv...
Jan 31, 2022•54 min•Ep. 26
TWiN answers listener questions on sex in neuroscience studies, rotating memories in the brain, odorant receptors in the brain, and neutrophils that promote neuron survival. Hosts: Vincent Racaniello , Jason Shepherd , and Timothy Cheung Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiN! Links for this episode Males and females in neuroscience studies (New Scientist) Brain rotates memories (Quanta) Odorant receptors in brain ( one , two ) Neutrophils promote neuron...
Dec 28, 2021•1 hr 3 min•Ep. 25
Ioana and Robert join TWiN to discuss their work demonstrating that rodents acquire maternal behavior by social transmission from an experienced mother to a virgin female how to care for a litter via endogenous oxytocin. Hosts: Vincent Racaniello and Timothy Cheung Guests: Ioana Carcea and Robert Froemke Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiN! Links for this episode Oxytocin neurons and social transmission of behavior (Nature) Timestamps by Jolene . Than...
Nov 24, 2021•1 hr 13 min•Ep. 24
Bruce Carter joins TWiN to discuss the peripheral nervous system: the development of nerves that convey sensory information like touch from the tips of your toes to the brain, and Schwann cells, which are necessary for ensuring that those sensory signals are sustained as they travel long distances to the brain. Hosts: Vincent Racaniello , Timothy Cheung , and Vivianne Morrison Guest: Bruce Carter Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiN! Links for this epi...
Oct 31, 2021•1 hr 11 min•Ep. 23
TWiN explains how anti-DNA antibodies present in lupus patients bind to GluN2A-containing NMDA receptors, act as positive allosteric modulators, and impair spatial memory. Hosts: Vincent Racaniello , Ori Lieberman , Jason Shepherd, Timothy Cheung , and Vivianne Morrison Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiN! Links for this episode Lupus autoantibodies bind GluN2A-containing NMDA receptors (Nat Commun) Timestamps by Jolene . Thanks! Music is by Ronald Je...
Sep 29, 2021•1 hr 8 min•Ep. 22
TWiN explores a study of hallucination-like perception in mice which supports the idea that hallucinations arise as faulty perceptual inferences due to elevated dopamine in the striatum. Hosts: Vincent Racaniello , Ori Lieberman , and Timothy Cheung Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiN! Links for this episode Listener poll - please take it Striatal dopamine and hallucination in mice (Science) Timestamps by Jolene . Thanks! Music is by Ronald Jenkees Se...
Aug 24, 2021•1 hr 28 min•Ep. 21
While perceptual constancy requires the brain to maintain a stable representation of sensory input, TWiN explores a study showing that odor-evoked responses in the olfactory cortex drift over periods of days to weeks. Hosts: Vincent Racaniello , Jason Shepherd , Timothy Cheung , and Vivianne Morrison Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiN! Links for this episode Representational drift in olfactory cortex (Nature) ( open preprint ) Ed Yong on representati...
Jul 14, 2021•1 hr 18 min•Ep. 20
On this episode, Vivianne gives a primer on glial cells, with the goal of thinking about the central nervous system holistically and appreciating the different cell types that contribute to its function. Hosts: Vincent Racaniello , Jason Shepherd , Timothy Cheung , and Vivianne Morrison Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiN! Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv...
Jun 21, 2021•1 hr 13 min•Ep. 19
Mauro Costa-Mattioli joins TWiN to discuss how his laboratory dissects the contribution of host genetics and the microbiome in complex neurodevelopment disorders such as autism spectrum disorders. Hosts: Vincent Racaniello , Ori Lieberman , Jason Shepherd , Timothy Cheung , and Vivianne Morrison Guest: Mauro Costa-Mattioli Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiN! Links for this episode Mauro's work on TWiM 131 and 193 Separating genetics and microbiome in...
May 12, 2021•1 hr 11 min•Ep. 18
Michael Nitabach joins TWiN to discuss the finding that the nematode C. elegans, which do not have eyes, can discriminate between colors to guide foraging decisions and move them away from harmful bacteria that produce a blue-pigment toxin. Hosts: Vincent Racaniello , Ori Lieberman , Jason Shepherd , Timothy Cheung , and Vivianne Morrison Guest: Michael Nitabach Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiN! Links for this episode C. elegans discriminates color...
Apr 21, 2021•1 hr 22 min•Ep. 17
Helen joins TWiN to discuss her work on understanding how the maternal microbiome modulates fetal neurodevelopment in mice. Hosts: Ori Lieberman , Andres Bendesky , Jason Shepherd , and Vincent Racaniello Guest: Helen Vuong Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiN! Links for this episode Maternal microbiome influences fetal neurodevelopment (Nature) Timestamps by Jolene . Thanks! Music is by Ronald Jenkees Send your neuroscience questions and comments to t...
Feb 17, 2021•50 min•Ep. 15
Ori, Jason, and Vincent discuss the use of antibodies to neutralize amyloid-β seeds before their deposition becomes detectable in transgenic mice, and the finding that the preclinical phase of Alzheimer's disease may be a late manifestation of earlier pathogenic seed formation. Hosts: Ori Lieberman , Jason Shepherd , and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiN! Links for this episode Reducing Alzheimer-like pathology in mice (Nat Neuros...
Jan 14, 2021•1 hr 11 min•Ep. 14
Ori, Jason, Erin, and Vincent dissect a study that utilizes single-cell RNA sequencing to reveal the genes that underlie remote memory storage in the medial prefrontal cortex of the mouse. Hosts: Ori Lieberman , Erin Calipari, Jason Shepherd , and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiN! Links for this episode Transcriptional programs associated with long-term memory (Nature) Timestamps by Jolene . Thanks! Music is by Ronald Jenkees Sen...
Dec 15, 2020•1 hr 8 min•Ep. 13
Ori, Jason, and Vincent reveal identification of an orphan receptor that modifies short-term memory in mice, and a mouse model of COVID-19 that includes anosmia or loss of smell. Hosts: Ori Lieberman , Vincent Racaniello , and Jason Shepherd Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiN! Links for this episode Thalamic orphan receptor in short term memory (Cell) Anosmia in SARS-CoV-2 infected mice (Nature) Letters read on TWiN 12 Timestamps by Jolene . Thanks! ...
Nov 11, 2020•1 hr 13 min•Ep. 12
