What if you could rewrite the code of your personality—on command? Not just cope with anxiety, overthinking, or social exhaustion… but delete the traits holding you back and install better ones? This episode challenges everything you’ve been told about identity. Dave dives deep into the science of personality change to reveal why your habits, moods, triggers, and even sense of self aren’t fixed—they’re fluid. And more importantly: they’re up for grabs. Joining him is award-winning journalist fro...
Apr 10, 2025•1 hr 6 min•Ep. 1268
Your brain isn’t broken—it’s underpowered. Energy crashes, poor sleep, brain fog, and emotional reactivity don’t just happen. You’re running on low voltage, and your mind pays the price. In this episode, Dave sits down with Dr. Patrick Porter , founder of BrainTap, to reveal how to reprogram your brain using light, sound, and guided visualization —no substances, no side effects, no BS. Dr. Porter breaks down how to activate gamma brainwaves, repair trauma loops, access psychedelic-like states, a...
Apr 08, 2025•29 min•Ep. 1267
You think you’re helping your kid. You clear the path. You smooth the bumps. You make sure they never feel too sad, too bored, too uncomfortable. It feels like love. But what if it’s making them weak? In this episode, Dave Asprey sits down with bestselling author, TED speaker, and resilience expert Jennifer Cohen to reveal how today’s parenting norms are quietly producing the most anxious, dependent, and emotionally fragile generation in history— Gen Z . Whether you’re raising kids, managing you...
Apr 03, 2025•51 min•Ep. 1266
For decades, gut health was reduced to yogurt commercials and vague promises from probiotics that barely worked. But what if we’ve been targeting the wrong bugs, using the wrong delivery, and ignoring the true source of chronic inflammation and accelerated aging? In this thought-provoking episode, Dave sits down with Hannah Kleinfeld, a leader in microbiome innovation, to expose why most probiotics fail—and how one company’s scientifically validated approach could redefine your gut, brain, immun...
Apr 01, 2025•1 hr 13 min•Ep. 1265
For nearly a century, scientists believed we had discovered ALL of the essential fatty acids the human body needs. But what if they were wrong? Stephanie Venn-Watson, a veterinary epidemiologist and longevity researcher, joins Dave to reveal a groundbreaking discovery— a newly identified essential fatty acid, C15, that may hold the key to healthier aging and even longer lifespans. Originally uncovered in an unlikely place— U.S. Navy dolphins that were outliving their wild counterparts by decades...
Mar 27, 2025•1 hr 18 min•Ep. 1256
You think you’re optimizing your brain—but what if the real culprit behind your brain fog, anxiety, and burnout is the modern world itself? In this episode, Columbia University psychiatrist and nutritional neuroscience pioneer Dr. Drew Ramsey joins Dave Asprey to decode the biological chaos hijacking your mind—and how to fight back. From inflammation and gut dysbiosis to screen-induced disconnection and hidden trauma, this is the ultimate roadmap for healing the modern brain. You’ll explore the ...
Mar 25, 2025•1 hr 11 min•Ep. 1263
You think, you feel, you are —but what if your consciousness isn’t just in your brain? What if reality itself is shaped by something beyond the physical? In this episode, Mark Gober—author, consciousness researcher, and former Silicon Valley banker—joins Dave Asprey to challenge everything you think you know about the mind, reality, and human potential. He explores groundbreaking research on near-death experiences, psychic phenomena, and why some scientists believe consciousness may exist beyond...
Mar 20, 2025•1 hr 28 min•Ep. 1262
You hold the door open. You say yes when you mean no. You put others first—always. It feels like the right thing to do… but is it costing you more than you realize? In this episode, Scott Barry Kaufman, Ph.D.—Columbia professor, psychologist, and author of Rise Above—joins Dave Asprey to expose the psychology of victim vs. empowerment mindsets . He reveals how toxic altruism, external validation, and emotional fragility keep people stuck—and how you can reclaim your confidence, set boundaries, a...
Mar 18, 2025•1 hr 15 min•Ep. 1261
What do vibrations and the psychedelic experience have in common? MDMA therapy is revolutionizing mental health treatment, helping people overcome PTSD, anxiety, and emotional trauma with unprecedented success. But what if you could tap into those same powerful benefits—without taking a single drug? It turns out your brain responds to more than just chemistry. Vibration, frequency, and rhythm have been shaping human consciousness for millennia—from ancient chanting rituals to modern neuroscience...
Mar 14, 2025•58 min•Ep. 1260
Your Brain is Lying to You—Here’s How to Take Back Control Every day, your brain is running subconscious scripts—hidden mental loops that shape your decisions, habits, and even your self-worth. But what if those loops are sabotaging you? In this episode, Bizzie Gold , mind architect and creator of The Break Method , joins Dave Asprey to expose the self-deception patterns controlling your thoughts —and how to reprogram your brain for true transformation . Bizzie’s method isn’t just another self-h...
Mar 13, 2025•1 hr 10 min•Ep. 1259
Is the Way You Speak Limiting How You Think? For years, scientists debated how language shapes the brain, but new research reveals it goes far beyond communication. Some languages lack numbers, grammar, or even complex sentences—yet their speakers navigate reality in ways that defy expectations. In this mind-bending episode, linguist Daniel Everett, known for challenging Noam Chomsky’s theories, shares how his time with the Pirahã people reshaped our understanding of language, cognition, and eve...
Mar 11, 2025•1 hr 12 min•Ep. 1258
For decades, we’ve been told that our DNA is a fixed blueprint—an unchangeable code that dictates our health and lifespan. But what if that’s only half the story? Sharon Hausman-Cohen, a physician, researcher, and genomics expert at IntellxxDNA, joins Dave to reveal the cutting-edge science of genetic optimization —how understanding your DNA can unlock longer life, better brain function, and even protection from chronic disease. Forget the old-school genetic reports that left you with useless pe...
Mar 06, 2025•1 hr 19 min•Ep. 1257
For years, we’ve been told that willpower and repetition are the keys to forming habits. But the truth is, habits don’t stick because of repetition—they stick because of emotion! In this all-time classic episode, Dave brings together two of the world’s top habit experts—BJ Fogg, PhD, and James Clear—to break down the real science of behavior change. BJ, the Stanford researcher behind Tiny Habits , explains why motivation, ability, and the right prompts are the real drivers of habits. Meanwhile, ...
Mar 05, 2025•28 min•Ep. 1256
In this first-ever AMA episode, Dave tackles your biggest biohacking questions—straight from The Upgrade Collective ! From optimizing brain power to pushing the limits of cold therapy, this episode is packed with cutting-edge hacks to supercharge your body and mind. If you’d like to have your questions answered on the next AMA, click the link below for details on The Upgrade Collective membership, and get all sorts of extra biohacking add-ons for your life! In today’s episode: What if you could ...
Feb 27, 2025•55 min•Ep. 1255
Can You Mimic Fasting—Without Actually Fasting? Chris Rhodes, a biochemist and longevity researcher, joins Dave to reveal a groundbreaking fasting mimetic that could revolutionize how we approach aging, metabolism, and health. Fasting is one of the most powerful tools for longevity, but what if you could achieve the same benefits without hunger, energy crashes, or social sacrifices? Scientists have identified key compounds that mimic fasting at the cellular level—offering a way to extend lifespa...
Feb 25, 2025•1 hr 7 min•Ep. 1254
Could a single molecule be the difference between vibrant longevity and early decline? Dr. Andrew Salzman—Harvard-trained physician, scientist, and creator of the first PARP1 inhibitor, Chief Medical Officer of Wonderfeel—joins Dave to reveal the real key to living longer, fighting disease, and maximizing your energy: NAD. This master molecule fuels your mitochondria, DNA repair, and cellular resilience , but here’s the catch—it plummets as you age. That means more fatigue, brain fog, inflammati...
Feb 21, 2025•1 hr 24 min•Ep. 1253
Welcome to the metabolism masterclass! Dr. Ben Bikman (Ph.D Professor BYU), a powerhouse in metabolism science, joins Dave to expose the truth about insulin resistance —the silent epidemic fueling obesity, chronic disease, and low energy. Forget the outdated calorie-counting nonsense (it doesn’t work)—Dr. Bikman reveals how your hormones, not just your diet, control your metabolism and what you can do to reset it fast. From debunking diet myths to uncovering why some people can eat 400 grams of ...
Feb 20, 2025•1 hr 20 min•Ep. 1252
Most people wait for inspiration. But what if you could train your brain to create on demand? Rick Rubin has spent decades shaping the sound of legendary artists—Jay-Z, Johnny Cash, Metallica, and countless others—by tapping into the unseen forces of creativity. But what’s the secret behind his genius? In this must-listen episode, Rick sits down with Dave to explore the science and soul of creativity , revealing how meditation, mindfulness, biohacking, and unconventional thinking fuel artistic b...
Feb 18, 2025•55 min•Ep. 1251
What’s keeping you stuck in a scarcity mindset instead of stepping into abundance? What truly sets successful people apart from those who struggle? Tony Robbins has spent decades answering these questions—coaching billionaires, world leaders, elite athletes, and everyday people to master their money, mindset, and mission. In this all-time classic podcast, he shares the hard-hitting truths about financial freedom, why fear is your biggest enemy, and how to break free from the psychological traps ...
Feb 13, 2025•57 min•Ep. 1250
From chart-topping hits to life-threatening lows—how did Timbaland go from producing for Jay-Z, Beyoncé, and Justin Timberlake to battling addiction and obesity? And more importantly, how did he take his life back? In this raw and revealing conversation, music icon Timbaland shares the blueprint behind his incredible transformation—how he broke free from opioid addiction, lost 130 pounds, and rewired his mindset for long-term success. He and Dave dive into the power of discipline, the dangers of...
Feb 11, 2025•40 min•Ep. 1249
Could the right form of a single vitamin be the difference between thriving and barely surviving? In this Part 2 conversation, human biologist and longevity expert Gary Brecka reveals the #1 overlooked factor that’s wrecking your health: methylation —your body’s ability to convert nutrients into fuel. If this process fails, your hormones, energy, and even mental health take a nosedive. Gary and Dave dive deep into the real cause of anxiety, ADHD, and mood disorders , the hidden genetic reason wh...
Feb 06, 2025•1 hr 2 min•Ep. 1248
Why were our grandparents stronger, healthier, and living longer—without the “advancements” of modern medicine? Gary Brecka, one of the world’s leading experts in human longevity and performance, exposes the hidden crisis that’s wrecking your hormones, slashing your energy, and cutting your lifespan short. In this no-holds-barred conversation with Dave Asprey, they break down the corporate greed, medical corruption, and environmental toxins designed to keep you sick, weak, and dependent. What’s ...
Feb 05, 2025•37 min•Ep. 1247
Billy Carson, a Harvard-certified expert in ancient civilizations and an MIT-trained scholar in neuroscience, has spent decades decoding the mysteries of lost technology, quantum reality, and human optimization. Alongside Elisabeth Carson, a biohacker and neuroscience researcher, they bridge the gap between ancient wisdom and modern science—revealing secrets that could transform your mind, body, and reality. What if the Great Pyramid wasn’t just a monument but a powerful energy device designed t...
Jan 30, 2025•1 hr 40 min•Ep. 1246
Everything you’ve been told about weight loss is a lie! In this episode, Dr. Nick Norwitz, a metabolic health expert with accolades from Oxford and Harvard, joins Dave to expose the biggest myth in dieting: Calorie Counting. Together, they dismantle outdated weight-loss advice and reveal the truth about metabolism that could revolutionize your health. Dr. Norwitz shares cutting-edge science and personal stories that challenge the “eat less, move more” narrative, uncovering why traditional dietin...
Jan 28, 2025•1 hr 28 min•Ep. 1245
What if the key to living longer isn’t avoiding stress—but mastering it Jeff Krasno, founder of Commune and renowned stress expert, joins Dave to reveal why most of us have stress all wrong. In this fascinating conversation, Jeff redefines how we think about stress—showing how it can be your greatest ally instead of your worst enemy. From his groundbreaking new book Good Stress to the ancient practices that have stood the test of time, Jeff shares how to unlock the hidden potential of stress to ...
Jan 23, 2025•1 hr 35 min•Ep. 1244
What if you could cheat aging, indulge in life’s guilty pleasures, and still thrive? Dr. Sandra Kaufmann, a pioneering longevity expert and fearless explorer of the biochemical frontier, joins Dave to reveal how you can bend the rules of biology to live longer, smarter, and stronger. Forget perfection—Dr. Kaufmann’s radically practical approach embraces the human side of longevity, showing you how to optimize your body while enjoying the ride. From downing Diet Cokes to defying traditional medic...
Jan 21, 2025•1 hr 29 min•Ep. 1243
Is there actual “magic” on this planet, or is it just in the movies? Dr. Barry Morguelan, a top surgeon and one of only nine living grandmasters of an ancient Lao Tzu lineage, joins Dave to share secrets that have been hidden for 5,000 years. Together, they explore how the principles behind quantum physics, energy mastery, and timeless healing techniques can revolutionize your health, mindset, and life. From breaking rocks with energy to healing broken bones with focused intent, Dr. Barry reveal...
Jan 16, 2025•1 hr 7 min•Ep. 1242
What happens when nearly 60 years of combined biohacking expertise collide in one podcast? Peter Diamandis is a world-renowned futurist, space entrepreneur, and innovator behind groundbreaking ventures like the XPRIZE and Abundance 360. Dave sits down with Peter to combine their nearly 60 years of biohacking expertise, delivering the ultimate playbook for living longer and healthier. They dive into revolutionary AI-driven health solutions, mindset shifts that fuel vitality, and practical routine...
Jan 14, 2025•1 hr 20 min•Ep. 1241
What if you could ditch your glasses forever by simply doing a 10-minute exercise each day? In this episode, Dave sits down with Dr. Bryce Appelbaum, a visionary in vision biohacking, to uncover how simple techniques can transform your eyesight. From near-far focusing to eye stretches, these exercises don’t just improve your vision—they enhance your brain’s performance, energy, and overall health. Dr. Bryce shares his own journey of overcoming severe vision challenges, the science behind vision ...
Jan 09, 2025•58 min•Ep. 1240
What if the secret to living to 250 was simply sitting in the garden? In this episode, Dave sits down with Christian Drapeau, a leading expert in stem cell science, to explore the plants and natural practices that could unlock extreme longevity. From goji berries to reishi mushrooms, these age-old remedies do more than nourish—they activate your body’s innate repair system, boosting stem cells and accelerating healing. Christian dives into the fascinating stories behind these plants, their ancie...
Jan 07, 2025•56 min•Ep. 1239
