Smart Biotech Scientist | Master Bioprocess CMC Development, Biologics Manufacturing & Scale-up, Cell Culture Innovation

David Brühlmann - CMC Development Leader, Biotech C-level Advisor, Business Strategist•smartbiotechscientist.com

The Go-to Podcast for Biotech Scientists Who Want to Master Biopharma CMC Development and Biomanufacturing.

**TOP 10 LIFE SCIENCES PODCAST**

Are you ready to simplify bioprocess development and scale with confidence to reduce time to market?

Are you feeling overwhelmed by the complexity and guesswork of biologics development and biomanufacturing?

Do you wish you had more time to enjoy the beauty of science, without worrying about failing your cell culture process development and commercialization?

There's a way to simplify and streamline so you can remove complexity, skip trials and errors, deliver your groundbreaking therapy to clinics and market without delay, and still enjoy every single step.

I'm David Brühlmann, a biotech entrepreneur and strategic advisor who partners with C-level biopharma leaders to tackle one of our industry's biggest challenges: reducing manufacturing costs to make lifesaving therapies accessible to more patients worldwide.

Through engaging conversations with industry pioneers and practical insights from the trenches, this podcast tackles the critical challenges in bioprocess CMC development and manufacturing of recombinant proteins and cell and gene therapy products. We cut through the complexity so you can:

Master bioprocess development with confidence and clarity

Excel at scale-up and manufacturing of biologics

Transform your innovative therapy and manufacturing technology into market-ready solutions faster

Optimize manufacturing costs without compromising quality

Make data-driven decisions that reduce the risk of failure

I can’t wait to help you do biotech the smart way.

Grab a cup of coffee and your favorite notebook and pen. Now is the time to take your bioprocessing game to the next level.

Ready to transform your biomanufacturing journey? Let's dive in!

Next Steps:

Book a free assessment to reduce biomanufacturing costs and make lifesaving therapies more accessible: https://bruehlmann-consulting.com/assessment

Fast-track bioprocess development with expert guidance: https://bruehlmann-consulting.com

Visit the Website: https://smartbiotechscientist.com

Email us: [email protected]

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Episodes

15: Bacon Without Pigs? Innovations in Cultivated Meat Manufacturing with Beat Thalmann - Part 1

Send us a text Is bacon without pigs the future? In this episode, join us as Beat Thalmann, a passionate innovator and serial entrepreneur specializing in the development of animal-free cell culture systems, unveils the exciting possibilities. Discover how he overcomes the challenges of production and envisions a future where cultivated steak competes on price. Beat Thalmann provides an insider's perspective on the complexities of cell lines and production processes, exploring the intersect...

Dec 19, 2023•18 min•Ep. 15

14: Digital Transformation in Biomanufacturing: A Rapidly Moving Tech Frontier w/ Abhijeet Satwekar - Part 2

Send us a text Are you struggling to unlock the full potential of Process Analytical Technology (PAT) in biomanufacturing? Look no further! Join us for a game-changing conversation with Abhijeet Satwekar, an Innovation Manager at Merck Guidonia-Rome, Italy. Discover how PAT can revolutionize your decision-making, accelerate development timelines, and propel your biotech company to new heights. Key Learnings: Decoding PAT's Impact: Abhijeet provides unprecedented insights into how PAT techno...

Dec 14, 2023•17 min•Ep. 14

13: Digital Transformation in Biomanufacturing: A Rapidly Moving Tech Frontier w/ Abhijeet Satwekar - Part 1

Send us a text Wondering how you can leverage the immense potential of the rapidly evolving world of digital transformation in biomanufacturing? Join us as we explore the frontiers of technology and innovation with Abhijeet Satwekar, Innovation Manager at Merck Healthcare. Discover how cutting-edge digital technologies are revolutionizing bioprocesses, optimizing efficiency, and ensuring consistent product quality. Key Learnings: Process Optimization: Discover the transformative impact of digita...

Dec 12, 2023•17 min•Ep. 13

12: From Lab to Patient: Steve Oh’s Guide to Mastering Cell Therapy Process Development - Part 2

Send us a text Welcome back to the second part of our exclusive interview with Steve Oh, former Institute Professor at the Bioprocessing Technology Institute (BTI) at the Agency for Science and Technology (A*STAR) and now Scientific Advisor to several international companies. In this episode, Steve dives deep into the challenges of manufacturing different cell types, sharing insights gained from his groundbreaking research. From preventing spontaneous differentiation to optimizing multi-stage pr...

Dec 07, 2023•17 min•Ep. 12

11: From Lab to Patient: Steve Oh’s Guide to Mastering Cell Therapy Process Development - Part 1

Send us a text Dive into the world of cell therapy process development with Steve Oh, former Institute Professor at the Bioprocessing Technology Institute (BTI) at the Agency for Science and Technology (A*STAR) and now Scientific Advisor to several international companies, as he shares thought-provoking perspectives and predictions on technologies that will impact the biotech industry. In this riveting conversation, Steve Oh unveils secrets to consistent bioproducts and forecasts the future of c...

Dec 05, 2023•25 min•Ep. 11

10: Revolutionizing Cell-Line Development: Unleashing the Power of Nanopens and Microenvironments w/ Tanner Nevill - Part 2

Send us a text Unlock the secrets of cell-line development with Tanner Nevill, the SVP of Applications at Bruker Cellular Analysis and one of the primary inventors and developers of the Beacon Optofluidic Platform. In this interview, Tanner delves into the transformative power of nanopens and microenvironments in cell-line development. Key Takeaways: Nanopens Redefining Norms: Tanner introduces the game-changing nanopens, disrupting traditional cell line development. Learn how these innovative t...

Nov 30, 2023•16 min•Ep. 10

09: Revolutionizing Cell-Line Development: Unleashing the Power of Nanopens and Microenvironments w/ Tanner Nevill - Part 1

Send us a text In this episode, Tanner Nevill, the SVP of Applications at Bruker Cellular Analysis and one of the primary inventors and developers of the Beacon Optofluidic Platform, shares insights into revolutionizing cell-line development through nanopens and microenvironments. Key Takeaways: Challenging the Status Quo: Tanner challenges conventional thinking, highlighting the limitations of planar cell cultures and the shortcomings of traditional approaches in the field. His perspective spar...

Nov 28, 2023•14 min•Ep. 9

08: Unveiling the Power of Microcarriers: Scaling Up Adherent Cell Cultures in Bioprocessing w/ Payar Radfar - Part 2

Send us a text In the second part of our insightful interview with Payar Radfar, CEO of Smart MCs, we delve into the practical steps of developing adherence cell cultures for bioprocessing scalability. Payar emphasizes the critical need for patience and a methodical approach, recounting how many clients rush into large-scale cultures prematurely. The key takeaways include: 1. Start Small, Stay Patient: Begin with small cultures and test various microcarriers. Patience is crucial; rushing can lea...

Nov 23, 2023•13 min•Ep. 8

07: Unveiling the Power of Microcarriers: Scaling Up Adherent Cell Cultures in Bioprocessing w/ Payar Radfar - Part 1

Send us a text In this episode, we explore the world of adherent cell cultures with Payar Radfar, CEO of Smart MCs. Smart MCs specializes in customized biomaterials and microfluidic solutions. Payar shares his unique journey in the biotech industry, driven by his passion for improving people's health. Key Takeaways: 1. Revolutionizing Bioprocessing: Payar discusses the challenges scientists face when transitioning from lab-scale to industrial-scale production. He emphasizes the importance o...

Nov 21, 2023•16 min•Ep. 7

06: Hybrid Modeling: The Key to Smarter Bioprocessing w/ Michael Sokolov - Part 2

Send us a text In the second part of our conversation with Michael Sokolov, the co-founder and COO of DataHow, we dive into practical insights on leveraging hybrid modeling in bioprocessing. You will discover: 1. Starting Small, Dreaming Big: Even in smaller companies, you can start with a minimal number of reactors and still leverage hybrid modeling effectively. Whether it's just a few shakers or a handful of bioreactors, you can begin the journey to process improvement. 2. The Power of Di...

Nov 16, 2023•19 min•Ep. 6

05: Hybrid Modeling: The Key to Smarter Bioprocessing w/ Michael Sokolov - Part 1

Send us a text In this insightful conversation, we explore how to accelerate bioprocess development and enhance manufacturing using hybrid modeling. Our guest, Michael Sokolov, COO of DataHow (a spin-off company from ETH Zurich), shares valuable insights. Discover the three major takeaways that could transform the bioprocessing industry: 1. Unlocking the Power of Hybrid Modeling : Michael Sokolov introduces the revolutionary concept of hybrid modeling, which combines mechanistic knowledge with m...

Nov 14, 2023•17 min•Ep. 5

04: How to Master Biotech Scale-up Without Guesswork w/ Leonardo Sibilio - Part 2

Send us a text In today's episode, we continue our fascinating conversation with Leonardo Sibilio, CEO of Biotech Academy and CSO at BetaPro Consulting. We delve into the pivotal role of structured training in the dynamic biotech industry. In this episode, you'll discover: - Foundation of Success : Leonardo emphasizes the importance of a strong foundation in GMP and an understanding of biotech facility operations. Whether you're an aspiring employee or a seasoned professional, a s...

Nov 09, 2023•13 min•Ep. 4

03: How to Master Biotech Scale-up Without Guesswork w/ Leonardo Sibilio - Part 1

Send us a text In this captivating episode, we delve into the world of biotech scale-up with the seasoned expert, Leonardo Sibilio, CSO at BetaPro Consulting and CEO of the Biotech Academy in Rome. Discover how mastering the art of biotech scale-up can transform your journey from doubt to dominance. Key Takeaways: 1. Early Planning is Paramount: Leonardo emphasizes the importance of initiating the scale-up process as early as possible. Waiting until later phases can lead to challenges and hinder...

Nov 07, 2023•17 min•Ep. 3

02: Unlock the Power of Rational Media Design in Bioprocessing w/ Tom Fletcher - Part 2

Send us a text Welcome to a fascinating Smart Biotech Scientist episode! In this conversation, we dive deep into the nuts and bolts of rational media development with our guest, Tom Fletcher, R&D Director, Process development, Fujifilm Irvine Scientific. Together, we explore the immense potential of Rational Media Design and how it's transforming the industry. Here are three major takeaways from this episode: 1. Define Your Goals: Tom emphasizes the importance of clearly defining your b...

Nov 07, 2023•16 min•Ep. 2

01: Unlock the Power of Rational Media Design in Bioprocessing w/ Tom Fletcher - Part 1

Send us a text In this episode with Tom Fletcher, R&D Director, Process development, Fujifilm Irvine Scientific, we delve into the world of bioprocessing. Tom shares insights into the transformative power of rational media design. From the complexities of bioprocess development to the game-changing potential of AI, this interview is a treasure trove of knowledge for both scientists and engineers. You will learn: - Learn about the evolution of priorities during bioprocess development, from sp...

Nov 07, 2023•18 min•Ep. 1

Biotech Simplified: Your Path to Bioprocess Mastery Unveiled (Trailer)

Send us a text Are you a busy biotech scientist, trying to navigate the complex world of bioprocessing while fueling your passion for science? Join us on the Smart Biotech Scientist Podcast, where we're about to unravel the secrets to bioprocess mastery. Hosted by a seasoned biotech leader and entrepreneur with over 15 years in the industry, this podcast is your compass through the maze of challenges. Picture yourself in the lab, deadlines looming, feeling like you're solving a puzzle ...

Oct 31, 2023•3 min

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