Two of the most popular previous guests are back: Sebastian Brunemeier , the General Partner of Healthspan Capital and CEO of ImmuneAGE Pharma, and Robin Hanson , Professor of Economics at George Mason University and iconic thinker. Sebastian previously talked about longevity biotech and decentralized science . Robin spoke about prediction markets and governance innovation . In this episode, we talk about the surprising science of health outcomes. Equipped with vast amounts of money and talent (...
Sep 14, 2023•1 hr 14 min
Olivier is an entrepreneur, investor, and independent author. He wrote “ The Way of the Intelligent Rebel ” and blogs at Disruptive Horizons . The blog is about the disruption of the nation states by the internet and globalization and how to transform from a mono country to a netizen without borders. Olivier's journey started with Tim Ferriss' book "The 4-Hour Work Week", as a way to unbundle his life through entrepreneurship and digital nomadism. As a digital nomad, Olivier recommends the "Six ...
Sep 05, 2023•1 hr 9 min
David Friedman is an economist, physicist, legal scholar, and author. His father is the legendary economist Milton Friedman, and his son is the founder of the Seasteading Institute and Pronomos Capital, Patri Friedman ( appeared on episode 32 ). His most popular book is The Machinery of Freedom , and he’s written books on microeconomics and the economics of law, such as Law's Order , Hidden Order, and Legal Systems Very Different from Ours. In this interview, we talk about the legacy of the Frie...
Aug 29, 2023•1 hr 19 min
This is a double-feature episode about the past, present and future of living. In the first episode, Thibault Serlet gives a historical view of migration patterns and labor mobility. In the second episode, Jackson Stegers gives an overview of modern-day co-living business models and practical learnings - we use both to think about a future where people have more choices, a more mobile and unbundled territory. Jackson Steger is the host of the Campfire by Cabin podcast. Besides podcasting, Jackso...
Aug 25, 2023•50 min
This is a double-feature episode about the past, present and future of living. In the first episode, Thibault Serlet gives a historical view of migration patterns and labor mobility. In the second episode, Jackson Stegers gives an overview of modern-day co-living business models and practical learnings - we use both to think about a future where people have more choices, a more mobile and unbundled territory. Thibault Serlet is the Director of Research at the Adrianopole Group , a special econom...
Aug 22, 2023•35 min
Dwarkesh Patel is a podcaster. The Dwarkesh Podcast ( YouTube | Spotify | Apple ) interviews intellectuals, scientists, historians, economists, and founders about their big idea. The themes of Dwarkesh are similar to this podcast: frontier technologies, how to accelerate progress and the implications for humanity. Recently, Dwarkesh has had prominent guests talking AI such as Marc Andreessen, Eliezer Yudkowsky, Carl Shulman, Ilya Sutskever and Dario Amodei. In this episode, Niklas and Dwarkesh d...
Aug 15, 2023•1 hr 1 min
Adam is one of the most experienced technology policy analysts in the world - he was writing about the internet on day 1 in the 1990s. Now, Adam is an innovation policy analyst at the R Street Institute , and the author of several books, including Permissionless Innovation (2016) & Evasive Entrepreneurs (2020). Isn't it striking - almost all popular sci-fi movies about technology are dystopian? Not only does that warp the public perception of technology as something dangerous, but it also in...
Aug 08, 2023•1 hr 10 min
Dr. Simon Whitney is a family physician and ethicist. He taught at Baylor College of Medicine in Houston, Texas for twenty-two years. He is retired from medical practice but continues to publish and teach about medical ethics. He wrote the book From Oversight to Overkill: Inside the Broken System That Blocks Medical Breakthroughs—And How We Can Fix It (Rivertowns Books, 2023). What Simon is talking about is not the behemoth U.S. Food and Drug Administration (FDA), one of the largest public agenc...
Aug 01, 2023•1 hr 1 min
Malcolm Collins is a parent, polymath serial entrepreneur, education nerd, pronatalist and a 5x bestselling author, including the Pragmatists’ Guide series . He has a podcast and YouTube channel called Based Camp . In this episode, we talk about a wide range of topics including: Demographic Collapse: At current fertility rates in developed countries, there will be 5 grandchildren per 100 people. This demographic trend is not economically sustainable and will lead to fundamental transformations o...
Jul 25, 2023•1 hr 2 min
Primavera De Filippi is a researcher at several institutes, including the Berkman Klein Center for Internet & Society at Harvard University. Her research focuses on the legal challenges and opportunities of blockchain technology and artificial intelligence, with a specific focus on governance and trust. Primavera is the author of the book “ Blockchain and the Law ,” published in 2018 by Harvard University Press (co-authored with Aaron Wright). Primavera led a collective effort during Zuzalu ...
Jul 18, 2023•1 hr 9 min
Walter Patterson is the co-founder and chief science officer of Minicircle , a biotech startup that produces reversible gene therapies. Minicircle is known for some of their bold moves that include medical self-experimentation, and conducting clinical trials on Roatan, Honduras within a special economic zone led by Próspera that offers an innovative legal framework. In this episode, we learn about Minicircle, gene therapy and regulatory challenges from one of the two iconic founders behind it (t...
Jul 11, 2023•52 min
Bryan Caplan is a professor of economics at George Mason University and the author of several books, including Open Borders - The Science and Ethics of Immigration , The Case Against Education and the Myth of the Rational Voter . Bryan is one of the most iconoclastic contemporary thinkers, and had a major influence on the themes of this podcast. His books explain much of the emergent incentives created by the political process that stymie economic growth. In this episode, we talk about his new b...
Jul 04, 2023•1 hr 17 min
Neil Chilson is a lawyer and computer scientist, he’s the former Chief Technologist at the Federal Trade Commission (FTC) and a current senior research fellow for technology and innovation at the Center for Growth and Opportunity , and the author of “ Getting Out of Control: Emergent Leadership in a Complex World ”. Neil has decades of first-hand experience in regulatory policy and introduces the distinction between outcome-based, more common law-like legal approaches to regulation vs. the more ...
Jun 20, 2023•1 hr 15 min
Michael Huemer is "the best living philosopher, possibly the best who ever lived." (Bryan Caplan) The podcast host Niklas Anzinger considers Michael Huemer to be the greatest intellectual influence on his life and work with Infinita VC to date. In fact, the name Infinita is a reference to Michael's book " Approaching Infinity ". Michael is Professor for Philosophy and the University of Colorado Boulder. He is the author of more than eighty academic articles in epistemology, ethics, metaethics, m...
Jun 13, 2023•1 hr 28 min
Today’s episode is another one in the style of episodes 10 and 25 with Niklas' thoughts, synthesizing 1 year of work with the podcast and a VC fund. First, you’ll hear a recording of Niklas's talk at Zuzalu, Vitalik Buterin’s pop-up city in Montenegro. The speech can be watched on YouTube as well. The talk shows the progress made by startup cities and network states, and argues that this is a pivotal moment to unleash a wave of new technological progress; the zero-to-ones are already out there -...
Jun 06, 2023•38 min
Alexander Bard is a Swedish cyber philosopher, futurologist, and the author of several books ("The Netocrats", "The Global Empire", "The Body Machines", "Syntheism - Creating God in The Internet Age", "Digital Libido - Sex, Power and Violence in The Network Society" together with Jan Söderqvist). He’s also a former music producer, artist and entrepreneur. We start with Alex' history in the music industry, and how he saw the emerging internet and Napster as a Hegelian "negation" of the status quo...
May 30, 2023•1 hr 20 min
Brian J. Robertson is a serial entrepreneur and the creator of Holacracy , a comprehensive practice for governing and running our organizations. Holacracy is an often misunderstood, massively influential social and management system. Yet it is more than that, Brian's goal with Holacracy is to give people a taste of self-governance, personal growth and empowerment to impact society. In this episode, we dive deep into the mind that has nurtured Holacracy and brought it to adoption within 10.000+ o...
May 23, 2023•1 hr 3 min
Jonathan Hillis is the founder of Cabin. Cabin is building a network city - a collection of remarkable coliving properties tied by a shared culture, community, economy, and governance. We start by talking about how a combination of science-fiction and American Wilderness romanticism inspired Jon to start Cabin in the Texas Hill Country. Neighborhood Zero is a development on 28 acres, with a creek that runs through the property, rolling hills, grasslands and forests, and pet longhorn cattle runni...
May 17, 2023•1 hr 6 min
Erik Voorhees is the founder of Shapeshift, a decentralized crypto exchange, and one of the most important voices in crypto. Erik virtually joined for a fireside chat during Decentralizing Finance 2023 - A Prospera Builders’ Summit on the island of Roatan. We start by establishing the ethics and principles of Bitcoin, crypto, and the separation of state and money. Money is one if not the most important good for a peaceful, market-led world. It does not belong in the hands of governments. Erik ha...
May 09, 2023•56 min
Today is the 70th anniversary of the discovery of the structure of DNA, and the 20th anniversary of the sequencing of the human genome. A perfect day to talk to John Cumbers . John is a molecular biologist. He is the founder and CEO of SynBioBeta which promotes synthetic biology to build a more sustainable universe. This episode is a primer on "synbio", the scientific breakthroughs and commercial applications of reading, sequencing and editing DNA to engineer the built world around us by manipul...
Apr 26, 2023•1 hr 5 min
Ingemar Patrick Linden is a professor for philosophy and bioethics who taught for 10 years at NYU. In his book " The Case Against Death ", Patrick points out that evolutionary biology explains why we age and die, but not that we must age and die, or that we ought to. “My experiences tell me that unless there is a good afterlife, death is a horrific evil and nothing is more important than preventing good people from dying. I am a death abolitionist and a life prolongevist.” As we've learned in pa...
Apr 18, 2023•59 min
Allison Duettmann is the iconic President of The Foresight Institute , the world's premier futurist think tank enabling science & entrepreneurship at the frontiers of technology. The conversation starts with Foresight's mission and strategy to avoid hype cycles - focusing on what's next, not current.The focus areas have particular learning and development trees: Intelligent Cooperation (Economics, Crypto, Incentive Design) Molecular Machines (Programmable Nanotechnology) Neurotechnology (inc...
Apr 11, 2023•1 hr 10 min
This is the recording of a webinar about Ciudad Morazán , the charter city in Choloma, Honduras - not to be confused with Prospera , another Honduran charter city. Recorded on-site, this episode is a deep dive into one of the most interesting developments in city governance in modern history. Located in one of the most dangerous regions in the world when it comes to crime, Morazán provides a beacon of stability, safety, and affordable housing. It also runs its internal economy 100% on crypto, ha...
Apr 04, 2023•2 hr 55 min
Trey Goff is coming back on to continue the previous discussion ( Episode 9 ) about Balaji Srinivasan's book " The Network State" (TNS). This is the right time to dig deeper for two reasons: 1) TNS has increasingly become a meme in crypto and technology circles, 2) Balaji is commanding a lot of attention for #BitSignal , a bet on US dollar hyperinflation + Bitcoin rising to 1m. Trey & Niklas have become friends through Prospera, the modern charter city on Roatan, Honduras, and the zero-to-on...
Mar 28, 2023•1 hr 42 min
Have you wondered what Próspera is all about? Start with the founders. Gabriel Delgado Ayau is the co-founder and chief development officer (CDO) of the zero-to-one modern startup city in Honduras. This is an extensive episode where we talk about Gabriel's past in Guatemala as a serial entrepreneur that founded 17 startups, learning about the challenges for entrepreneurs in Central America, and how his grandfather's teachings showed him a better way - radically improving the institutions towards...
Mar 21, 2023•2 hr 10 min
Joey Krug is the co-CIO at Pantera Capital , the first U.S. institutional asset manager focused exclusively on blockchain technology, with 4.1bn assets under management. Joey is also the co-founder of the Forecast Foundation , contributing to the development of Augur (a decentralized oracle and prediction market protocol). Joey is a pioneer in the world of blockchain finance, and I want to take this opportunity to discuss two leading questions: how might the final takeover of defi (decentralized...
Mar 14, 2023•53 min
Alex Tabarrok is a professor of economics at George Mason University, and a research fellow with the Mercatus Center . Alex is one of the world’s best teachers of economics and reaching a large, worldwide audience as the cofounder of Marginal Revolution University and the popular Marginal Revolution blog together with Tyler Cowen . This episode is an intellectual journey that discovers insights that can be used by entrepreneurs and city developers. Alex has been teaching economics for decades, s...
Mar 07, 2023•1 hr 27 min
Alicia Nahmad is a born entrepreneur, starting in the construction industry before doing her PhD. Now with The Circular Factory , she is translating advanced technology into real-world progress in the built environment. The Circular Factory is a kaleidoscopic and ambitious startup that aims to fix the construction industry through on-site construction mini-factories with software-driven robotic arms, 3D printing and sourcing local material and labor. Alicia talks to Niklas about how the construc...
Feb 28, 2023•57 min
Does this sound straight out of a science-fiction novel? That's because it is. In " Termination Shock ", Neil Stephenson described a near-future earth where climate change has significantly altered human society and follows the attempts of a businessman using solar geoengineering to cool the planet. Luke Iseman , a hardware entrepreneur and solarpunk, read the book and dug into Stephenson's research on solar geoengineering. To his amazement, he found that it was possible and nobody is trying it ...
Feb 21, 2023•1 hr 2 min
David A. Johnston is the Chief Strategy Officer at DLTx , the first public tech company run by decentralists who believe the future will be built on open public blockchains, owned and operated by their users. David is a major crypto OG, he was the chairman of the board of Mastercoin and facilitated the world’s first ICO (initial coin offering), he was one of the first people to analyze the Ethereum white paper. This episode is to understand the thinking that leads David to his current beliefs, t...
Feb 15, 2023•1 hr 10 min
