Synthetic Screens, Genes, and De Novo Proteins: Training AI Models with More Sequence Diversity to Improve Hits

Synthetic technologies allow scientists to venture into uncharted waters, asking unique research questions and finding previously unattainable solutions to some of life’s biggest mysteries. From gene editing to protein engineering, synthesized DNA libraries enable researchers to grasp once unreachable high-throughput screening applications and dismantle barriers between experimental ideation and execution. In this podcast series, Synthetic Screens, Genes, and De Novo Proteins, The Scientist’s Creative Services Team talks to experts about their experiences implementing Twist Bioscience’s synthesized long double-stranded gene pools, called Multiplexed Gene Fragments, for high-throughput screening.

In this episode, Deanna MacNeil from The Scientist spoke with Pierce Ogden, co-founder and chief scientific officer of Manifold Biotechnologies, about the power of pairing large gene fragment pools with AI-designed libraries for better therapeutic discovery and delivery.