In this episode, Joe discusses skin health, anti-aging strategies, and the science behind skincare with biohacker and beauty industry leader Amitay Eshel, CEO of Young Goose. Amitay shares his expertise on improving skin health through a combination of internal health, high-quality skincare products, and biohacking techniques. The conversation covers topics such as the efficacy of various skincare ingredients, the impact of sun exposure, and innovative approaches to anti-aging. Amitay also delve...
Mar 15, 2024•1 hr 6 min•Season 6Ep. 3
In this episode, we uncover the significance of the CLOCK and PER2 genes, pivotal players in regulating your body's circadian rhythm. Learn how these genes influence your sleep patterns, alertness levels, and even your predisposition to certain health conditions. Discover how variants in the CLOCK gene can impact your circadian rhythm, sleep duration, and daily activity patterns. Explore the associations between genetic variations in the PER2 gene and your tendency to be an early riser or a nigh...
Mar 12, 2024•4 min
In this episode, Joe brings on Dr. Ben Lynch - renowned geneticist and author of Dirty Genes - to unreavel the science of methylation, MTHFR, folates, and homocysteine. Dr. Lynch intricately unpacks the complexities of methylation pathways, shedding light on how genetic variations can impact these crucial processes. Joe and Ben then delve into the specifics of homocysteine metabolism and the role of B vitamins in maintaining optimal levels. They provide invaluable insights into personalized supp...
Mar 08, 2024•1 hr 37 min•Season 6Ep. 2
In this episode of SNPit, we delve into the fascinating world of the FOXO3 gene, a genetic guardian that holds the key to a longer life. But here's the twist: did you know that certain variants of this gene could impact your lifespan more than smoking a pack of cigarettes every day for 25 years? We uncover the research behind this startling revelation and discuss the implications for our health and well-being. Plus, we reveal actionable steps you can take to optimize your FOXO3 gene for better l...
Mar 06, 2024•4 min
Joe delves deep into the world of biohacking alongside esteemed naturopath Michael Smith. Drawing on two decades of expertise, Michael shares invaluable insights into optimizing health, particularly focusing on gut health and the microbiome. From his personal journey to professional practice, Michael discusses the latest advancements in gut health research, tackling issues such as fatigue, autoimmune conditions, and more. Michael shares some practical strategies for enhancing gut health and addr...
Mar 01, 2024•53 min•Season 6Ep. 1
Today, we're excited to bring you the cream of the crop – the top 6 health advice of Season 5 - that have not only resonated most with our listeners but have the power to transform your approach to health and wellness. These highlights encapsulate the essence of what it means to live well in today's world. Each clip has been handpicked for its impact, insight, and potential to inspire positive change in your life. Whether you're a long-time listener or just joining us, this episode is your gatew...
Feb 23, 2024•55 min
Get an in-depth overview of the components of the immune system, learn how to identify when they're compromised, and get insights on how to support them to prepare your body for illness. Joe discusses the importance of focusing on immune support before illness occurs, diving deep into the roles of mitochondria, extracellular matrix, and inflammation, and how their strengths affects the immune system - sharing key supplements that help optimize each component! - Check out SelfDecode: https://self...
Feb 16, 2024•28 min•Season 5Ep. 13
In this episode, we focus on the FTO gene's pivotal role in fat metabolism, appetite, and weight management. Get an in-depth analysis of how the FTO gene not only influences body weight and obesity risk but also regulates appetite and fat metabolism, alongside managing emotional eating and hunger levels. We discuss the gene's connection to weight-related challenges, including its effects on insulin resistance, blood sugar levels, and energy expenditure. By understanding one’s genetic predisposit...
Feb 14, 2024•6 min
In this episode, Dr. Matt Kaeberlein, CEO of OptiSpan and co-director of the Dog Aging Project, and Joe explore the fascinating realm of rapamycin and its implications for longevity and healthspan. Dr. Kaeberlein delves into the biological mechanisms underlying rapamycin's effects, the best way to take it, and its impact on immune system processes. Gain insights from Dr. Kaeberlein's research on the mTor mechanism and rapamycin, uncovering their promising potential in extending healthspan and en...
Feb 09, 2024•1 hr 8 min•Season 5Ep. 12
Dive into the world of lab testing and unlock the secrets to optimal health. In this episode, Joe sheds light on the crucial role lab tests play in understanding our health, cautioning against the limitations of standard tests often offered by conventional medicine. Delve deep into the realm of comprehensive testing as Joe shares his insights on a variety of essential lab markers, including Complete Metabolic Panel, Complete Blood Count, Thyroid Panel, and Amino Acid Panel, among others. Learn w...
Feb 02, 2024•48 min•Season 5Ep. 11
We unravel the intricate relationship between sunlight, Vitamin D, and your genetic makeup, as we explore the pivotal role of Vitamin D in optimizing health and well-being. At the heart of this discussion lies the VDR gene, a genetic blueprint responsible for producing the Vitamin D receptor, as we uncover it’s role alongside Vitamin D in the body. We delve into the fascinating journey of Vitamin D synthesis, from sun-kissed skin to the activation of calcitriol, the biologically active form of V...
Jan 30, 2024•4 min
Join Joe in a conversation with successful biohacker and CEO of Neurohacker Collective, James Schmachtenberger. James shares his two-decade-long journey with biohacking, focusing on improved energy, cognitive function and how NAD changed his life. Learn about utilizing research, software solutions like genetics and lab tests, lifestyle changes, and supplementation for optimizing your health. - Use code “SELFDECODE” to get 15% OFF any product at neurohacker.com - Check out SelfDecode: https://sel...
Jan 26, 2024•1 hr 13 min•Season 5Ep. 10
Ever wondered why some people seem to avoid sickness effortlessly, while others catch every bug in the vicinity? It turns out, luck and genetics may both play a role. In this episode, we uncover the secrets of the IL6 gene, responsible for coding interleukin 6 (IL-6), a crucial immune messenger. Discover how certain variants of the IL6 gene, such as rs1800795, are linked to higher or lower IL-6 levels, affecting immunity and susceptibility to infections. But the story doesn't end there – we expl...
Jan 23, 2024•3 min
Unlock the secrets to longevity with our deep dive into biohacking, lab tests, and supplements! In this episode, we explore the crucial role of lab markers in longevity, optimal lab test ranges, and associations that impact aging. Dive into the world of supplements, addressing concerns about tolerance and when is the right time to supplement for lifespan. Joe and Michael discuss the Dunedin Pace Test and its significance in aging, while shedding light on the impact of lifestyle changes and immun...
Jan 19, 2024•1 hr 50 min•Season 5Ep. 9
This episode explores the transformative potential of the UGT1A1 gene in your body’s ability to detox toxins. Uncover the role of this gene in Glucuronidation, a crucial chemical reaction that enhances the body's ability to detoxify. Learn about the impact of genetic variations which can reduce the activity of the UGT enzyme, hindering the body's detox capabilities. Discover practical solutions to counteract toxic buildup and support the body's natural detoxification processes. This episode unve...
Jan 16, 2024•5 min
In this episode, Joe discusses the fascinating topic of methylation and its importance for overall health. From explaining the tests that can determine if you're an over or under methylator, to providing recommendations on how to support your methylation process, Joe covers everything you need to know. Discover how genetic variations, such as MTHFR and MTRR, can impact your need for nutrients like folate and B12. Get insights into specific lab markers and supplements that can help optimize your ...
Jan 12, 2024•32 min•Season 5Ep. 8
Join us on an exhilarating journey into the intricate world of choline and the PEMT gene. Delve into the significance of choline and how it impacts cellular health, brain function, and beyond, and how PEMT plays a role in choline production. Discover the intricate genetic variants within PEMT, unravelling how certain alleles influence susceptibility to choline deficiency and associated risks. Plus, learn how estrogen stimulation plays a crucial role, posing unique challenges for different demogr...
Jan 09, 2024•6 min
In this episode, we delve deep into the importance of the immune system and how you can optimize it for peak performance. Immunity isn't just about avoiding the common cold; it can impact all areas of health, from physical wellness to mental clarity. Joe, a seasoned biohacker, shares his personal experiences and strategies for ramping up immunity, shedding light on how a data-driven approach can yield significant benefits. We also explore a comprehensive protocol for when you do get sick, outlin...
Jan 05, 2024•1 hr 1 min•Season 5Ep. 7
In this episode, Joe dives deep into the fascinating world of MTHFR and what you can do if you carry the negative variants! Join us as we unravel the mysteries surrounding these important topic and explore everything you need to know about genetic variations, folate metabolism, and the crucial role of methylation in our bodies. Joe breaks down the science behind MTHFR, explains how to interpret your genetic results, and shares valuable insights on optimizing your folate levels. Discover the bene...
Dec 29, 2023•24 min•Season 5Ep. 6
You’ve probably heard of the hype around MTHFR and how it affects methylation, but what about other genes implicated in the methylation process? In this SNPit the spotlight shifts to MTR and MTRR, and how they can affect levels of homocysteine in the body. Learn all about why homocysteine is important, how genetic variants can affect your levels, and other factors that affect methylation. … Because MTHFR doesn’t tell the whole story. If you're interested in learning more about how your DNA and g...
Dec 15, 2023•5 min
In this episode of the Joe Cohen Show, we welcome Dr. Darshan Shah, a renowned health specialist, surgeon, author, and founder of Next Health. We dive deep into the cutting-edge health optimization methods used at his clinic to extend lifespan and health span. Dr. Shah shares intriguing insights on the role of biohacking, the importance of managing metabolic disease, micronutrient testing, and the function of certain nutrients in our bodies. Throughout the discussion, Joe demonstrates how he use...
Dec 08, 2023•52 min•Season 5Ep. 5
Dive deep into the fascinating world of brain health, brain mapping, and the game-changing impact of neurofeedback on anxiety, sleep, executive function, and so much more. In this episode, Dr. Andrew Hill - a neuroscientist with a Ph.D. in Cognitive Neuroscience from UCLA and is best known as an expert neurofeedback practitioner and brain fitness coach - shares his decades of knowledge to help us understand the power of neurofeedback. Discover the pivotal role of brain mapping in tailoring perso...
Dec 01, 2023•1 hr 16 min•Season 5Ep. 4
Dive into the world of immunity optimization with Joe and Siim Land - all the way from India! From supplement stacks to proactive measures for bolstering the immune system, Siim and Joe dissect their distinct immune-boosting protocols aimed at fortifying immunity and enhancing the body's defense mechanisms. Joe and Siim share their tailored approaches to prevent illness and expedite recovery when under the weather. Gain exclusive insights into their supplement regimens, tailored to optimize immu...
Nov 24, 2023•1 hr 9 min•Season 5Ep. 3
Unlock the mysteries behind methylation, MTHFR, and homocysteine! Join us as we dive into these widely recognized yet often misunderstood terms that impact heart health, mental well-being, fertility, and more. The surge in popularity around methylation, MTHFR, and homocysteine has led to a barrage of misinformation. In this enlightening episode, we've invited Dr. Denise Furness, a distinguished molecular geneticist boasting over two decades of expertise in folate nutrigenomics, methylation, and ...
Nov 17, 2023•1 hr 15 min•Season 5Ep. 2
I’m thrilled to be back with a brand-new season of The Joe Cohen Show! We’re kicking off the season with truly life-changing knowledge with a popular returning guest, Dr. Oz Garcia! In this episode, Dr. Oz Garcia and I explore the keys to happiness, the transformative power of meditation, and the world of biohacking for pain reduction and sleep optimization! We dive into the intricacies of mood, discussing all the different pathways that affect your overall mood and the different approaches to c...
Nov 10, 2023•1 hr 1 min•Season 5Ep. 1
In this special episode, we've curated the most influential moments and expert insights from some of our remarkable guests of Season 4. Get ready to uncover a treasure trove of tips and tricks to supercharge your health and well-being. From optimizing gut health to longevity secrets, this episode is your ultimate guide to living your best, healthiest life. Tune in now for a power-packed journey into the world of wellness and discovery. Don't miss out on this collection of wisdom from the best in...
Nov 03, 2023•28 min
Have you ever wondered if a single gene could hold the key to unlocking your cognitive potential, or perhaps, be the culprit behind those moments of brain fog? Discover the fascinating world of the BDNF gene in this episode of SNPits. Explore how your genetic makeup can impact your cognitive function and memory and uncover the association between BDNF variants and brain health. Plus, learn how to naturally boost your BDNF levels for improved learning and mental performance. If you're interested ...
Oct 20, 2023•4 min
Do you find it hard to drift off to sleep at night? Wondering why some nights are filled with vivid dreams while others leave you feeling like you've barely closed your eyes? What's the true impact of those late-night screens and the foods we consume on our sleep cycle? In this episode, Joe and Dr. Greg answers questions unraveling the mysteries of sleep and revealing the intricacies of our body's internal clock. Together, they explore the pivotal role of sleep in our overall health, spotlightin...
Oct 13, 2023•50 min
In this episode of the Joe Cohen Show, we dive deep with renowned nutritionist Dr. Oz Garcia. With a lifetime of experience in the realm of nutrition, Oz shares his transformational journey from being a "rockstar nutritionist" to confronting the challenges of his own health issues. We explore the importance of not just focusing on what we eat, but also delving into data-driven wellness practices that can pave the path to optimal health. Learn about the markers and biomarkers that matter, how to ...
Oct 06, 2023•1 hr•Season 4Ep. 7
The pursuit of optimal health is a lifelong journey, so finding the motivation to continue to make the right decisions can sometimes be difficult. If you’re not working on a tangible goal - like running a marathon or reaching a PR in squats - then how can you keep yourself from falling into unhealthy habits? In this episode, Andrew Steele - former Olympian and co-founder of DNAfit and Aila - and Joe share tips on how to set realistic goals that keep you striving for optimal health and performanc...
Sep 29, 2023•58 min•Season 4Ep. 6
