Episode #265. Escaping an echo chamber and admitting that you have changed your mind – particularly when you have a large, engaged audience – is no easy feat. In this conversation, I sit down with Thomas DeLauer to break down some of the existing walls between different dietary camps, opening the conversation around nuance and an open-minded approach. We cover: Intro (00:00) Simon makes assumptions about Thomas DeLauer (5:03) Thomas on working out (6:58) Biohacking (8:37) Cold plunges and sauna...
Jun 15, 2023•2 hr 5 min
Episode #264. Every day for more than 20 years, Adam Sud woke up to a life that didn’t feel like a safe, secure, or hopeful place to be. Struggling with mental health from an early age and relying on addiction as the only dependable “solution”, he spent years facing each day as the most painful one he’d ever had. More than a decade on from the turning point in his journey towards recovery, Adam shares his story and some defining realisations that helped shaped the life he is now excited to exper...
Jun 12, 2023•2 hr 1 min
Episode #263. Delve into the complex world of neurodegenerative diseases in this evidence-loaded episode with Drs Dean and Ayesha Sherzai. Unpack the current scientific understanding of diseases like Alzheimer's and Parkinson's, bust popular food myths related to brain health, and discover actionable lifestyle tips for long-term brain health. Join us on this evidence-based journey that blends science with practical, real-life advice. Specifically, we discuss: Intro (00:00) Drs. Ayesha and Dean p...
Jun 05, 2023•3 hr 16 min
Episode #262. Discover the science of getting older without getting old in this conversation with Dr Andrew Steele. From understanding what impacts your lifespan to revealing potential future scientific breakthroughs, this episode is an intriguing journey into the world of aging science. Specifically, we discuss: Intro (00:00) Dr. Andrew Steele on aging (01:38) Age-related diseases and lifespan extension (10:47) Genetic factors, lifestyle, and gene editing for longevity (19:18) Could gene editin...
May 29, 2023•2 hr 23 min
Episode #261. When it comes to cancer and nutrition, sorting fact from fiction is critical. Join me as I sit down with Dr Krystle Zuniga, an expert in this field, to debunk harmful myths, clarify the role of nutrition during cancer treatment, and empower listeners with reliable, science-based knowledge. Tune in to understand how to navigate dietary choices amidst a cancer diagnosis and to learn how to best support those on their cancer journey. Don't miss this essential conversation – it's time ...
May 22, 2023•2 hr 33 min
Episode #260. Are you struggling to maintain a healthy weight and navigate the confusing world of diets and weight loss solutions? In this episode, join me as I dive into the science behind eating behaviours, obesity, and the challenges of losing weight with renowned researcher Dr Stephan Guyenet. Discover the different types of eating, the importance of controlling our food environment, and various evidence-based strategies for weight loss. With practical advice and insights from Dr Guyenet, yo...
May 15, 2023•2 hr 14 min
Episode #259. Have you ever put much thought into your hydration? If you think that drinking two litres of plain water a day meets your hydration needs, then this conversation is for you. In this episode, I’m joined by Dr Stacy Sims to explore the science behind optimal hydration and its impact on performance. You’ll learn how to determine proper hydration, the role of electrolytes and glucose, and which commonly held beliefs about hydration are myths. Dr Sims shares her research findings and pr...
May 08, 2023•1 hr 6 min
Episode #258. Join me as I sit down with renowned soy expert Dr Mark Messina to clear up misconceptions and address concerns about soy consumption. We dive deep into isoflavones, how much soy you can safely consume, and soy’s safety in relation to male feminisation, breast cancer, and thyroid function. If you’ve been hesitant about incorporating soy into your diet, this episode is packed with essential information you need to make an informed choice. Specifically, we discuss: Intro (00:00) Soy t...
May 01, 2023•2 hr 44 min
Episode #257. Uncover the powerful strategies to transform your gym experience and unpack the blood lipids series in this captivating conversation with Drew Harrisberg. You’ll learn more about CGMs for people without diabetes, menopause and osteoporosis, our thoughts on stretching, and much more. Specifically, we discuss: Do CGMs have potential beyond diabetes management? (4:14) Blended fruit vs whole fruit for glycemic response (14:35) Effects of long-term stretching (24:02) Bone mineral densit...
Apr 24, 2023•2 hr 58 min
Episode #256. Professor Susan Davis, AO returns to answer your questions on menopause. We cover The Proof community’s most common questions, looking towards mental health and menopause, how other conditions such as PCOS impact menopause, common issues including weight gain, different drug treatment options, and much more. Specifically, we discuss: Intro (00:00) Feedback from the Proof community (02:13) Concerns about misleading health information about menopause (05:57) Oral contraception and fe...
Apr 17, 2023•2 hr 2 min
Episode #255. Have you ever wondered about the power of psychedelics in treating mental health conditions? Join me as I sit down with Professor Susan Rossell to examine what the research says on psilocybin and MDMA and whether these revolutionary interventions can assist in the treatment of depression, eating disorders, PTSD, and more. Specifically, we discuss: Intro (00:00) Dr. Susan Rossell on mental health research (02:40) The history of psychedelics (11:53) Concerns over the safety of psiloc...
Apr 10, 2023•2 hr 34 min
Episode #254. How does a plant-based diet weigh up against a ketogenic diet when it comes to cancer treatment and prevention? Discover the answer to this question and more in The Proof’s first episode dedicated to understanding cancer. In this episode, I sit down with Dr Urvi Shah and Dr Neil Iyengar to examine how cancer develops and the lifestyle measures that can be taken to reduce the risk of cancer, treat cancer, and prevent cancer recurrence. Specifically, we discuss: Intro (00:00) Cancer ...
Apr 03, 2023•2 hr 11 min
Episode #253. In Part Three of the blood lipids series, we take a deep dive into interventions to lower the risk of atherosclerotic cardiovascular disease (ASCVD). While nutrition is the most powerful lifestyle tool we have to dramatically decrease ApoB, there certainly remains a need for pharmacological interventions – and in this episode, Dr Thomas Dayspring and I walk through four main drug classes, discussing their mechanism of action, effectiveness, and safety profile. We discuss: Intro (00...
Mar 27, 2023•2 hr 20 min
Episode #252. In Part One of the blood lipids series, you learned what lipids are and how they work. In Part Two, Dr Thomas Dayspring returns to talk about the individualised testing you can get to understand where your lipids are now. Discover the tests you need, the ones you don’t, and when to start testing to protect yourself against atherosclerotic cardiovascular disease. We discuss: Intro (00:00) What is Lp(a), and why do you need it checked? (02:05) Does diet influence Lp(a)? (20:36) The o...
Mar 20, 2023•3 hr 34 min
Episode #251. Cardiovascular disease is one of the biggest killers in the Western world, and it’s vital that we understand cardiovascular health in order to improve lifespan and healthspan. In this episode, I sit down with Dr Thomas Dayspring for Part One of a three-part deep dive into cardiovascular disease and blood lipids. In this introductory episode, we examine how our body absorbs lipids and transports them throughout the body – and what happens when it goes wrong. Specifically, we discuss...
Mar 13, 2023•2 hr 8 min
Episode #250. Ice baths and other forms of cold water exposure have gained a huge amount of traction in the past few years. I’m joined by expert Dr Susanna Søberg to examine what the science says – is cold water exposure safe? What does the research say about the bold health claims? Is brown fat just a buzzword? How do you safely and effectively implement hot and cold exposure into your life? Dr Søberg answers these questions and many more in this three-hour deep dive into cold water immersion. ...
Mar 06, 2023•3 hr 55 min
Episode #249. Have you ever wondered how long humans can healthily live for? Professor Matt Kaeberlain joins me in this episode to explain the biological processes of aging, explaining the significance of genetics vs lifestyle, protein restriction, polyphenols, and much more. Specifically, we discuss: Intro (00:00) Aging and disease (03:42) Evolutionary conserved processes and human life span (17:41) Biological aging: Are epigenetic tests more accurate in telling how well you’re aging? (26:29) A...
Feb 27, 2023•3 hr 5 min
Episode #248. There is a huge research and science communication gap when it comes to nutrition and exercise for women. Stacy Sims, MSc, PhD joins me today to address this inadequacy, providing guidance on how women can optimise training and nutrition at each stage of life. Specifically, we discuss: Intro (00:00) Dr. Stacy Sims' academic journey (02:00) Female physiology (05:38) Implications of applying results of male-centric studies to women (09:12) Discerning the variances in physiological ma...
Feb 20, 2023•2 hr 8 min
Episode #247. It's widely accepted that we are in a climate crisis. But what does that mean? Renowned author and journalist George Monbiot joins me in this episode to examine how our food systems are directly impacting our planet's health, and what we can do about it. What do soil and the human gut have in common? Why is food a political issue? What does radical change in the food system look like, and how do we get there? We cover these questions and more, discussing: Intro (00:00) George Monbi...
Feb 14, 2023•1 hr 19 min
Episode #246. Have you ever considered the way our current food system was shaped? Or the way it continues to impact modern dietary guidelines? This episode is for you. In this conversation with distinguished researcher Professor Dariush Mozaffarian, we analyse the past 120 years of nutrition science and assess how this research continues to impact the modern diet. We cover: Introduction (00:00) A Journey Through Nutrition Science History (03:49) The Food Industry's Contributions to Improving Vi...
Feb 07, 2023•2 hr 36 min
In Episode #245, I'm joined by endocrinologist and clinical researcher Professor Susan Davis, AO. In this detailed exchange – taking place over more than two hours – Professor Davis shares the best practice guidelines for managing menopause. You will learn from a world-leading expert about sex hormones, the physiological changes underpinning menopause, signs and symptoms of peri-menopause/menopause, the struggles of menopause, medical and lifestyle interventions for managing menopause (including...
Jan 30, 2023•2 hr 29 min
In Episode #244, cardiologist Dr Mohammed Alo joins me to talk about cardiovascular disease myths, many of which he has been brilliantly covering on Tik Tok over the past year. Is it perfectly ok to eat a lot of saturated fat and red meat if your triglycerides and HDL are normal? Does a coronary artery scan of zero mean we won’t have a heart attack? What’s better - a coronary artery scan or a CT angiogram for measuring plaque in our coronary arteries. Are statins beneficial? Is too low cholester...
Jan 27, 2023•2 hr 11 min
Episode #243. It’s time to face the facts on saturated fat. Dr Gil Carvalho returns to examine a bold new study on this controversial topic, breaking down whether you need to reconsider your food choices in the wake of this study’s release. We discuss: Intro (00:00) Saturated fat misunderstandings: Is saturated fat bad? (17:20) Principle 1: Dose matters? — How much saturated fat is too much? (22:07) Is no saturated fat the goal? (30:12) Principle 2: Replacement nutrient matters (31:54) Principle...
Jan 16, 2023•2 hr 47 min
Last week we featured Part 1 of the best moments from The Proof in 2022, and this week we bring you part 2. Episode #242 is a compilation that mostly focuses on sleep, exercise and planetary health featuring a range of guests from across the year. Guests featured include Drs Dean and Ayesha Sherzai, Dr Alan Flanagan, Dr Andrew Huberman, Dr David Jenkins, Dr Kieron Rooney, Paul Taylor, Fritz Horstmann, Drew Harrisberg and Nicholas Carter. Specifically, we cover: Intro (00:00) Sleep and weight gai...
Jan 09, 2023•3 hr 35 min
To bring in the new year I thought it would be good to take a moment and consolidate some of the memorable moments, and key takeaways, from 2022. In Episode #241, part 1 of a 2 part year in review, we traverse how to think about nutrition, so we can better make sense of claims online, diet, and cardiometabolic health, how you can flip the switch on your microbiome so the trillions of gut bugs in your large intestine reward you with better health, and the benefits up for grabs through consuming o...
Jan 03, 2023•2 hr 28 min
Episode #240. There’s a lot of noise about cardiometabolic health: claims that certain diets will work miracles, and hype that specific foods must be avoided at all costs. Research dietitian Dr Andrea Glenn joins me today to get to the core of which dietary patterns will actually improve your cardiometabolic health outcomes. We discuss: Intro (00:00) Andrea Glenn on dietary patterns (07:31) Which country has the best dietary guidelines today? (11:35) What is cardiometabolic health? (13:15) Simil...
Dec 27, 2022•2 hr 48 min
Episode #239. Looking for simple, practical ways to improve your exercise regime and eat for better health? Coach Fritz Horstmann understands the difficulties of balancing health with a busy life, and joins me today to offer guidance on how you can do just that. We discuss: Intro (0:00) Fritz’s Vegan Fitness Transformation (12:48) Combining Intuitive & Educated Eating (30:52) Fritz’s Coaching with Calorie Counting (42:04) Plant-Based Protein Sources (46:55) Bloating (55:32) Results in Fritz’s Pr...
Dec 20, 2022•3 hr 23 min
Episode #238. Left with questions after last week’s conversation with Dr Valter Longo? You’re not alone. In this episode, Dr Longo returns to answer some of the queries I had in the wake of our last episode, tying off some loose ends and clarifying his stance on protein consumption and longevity. Specifically, we discuss: Intro (0:00) Reduce Cancer Risk with IGF1 (1:47) Biological Age Test (4:11) Laron Syndrome & Longevity (6:24) Does Everyone with High IGF1 get cancer? (13:06) Pressure for Long...
Dec 13, 2022•37 min
Episode #237. Dr Valter Longo introduces intriguing questions to the show: could protein consumption actually be harmful to our health? How important is muscle tissue? Can fasting be used as an adjunct cancer treatment? We investigate these questions and many more, diving into the research on IGF-1, mTOR, and the fasting-mimicking diet. Specifically, we discuss: Intro (0:00) Ideal diets for longevity (2:58) Important Pathways for aging (9:15) IGF1 Elevation (16:24) Actue vs Chronic elevation of ...
Dec 06, 2022•2 hr 43 min
Episode #236. Dr Donald Layman is an expert in protein synthesis and metabolism. With endless online dialogue on protein, Dr Layman offers clarity and answers pressing questions in this episode: how does protein interact with skeletal and metabolic health? Is aging dependent on our DNA? How much protein should I consume, and when? These questions, and many more, are answered in this week’s episode. We cover: Intro (0:00) Muscle & Metabolic Health (5:00) Moderate vs HIIT Training (14:00) Are Agin...
Nov 28, 2022•2 hr 4 min
