Episode 12: Sickle Cell Nephropathy

Dr. Marianne Yee, a pediatric hematologist at Emory, and Dr. Rima Zahr, a pediatric nephrologist at the University of Tennessee, share their clinical pearls regarding sickle cell disease and its subsequent kidney involvement. These experts bring up excellent points of discussion including albuminuria screening, hyperfiltration injury, the role of a kidney biopsy, papillary necrosis, nocturnal hypertension, kidney transplant outcomes, renal medullary carcinoma and health disparities that these patients face. This episode is helpful for both pediatric and adult nephrologists, primary care providers and hematologists! 

Check out these high-yield publications:

Genetics of medullary carcinoma: https://pubmed.ncbi.nlm.nih.gov/34261517/

Sickle cell ESRD patient disparities: https://pubmed.ncbi.nlm.nih.gov/36191963/

Pediatric sickle cell kidney biopsy findings: https://pubmed.ncbi.nlm.nih.gov/30945006/

Losartan for sickle cell albuminuria: https://pubmed.ncbi.nlm.nih.gov/28951038/

CKD and albuminuria prevalence in pediatric sickle cell disease: https://pubmed.ncbi.nlm.nih.gov/21940843/