Jose Luis Ricón Fernández de la Puente is widely known for his influential blog “Nintil” and in his current role as Head of Theory at Retro Biosciences, a leading company in the longevity biotech space funded with $180m by Sam Altman. Niklas and Jose Luis dive into: * Why the current scientific institutions often fail to deliver on its promises * The most promising pathways and bottlenecks in longevity biotech * Lessons from libertarianism and economics for building better scientific institution...
Jul 04, 2025•1 hr 13 min
Cush is the founder of Odisea Labs , an accelerator for Latin American frontier tech (crypto, AI). Cush is inspired by effective accelerationism (e/acc) and consequently coined the memes “latam/acc” and “Latin American Dynamism” in reference to their US-based counterpart. In this episode, we learn all about why Latam is awesome for tech. Financial innovation and crypto have a fertile ground here and are widely adopted due the lack of banking access for large populations, regulatory capture and g...
Apr 10, 2025•1 hr 1 min
Jack Scannell is a consultant, researcher, and entrepreneur. Jack is one of the world’s leading authorities on pharmaceutical R&D productivity. He co-authored the influential 2012 paper in Nature Reviews Drug Discovery that introduced “Eroom’s Law,” a concept highlighting how drug discovery has become slower and more expensive over time—essentially the opposite of Moore’s Law. Scannell has advised major pharmaceutical firms and is a noted commentator on strategies to improve innovation effic...
Mar 28, 2025•46 min
Jean-Philippe (JP) Vergne is an Associate Professor of Strategy at Western University’s Ivey Business School, renowned for his research on organizations operating at the fringes of legality—particularly pirates. Along with Rodolphe Durand, he co-authored The Pirate Organization: Lessons from the Fringes of Capitalism , which explores how historical piracy and other unconventional ventures can shed light on modern forms of competition, regulation, and innovation. JP Vergne’s work extends to topic...
Mar 19, 2025•1 hr 17 min
Ivan Morgunov is an experienced entrepreneur driven by the goal of stopping aging. He founded Longaevus Technologies, a venture studio in the field of longevity, and Unlimited Bio —one of the two companies that administer genetic therapies in Prospera Dr. Anna Vakhrusheva has over a decade of experience in advancing vaccines and gene therapies. She led the development of Russia’s first recombinant SARS-CoV-2 vaccine (Betuvax JSC), driving it from R&D to clinical trials within two years. As a...
Feb 19, 2025•1 hr 4 min
Nathan Cheng is a community builder, educator, and investor in the longevity biotech field. He has been closely involved with key initiatives such as the Longevity Biotech Fellowship (LBF), Healthspan Capital, and Longevity List, working to solve the problem of aging and death. In this conversation, Nathan Cheng discusses his journey into the longevity biotech field, exploring the quest for an indefinite lifespan and the various strategies to combat aging. He shares insights on community buildin...
Feb 13, 2025•1 hr 3 min
Samo Burja is a researcher, strategist, and founder of Bismarck Analysis and on the editorial board of Palladium Magazine. Samo is known for his work on how institutions shape civilization and his book “The Great Founder Theory.” Explore Infinita City: * Explore the Archive: The Infinita City Times * Visit Infinita City * Join the Builders’ Hub on Telegram * Follow Infinita City on X This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episode...
Jan 29, 2025•1 hr 14 min
Terence is a British biochemist who was Vice-Chancellor of the University of Buckingham, Adjunct Scholar at the Cato Institute, and the author of numerous books. Terence is well-known for his case against government funding of science, which made him an influence in the decentralized science movement. We’ll talk about his views on the economics of science and the myth of scientific objectivity. Importantly, we’ll talk about something that Terence has never talked about in public. A new project t...
Jan 22, 2025•1 hr 8 min
Our guest is Anders Sandberg. Anders is a Swedish researcher, futurist and transhumanist . He holds a PhD in computational neuroscience from Stockholm University , and is a former senior research fellow at the Future of Humanity Institute at the University of Oxford . This conversation is about the governance of innovation, and the innovation of governance. Explore Infinita City: * Website: www.infinita.city * X: @InfinitaCity * The Infinita City Times * Join Events This is a public episode. If ...
Jan 15, 2025•1 hr 14 min
Brian is the Co-founder and CEO of Coinbase; he began his journey studying computer science and economics. Back early in his career, after a trip to Argentina and seeing hyperinflation, he was inspired by Bitcoin’s potential to update the financial system and increase economic freedom in the world. He started Coinbase in 2012, and by 2021, it had become a public company worth $50B by 2024. Post-IPO, he started thinking about longevity; he started organizing biotech dinners to explore innovative ...
Sep 20, 2024•56 min
In this conversation, we're discussing with Joe Lonsdale the potential for building new cities and network states to improve governance in countries with broken institutions. Joe Lonsdale is a technology entrepreneur and investor. He is the managing partner at 8VC, a multi-billion dollar firm in the US. Previously he co-founded Palantir. Agencies and institutions are broken. The SEC on the fight with crypto, the FDA on the battle to bring needed drugs to market, and the FTC on not allowing compa...
Aug 16, 2024•30 min
Bradley Tusk is a cofounder of Tusk Venture Partners, which invests in early-stage technology companies operating in highly regulated industries. Bradley was also Uber's first political advisor and instrumental in developing their strategy to disrupt the incumbent taxi monopolies. This is one of the most fascinating stories in the recent history of regulatory hacking. In this episode, we're demystifying political misconceptions and looking into practical advice for entrepreneurs on navigating re...
May 07, 2024•53 min
What if you could choose the set of laws under which your company is regulated? Honduran reformers have developed a model to facilitate collaboration between foreign capital and local institutions in Honduras, leveraging external resources and expertise to develop an alternative to the levels of instability, crime, and corruption that prevailing institutions have been unable to address sufficiently. But how do you encourage foreign investment in a country with this high-risk level? That's where ...
Apr 20, 2024•49 min
In this conversation, we're discussing with Vitalik the connection between longevity and Ethereum, what he's looking to build, frontier technologies, and how pop-up or startup cities can supercharge the longevity movement. In the early days, when crypto started as a new frontier technology and experienced a Cambrian Explosion—rapid and transformative development and growth—How can the longevity movement experience something similar as it emerges? This discussion highlights potential similar obst...
Apr 06, 2024•54 min
“What’s more important than living forever?” At Vitalia, Naval Ravikant outed himself as a longevity maximalist. This is a compilation article with 7 key takeaways from the Fireside Chat with Niklas Anzinger at the AI & Technological Progress Conference, a summit in Roatán, Honduras. #1 | The Future Is *Actually* Brighter. “It just takes one person to make a breakthrough for humanity. One person who invents the steam engine, one person who discovers relativity, one person who discovers an an...
Mar 06, 2024•49 min
How compatible are two very different giants in the longevity movement? Aubrey de Grey, the iconic and highly academically decorated bioscientist, paved the way for the early stages of scientific development, and Bryan Johnson, the software mogul turned one-man experiment and chief meme officer of longevity, focuses on the intersection of lifestyle and research. Do their very different approaches go together? They do! Let’s explore how they overlap with each other and how they are giving shape t...
Feb 21, 2024•1 hr 1 min
In this fireside chat with Balaji Srinivasan and Niklas Anzinger at the Startup Societies & Crypto Cities Conference in Vitalia, they discussed the importance of longevity and its impact on technologies, as well as a strategy to breakthrough existing systems to develop your project. This brief article summarizes key points of the conversation, giving you an advisory perspective on how to approach your journey in innovation. Having More Time To Do More Things Longevity is the ultimate technol...
Feb 12, 2024•32 min
Tyler Cowen is a professor at George Mason University, creator of the Marginal Revolution blog, founder of the Emergent Ventures grant program, podcast host of "Conversations with Tyler," and author of numerous books, including "The Great Stagnation." Evaluating Economists and Their Contributions In Tyler’s latest book, "GOAT: Greatest Economist Of All Time," he explores the contributions of renowned economists like Milton Friedman, John Maynard Keynes, Friedrich Hayek, John Stuart Mill, Malthus...
Jan 05, 2024•58 min
* Iyinoluwa (“E”) Aboyeji had an outsized influence on the startup landscape in Africa with Andela and Flutterwave (both top-10 unicorns in Africa) * Surprisingly, to become a successful startup entrepreneur he had to become a policy entrepreneur and remove regulatory bottlenecks * With Itana, a charter city in a free zone in Lagos, Nigeria, E is doubling down on creating an enabling policy environment for African’s tech talent E’s entrepreneurial journey began with a spark of inspiration - watc...
Dec 15, 2023•37 min
In this episode, we debate with two major thinkers with different philosophies but also commonalities about governance and social evolution. Max Borders, author of “The Decentralist,” "The Social Singularity," and “After Collapse,” (a previous guest on the show) and Michel Bauwens, founder of the P2P Foundation and author of “The Political Economy of Peer Production”. The definition of “commons” is already a challenge, but we typically refer to inherited and collectively created goods, like air,...
Dec 09, 2023•51 min
Ever wondered where SEZs in Latam are already a backbone of the economy? It’s in Uruguay, a country with stable governance, clear legal frameworks and many other advantages for export-focused businesses. Uruguay did many things right to create a business-friendly environment. It’s touted as the safest spot in Latam, and enjoys a high degree of civil and economic freedom. Now meet David Luftglass, the founder of the “Zenith” (TBD) Special Economic Zone. One of many zones, each with its unique fla...
Nov 25, 2023•34 min
If you’re not excited *yet* about insurance regulation, this episode is for you! Matthew Queen and I uncover the often underestimated impact of insurance regulation on the global economy. In this podcast, we learn the importance of the legal structures of societies, and what SEZs like Próspera can do to improve them. Insurance is a peculiar product. It’s purely digital. It’s math about risks & probabilities. It is an important backbone of the global economy, not only for people to have a fal...
Nov 22, 2023•55 min
Magatte Wade is an entrepreneur, author and promoter for African entrepreneurship. Magatte shares her impactful personal journey of migration, education, and entrepreneurship and calls attention to the economic difficulties in African countries. She discusses her book " Heart of a Cheetah ", where she explores the misrepresentations of African poverty and how startup cities can help unleash entrepreneurship for Africa's development. She shares anecdotes from her entrepreneurial journey, highligh...
Nov 08, 2023•1 hr 43 min
Richard Hanania is the founder and president of the Center for the Study of Partisanship and Ideology , and author the books “ The Origins of Woke ” and “ Public Choice Theory and the Illusion of Grand Strategy ”.This is a far-ranging conversation with an emerging star public intellectual.In this episode we discuss: * Political theory: Nietzschean Liberalism, the worldview that greatness is a higher value than equality coupled with the insight that the liberal institutions of markets & democ...
Oct 25, 2023•58 min
Andrew Côté is a nuclear fusion engineer at Stellerator Systems and a scout at Andreessen Horowitz (a16z). He has a Substack called " Ulysses ". Right in time with the release of Marc Andreessen's " The Techno-Optimist Manifesto ", this episode has good news: nuclear fusion has a real shot. There are engineering challenges, but the science has paved the way for some promising methods to achieve energy superabundance from nuclear fusion. Is fusion even necessary? Isn't nuclear fission enough? Wha...
Oct 17, 2023•1 hr 9 min
This is a two-part episode - in the first part Janine Leger, one of the driving forces behind Zuzalu talks about community development and Zuzalu's future. In the second part, Niklas introduces Vitalia - a Zuzalu-inspired network society that aims to radically accelerate the development of life extension technologies. Engage with Zuzalu here: https://zuzalu.city/ Engage with Vitalia here: https://vitalia.city/ This is a public episode. If you would like to discuss this with other subscribers or ...
Oct 10, 2023•24 min
This is a two-part episode - in the first part Janine Leger, one of the driving forces behind Zuzalu talks about community development and Zuzalu's future. In the second part, Niklas introduces Vitalia - a Zuzalu-inspired network society that aims to radically accelerate the development of life extension technologies. Engage with Zuzalu here: https://zuzalu.city/ Engage with Vitalia here: https://vitalia.city/ This is a public episode. If you would like to discuss this with other subscribers or ...
Oct 10, 2023•47 min
Jim Pethokoukis is a policy analyst at the American Enterprise Institute, and writes the Faster, Please! newsletter on Substack. The subject of this conversation is Jim's new book " The Conservative Futurist - How to Create the Sci-Fi World We Were Promised. " Ray Kurtzweil said in 1999: “The twenty-first century will be different. The human species, along with the computational technology it created, will be able to solve age-old problems of need, if not desire, and will be in a position to cha...
Oct 04, 2023•57 min
Bob is the world’s greatest expert on special economic zones or "opportunity zones" as he likes to call them, having worked in setting them up in 174 countries. Max Borders said about Bob: “ I would argue no living human being is responsible for helping lift more people out of poverty than Bob Haywood:” Bob is notoriously low-key about his work. This podcast episode together with Max' written 2-part series ( part 1 , part 2 ) is a rare look behind the scenes of a trend little understood or notic...
Sep 26, 2023•1 hr 23 min
Sam Peltzman is professor emeritus at the University of Chicago . Sam is was a graduate student to Milton Friedman and a contemporary to George Stigler, the famous economist who coined the term "regulatory capture". Regulatory capture is an important concept. AI and crypto is under fire by regulators. The legendary venture capitalist Bill Gurley gave a talk at the All-In Summit 2023 that went viral. He quoted Stigler's adage that "as a rule regulation is acquired by the industry and is designed ...
Sep 20, 2023•1 hr 17 min
