Ep 141: “iPSC-Derived Myogenic Progenitors” Featuring Dr. Rita Perlingeiro

Guest: Dr. Rita Perlingeiro is the Lillehei Professor in Stem Cell and Regenerative Cardiovascular Medicine at the Lillehei Heart Institute. Her lab is interested in understanding the molecular mechanisms controlling lineage-specific differentiation of pluripotent stem cells, and applying this information to generate tissue-specific stem/progenitor cells endowed with in vivo regenerative potential. Much of her work is focused on muscular dystrophies. Featured Products and Resources: Muscle Cell News MyoCult™ Resources and Links New CAR T-Cell Therapy Less Toxic - A Phase I clinical trial has shown that a redesigned CAR T-cell molecule was less toxic and produced fewer side effects in patients, making the treatment safer. Using MSCs to Engineer an HSC Niche - Researchers have identified genes in mesenchymal stem cells that enhanced the production of niche factors that could maintain hematopoietic stem cells in culture. Generating Ovarian Cancer Organoids - Investigators developed a protocol for generating and expanding ovarian cancer organoids, and demonstrated their potential applications. Stress-Resistant Muscle Stem Cells - Scientists have identified a population of muscle stem cells that resist radiation and are able to expand under severe stress. Muscle Stem Cells Protected from Environmental Stress - The expression of a transcription factor has been shown to protect muscle stem cells against environmental stress caused by a toxic pollutant.   Photo Reference: Courtesy of Dr. Rita Perlingeiro Subscribe to our newsletter! Never miss updates about new episodes. Subscribe