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CURE for Engagement

Jan 29, 202539 minEp. 378
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Episode description

Authentic learning experiences help to create intrinsic motivation for students. In this episode, Julia Koeppe, Bonnie Hall, Paul Craig, and Rebecca Roberts join us to discuss BASIL, a course-based undergraduate research experience in Chemistry that has been implemented in many institutions.

Julia is an Associate Professor and Chair of the Chemistry Department here at SUNY-Oswego. Bonnie is an Associate Professor and Chair of the Chemistry & Physics Department at Grand View University. Paul is a Professor in the School of Chemistry and Material Science at the Rochester Institute of Technology. Rebecca is a Professor in the Biochemistry and Molecular Biology Program in the Department of Biology at Ursinus College.

A transcript of this episode and show notes may be found at http://teaforteaching.com.

Transcript

Authentic learning experiences help to create  intrinsic motivation for students. In this episode, we discuss a course-based undergraduate  research experience in Chemistry that has been implemented in many institutions. Thanks for joining us for Tea for Teaching, an informal discussion of innovative and  effective practices in teaching and learning. This podcast series is hosted by  John Kane, an economist...

...and Rebecca Mushtare, a graphic designer... ...and features guests doing important research and advocacy work to make higher education more  inclusive and supportive of all learners. Our guests today are Julia Koeppe, Bonnie Hall,  Paul Craig, and Rebecca Roberts. Julia is an Associate Professor and Chair of the Chemistry  Department here at SUNY-Oswego. Bonnie is an Associate Professor and Chair of the Chemistry  & Physics Department at Grand View University.

Paul is a Professor in the School of Chemistry  and Material Science at the Rochester Institute of Technology. Rebecca is a Professor in the  Biochemistry and Molecular Biology Program in the Department of Biology at Ursinus College.  Welcome Julia, Bonnie, Paul, and Rebecca. Today's teas are:... Julia, what  tea are you drinking today? I have a wild raspberry hibiscus tea. Very nice. Bonnie? I have an iced tea because it is  quite warm at our location today.

And where is your location today? We are currently in San Juan, Puerto Rico, doing some workshops to support  universities here in Puerto Rico. Excellent. And Paul? I like Irish Breakfast tea. That's a favorite of mine, too. And Rebecca? Like Bonnie, I'm doing the sweetened  iced tea because it is warm here in San Juan. And the other Rebecca? John, I have a new tea that I got this holiday season. It's called Blue Lady. It's  a flavored black tea, and it's very tasty.

Very good. Maybe I'll share with you next time I see you. Usually that only happens when  you don't like the tea. I know, I know. Usually I give  them the stuff I don't like. And I'm drinking some of the last of the Christmas  tea left over from our celebrations several weeks back. It's not quite as warm here in Oswego right  now. I think it's about 15 degrees, 20 degrees, something like that. Not if you figure in the wind chill. John, really… Yeah, it's cool.

Well, we wish we were in Puerto Rico with you,  but we're not. So we've invited you here today, virtually, to discuss the biochemistry authentic  scientific inquiry laboratory community. Can you give us an overview of this project? Sure, the BASIL project is a CURE. CURE stands for

course-based undergraduate research experience.  And what that means is that we teach a course, a laboratory course, but instead of being a  traditional cookbook lab where the instructor knows exactly what's happening, the students are  given directions, and they follow directions and complete their assignments, in a CURE, students  actually engage in research. Neither the students nor the instructors know the answer to the  question, and so this is open-ended basic

research, where discovery actually happens in  the course. Our course is focused on predicting protein function. We begin with computational  methods, computational tools, these are all web based resources that our students use, and  then once they have a prediction, they go in the wet lab, they express and purify the protein,  and then they run some assays to see if their

prediction is correct. And our overwhelming goal  in this process is that we want to transform our students from thinking of themselves as students  to thinking of themselves as scientists. So if someone were to visit one of  your classrooms, what would it look like? What would be taking place? What would  students be doing? What would you be doing?

This is Rebecca. It would basically look like a  research lab, but going on with a lot of people in the room doing their experiments, and they  might be doing different things at different times. So it's quite an exciting place to be. We  have designed BASIL with a flexible structure. So it's modular, it's adaptable, and faculty can  choose to take as much or as little as they'd

like. So we have some faculty that might do only  the computational modules with our students, and others might do all of it, or some might choose  one module and do it more as a one time in the lab, let's introduce you to a computational tool.  And because of that, it's been really nice to see how different faculty have chosen to run BASIL  at their institutions, depending on their own

learning outcomes and student population and the  resources that they have at their disposal. We've mostly designed it to be at the undergraduate  level, but it's been used at the master's level. Julia uses it at Oswego in one of her master's  level computational chemistry courses. And we've even had some high school faculty take it  on for their advanced students at the high

school level. The great thing about this flexible  structure is it's what we started with, and it's what we've really maintained a passion for, so  that people can use it how they want to use it, and it's accessible, so it's open access; all  of the computational modules are free web based modules to, again, improve student accessibility  and flexibility for the instructors. Can you talk a little bit about  how this differs from traditional

instructional approaches in biochemistry? So in a traditional biochemistry lab, you might do what's called, often, a cookbook experiment, where  we give you some specific instructions to follow, to learn a particular technique with and then  to achieve a known outcome. And in our approach,

again, we're looking at doing some more authentic  inquiry and research-based experiments. And so one of the things that is very different from some of  the traditional biochemistry lab is the inclusion of the computational tools that we use, and these  tools help us to study protein structures in order to predict a function, and then students can  use more traditional wet lab techniques in biochemistry to then create their protein sample  and do some analysis of that protein to confirm

the function. And so there's a lot more research  going on, as far as the instructor doesn't know the outcome, the student doesn't know the outcome.  The students are really having to come up with a hypothesis based on their initial computational  analysis and then design the experiments to test that hypothesis, and when I say they have to do  that, it's because the instructor also doesn't know what we're looking for, except that you  have the same data the students have already

collected computationally. And one of the reasons  that I do this in the biochemistry lab is because I like the idea that the students are driving the  project, and I also see the students are engaged with the project because they have connections.  So they're learning the different biochemistry lab techniques because they need to use them to solve  a problem, rather than just learning techniques, because techniques are important. And I'll throw  it over to Bonnie and Rebecca to talk some about

why they're using the project as well. So I chose to adopt BASIL because we have a pretty diverse group of students on our campus.  We have traditional students coming in at 18. We have a lot of retired military that come in,  so veterans, international students, immigrants, and they really go into a wide variety of career  options after: some go into industry, some go into

sales, some go to graduate programs. And the one  thing that we know that every employer, graduate program, whatever it's going to be, wants them  to be able to do, is to learn how to get stuck, which happens in real research, and how to figure  out how to get unstuck, how to move forward when you run into a barrier. How do you problem solve  and how do you motivate yourself to get through that? And so that's an experience we really  want every student in our program to have.

And at Ursinus, I was really interested in the  idea of interdisciplinary learning. And again, that's a tool that students need to be able  to have the ability to talk to others in a

different field when they're out of school. And  so at Ursinus we leverage the flexible nature of BASIL in that I teach a course in structural  biology, and we do all the computational work, the students there, and they then go to the  students enrolled in biochemistry and tell them about what they've learned, what their hypothesis  is, and then the biochemistry students kind of roll with it from there, and they have to talk  to each other, and that's engineered into the

syllabus. And they end their semester with a  joint poster presentation to the entire campus community during our celebration of student  achievement day. And it really forces them to learn from each other and talk to each other, and  that is a model that I've used to try to engage students in this idea of interdisciplinary  conversations across disciplines. I imagine that the prep for faculty is a  little bit different in a course like this

than maybe a traditional bio chem class.  Can you talk a little bit about that? Yeah. And so as far as the computational  analysis, that is going to be something that many instructors are not familiar with. And  so one of the things that we have done as the developers of the curriculum is try to make these  things accessible to the instructors as well as

to the students. So one of the reasons we're here  in Puerto Rico right now is that we regularly run workshops to help train instructors how to take  on this project and to help them to design their curriculum, to use our modules. And then we also  regularly run instructor support workshops, where we will go through how the computational modules  work and what you can learn from them, and the kind of data you get, how to analyze those data.  As far as the wet lab goes, many of the wet lab

experiments, students do follow more traditional  labs. It's just that the focus for each one is a little bit different. Rather than give students  a mixture of proteins and ask them to separate that mixture, just to teach them a separation  technique, the students have a mixture of proteins because they express a sample using E. coli,  and now they need to separate that mixture to isolate their protein of interest, the same as you  would do in a research lab. And so many of the wet

lab techniques are the same as we would see in a  traditional biochemistry lab. And so planning for

that is very similar to what you would do for the  traditional lab. It's just your starting material might change from semester to semester, and then  the end point for how you test your predictions can change from semester to semester, so that can  require the instructor to do a little extra work ahead of the semester, to pick the targets, so  that you know what you might need to test, and be able to order your supplies ahead of time, so that  you're not running into difficulties mid semester:

I need this thing because these students predicted  this function, but the wait time from the company is going to be six weeks, and then graduation will  have already happened. So there is some prep time that you have to do ahead. And then there's also  some training. We provide support for that.

For my course, I have my students do a lot of  the prep work. When they graduate, if they go into a work or industry environment or an academic  environment, there's going to be the expectation that they can run experiments without a prep  person making all their solutions and finding all the reagents. So mine get protocols that look like  they do when they come out of the literature. This is what you need to make. How do you take what  you took from literature and translate that into

steps that you take in the lab? So in fact, we  don't do a lot of prep in advance for my course. I need to know what they're doing so I can guide  them in the right direction, but they're doing the actual prep work, because that's experience that's  really valuable for them after they graduate. You've all addressed this to some extent,  but could you talk a little bit more about

the student reaction to this type of instruction?  Because it seems like this is providing a really authentic learning experience, which is  different from the type of cookbook type approach that was mentioned earlier. And I would  think that would make students much more excited, much more curious about the outcomes  and so forth, than just doing something

that everyone else has done in the past. Students do get excited and when the beginning of the semester starts and I’m explaining  what we'll be doing for the semester, you can see some of the students’ eyes just light  up at the thought of doing some real research. One of the powers of course-based undergraduate  research experience in general is that you can

engage more students in the research better than  in the one-on-one mentoring model. And the data in the literature shows that experiences with CUREs  do improve the student's identity as a scientist. They feel more project ownership. They begin to  appreciate the reasons behind why they're doing a

certain method. And so that is all really exciting  for the students. What was mentioned earlier is this idea of failing, and that happens a lot, and  that could be really scary for an instructor who's taking on a CURE for the first time, because you  do lose a little bit of the power and control,

because you don't really know what might happen  that day in the lab. And I've really embraced that idea of having the students do research, take the  risk, experience the failure that was mentioned before, and pushing through it, not taking  it personally, learning how to troubleshoot, learning how to celebrate the little things in  research that actually do go well and not to get

so frustrated by failure. So I like doing a CURE  in my courses, because it allows for a safe space, a slightly more controlled space, for  students to engage with failure and get the experience of overcoming that. Yeah, and I can add that there are students who get very excited that I don't know what the  answer is, so I cannot gauge their ability to do

this based on whether they got the correct answer.  However, there are also students that are very frustrated by the fact that we don't know what  the answer is, so I cannot tell you if you are correct. And so you see both sides of that, but  there's some students that are very happy to hear: “I don't know.” I can't grade them on whether  they are correct or not. I can grade them on

what they learned, and I really emphasize that as  well. I'm gonna see that you can tell me something that you learned and show me that you have some  understanding of what you're doing, but even I don't know if you've got the right answer. Can you talk a bit about how this project got started? I mean, there's four of you.  You're together, you're in Puerto Rico, and you're doing a lot of work together. How  did this all get started in the first place?

Well, I'm a computational biochemist, and if  I never go into another wet lab again or touch a test tube or make up a buffer or grow E coli  again, I'll be perfectly happy when that will be fulfilled. If I'll never run another gel, I'll be  very happy. And so I had students working with me, and they designed some stuff. And the software  they designed, you could feed it protein structure and would give you information back about what  that protein probably did. So we developed this

original software, and that was fun. But what  I found as they developed the software is they would predict the function. Well, they wanted to  go in the wet lab and find out what it was. So they started doing that. And then what we found…  this is in my research lab, and I was sharing this with a couple other professors… and what we found  was that they started acting like scientists. They started looking in the literature to find  a better assay to use, they started walking up

to me and saying, “You know, Dr. Craig, we think  that's not a good idea. We should do it this way instead.” They came up with alternative proposals.  So we talk about experimental design as scientists and part of that is making something that's  going to be statistically robust, but part of the experimental design is choosing the tools.  And they started choosing the tools. One of my students actually called up the Head of Research  at Argonne National Lab and talked to him for an

hour about our project, and never even asked my  permission. And that was fantastic. So they're collaborating with each other. They're going to  people in other departments and saying, “We tried to do this, it didn't work. Can you help?” As I  said, I’m a computational biochemist, if something wasn't working in the lab, I wasn't the guy to  ask. They asked the other faculty in chemistry and biology and biomedical sciences. And so we saw  that, we started to incorporate additional tools.

About the time this project really started working  well in our research lab, we had funding from the National Institute of Health, and they decided to  go a different direction. And so our funding dried up, but our program officer was very supportive  at NIH, and she recommended we contact NSF and go through their program. They have a program  called Improving Undergraduate STEM Education.

STEM stands for science, technology, engineering,  and math. So we approach them, and at the same time, our first round of money was unsuccessful,  but I presented a poster at a conference, and at that conference, I met Rebecca, and I also met  Mike Pikaart, who's another member of the team, a couple other folks who had joined the BASIL  project at that point, and we've had new people join us since then. And so Rebecca went back to  Ursinus all excited, and presented it to Julia,

who was at Ursinus at the time, and Julia signed  up. Rebecca was attending a conference hosted by another organization that they’re all affiliated  with, called BioMolViz, which is focused on molecular visualization of biological molecules.  And that's where she met Bonnie. And so Bonnie joined the team, and she was, as far as I could  tell, it was like the day she joined the team,

she'd been there all along. It was a very smooth  fit. One of our other team members was doing some stuff very much like what we do, and one of his  colleagues at the University of Richmond said, “You know, there's some people doing this called  BASIL. You should contact them.” And so now he’s part of our team. And so we have other people  that attend our presentations at conferences, and they join the team. And so there have been  ongoing themes. We want to have continuing use

computational tools and building for the future,  I think. We also want to have authentic science, they really do get into the wet lab and do  stuff. We want to share what we're doing at conferences. We want to write papers about it,  and we want to act like scientists. We want to model that behavior for our students. So I'll just add that Paul gave a very good

introduction to how we got started, and we've been  working together on this for 10 years now. So we started in 2015, so this is a very timely podcast,  in that we are in our 10th anniversary. Yay, BASIL. So, how many faculty are involved in the project overall? You've mentioned a few people  in addition to those of you on the podcast. So we have a core team, and that varies between  about 8 and 10 instructors. So there were the

original folks who were involved with the project.  People retire. They find other projects they're even more passionate about, new people come  into BASIL, but that core team sits at about 8 to 10 people, and there's a variety of roles.  As the number of users of the material has grown,

we've had to be more organized about how we keep  ourselves, as the community, organized. So we are all members of the steering committee,  so we're responsible for high-level things, thinking about funding, thinking about how  the different subcommittees work together, about how to let folks know we exist. We also have  an instructor recruitment onboarding committee, so they help show new users what our curriculum  looks like and support them as they start to

adopt that curriculum, or think about how they  can adopt it on their campus. We also have an instructor support committee that's focused less  on new folks and more on supporting the folks that are already using BASIL. So as we update  modules or find new tools, offering workshops about how to use those and supporting people when  they look at things like promotion and tenure:

how can faculty use this as part of their natural  professional development cycle? We also have an assessment committee that looks at both how do you  as an individual instructor assess the work your students are doing in class, but also on a larger  scale, how do we assess that this curriculum is achieving educational goals that we want it to  achieve. There's also just some housekeeping. We have a website and data management team. We do  collect data. We run a website. So there's just

some logistical support that has to be provided.  Another key part is keeping modules updated. So some of that happens organically as we use them in  our courses and we say, “Oh, in our instructions, we say, you will see a button to click on the  right hand side. It's no longer a button. Here's a different workflow.” Sometimes the online  tools that we use get a complete redo, and we

don't know when that's coming. We don't run those  tools. That happened with our SwissDock module, we had great instructions, and then they did an  update, and none of our instructions were relevant really anymore. So we had to go in and do a major  update on that one so that it would be usable for faculty again. There's also tools that get retired  and new tools that we discover. Probably the last thing that drives those changes in modules are  pedagogical demands. Certainly, the pandemic is

a good example of how you need to adapt suddenly.  And so the computational modules were really great for transitioning to a remote model. But we also  had a faculty member develop some Choose Your Own Adventure wet lab substitutes, where the students  come into a Google form, they have to choose what they want to use, and if they make the wrong  choice, it routes them back and says, “That's not

right. Try again.” And so they couldn't be in the  wet lab at that point, but they were able online to kind of step through that whole lab experience  and really get a sense of what it would have been

like had they been able to be in person. If I can jump in… And a great thing that happened during that time is, because we are a  community, we were sharing data so if one of us had gotten far enough with our students that  we had some data, we were sharing that with other BASIL users so that their students could,  even if they couldn't be in the lab anymore to actually collect their own data, they had  data to analyze. So that's how some of the

community can help each other out too. I think the original question was, how many people are involved? And so we have  our core team, but then we have a lot of other

people who have attended our workshops, or are  using our stuff. Whenever I go to a conference, I search the abstracts in the conference to  see if anybody mentions BASIL, and inevitably we find one or two folks who are doing stuff  that we've never met before, and we talk to them and we offer them our support, and we  have a Slack channel for BASIL participants,

and we have, what, 200 people there? Yeah. So we just checked the numbers yesterday, where over 200 people are connected to us on  Slack, and we estimate that we have at least 50 campuses using the curriculum in some form or  another. And as Paul said, part of that estimate comes from conferences, the people who reach  out to us, the people who are attending any of

our workshops. So most of our instructor support  workshops are virtual, and we have gotten much better at record keeping to keep track of who is  attending, where the people are that are using things. And like I said, we're in Puerto Rico  right now, running a couple workshops. We did a workshop here in San Juan yesterday, and we'll be  traveling to Mayagüez this afternoon and running a workshop tomorrow. We've done a number of other  in-person workshops, new adopters, the community,

and we've done even more virtual workshops to  recruit new adopters to the community. We also give presentations at conferences, so there  are lots of people. There is broad interest. And so I think Paul mentioned that we regularly  attend ASBMB meetings, the American Society for Biochemistry and Molecular Biology, but members of  our core team have also been invited to speak at American Chemical Society meetings, at biophysical  society meetings. Schrodinger is a software

developer, and they've invited us to speak during  their educators’ week. And this is driven by the community often, that people hear about us,  they talk about us, and more people come in. With a project that seems to be scaling up and  up and up, I'm sure sustainability and scale and thinking at scale is always at the front  of your mind; these things aren't free. So what's on your mind related to these issues? I do think about costs. So it costs about as

much to run BASIL on a campus as it costs to run a  traditional biochemistry lab. So the expenses for BASIL are not unusual. The equipment that we use  is not unusual. All of our software is free, and it all works through a browser, and so that's very  sustainable. Now, the people are really, really important, and we really like working together.  It's a very cohesive group, good friends. We work together, we socialize, we stay in each other's  houses, whatever, when we're in town, and that

kind of stuff. And so there's a very positive  reaction and relationships that exist here. I think that's an important part of sustainability.  Also talk about making it work on our campuses, and there's something called the four frames  model and thinking about the factors and effective process. And there's also, what are the barriers  to getting people involved and try to identify and overcome those barriers? Our current grant  funding is actually focused on those barriers.

So, as Paul said, our current grant funding is  focusing on identifying barriers, and especially

barriers that might exist at different institution  types. So one of the things we're doing in our current workshop, is really exploring that with  the attendees and the barriers that we identify, of course, are time and expertise, and those seem  to be common across all institution types, because this sounds like it could require some different  things than a traditional biochemistry lab and so for sustainability and trying to overcome that  barrier of time, that's where our core team has

really tried to do a lot of the work to make the  curriculum something that you can adopt without having to put in as much of the time to create all  the materials that you might have to do if you're just creating a new curriculum on your own. As for  cost, we've really tried to keep the cost down as well, so we use web-based computational tools, so  that there's no requirement to purchase software

or software licenses. It makes it more accessible  to students who have different devices. So you need a device that connects to the internet, but  you don't need to have a laptop with a certain

processor speed or capacity to install software.  You can work from a tablet or a Chromebook, and we've also tried to use the traditional wet  lab method, so that the cost of the wet lab is not any more than a traditional biochemistry lab  might cost, and we may even be able to have it cost less than a traditional lab, because half  of the work is using free computational tools, which means, if you used to purchase  materials for 14 weeks worth of experiments,

now you're purchasing materials for maybe  seven weeks worth of wet lab experiments. I'd like to talk just a little bit about this  idea of CURES as a pedagogy, and part of the excitement that I find being involved in BASIL  is introducing this pedagogy to faculty around the country, and whether they're choosing to  use BASIL or not, just opening their eyes to a different way of teaching biochemistry, or  whatever it is that they happen to be teaching,

and that is really an exciting place for me,  personally, to be. I've seen the power of it. I've

seen how scary it can be from an instructor point  of view. And I get scared every time I'm about to start my BASIL curriculum, which will start in a  week for me, but I know that I have the support, and I know that it's so important and so  effective for these students that spreading the word is really satisfying to me. I think another issue that comes up in terms of sustainability is that at one point, BASIL  was small enough that everybody doing it could

hop into a online meeting room together and have  sort of a town hall meeting format and just talk about things. Now with over 50 campuses and all  the different time zones that are represented, that's not a supportable model, and so we've  had to do things like create the Slack channel, where we can have asynchronous communication and  figure out ways to offer virtual workshops. And we also now have begun offering something called  BASIL week, where it's a full week of workshops

about all of the different kinds of topics that  users of the material might be interested in. So some walkthroughs of computational material, some  conversations about how to assess student work, conversations about how to leverage the work  that you do with BASIL in terms of required professional activities that your institution asks  you to do. So really thinking about how to build that community and how to sustain that community  as it grows is another part that we focused on.

Is this something you'd recommend to other STEM  disciplines, because we do know that we lose a lot of students in the STEM pipeline, and maybe  this way, we'd get more people intrigued by the process of being a scientist or becoming more  engaged with science as a potential career. Yes. So we ran a workshop about a year and  a half ago at Prairie View A&M University, outside Houston, Texas, and they had encouraged  people from across the sciences to attend our

workshop. So we had attendees from biology and  chemistry, as we expected, but also from physics, math, computer science, the School of Education,  and they even had a couple Deans come to our workshop to see what was going on, and that was  a very useful space for them, but also for us to see how others might be inspired by what  we've put together and looking for ways that they could use our curriculum as a model for  creating some additional kinds of experiments,

some more research-based things in the labs across  the disciplines. And the person who was there from education was also very interested to know that  this was happening, because there seems to be a disconnect in those who are training in education  departments and schools and those who are in STEM departments and divisions. We don't necessarily  talk to each other, so we don't know that we're all thinking about student assessment to some  extent and student learning and what the outcomes

are. And so I think that this is a good way to  engage students in science. And I use it in my courses for Chemistry and Biochemistry majors,  but also in my courses for non majors. I think additionally, one of the drivers for other  STEM disciplines using a CURE is that the research

shows that it engages students. Students are  retained, they're excited. It's increasing the number of students who have a research experience  under their belt, especially underrepresented students in that field, and that, in and of  itself, is going to increase the pipeline of

students moving through to the next level of  their careers. Anecdotally, I have students always coming back to tell me that when they were  on a job interview or a graduate program interview or a medical school interview, that they talked  about their experience with BASIL and that it made a difference, and people were really excited  to talk with them about their experiences.

Yes, and I think we did mention earlier, but  I'll just re-emphasize that the CURE model, the course-based undergraduate research experience  model, is a way to engage more students in authentic research experiences. So many of us  are familiar, especially in the STEM fields, with the one-on-one research model, where a  student approaches me to join my research lab.

But there's a limit to how many individual  students I can take into my research lab, due to the space in the lab, my capacity to mentor  each one of them and the resources to support their projects. But if we can do some level of  research in the courses that we teach, then that

really gives every student some amount of research  experience. And the studies show that whether it's a week or a couple weeks, even, you are going  to gain some more identity as a scientist and project ownership than in a traditional  lab setting or a traditional lab course and a semester-long project can be even better for  that science identity and project ownership. It also is a way of reducing the barrier  for those students who might not know or

be brave enough to approach a faculty member  to ask about individual research. If they're enrolled in your course, they're doing it, and  so it lowers that barrier, and may be attracting and retaining some students who otherwise  might drop out of the pipeline of STEM. So, we always wrap up by  asking: “what's next?” So part of what we'll keep doing as we go into the  future is to maintain the baseline that we have:

keep updating modules, keep looking at new  tools, replacing tools that get deprecated. We'll also focus on maintaining community. We're also  beginning to have collaborations with other active learning communities, so communities that are not  the BASIL CURE, but that provide active learning opportunities to embed in your campus curriculum  and trying to see how we can all work together to improve biochemistry and STEM education  collectively. So to put all our efforts together

and pull in one direction together. We're also  especially interested in BASIL in computational tools. So a big breakthrough in biochemistry  in the last couple of years is the ability to use computation to fold proteins and determine  their structures. So when we started with BASIL, there were about somewhere between a hundred and  150,000 protein structures. That had been solved with the computational tools available now, there  are over 700 million folded protein structures,

structures that anyone could use to do research.  So we're interested in adapting BASIL to, first of all, work with data sets that are so  large now, every year they've grown tenfold. So how do we keep up with data sets that are so  large, and there's also a lot of new tools coming out? So how do we keep our curriculum up to date  and relevant? But a really great thing about this is that before there were 150,000 proteins,  many of which already had assigned function,

now, with 700 million protein structures, most  of those don't have a verified function. So there's an opportunity for anybody who wants  to do BASIL to keep as many undergraduates as they have engaged in research for as long as  they wish. So it's a very exciting time for BASIL and for the biochemistry community. Yeah, we're hoping that the outcome of our research on barriers will lead us to be able to  aid in overcoming those barriers to CURE adoption

and implementation. Are there ways that we can  address that? So I think that's another future goal for us is really looking at not just  adoption of BASIL but adoption of CUREs in general. And as Bonnie said, we're working with  some active learning communities, and if we can identify what the barriers are, that's the first  step in being able to overcome those barriers.

We've been using these computational methods and  emphasizing them and it's really about that, which is probably the most of any CURE that’s out  there, and we're hoping to have an impact, at least to help other people who are  doing course-based undergraduate research

experience with their students, to identify and  implement those tools. And based on our experience with getting these tools into our teaching  labs, I think we could probably provide helpful insight to any group that wants to introduce  computational tools into their teaching lab, even if it's botany or nutrition, whatever  is out there. I think we could do that. Well, thank you so much for joining us. There's  lots of great information that you've shared. I

think no matter what discipline one might be  in, there's lots of rich information. Thank you so much. Thank you. You’re welcome. Thank you. Thank you. Yeah, thanks a lot. This was great. If you've enjoyed this podcast, please  subscribe and leave a review on iTunes or your favorite podcast service. To  continue the conversation, join us on our Tea for Teaching Facebook page. You can find show notes, transcripts and other materials on teaforteaching.com.  Music by Michael Gary Brewer.

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