The Human Upgrade with Dave Asprey - podcast cover

The Human Upgrade with Dave Asprey

Dave Aspreydaveasprey.com

For a decade, Dave Asprey, “the father of biohacking,” elevated what you knew about the capabilities of your mind and body across a thousand episodes of Bulletproof Radio. Now, he’s evolving it even further in his plan to upgrade humanity. You’re invited to expand your knowledge, explore your own performance and embrace possibility with The Human Upgrade™.

You’ll meet bright thinkers and radical doers who push the boundaries of science, technology, personal development, and human performance in every way imaginable. You’ll learn from experts around the world who elevate what it means to be human.

Every guest you listen to, every topic you learn about, every new idea you discover on this podcast moves you forward.

Join The Human Upgrade™ with Dave Asprey on this next evolution to upgrade your mind, body and life. 

Episodes

60 Days Alone in Antarctica: Amputation, Frostbite, and Lessons from Extreme Suffering | Akshay Nanavati : 1286

This episode dives into the brutal, mind-altering experience of spending 60 days alone in Antarctica, and how extreme suffering became a catalyst for spiritual awakening, peak performance, and deep inner peace. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with elite adventurer, Marine Corps veteran, and Fearvana founder Akshay Nanavati , who dragged a 420lb sled solo across Antarctica in a brutal test of endurance,...

May 29, 20251 hr 15 minEp. 1286

10-Second Breath Hack to Reset Your Body & Mind | Aaron Alexander : 1285

This episode reveals how one simple breath pattern can rewire your nervous system, regulate stress in seconds, and become your most powerful tool for human performance and longevity. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Aaron Alexander, a world-renowned human performance coach, manual therapist, and creator of The Align Method . Aaron has worked with elite athletes, high-level entrepreneurs, and celebr...

May 27, 202559 minEp. 1285

Ayurveda Meets Biohacking: 5000-Year-Old Medicine Secrets for Modern Stress | Mona Sharma : 1284

This episode reveals the ancient health protocols Western medicine forgot, and how they are now being used to heal stress, rewire the nervous system, and radically improve human performance. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Mona Sharma , a renowned Ayurvedic practitioner, celebrity wellness expert, and functional medicine advocate who grew up in a Canadian ashram. Mona combines ancient Vedic practi...

May 22, 202559 minEp. 1284

The Biohacker’s Guide to CIA Mind Control & Brainwashing : 1283

You’re being programmed, and it’s more subtle and pervasive than you think. From invisible influence to psychological manipulation, this episode shows you how to recognize when your thoughts aren’t really yours. Host Dave Asprey uncovers the hidden science of mind control with Harvard historian Rebecca Lemov. She is a professor of the History of Science at Harvard University and one of the world’s leading experts on psychological manipulation, surveillance science, government experimentation, an...

May 20, 20251 hr 4 minEp. 1283

Military Tech Goes Public: Think 30% Faster with This Brain Hack | Geoffrey Woo : 1282

Your brain runs slow when it’s running on the wrong fuel. In this episode of The Human Upgrade , Dave Asprey sits down with Geoffrey Woo, Stanford-trained computer scientist and founder of Ketone-IQ, to reveal the high-performance brain fuel once reserved for Special Forces and elite athletes. Discover how ketones helped operators in combat zones sharpen focus, recover faster, and boost reaction speed by up to 30%. Learn why glucose falls short, how to hack your mitochondria for better cognition...

May 16, 20251 hr 27 minEp. 1282

The Anti-Aging Chamber That Rewinds Your Biological Clock|Dr. Jason Sonners : 1281

Your cells are starving. Not for food—but for oxygen. In this episode of The Human Upgrade , Dave Asprey sits down with Dr. Jason Sonners , world-renowned hyperbaric expert and regenerative medicine pioneer, to reveal how controlled oxygen under pressure is becoming one of the most powerful tools in anti-aging and performance science. You’ll learn how hyperbaric oxygen therapy (HBOT) triggers stem cell activation, rewires your epigenome, boosts mitochondrial energy, and reverses biological aging...

May 15, 202549 minEp. 1281

The New Science Behind Psychedelics, Exotic Shrooms, & Daily Flow-States | Matt Zemon : 1280

Your brain has a gear you’ve never touched. Psychedelics can shift you into it. In this episode of The Human Upgrade, Dave Asprey uncovers how high-performance psychedelic mushrooms help you access flow states, rewire your brain, and enhance clarity, energy, and emotional resilience. This is next-level biohacking rooted in real science. You will learn how to use psychedelics with intention. When to microdose. When to go deep. How to stack them with nootropics for even stronger results. Dave brea...

May 13, 20251 hr 11 minEp. 1280

Why Oral Testosterone Is the Ultimate Upgrade for Energy, Mood and Longevity (Men AND Women) | Shalin Shah : 1279

Low testosterone is sabotaging your health, motivation, and longevity. Diet alone will not fix it. In this episode of The Human Upgrade , Dave Asprey sits down with Shalin Shah, CEO of Marius Pharmaceuticals, to expose the truth about testosterone decline in both men and women. They break down why testosterone is crashing worldwide, why natural fixes almost always fail, and how the latest science finally makes testosterone therapy safer, simpler, and more effective than ever before. You will dis...

May 09, 20251 hr 5 minEp. 1279

The Deadliest Room in Your House — And How to Detox It for Better Health | Aly Cohen MD : 1278

Your environment is rewiring your hormones, fertility, and long-term health without your consent. In this episode of The Human Upgrade , Dave Asprey sits down with Dr. Aly Cohen , board-certified rheumatologist, integrative medicine specialist, and environmental health educator. Together they expose how common toxins in plastics, pesticides, drinking water, personal care products, and food packaging are hijacking your biology. Dr. Cohen explains how daily chemical exposures contribute to autoimm...

May 08, 20251 hr 13 minEp. 1278

Biohacking Your Heart Health: The Life-Saving Molecule You NEED to Know | Dr. Anurag Singh : 1277

What if you could reverse the age of your heart...without leaving home? In this episode of The Human Upgrade , Dave Asprey sits down with Dr. Anurag Singh, Chief Medical Officer of Timeline, to reveal groundbreaking science that targets cardiovascular aging at the cellular level. You’ll discover how mitochondrial decline drives heart failure, why postmenopausal women face skyrocketing cardiac risks, and how one powerful molecule, Urolithin A, can rejuvenate your heart’s energy systems. Dr. Singh...

May 06, 20251 hr 4 minEp. 1277

How Laser Therapy Boosts Mood, Mental Clarity, and Consciousness with Dr. Brandon Crawford : 1276

What if a laser could help a child speak for the first time—or reverse an “incurable” brain condition? In this episode of The Human Upgrade , Dave Asprey talks with Dr. Brandon Crawford, a leading neurotherapist and founder of 528 Innovations, about the emerging science of laser therapy for the brain and body. You’ll learn how light—when precisely pulsed and targeted—can rewire brainwaves, heal trauma, and even influence states of consciousness. Dr. Crawford explains how specific laser frequenci...

May 01, 202541 minEp. 1276

Conscious Bacteria? The Secret New Science of Cellular Intelligence | Zach Bush : 1275

What if mitochondria weren’t just energy engines — but conscious beings guiding your survival and evolution?   In this episode, Dave Asprey sits down with Zach Bush, MD, to uncover a radical new science of cellular intelligence. Together, they reveal how your mitochondria, microbiome, and genetic memory do far more than support survival—they actively shape consciousness, drive healing, and accelerate human evolution.  You’ll discover why chronic disease, fatigue, brain fog, and emotion...

Apr 29, 20251 hr 43 minEp. 1275

The End of Cardio? Burn Fat & Boost VO₂ Max in Just 8 Minutes a Week – with REHIT | Ulrich Dempfle : 1275

You’ve probably heard of HIIT—but have you heard of “REHIT?”  This isn’t just another workout trend...it’s a new science-backed way to train with maximum efficiency and zero wasted time . If you’re still jogging, you’re wasting hours for minimal results.  In this episode of The Human Upgrade , Dave Asprey sits down with Ulrich Dempfle , German-trained engineer and co-founder of CAROL Bike , to dismantle outdated cardio advice and introduce the 5-minute protocol that’s obliterating fitn...

Apr 25, 20251 hr 6 minEp. 1275

The Real Reason You Still Feel Tired—Even When Your Bloodwork Looks Perfect | Dr Pompa : 1273

Your bloodwork looks normal. Your doctor says you’re fine. But you still feel exhausted, inflamed, anxious—or worse.   In this episode, Dave Asprey talks with  Dr. Daniel Pompa , a leading voice in  cellular detox and root-cause healing , to expose the hidden stressors hijacking your energy, hormones, and metabolism—even when your labs say you’re healthy.  Dr. Pompa shares his personal health collapse and reveals how  cellular dysfunction, neurotoxicity, and hormone resi...

Apr 24, 20251 hr 19 minEp. 1273

The $500 Billion Secret: Why Top Leaders Chase Stress | Sébastien Page : 1272

Most people run from stress. The world’s highest performers run toward it.   Sébastien Page manages over  $500 billion in global assets . He’s the CIO of one of the world’s largest investment firms, and he wrote  The Psychology of Leadership  while living under relentless pressure. His secret? He doesn’t avoid stress—he uses it as a tool for performance, clarity, and control.  But here’s the twist: this isn’t just about boardrooms or billion-dollar trades.  Whether ...

Apr 22, 20251 hr 20 minEp. 1272

Web3 & the Future of Genetics: AI, Blockchain & Data Ownership with Nillion : 1271

Your DNA, health data, and digital identity are encrypted, monetized, and weaponized against you.   But what if there was a way to take it back… and hack the system?  In this mind-expanding episode, Dave sits down with two elite hacker-founders— Michael Tiffany , CEO of  Fulcra.ai , and  Vishakh , founder of  Monadic DNA —to explore a radical shift in the way we store, protect, and use our most personal data.  Together, they break down the  Web3 tech stack...

Apr 17, 20251 hr 30 minEp. 1271

Dr. Steven Gundry: Is Fungus Secretly Running the World—and Your Gut? : 1270

If your brain feels foggy, your mood swings like a pendulum, or your cravings seem to control you—this episode will flip what you think you know about your body and your mind. Because what if your thoughts… aren’t really yours?  In this mind-altering episode of  The Human Upgrade , Dr. Steven Gundry reveals a startling new theory: your gut microbiome might be controlling your thoughts. From addiction and depression to obesity and inflammation, the microbes living in your gut—bacteria, ...

Apr 15, 202554 minEp. 1270

Longevity Scientists Discover a Breakthrough Peptide That Reverses Hair Loss | Carolina Reis Oliveira : 1269

If your hair is thinning, shedding, or simply not what it used to be—and nothing seems to work—this episode is for you. Because what if the story you’ve been told about balding… is wrong?  For decades, hair loss has felt like fate: genetic, inevitable, untouchable. But science is catching up to something deeper—something root-level. What if the real culprit behind age-related hair loss is cellular dysfunction? And what if we could change that?  In this episode, Dave Asprey uncovers the...

Apr 11, 20251 hrEp. 1269

Identity Hacker: How to Completely Change Your Personality at ANY Age | Olga Khazan : 1268

What if you could rewrite the code of your personality—on command?  Not just  cope  with anxiety, overthinking, or social exhaustion… but  delete  the traits holding you back and install better ones?  This episode challenges everything you’ve been told about identity. Dave dives deep into the science of personality change to reveal why your habits, moods, triggers, and even sense of self aren’t fixed—they’re fluid. And more importantly: they’re up for grabs.  J...

Apr 10, 20251 hr 6 minEp. 1268

Psychedelic States On-Demand (No Substances Needed) | Dr. Patrick Porter : 1267

Your brain isn’t broken—it’s underpowered.  Energy crashes, poor sleep, brain fog, and emotional reactivity don’t just happen. You’re running on low voltage, and your mind pays the price.  In this episode, Dave sits down with  Dr. Patrick Porter , founder of BrainTap, to reveal how to  reprogram your brain using light, sound, and guided visualization —no substances, no side effects, no BS.  Dr. Porter breaks down how to activate gamma brainwaves, repair trauma loops, acc...

Apr 08, 202529 minEp. 1267

Why Gen Z Can’t Handle the Real World (and How We Can Help Them) | Jennifer Cohen : 1266

You think you’re helping your kid. You clear the path. You smooth the bumps. You make sure they never feel too sad, too bored, too uncomfortable.  It feels like love.  But what if it’s making them weak?  In this episode, Dave Asprey sits down with bestselling author, TED speaker, and resilience expert  Jennifer Cohen  to reveal how today’s parenting norms are quietly producing the most anxious, dependent, and emotionally fragile generation in history— Gen Z .  Wheth...

Apr 03, 202551 minEp. 1266

The Dirty Secret Behind Ozempic: How It Wrecks Your Gut (Here’s How to Fix It) | Hannah Kleinfeld : 1265

For decades, gut health was reduced to yogurt commercials and vague promises from probiotics that barely worked. But what if we’ve been targeting the wrong bugs, using the wrong delivery, and ignoring the true source of chronic inflammation and accelerated aging?  In this thought-provoking episode, Dave sits down with Hannah Kleinfeld, a leader in microbiome innovation, to expose why most probiotics fail—and how one company’s scientifically validated approach could redefine your gut, brain,...

Apr 01, 20251 hr 13 minEp. 1265

Scientists Just Discovered the Essential Nutrient That DOUBLES Dolphin Lifespan—But Should YOU Take It? | Stephanie Venn-Watson : 1256

For nearly a century, scientists believed we had discovered ALL of the essential fatty acids the human body needs. But what if they were wrong?  Stephanie Venn-Watson, a veterinary epidemiologist and longevity researcher, joins Dave to reveal a groundbreaking discovery— a newly identified essential fatty acid, C15,  that may hold the key to healthier aging and even longer lifespans. Originally uncovered in an unlikely place— U.S. Navy dolphins that were outliving their wild counterpart...

Mar 27, 20251 hr 18 minEp. 1256

This Is Your Brain on 2025: The Biohacker’s Guide to Mental Clarity & Mood | Dr. Drew Ramsey : 1263

You think you’re optimizing your brain—but what if the real culprit behind your brain fog, anxiety, and burnout is the modern world itself?  In this episode,  Columbia University psychiatrist and nutritional neuroscience pioneer  Dr. Drew Ramsey joins Dave Asprey to decode the biological chaos hijacking your mind—and how to fight back. From inflammation and gut dysbiosis to screen-induced disconnection and hidden trauma, this is the ultimate roadmap for healing the modern brain.&n...

Mar 25, 20251 hr 11 minEp. 1263

The Science of Consciousness: What’s Beyond the Brain? | Mark Gober : 1262

You think, you feel, you  are —but what if your consciousness isn’t just in your brain? What if reality itself is shaped by something beyond the physical?  In this episode,  Mark Gober—author, consciousness researcher, and former Silicon Valley banker—joins Dave Asprey  to challenge everything you think you know about the mind, reality, and human potential. He explores groundbreaking research on near-death experiences, psychic phenomena, and why some scientists believe consci...

Mar 20, 20251 hr 28 minEp. 1262

The Hidden Cost of Being Too Nice: Why People-Pleasing is Silently Killing Your Success | Scott Barry Kaufman : 1261

You hold the door open. You say yes when you mean no. You put others first—always. It feels like the right thing to do… but is it costing you more than you realize?  In this episode, Scott Barry Kaufman, Ph.D.—Columbia professor, psychologist, and author of Rise Above—joins Dave Asprey to expose the psychology of victim vs. empowerment mindsets . He reveals how toxic altruism, external validation, and emotional fragility keep people stuck—and how you can reclaim your confidence, set boundar...

Mar 18, 20251 hr 15 minEp. 1261

MDMA Therapy Without the Drugs? How Vibration Hacks Your Brain for Neuroplasticity | Dave Rabin : 1260

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Mar 14, 202558 minEp. 1260

Brain Hacking 101: The Science of Self-Sabotage & Mind Reprogramming | Bizzie Gold : 1259

Your Brain is Lying to You—Here’s How to Take Back Control  Every day, your brain is running subconscious scripts—hidden mental loops that shape your decisions, habits, and even your self-worth. But what if those loops are sabotaging you?  In this episode,  Bizzie Gold , mind architect and creator of  The Break Method , joins Dave Asprey to expose the  self-deception patterns controlling your thoughts —and how to  reprogram your brain for true transformation . ...

Mar 13, 20251 hr 10 minEp. 1259

How Learning a New Language Rewires Your Brain—Lessons from the Pirahã Tribe | Daniel Everett : 1258

Is the Way You Speak Limiting How You Think? For years, scientists debated how language shapes the brain, but new research reveals it goes far beyond communication. Some languages lack numbers, grammar, or even complex sentences—yet their speakers navigate reality in ways that defy expectations. In this mind-bending episode, linguist Daniel Everett, known for challenging Noam Chomsky’s theories, shares how his time with the Pirahã people reshaped our understanding of language, cognition, and eve...

Mar 11, 20251 hr 12 minEp. 1258

Your Genes AREN’T Your Fate—The NEW Science of DNA Biohacking for SuperHuman Health | Sharon Hausman-Cohen : 1257

For decades, we’ve been told that our DNA is a fixed blueprint—an unchangeable code that dictates our health and lifespan. But what if that’s only half the story?  Sharon Hausman-Cohen, a physician, researcher, and genomics expert at IntellxxDNA, joins Dave to reveal the cutting-edge science of  genetic optimization —how understanding your DNA can unlock  longer life, better brain function, and even protection from chronic disease.   Forget the old-school genetic reports that...

Mar 06, 20251 hr 19 minEp. 1257
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