Intro: Back in June 2019, we attended the International Society for Stem Cell Research's (ISSCR) annual conference in Los Angeles, California! Here is the first of three special episodes featuring interviews with some of the top researchers in the stem cell field, as well as with up-and-coming junior trainees who talked to Daylon about their research and experience at the conference. Junior Trainees: We asked Junior Trainees the following question: WHAT IS THE MOST EXCITING RESEARCH THAT YOU'VE ...
Aug 27, 2019•1 hr 20 min
Guest: Dr. Steve Szilvassy is the Senior Director, Head of Hematopoietic Products at STEMCELL Technologies. He has over 25 years of experience in the fields of hematology and oncology, having held a variety of research positions, including research scientist and project team leader, in both academia and industry. Featured Products and Resources: Live Webinar: Optimized Workflows for High-Efficiency Genome Editing in Stem and Primary Cell Types Jobs at STEMCELL Technologies Resources and Links Bl...
Aug 20, 2019•1 hr 31 min
Guest: Dr. Ubaka Ogbogu is an Associate Professor at the University of Alberta cross-appointed to the Faculties of Law and Pharmacy & Pharmaceutical Sciences. He is interested in the ethical, legal and societal implications of novel and emerging biomedical research and health care technologies. Featured Products and Resources: Jobs at STEMCELL Technologies Mesenchymal Stromal Cell Updates and Debates Resources and Links Major 'Don't Eat Me' Signal Found in Cancer Cells - Researchers have ide...
Aug 06, 2019•1 hr 38 min
Guest: Dr. Jennifer Adair is an Assistant Member in the Clinical Research Division at Fred Hutchinson Cancer Research Center. Her lab uses a combination of cell biology, molecular biology, chemistry, engineering, nanomedicine and bioinformatics to develop new gene therapy treatments for many different diseases, including cancer. Her goal is to develop safe, cost-effective and clinically relevant applications for gene therapy that can be implemented worldwide. Featured Products and Resources: Sci...
Jul 23, 2019•1 hr 23 min
Guest: Dr. Arun Sharma is a Senior Research Fellow in the Svendsen lab at Cedars-Sinai. His research focuses on the applications of iPSCs for studying cardiovascular biology, modeling diseases in a dish with genome editing technologies, and developing high-throughput platforms for screening drug toxicity and efficacy. Featured Products and Resources: STEMdiff™ Cardiomyocyte Webinar: Modeling Arrhythmias Using hPSC-Derived Cardiomyocytes and Tracking Their Excitability Resources and Links Regener...
Jul 09, 2019•1 hr 18 min
Guest: Dr. James Hudson is Group Leader of the Organoid Research Laboratory at the QIMR Berghofer Medical Research Institute in Brisbane, Australia, whose research is focused on developing state-of-the-art bioengineering approaches for human 3D organoids to use for studying cardiac biology and discovering new heart disease therapeutics. Featured Products and Resources: STEMdiff™ Cardiomyocyte Webinar: Modeling Arrhythmias Using hPSC-Derived Cardiomyocytes and Tracking Their Excitability Resource...
Jun 25, 2019•1 hr 4 min
Guest: Dr. Tannishtha Reya is a Professor of Pharmacology and Medicine at the University of California, San Diego. Her lab focuses on understanding the signaling pathways that regulate the choice between stem cell renewal and commitment, and define how the same signals are subverted in cancer. Featured Products and Resources: Cancer Stem Cell News Dunn Webinar: Understanding Pancreatic Development and Diabetes Using Patient-Specific iPS Cells Resources and Links HIV-Preventing Gene Mutation Link...
Jun 11, 2019•1 hr 27 min
Guest: Dr. Bertie Göttgens is a Professor of Molecular Hematology at the University of Cambridge. His lab studies how transcription factor networks control the function of hematopoietic stem cells, and how mutations that perturb such networks cause leukemia. In this episode, he talks about his research and his groundbreaking paper that mapped mouse gastrulation and early organogenesis. Featured Products and Resources: mTeSR™ Plus #StemCellfie Contest Resources and Links New Neurons Form in Old A...
May 28, 2019•1 hr 7 min
Guest: Dr. Adrian Teo is a Principal Investigator at the Institute of Molecular and Cell Biology at the Agency for Science, Technology and Research (A*STAR) in Singapore. His research focuses on using stem cell technology to model human pancreatic development in vivo and to study the mechanisms that cause diabetes and underlie diabetic complications. Featured Products and Resources: Pancreatic Cell News Ray Dunn Webinar Resources and Links Advancing Cell Therapies for Diabetes - Researchers mapp...
May 14, 2019•1 hr 12 min
Guest: Dr. Rita Perlingeiro is the Lillehei Professor in Stem Cell and Regenerative Cardiovascular Medicine at the Lillehei Heart Institute. Her lab is interested in understanding the molecular mechanisms controlling lineage-specific differentiation of pluripotent stem cells, and applying this information to generate tissue-specific stem/progenitor cells endowed with in vivo regenerative potential. Much of her work is focused on muscular dystrophies. Featured Products and Resources: Muscle Cell ...
Apr 30, 2019•1 hr 11 min
Guest: Dr. Josef Penninger is the Director of the Life Sciences Institute at the University of British Columbia and a Canada 150 Chair in Functional Genetics. He was previously the Scientific and Founding Director of the Institute for Molecular Biotechnology of the Austrian Academy of Sciences. His research is focused on understanding the complex mechanisms of how diseases develop, particularly in cardiovascular, autoimmune and bone diseases, and cancers. Featured Products and Resources: Science...
Apr 16, 2019•1 hr 16 min
Guest: Dr. Kristen Brennand is an Associate Professor of Genetics and Genomics, Neuroscience, and Psychiatry at the Icahn School of Medicine at Mount Sinai in New York. A major focus of her work is in developing in vitro models for schizophrenia in order to identify novel insights into the molecular and cellular phenotypes of mental illness. Her lab has established a new mechanism using iPSC-based models to systematically test the impact of causal variants in human cells. Featured Resource: Subs...
Apr 02, 2019•1 hr 5 min
Guest: Dr. Robert Mays is the Co-founder and Vice President of Regenerative Medicine and Head of Neuroscience Programs at Athersys Inc. He focuses on Athersys' proprietary stem cell product, MultiStem®, and its applications in regenerative medicine and drug discovery, with a specific focus on injuries and diseases affecting the central nervous system. Featured Resource: Apply to become a co-host on the Stem Cell Podcast! Cytokines Resources and Links New Drug Developed to Treat Heart Attack Dama...
Mar 19, 2019•1 hr 14 min
Guest: Dr. Andrew Murphy is an Associate Professor at the Baker Heart and Diabetes Institute and Monash University in Melbourne, Australia. He seeks to understand the processes by which hematopoietic stem cells and the bone marrow niche become affected in disease, specifically in the context of cardiovascular and metabolic disease. Featured Resource: Apply to become a co-host on the Stem Cell Podcast! Hematopoiesis Hub Resources and Links Quiescence Increases the Resistance and Function of Old N...
Mar 05, 2019•57 min
Guest: Dr. Paul Frenette is the Chair and Director of the Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research at the Albert Einstein College of Medicine. Dr. Frenette's research focuses on the molecular and cellular constitutents of the stem cell niche, mechanisms of sickle cell vaso-occlusion, the role of the nervous system in cancer, and understanding how hematopoietic stem cells and mature blood cells traffic in vivo. Featured Resource: STEMvision™ Resour...
Feb 19, 2019•1 hr 18 min
Guest: Dr. Stephanie Willerth is an Associate Professor and Canada Research Chair at the University of Victoria. Her research focuses on using engineering-based approaches to stem cell biology. Her team develops bioactive scaffolds for directing stem cell differentiation, and investigates the expression of transcription factors that regulates this process. The goal of her group's research is to develop engineered tissues that can be transplanted in the human nervous system to treat diseases like...
Feb 05, 2019•51 min
Guest: Dr. James Wells is the Director for Research in the Division of Endocrinology at Cincinnati Children's Hospital, as well as the Chief Scientific Officer at the Center for Stem Cell and Organoid Medicine (CuSTOM). His research focuses on understanding the embryonic development of the pancreas and gastrointestinal organs by identifying mechanisms involved in the embryonic development of endocrine cells. His translational projects include generating 3D human tissues from pluripotent stem cel...
Jan 22, 2019•58 min
Guest: Dr. Carla Kim is a Professor in the Division of Hematology/Oncology and Pulmonary Respiratory Diseases at Children’s Hospital Boston, as well as in the Department of Genetics at Harvard Medical School and in the Harvard Stem Cell Institute. Her research involves characterizing the biology of stem cells in the normal lung and in lung cancer using a combination of mouse genetics, cell biology and genomics approaches. Her lab has also developed 3D lung organoid systems that makes it possible...
Jan 08, 2019•59 min
Guest: Dr. Jeffrey Millman is an Assistant Professor of Medicine and Biomedical Engineering at the Washington University in St. Louis. His research focuses on the in vitro production and study of pancreatic insulin-producing β cells from human pluripotent stem cells for use in cellular replacement therapy and drug screening. He joins us to discuss his research. Resources and Links Efficient Scarless Genome Editing in Human Pluripotent Stem Cells - Researchers have established a new method for ge...
Dec 18, 2018•1 hr 2 min
Guest: Dr. Sandra Ryeom is the Assistant Professor of Cancer Biology at the University of Pennsylvania's Perelman School of Medicine. Dr. Ryeom’s lab focuses on understanding the contribution of endothelial cells in different organs towards maintaining stem cell populations. She joins us to discuss her work and recent paper in Nature Communications. Resources and Links Zaps to Brain to Ease Depression - People’s moods quickly improved after scientists stimulated the orbitofrontal cortex in the b...
Dec 06, 2018•1 hr 10 min
Guest: Dr. Karun Singh is a Principal Investigator, Associate Professor and the David Braley Chair in Human Stem Cell Research at McMaster University. The overall goal of Dr. Singh’s research program is to use stem cell-based models to study neurological disorders and devise new therapies for these conditions. His latest paper discusses an iPSC knockout resource for functional studies of autism-risk genes. Resources and Links Microneedles for Eyes - A team of researchers developed a contact lens...
Nov 20, 2018•1 hr 6 min
Guest: Dr. Pamela Robey is a senior investigator at the National Institute of Dental and Craniofacial Research at the NIH. Dr. Robey’s work focuses on skeletal biology, and the characteristics and biological properties of bone marrow stromal cells, a subset of which are multipotent skeletal stem cells. In late September, Dr. Robey co-authored a commentary article in Nature discussing the ever famous, but dubious, mesenchymal stem cell. She comes on the show to talk about this and more. Resources...
Nov 07, 2018•1 hr 6 min
Guest: Dr. Benjamin Dekel is a leading investigator in the field of human renal stem cell biology and regenerative medicine. He is the Head of the Pediatric Stem Cell Research Institute and the Director of the Division of Pediatric Nephrology at the Edmond and Lily Safra Children’s Hospital, Sheba Medical Center, Israel. Resources and Links Gene Editing Creates Mice with Two Dads - Researchers gathered fathers’ stem cells, and used them to produce embryos that were implanted into surrogate mothe...
Oct 26, 2018•1 hr 16 min
Guest: Dr. Tsvee Lapidot is a Professor at the Weizmann Institute of Science. His research investigates the regulation of normal and leukemic hematopoietic stem cells by the brain-bone-blood triad in transplanted mice. In this episode we talk to him about his research and his latest study in Cell Stem Cell looking at the influence of circadian rhythms on regulation of blood stem cells. Resources and Links Nobel Congratulations - This year’s Nobel laureates discovered brakes that keep immune cell...
Oct 09, 2018•1 hr 11 min
Guest: Dr. Louis Vermeulen is a Principal Investigator at the Center for Experimental Molecular Medicine at the Academic Medical Center in Amsterdam, and the New York Stem Cell Foundation, where he is focusing on the role of stem cells in colorectal cancer development and progression. He aims to develop improved preventative strategies and novel therapies for this disease by studying the effects of genetic mutations on the behavior of stem cells in the gut. Resources and Links Recount of the Hum...
Sep 25, 2018•1 hr 5 min
Guest: Dr. Kelly Frazer is the Director of the UC San Diego Institute for Genomic Medicine and Founding Chief of the Division of Genome Information Sciences in the Department of Pediatrics at UC San Diego. Dr. Frazer has spent the past 25 years studying various aspects of functional and structural human genomics. In this episode she talks to us about her recent paper looking at the mutational burden of human induced pluripotent stem cells. Resources and Links New Found Skull Tunnels – Using a mi...
Sep 11, 2018•1 hr 11 min
Guest: Dr. Joseph C. Wu, MD, PhD is Director of the Stanford Cardiovascular Institute and Simon H. Stertzer Endowed Professor in Department of Medicine (Cardiology) and Department of Radiology at the Stanford School of Medicine. Dr. Wu is a pioneer in using iPS cells in personalized medicine and we talk to him about his work and the state of the field in respect to novel stem cell therapies for cardiovascular disease. Resources and Links First FDA Approved RNAi Therapy - The FDA has approved Aln...
Aug 28, 2018•1 hr 10 min
Guest: Dr. Charles Murry is the Woods Professor of Pathology, Bioengineering and Medicine/Cardiology at the University of Washington. He also serves as Director of the UW’s Heart Regeneration Program, with the goal of achieving stem cell-based heart regeneration in patients. He has recently published a paper that used stem cell derived heart cells to treat heart damage in monkeys. Featured Resource: CloneR™ Defined Supplement for Single-Cell Cloning of Human ES and iPS Cells Resources and Links ...
Aug 14, 2018•1 hr 5 min
Guest: Dr. David Knapp is a Post-Doctoral Fellow at the University of Oxford. Colin Hammond is a graduate student in Dr. Connie Eaves' lab at the BC Cancer Agency. Dr. David Knapp and Colin Hammond talk about their recent publication in Nature Cell Biology regarding stem cell populations in cord blood cells. Featured Resource: Webinar: Re-Creating Disease with Kidney Organoids and CRISPR Resources and Links Anti-CRISP Protein Production - Phages produce Anti-CRISPR proteins (Acr-proteins) that b...
Jul 31, 2018•1 hr 8 min
Guest: Samantha is an enthusiastic Science Communicator completing her PhD at the University of Toronto. Her doctoral research focuses on brain development and stem cell biology, under the supervision of renowned scientist Dr. Derek van der Kooy. We talk with Sam about her research and also about how she embraces science communication, using it to tell her science story! Featured Resource: STEMdiff™ Cerebral Organoid Kit Resources and Links Most Americans Believe Funding Science Pays Off - A new...
Jul 17, 2018•1 hr 11 min
