Episode description

For decades, we’ve been told that our DNA is a fixed blueprint—an unchangeable code that dictates our health and lifespan. But what if that’s only half the story? 

Sharon Hausman-Cohen, a physician, researcher, and genomics expert at IntellxxDNA, joins Dave to reveal the cutting-edge science of genetic optimization—how understanding your DNA can unlock longer life, better brain function, and even protection from chronic disease. 

Forget the old-school genetic reports that left you with useless percentages. The new frontier of precision genomics goes beyond risk factors to actionable insights, showing you exactly how to turn on your body’s most powerful longevity genes and turn off the pathways driving inflammation, cognitive decline, and disease. 

What You’ll Learn in This Episode: 

• Why genetics alone don’t determine your future—and how to use epigenetics to control your health 

• The truth about MTHFR, APOE4, and other “bad” genes—are they actually harming you? 

• How genetic reports can predict and eliminate brain fog, fatigue, and pain 

• The hidden genetic reasons behind ADHD, depression, and anxiety—and how to fix them 

• Why some people age faster—and the one longevity gene that determines your biological age 

• Cutting-edge breakthroughs in DNA-based biohacking—is it possible to edit your genes for peak performance? 

This is the future of personalized medicine. By understanding your own genetic blueprint, you can stop guessing and start making the precise changes that will optimize your energy, brainpower, and lifespan! 

** Visit IntellxxDNA at https://intellxxdna.com/asprey/ When you go to the website to find a clinician please select “human upgrade/longevity” as the type of consult to get specialized biohacking clinicians! ** 

SPONSORS 

-Timeline | Head to https://www.timeline.com/dave to get 10% off your first order. 

-Leela Quantum Tech | Head to https://leelaq.com/DAVE for 10% off. 

Resources:  

• Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ 

• IntellxxDNA Website: https://intellxxdna.com/asprey/ 

• 2025 Biohacking Conference: https://biohackingconference.com/2025 

• Danger Coffee: https://dangercoffee.com 

• Dave Asprey’s Website: https://daveasprey.com 

• Dave Asprey’s Linktree: https://linktr.ee/daveasprey 

• Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com 

• Own an Upgrade Labs: https://ownanupgradelabs.com 

• Upgrade Labs: https://upgradelabs.com 

• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com 

Timestamps: 

• 00:00 – Intro 

• 02:00 – The Role of Genetics in Longevity 

• 03:37 – Gene Variants & Cognitive Health 

• 05:58 – Epigenetics vs. Genetics 

• 08:21 – Genomics & Pain Management 

• 09:26 – Breakthroughs in Genetic Research 

• 12:33 – The Future of Genomic Medicine 

• 14:27 – How to Use Genomic Reports 

• 38:25 – Mitochondria & Longevity 

• 42:40 – BH4 & Mental Health 

• 43:42 – Folinic Acid & Brain Function 

• 44:37 – Genomics & Autism 

• 46:06 – Personalized Medicine 

• 56:00 – APOE4 & Alzheimer’s Risk 

• 59:44 – Genetics & Heart Health 

• 01:04:54 – The Future of Precision Medicine 

• 01:20:23 – Conclusion & Next Steps 

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