Dr. Martin Pera is a Principal Investigator at the Jackson Laboratories and Editor-in-Chief of the ISSCR's journal Stem Cell Reports. His lab studies the regulation of self-renewal and pluripotency, heterogeneity in pluripotent stem cell populations, and neural specification of pluripotent stem cells.
Dr. Dominique Bonnet is the Group Leader of the Hematopoietic Stem Cell Laboratory at the Francis Crick Institute. Her lab is interested in the extrinsic mechanisms that regulate hematopoietic stem cells, and how they can intervene in order to eradicate the leukemic stem cell.
Dr. Kristy Red-Horse is an Associate Professor of Biology at Stanford University. Her lab uses cardiovascular development as a model to study the signals that instruct cell fate and guide morphogenesis during organ formation in the mammalian embryo.
Dr. Valentina Greco is the Carolyn Slayman Professor of Genetics at Yale University. Her lab has developed novel live imaging approaches to track and manipulate stem cells in live animals, allowing them to study the complex orchestration of tissue regeneration using the skin as a model system.
Dr. Madeline Lancaster is a Group Leader at the MRC Laboratory of Molecular Biology in Cambridge, UK. The Lancaster lab has developed cerebral organoids as a model system to better understand human brain evolution, development, and neurodevelopmental disorders. She joined us to discuss her research presentated at the ISSCR 2020 conference.
Dr. Benoit Bruneau is the Director of the Gladstone Institute of Cardiovascular Disease. His lab uses mouse models and human iPSCs to investigate the transcription factor networks that regulate sets of genes critical for heart development.
Dr. Karl Koehler is an Assistant Professor of Otolaryngology at Harvard Medical School. His lab focuses on using human organoid systems as a platform to model congenital diseases and develop regenerative medicine therapies for the inner ear and various craniofacial tissues.
Dr. Freda Miller, from the Hospital for Sick Children Research Institute and the University of Toronto, studies the cellular mechanisms that regulate development of the mammalian nervous system, with a particular interest in stem cells and trophic factors.
Dr. Hans Clevers from the Hubrecht Institute for Developmental Biology and Stem Cell Research is a pioneer in the field, studying the molecular mechanisms of tissue development and cancer of various organs using organoids made from adult Lgr5 stem cells.
Dr. Sheila Chari is the Editor-in-Chief at the journal Cell Stem Cell, and Executive Editor at Cell Press. As the Editor-in-Chief, Dr. Chari’s primary responsibilities are knowing and publishing the top stem cell discoveries, driving journal publishing strategy, and managing a global editorial staff.
Dr. Josef Penninger is from the University of British Columbia and the Institute for Molecular Biotechnology of the Austrian Academy of Sciences in Vienna, Austria. He was previously on the podcast to talk about his research developing human blood vessel organoids. Dr. Penninger’s team has identified a trial drug that can significantly block early stages of COVID-19 in human blood vessel and kidney organoids.
Dr. Darcy Wagner from the Lund Stem Cell Center uses a multidisciplinary approach to understand how the extracellular environment directs stem cell behavior for endogenous and exogenous lung tissue regeneration.
Dr. Deepak Srivastava is the President of the Gladstone Institutes and the International Society for Stem Cell Research, and the co-founder of Tenaya Therapeutics. His lab investigates the gene networks that guide cardiogenesis by developing models of heart disease using patient-derived iPSCs and CRISPR technology.
Dr. Jeanne Loring is a Professor Emeritus and Director of the Center for Regenerative Medicine at the Scripps Research Institute, and the co-founder of Aspen Neuroscience. Her lab works on a diverse range of projects using iPSCs, including developing cell replacement therapies for Parkinson’s disease, sending neural organoids into space, and partnering with the San Diego zoo to make iPSCs from engangered species.
Dr. Joy Wu is an Associate Professor of Medicine at Stanford University, and a a board-certified endocrinologist. With both basic and translational research, her lab studies stem cell therapies for bone formation and the prevention of cancer metastases to bone, as well as the bone marrow hematopoietic niche.
Dr. Thomas Reh is a Professor of Biological Structure at the University of Washington School of Medicine. His research is aimed at stimulating more effective regeneration in the retina to restore vision in people that have lost their sight.
Priye Iworima is a PhD student at the University of British Columbia. Her project is focused on developing and optimizing a differentiation protocol for generating insulin-producing cells derived from stem cells that could be used as a potential therapy for type 1 diabetes.
Dr. Kacey Ronaldson-Bouchard is an Associate Research Scientist at Columbia University focusing on biomedical engineering. She is also the co-founder of TARA Biosystems, which offers physiologically relevant human “heart-on-a-chip” tissue models for cardiac risk assessment and drug discovery applications.
Dr. Todd McDevitt is a Senior Investigator at the Gladstone Institutes and a Program Director and Professor at UCSF. His research focuses on engineering 3D, multicellular systems that can be used to study principles of stem cell and developmental biology.
Dr. Nicole Quinn is the Associate Director of Scientific Communications at STEMCELL Technologies, and one of the people hard at work behind the scenes of the Stem Cell Podcast. After completing her PhD in genomics and discovering her love of communicating science, Nicole left the bench to pursue a science communications career in the biotech industry.
Dr. Camilla Forsberg is the Co-Director of the Institute for the Biology of Stem Cells, and a Professor of Biomolecular Engineering at the University of California, Santa Cruz. Her lab seeks to understand the molecular determinants of hematopoietic stem cell fate decisions.
Dr. Peter Zandstra is the Director of the School of Biomedical Engineering at the University of British Columbia. His lab applyies engineering design principles, computational modeling, and fundamental stem cell biology to study the mechanisms that control stem cell fate, and to develop technologies for the propagation of stem cells and their derivatives.
Dr. Celina Juliano is an Assistant Professor at the University of California, Davis. Her lab studies development and regeneration in the aquatic animal Hydra, which undergoes continual self-renewal, lacks senescence and has incredible regenerative capabilities.
Dr. Rameen Shakur is a Jansen Fellow in Cardiology and Personalized Medicine at the Koch Institute for Integrative Science at MIT, and the Founder of the medical device and algorithm company Cambridge Heartwear Ltd.
Dr. Stephane Angers is a Professor at the University of Toronto. He is an expert in the field of signal transduction, working to understand the signaling mechanisms underlying the Wnt and Hedgehog families of growth factors and the large family of G protein-coupled receptors.
Dr. Paul Burridge from Northwestern University talks about his work using human iPSCs to model cardiomyopathy and heart failure.
Back in June 2019, we attended the ISSCR annual conference in Los Angeles, California! Here is the last of three special episodes featuring some of the top researchers in the field, and junior trainees.
Dr. Pekka Katajisto studies the mechanisms that lead to the decline in tissue regeneration during aging.
Back in June 2019, we attended the ISSCR annual conference in Los Angeles, California! Here is the second of three special episodes featuring some of the top researchers in the field, and junior trainees.
Guest: Dr. Alysson Muotri is a Professor in the Departments of Pediatrics and Cellular & Molecular Medicine at the University of California, San Diego (UCSD) School of Medicine, and Co-Director of the UCSD Stem Cell Program. His research focuses on modeling neurological diseases using human iPSCs, and he is leading a project investigating the effect of microgravity on human brain organoids. Featured Products and Resources: STEMdiff™ Cerebral Organoid Kit Organoid Research Resources Resources...
