Send us a text Dive into the fascinating world of cultivated meat with our guest, Petra Hanga, Lecturer in Biochemical Engineering – Cellular Agriculture at University College London and the Chief Scientific Officer of Quest Meat Ltd. In this episode, Petra sheds light on the intricacies of developing cultivated meat and reveals the key hurdles biotech scientists face. Highlights: Learn how scientists tackle the complexity of replicating animal meat, ensuring a truly authentic taste and texture ...
Apr 16, 2024•14 min•Ep 45•Transcript available on Metacast Send us a text Does uncovering the secrets of glycan engineering feel like navigating a maze of molecular complexity? In this captivating continuation of our exploration into the world of glycan engineering, we delve deeper into groundbreaking innovations and the crucial role of analytics in ensuring consistent quality. Henning von Horsten, Professor of Industrial Bioengineering at HTW Berlin (University of Applied Sciences in Berlin), shares the fascinating story behind a groundbreaking technol...
Apr 11, 2024•18 min•Ep 44•Transcript available on Metacast Send us a text Does unlocking the secrets of glycan engineering seem like navigating a labyrinth of molecular complexity? In this episode, we delve into the pivotal role of glycans as critical quality attributes (CQAs) in biotherapeutics. Henning von Horsten, Professor of Industrial Bioengineering at HTW Berlin (University of Applied Sciences in Berlin), sheds light on the art and science of glycan engineering and analysis. Key highlights: Discover various methods scientists are utilizing to imp...
Apr 09, 2024•23 min•Ep 43•Transcript available on Metacast Send us a text Hey, fellow scientists! Do you find yourself buried under an avalanche of tasks, unsure which one truly matters? If you're tired of the chaos and want to reclaim control of your time and energy, stick around. Today, we're unlocking the secrets of Essentialism, tailor-made for busy biotech scientists like you. We discuss the importance of focusing on the vital few tasks that contribute significantly to your goals, celebrating small wins, and protecting your time. We also ...
Apr 04, 2024•13 min•Ep 42•Transcript available on Metacast Send us a text Hey, fellow scientists! Do you find yourself buried under an avalanche of tasks, unsure which one truly matters? If you're tired of the chaos and want to reclaim control of your time and energy, stick around. Today, we're unlocking the secrets of Essentialism, tailor-made for busy biotech scientists like you. We discuss the importance of focusing on the vital few tasks that contribute significantly to your goals, celebrating small wins, and protecting your time. We also ...
Apr 02, 2024•15 min•Ep 41•Transcript available on Metacast Send us a text Explore the intricate world of perfusion and its sustainability challenges in the part 2 of this episode. Dive into the operational side of managing vast quantities of media production and storage, and discover smart strategies to address these challenges. Jochen Sieck, Director of Cell Culture Media and Process Development at Merck Life Science, discusses the distinction between facility designs for batch and perfusion bioreactors, shedding light on the need for extensive tank fa...
Mar 28, 2024•15 min•Ep 40•Transcript available on Metacast Send us a text Explore perfusion processes and sustainability with our guest, Jochen Sieck, Director of Cell Culture Media and Process Development at Merck Life Science. Learn about the evolution of perfusion methodologies, its historical roots in addressing product stability, and its recent return to continuous and integrated manufacturing. Jochen discusses the economic and strategic reasons behind perfusion's resurgence, emphasizing the need for flexible, smaller-scale facilities. Key Lea...
Mar 26, 2024•24 min•Ep 39•Transcript available on Metacast Send us a text In part 2 of this insightful episode, we embark on a journey into the intricate world of biotech purification processes. Our guest, Wei Zhang, DSP Group Head at A*STAR Bioprocessing Technology Institute, delves into three key modalities, shedding light on the challenges and advancements in virus, RNA, and traditional vaccine purification. You will learn: Learn how to master the purification of viruses Get an overview of the advancements in RNA purification techniques: the evolutio...
Mar 21, 2024•17 min•Ep 38•Transcript available on Metacast Send us a text In this episode, Wei Zhang, DSP Group Head at A*STAR Bioprocessing Technology Institute, delves into the complexities of purification. Wei’s team pioneers bioprocessing processes for diverse biotherapeutics. You will gain valuable insights into the intricate challenges and innovative solutions in bioprocessing purification. You will learn: Master scale-up challenges Understand how you can ensure product stability Get an overview of the advancements in purification techniques The c...
Mar 19, 2024•20 min•Ep 37•Transcript available on Metacast Send us a text Welcome back to the second part of our insightful interview with Joel Eichmann, Managing Director of Green Elephant Biotech. In this episode, we delve deeper into the technical aspects of adherent cell expansion systems, explore sustainable biotech practices, and discuss key considerations for cost-efficient and environmentally friendly bioprocessing. Key Insights: How to adopt a strategic approach to adherent cell culture development Delve into the intricacies of scaling up adher...
Mar 14, 2024•18 min•Ep 36•Transcript available on Metacast Send us a text Get ready for a deep dive into the world of bioprocess development as Joel Eichmann, Managing Director of Green Elephant Biotech, shares his expertise on smart strategies for adherent cell culture . Join us as we unravel the intricacies of adherent cell culture and discover the innovative strategies shaping the future of bioprocess development. You’ll get: Acquire a comprehensive understanding of the key challenges in developing an adherent cell culture process. Gain a fresh persp...
Mar 12, 2024•19 min•Ep 35•Transcript available on Metacast Send us a text Uncover the secrets of successful innovators, including Steve Jobs, Elon Musk, and Thomas Edison, in this enlightening episode of our podcast. We dive deep into the habits that set these trailblazers apart and fuel their innovative spirit. Key learnings include: The power of curiosity and how it leads to groundbreaking ideas and improvements. The importance of connecting the dots to gain new insights and see invisible relationships. The role of risk-taking in pushing boundaries an...
Mar 07, 2024•11 min•Ep 34•Transcript available on Metacast Send us a text Uncover the secrets of successful innovators, including Steve Jobs, Elon Musk, and Thomas Edison, in this enlightening episode of our podcast. We dive deep into the habits that set these trailblazers apart and fuel their innovative spirit. Key learnings include: The power of curiosity and how it leads to groundbreaking ideas and improvements. The importance of connecting the dots to gain new insights and see invisible relationships. The role of risk-taking in pushing boundaries an...
Mar 05, 2024•11 min•Ep 33•Transcript available on Metacast Send us a text Discover the hurdles and breakthroughs in glycoengineering, including the high costs of activated sugars. Thomas Rexer, CTO of eversyn, a spin-off of the Max Planck Institute Magdeburg, unveils eversyn's multi-step biocatalysis process, designed to significantly drive down costs and make in vitro glycoengineering more accessible on a large scale. Key Insights: Uncover the power of multistep biocatalysis in driving down costs and making in vitro glycoengineering more accessibl...
Feb 29, 2024•17 min•Ep 32•Transcript available on Metacast Send us a text Get ready for a crash course in glycoengineering as Thomas Rexer, CTO of eversyn, a spin-off of the Max Planck Institute Magdeburg, breaks down the significance of modifying glycans in biopharmaceuticals. Explore the science behind glycoengineering and its potential to enhance the properties of therapeutic proteins. Key Insights: Unlock new frontiers in glycoengineering Explore the potential of glycoengineering to revolutionize biopharmaceuticals Ensure seamless integration of gly...
Feb 27, 2024•18 min•Ep 31•Transcript available on Metacast Send us a text In our insightful second part of the conversation, we broaden our perspective to delve into the various modalities within the biotech industry, highlighting the unique and shared aspects of process development and scale-up. Neil Templeton, the Director of Upstream Process Development at Solid Biosciences, passionately articulates his commitment towards making gene therapy more accessible. He does this by outlining strategic solutions to reduce the costs of development and manufact...
Feb 22, 2024•15 min•Ep 30•Transcript available on Metacast Send us a text In this enlightening episode, we're joined by Neil Templeton, Director in Upstream Process Development at Solid Biosciences, who pulls back the curtain on the intricate world of bioprocess development and manufacturing. Neil delves into the shifting paradigms of the industry, sharing his expert insights on overcoming the unique challenges that surface when transitioning from R&D to GMP production. This episode is packed full of invaluable knowledge that's crucial for...
Feb 20, 2024•23 min•Ep 29•Transcript available on Metacast Send us a text Tackling bioprocess development and scale-up can be complex. While the science might be challenging, project management within biotech doesn't have to be. In this engaging episode, we'll guide you on how to streamline your CMC development, demystifying the complexities of project planning and execution. Here's what you'll gain: Discover the secret to 'Successful Planning,' - a strategy to ensure your projects are well-organised, resource-smart, and ti...
Feb 15, 2024•13 min•Ep 28•Transcript available on Metacast Send us a text Bioprocess development and scale-up are complex. Science may give you headaches, but biotech project management should not. In this riveting episode, you'll learn how to simplify your CMC development, guiding you through the maze of project planning and execution. Key Takeaways: Uncover how to "Plan for Success," ensuring your projects are well-structured, resource-efficient, and delivered on time. Learn the importance of "Evaluating the Scalability Potential,&...
Feb 13, 2024•16 min•Ep 27•Transcript available on Metacast Send us a text In this riveting episode of the Smart Biotech Scientist podcast, we navigate the intricate labyrinth of biotech scale-ups. We distill the process down to 9 essential steps for a smooth transition from laboratory to large-scale production. Key Insights: Acquire Comprehensive Process Understanding: Bolster your decision-making and problem-solving skills with an in-depth understanding of your process, molecule, and expertise at your disposal. Span the Technology Gaps: Tackle obstacle...
Feb 08, 2024•13 min•Ep 26•Transcript available on Metacast Send us a text In this enlightening episode of the Smart Biotech Scientist podcast, we delve into the complex world of biotech scale-ups. We break down the 9 crucial steps to ensure a seamless transition from lab to large-scale production. Top 3 Takeaways: Gain Comprehensive Process Understanding: Enhance your decision-making and problem-solving abilities by thoroughly understanding your process, molecule, and available expertise. Bridge the Technology Gaps: Overcome challenges and increase effi...
Feb 06, 2024•19 min•Ep 25•Transcript available on Metacast Send us a text If you've ever wondered how to seamlessly transition from R&D to process development, this is your golden ticket. Uncover practical strategies and expert advice that can be your compass through the intricate landscape of mastering CMC development. Uncover the challenges and tactics to seamlessly navigate this critical phase. Conduct Early Developability Assessments: By assessing productivity, aggregation propensity, and manufacturability early on, you can strategically av...
Feb 01, 2024•23 min•Ep 24•Transcript available on Metacast Send us a text Embark on a journey into the intricate world of CMC development with our latest episode, unraveling the challenges that often baffle biotech scientists. The complexity of CMC development is a formidable hurdle, and in this insightful discussion, we delve into strategies to master this critical process. Key Takeaways: Start Early: Learn how starting CMC development early, even without a complete understanding of your drug, can reduce risks and prepare you better for clinical milest...
Jan 30, 2024•18 min•Ep 23•Transcript available on Metacast Send us a text Are you looking for advanced strategies to enhance the quality and efficiency of cell therapy manufacturing processes? In this episode with Shin Kawamata, CEO of Cyto-Facto Inc., we dive into the transformative power of digitization in cell therapy manufacturing and explore strategies to enhance efficiency and reduce costs. Actionable Takeaways: Initiate Digital Transformation: Take the first step toward transforming your manufacturing processes by incorporating robust data busine...
Jan 25, 2024•19 min•Ep 22•Transcript available on Metacast Send us a text Are the escalating costs and intricate technical hurdles of cell therapy development causing you stress? Tune into this insightful podcast episode featuring Shin Kawamata, CEO of Cyto-Facto Inc. in Kobe, Japan, who shares his expertise and innovative solutions to these pressing issues in the cell therapy industry. Discover how to streamline your manufacturing processes, reduce costs, and enhance product quality, transforming the way you approach cell therapy development. Key Takea...
Jan 23, 2024•22 min•Ep 21•Transcript available on Metacast Send us a text Welcome to Part 2 of our conversation with Bernardo Estupiñán Gaisbauer, Principal at Drug Biologics Consulting. In this insightful episode, we dive into the complex world of taking a molecule from the lab to clinical trials. Our guest shares invaluable insights into outsourcing strategies for biotech companies. Key Learnings: Strategic Outsourcing: Discover when and why outsourcing is crucial for biotech companies, particularly in areas like analytical work and process developmen...
Jan 18, 2024•17 min•Ep 20•Transcript available on Metacast Send us a text Are you ready to unlock the secrets of taking your molecule from the lab to clinical trials? Join us in an exclusive interview with Bernardo Estupiñán Gaisbauer, a seasoned expert and principal at Drug Biologics Consulting, as he reveals the crucial steps and strategies necessary for a successful journey in CMC development. Biotech scientists often underestimate the challenges of transitioning a molecule from the lab into large-scale production. Bernardo emphasizes the critical im...
Jan 16, 2024•20 min•Ep 19•Transcript available on Metacast Send us a text In part 2 of this interview with Ioscani, Assistant Professor at the School of Chemical & Bioprocess Engineering, University College Dublin, we delve into the art and science of accelerating process development through the strategic extraction of valuable insights from data. Our guest, a seasoned expert in computational modeling, unfolds the intricate dance between quality by design principles and data-driven approaches. Key takeaways from this insightful conversation include:...
Jan 11, 2024•14 min•Ep 18•Transcript available on Metacast Send us a text Join us as we unravel the complexities of computational methods in bioprocessing, featuring cutting-edge research on glycosylation and process development. Ioscani Jiménez del Val, Assistant Professor at the School of Chemical & Bioprocess Engineering, University College Dublin, explores the intricacies of creating computational models, closing the loop, and optimizing with numerical methods. Discover the two broad flavors of modeling – kinetic and metabolic models – and how t...
Jan 09, 2024•19 min•Ep 17•Transcript available on Metacast Send us a text In part 2, we explore the details of cost reduction in cultivated meat manufacturing, with a focus on two important factors: media and simplified bioreactors. Beat Thalmann, a passionate innovator and serial entrepreneur specializing in the development of animal-free cell culture systems, highlights the strategic importance of selecting the right cells and advocates for a streamlined process that incorporates plant-based structures. This approach offers a cost-effective entry poin...
Dec 21, 2023•20 min•Ep 16•Transcript available on Metacast 
