By last count, there are 5,000 genetic diseases in the human body. A few are merely annoying, but far more are devastating and without cure. In the last decade, much popular attention has been focused on the potential for stem cells and gene therapies to cure these once-intractable diseases. While the promise is clear, Tony Oro cautions patience. Oro is a dermatologist and associate director of the Center for Definitive and Curative Medicine at Stanford. He is a leading expert in the scientific ...
Apr 22, 2019•29 min•Ep 75•Transcript available on Metacast Brain cancers are known to be elusive and clever killers, but Michelle Monje, associate professor of neurology and neurological sciences, is helping to find new treatments through a better understanding of how healthy brain cells develop and how cancers often hijack those very same processes in order to grow themselves. Monje says that the last decade has seen tremendous progress in our understanding of how cancers thrive and in the development of new drugs and therapies to kill the killers. Unf...
Apr 22, 2019•28 min•Ep 74•Transcript available on Metacast The current process for diagnosing autism requires no less than 10 hours of intensive doctor-to-patient observation. It is expensive and time-consuming, says autism expert Dennis Wall, an associate professor of pediatrics and of biomedical data science at Stanford. Wall is developing new ways to tackle the problem. He says advances in machine learning, a branch of artificial intelligence focused on training computers to perform important medical tasks, stand to shake up the field. He’s developin...
Apr 03, 2019•28 min•Ep 76•Transcript available on Metacast Mechanical engineer Xiaolin Zheng really likes to burn things, but she is more like a modern-day Prometheus than a pyromaniac. She uses combustion to create minute nanoparticles of various metal oxides that have many practical and valuable uses in today’s world. For instance, she has created nanoparticles that can turn water into hydrogen peroxide using only energy from the sun. Hydrogen peroxide is a powerful disinfectant that kills microbes and removes other pollutants from water. Zheng imagin...
Mar 12, 2019•28 min•Ep 73•Transcript available on Metacast In safety engineering, ergonomic differences between men and women are important. Conventional seat belts do not fit pregnant women properly and motor vehicle crashes are the leading cause of fetal death related to maternal trauma. Analyses of sex differences have led to the development of pregnant crash test dummies that enhance safety in automobile testing and design. In medicine, osteoporosis has been conceptualized primarily as a women's disease, yet after a certain age men account for nearl...
Mar 06, 2019•28 min•Ep 72•Transcript available on Metacast Stanford radiation oncologist, Billy Loo, says that a new generation of radiation therapy technology called PHASER will be so fast that it can even compensate for the patient moving during treatment. High-energy X-rays will be fired so quickly, like a flash photograph, that motion is frozen and radiation can be more precisely focused on tumors. His research team is also finding that such ultra-fast “FLASH” radiation kills cancer cells through new biological mechanisms while causing less damage t...
Mar 05, 2019•28 min•Ep 71•Transcript available on Metacast Carlos Bustamante is an expert in genomics—the study of genetic variation and its effects on the living world. He says genomics holds tremendous promise but, so far, virtually all sequenced DNA comes from European blood lines and this presents a problem. Without greater diversity in the genomic data that is collected, he notes that we cannot fully reap the benefits of this knowledge, particularly in areas such as healthcare. "Genomics is the new oil," Bustamante says, of the opportunit...
Feb 14, 2019•28 min•Ep 68•Transcript available on Metacast Why do well-off public schools often demand that parents supplement school programs with personal contributions? Why do many rare diseases receive the lion’s share of donor attention and money? Is basic science being driven by the whims of big donors? These are questions that keep Stanford political philosopher Rob Reich up at night. Reich says that philanthropy is at an ethical crossroads in which the heart often leads the head in determining which causes get showered with money while other, pe...
Feb 11, 2019•28 min•Ep 70•Transcript available on Metacast Of the many nations that have implemented some measure of digital democracy, none perhaps has had more success than Estonia. Toomas Ilves, a Distinguished Visiting Fellow at the Hoover Institution, would know: He served as president of the Baltic state for two terms. Ilves says that all Estonians have verifiable digital identities and they use them to vote, sign legal documents, order prescription medication, file taxes and more online. Estonian digitization began with schools and banking in the...
Feb 04, 2019•28 min•Ep 69•Transcript available on Metacast In hospitals across the world, the unmet need for end-of-life palliative care threatens to overwhelm the few doctors who are equipped to adequately provide counseling that can help patients die on their own terms. There are just too many patients and too few doctors. Stanford’s Nigam Shah, an expert in medical informatics, says that such scenarios may soon become a thing of the past. Artificial intelligence, founded on tens-of-thousands of data points gathered from millions of patients, is flipp...
Dec 20, 2018•28 min•Ep 63•Transcript available on Metacast The worlds of academic economics and ride sharing are not so far removed – just ask Stanford labor economist Paul Oyer. When Oyer wanted to study the gig economy, he didn’t do it from afar; he became an Uber driver. Oyer says lessons from the gig economy hold deep lessons for the job market for more traditional jobs. Uber’s surge pricing, for instance, is more than a payment structure – it entices Uber drivers to work odd hours or at times of peak demand. He says Uber is constantly reworking its...
Dec 20, 2018•28 min•Ep 62•Transcript available on Metacast It’s nothing we haven’t already heard – the news you read is being shaped by the ubiquitous presence of social media. So-called “fake news” spread by bots and social media may continue to influence American elections and, ultimately, democracy. Alex Stamos, the former chief security officer at Facebook and an adjunct professor with Stanford’s Freeman Spogli Institute for International Studies, explained at a recent live taping of “The Future of Everything” that the emergence of social media has ...
Dec 20, 2018•32 min•Ep 65•Transcript available on Metacast The next job search you conduct will likely be shaped by artificial intelligence. In the age of LinkedIn and Monster.com, job hunters can count on their resumes being screened by non-human intelligence. So what does this mean for the future of hiring? At a recent live taping of the Stanford School of Engineering podcast “The Future of Everything,” Adina Sterling, an assistant professor of organizational behavior at Stanford Graduate School of Business who studies labor markets, said that roughly...
Dec 20, 2018•24 min•Ep 64•Transcript available on Metacast Earthquakes come in species, says Greg Beroza, professor of geophysics at Stanford and an expert in seismology. There are, of course, the well-known sudden shocks, but there are also “slow earthquakes” that transpire imperceptibly in contrast to the obvious temblors, but which can measure 7 on the Richter Scale or more — a major quake by any standard. Beroza knows about slow and other species of earthquakes because of a recent explosion in the availability of seismic data recorded by an expansiv...
Nov 17, 2018•29 min•Ep 66•Transcript available on Metacast Like clockwork, every time a large natural disaster hits and wipes out billions in built infrastructure, public officials, developers and private citizens cry, “never again.” And every time, equally like clockwork, very little gets done, says Stanford civil engineer Anne Kiremidjian, one of the world’s foremost authorities on constructing buildings that can withstand major natural disasters. She says there are technologies available that could move us toward stronger, safer buildings, but a lack...
Nov 17, 2018•27 min•Ep 67•Transcript available on Metacast While Alzheimer’s disease has cut short too many lives and devastated more families than can be counted, its root causes and effective treatments have eluded researchers for decades. But, says Stanford bioengineer Annelise Barron, new science indicates that many Alzheimer’s cases are coincident with viral or bacterial infections in the brain, pointing to possible new approaches to treatment or prevention. Barron says that one human protein in particular, LL-37 — which she refers to as a “Ninja p...
Oct 24, 2018•29 min•Ep 59•Transcript available on Metacast Riana Pfefferkorn is a digital security expert and Cryptography Fellow at the Stanford Center for Internet and Society. She says that we are living in the “Golden Age of Surveillance,” in which the growing ubiquity of data-rich smart devices has produced a fundamental tension between the rights of users to protect their personal data and the needs of law enforcement to investigate or prevent serious crimes. She says draft legislation in Australia could have major privacy and security implication...
Sep 22, 2018•28 min•Ep 57•Transcript available on Metacast While climate change is likely to bring rising sea levels, more frequent and stronger storms, as well as vanishing glaciers and coral reefs, experts say there are other lurking impacts that could have a more lasting effect on human behavior and health. Marshall Burke is a professor of Earth System Science and a fellow at Stanford’s Freeman Spogli Institute for International Studies who says that recent research shows rising global temperatures will lead to more wars, higher crime rates and great...
Sep 22, 2018•28 min•Ep 58•Transcript available on Metacast Professor David Magnus, director of the Stanford Center for Biomedical Ethics, says that artificial intelligence and machine learning are reshaping the landscape of medical care, but the underlying algorithms and the overarching challenges of how to employ the data are begetting new and vexing ethical questions. Magnus explains that concerns begin with who designs, builds and pays for the algorithms and whether the ultimate goal of AI is better outcomes for patients, or better bottom lines for p...
Sep 08, 2018•29 min•Transcript available on Metacast While well-known mapping apps have transformed the daily commute through better information, Stanford electrical engineer Balaji Prabhakar is exploring ways to digitally incentivize people to improve their driving habits. He calls it “nudging,” and says that small shifts in commute times — just 20 minutes earlier or later — can make a considerable impact on the day’s congestion in highly trafficked urban areas, like San Francisco. A few years ago, Prabhakar made headlines with a Stanford-only st...
Sep 08, 2018•27 min•Transcript available on Metacast Am I saving enough for retirement? Will I outlive my money? Can I count on Social Security? These are but a few of the nagging questions most every American grapples with when contemplating retirement. Gopi Shah Goda of the Stanford Institute for Economic Policy Research (SIEPR) says that the migration from once ubiquitous and relatively secure pension programs to today’s self-directed retirement plans are producing anxiety and indecision in retirement planning precisely at the worst time, and i...
Jul 28, 2018•27 min•Ep 53•Transcript available on Metacast While cryptocurrencies Bitcoin and Ethereum gather the lion’s share of headlines, few know that these “killer apps” are just the first generation of products based on a relatively new ledger-like technology called blockchain. Founder of the Center for Blockchain Research at Stanford, Dan Boneh says that blockchain is generating a swell of excitement among coders and computer scientists not witnessed since the earliest days of the internet. While the true killer apps are still to come, Boneh says...
Jul 28, 2018•29 min•Ep 54•Transcript available on Metacast Over the last three-quarters of a century, global corporations have lost sight of their broader role in society and now are focused almost exclusively on serving their shareholders. That reality has had dire consequences for the workers of the world who are, quite literally, dying for a job, says guest Jeffrey Pfeffer, a professor of organizational behavior at Stanford Graduate School of Business. Pfeffer says the workplace is the fifth leading cause of death and that as many as 1 million people...
Jul 14, 2018•29 min•Ep 52•Transcript available on Metacast Sarah Billington began her career in civil engineering studying concrete, a remarkable material that has literally shaped the world as we know it. Concrete is one of the most-consumed materials on Earth — second only to water, but this one material alone is also responsible for 6 percent of carbon dioxide emissions in the atmosphere. That cold realization and a dispiriting morning meeting spent in a bunkerlike concrete-walled room led Billington to alter her research focus. She now studies how w...
Jul 14, 2018•27 min•Transcript available on Metacast Populism can be a powerful force in a democratic society. But according to Anna Grzymala-Busse, a Stanford professor of political science and senior fellow at the Freeman Spogli Institute for International Studies, once in power populists often implement authoritarian policies that threaten the very foundations of democracy itself. Grzymala-Busse says that the antidote to authoritarianism is to defend democratic norms, to speak out and to vote. She discusses the issue in this episode of The Futu...
Jun 30, 2018•27 min•Ep 50•Transcript available on Metacast Beginning in the 1980s, medical doctors started treating pain with increasing amounts of opioid medications. That shift was driven in part by an effort by the profession to be more humane to those in serious pain, but also by misinformation and aggressive marketing by the pharmaceutical industry, which wrongly convinced doctors that their drugs were both safe and not addictive. According to Anna Lembke, an associate professor of psychiatry and behavioral sciences, those changes wrought the curre...
Jun 16, 2018•28 min•Ep 49•Transcript available on Metacast From Bitcoin theft to the embarrassing revelations in the Sony Pictures hacking to the recent assault on the U.S. election, the threats of international cyberattack are growing in both number and consequence. As our technology steadily becomes more cloud based, these threats will only grow and could be soon be directed at fundamental institutions we all trust and rely upon, including the electrical grid and our financial systems. Our guest in this episode of The Future of Everything radio show i...
Jun 16, 2018•27 min•Ep 48•Transcript available on Metacast When Stanford’s Martha Crenshaw, senior fellow at the Freeman Spogli Institute for International Studies and an expert on terrorism, is asked if she thinks terrorism is evolving, growing more widespread, violent and shocking by the year, she has one response: It’s complicated. She says that many of those trends are true, but they are driven both by the intense motivation of the terrorists and by their ability to broadcast images and messages across the world in a flash. This ability to communica...
Jun 02, 2018•26 min•Ep 47•Transcript available on Metacast It may not be widely known, but before he launched Apple, Steve Jobs lived for a year on a commune. The fact that he became one of the wealthiest capitalists in America, however, should not surprise anyone who knows anything about the antecedents of Silicon Valley, says Stanford’s Fred Turner, professor of communication and history. The truth is that there is a strong countercultural thread running through the fabric of today’s digital world. From “phreaking” scams of the long-distance telephone...
May 19, 2018•25 min•Ep 46•Transcript available on Metacast Can an expectant mother’s exposure to air pollutants or even extreme temperatures impact her unborn child’s earning potential 30 years later? Can paid family leave improve workforce attachment for new mothers? According to Maya Rossin-Slater, economist and an assistant professor of health research and policy at Stanford School of Medicine, the answer to these and other questions is “yes.” She says that research on these topics can provide policy makers with more comprehensive information on the ...
May 19, 2018•27 min•Ep 45•Transcript available on Metacast 
