Send us a text In this eye-opening episode, we explore the intricate landscape of Advanced Therapy Medicinal Products (ATMPs) with Oliver Kraemer, a technical development leader at Flagship Pioneering. Drawing from his extensive experience at industry giants like BMS, Sanofi, and Boehringer Ingelheim, Oliver challenges conventional wisdom about automation in cell and gene therapy while illuminating the crucial differences between biologics and ATMPs. Key Takeaways for Biotech Scientists: Discove...
Nov 12, 2024•22 min•Ep. 105
Send us a text Want to peek behind the curtain of a leading Contract Development and Manufacturing Organization (CDMO)? In this inspiring episode, KBI Biopharma's Chief Scientific Officer Sigma Mostafa reveals the intricate world of bioprocess development and manufacturing. Sigma shares game-changing insights into accelerating biologics development without compromising quality. She also unveils how KBI is leveraging AI and machine learning to revolutionize everything from protein sequence a...
Nov 07, 2024•17 min•Ep. 104
Send us a text In this insightful episode, we're joined by Sigma Mostafa, Chief Scientific Officer at KBI Biopharma, who shares crucial insights on selecting the right CDMO partner for biotech development. Sigma brings a unique blend of scientific rigor and practical experience to the discussion, having worked on both sides of the CDMO relationship. Key Takeaways: Why harvest steps deserve more attention in bioprocess development The truth about one-stop-shop CDMOs versus specialized partne...
Nov 05, 2024•24 min•Ep. 103
Send us a text Struggling to unravel the complexities of your bioprocess? Prepare for a paradigm shift as we dive into the world of Process Analytical Technology (PAT) with Katharina Dahlmann who is Application and PAT Expert at Hamilton. This eye-opening episode dissects how PAT is redefining biologics manufacturing, balancing its immense potential against real-world implementation hurdles. Katharina navigates us through the intricate journey of scaling up, from micro-bioreactors to large-scale...
Oct 31, 2024•15 min•Ep. 102
Send us a text Unlock the hidden potential of your bioprocess! In this eye-opening episode, David Brühlmann sits down with Katharina Dahlmann, Application and PAT Expert at Hamilton, to explore the game-changing world of Process Analytical Technology (PAT). Discover how PAT is revolutionizing biotech by providing unprecedented insights into cell behavior and process dynamics. Katharina challenges conventional wisdom, revealing that what we think we know about our processes may just be the tip of...
Oct 29, 2024•23 min•Ep. 101
Send us a text Imagine predicting your bioprocess outcomes as easily as checking the weather forecast. Sound impossible? Not anymore. In this insightful episode, we dive deep into the world of digital twins and process models with Fabian Feidl, co-founder and CTO of DataHow. Discover how these cutting-edge tools are reshaping the biotech landscape, from simplifying complex processes to enabling personalized medicine. Fabian shares invaluable insights on implementing data-driven approaches, even ...
Oct 24, 2024•18 min•Ep. 100
Send us a text Are you ready to decode the future of bioprocessing? In this eye-opening episode, we dive deep into the world of digital bioprocess development with Fabian Feidl, co-founder and CTO of DataHow. Discover how cutting-edge process models are transforming the biotech industry, bridging the gap between raw data and actionable insights. Key takeaways: Learn how process models can streamline development, reduce costs, and accelerate time-to-market for groundbreaking therapies. Explore th...
Oct 22, 2024•22 min•Ep. 99
Send us a text Are you ready to dive into the cutting-edge world of biomanufacturing? In this episode, strategic consultant James Ryall unveils the staggering potential of bio-based products to revolutionize industries. From cultured meat to human breast milk, discover how cells are becoming the ultimate manufacturing facilities. James shares invaluable insights on scaling challenges, regulatory hurdles, and the critical importance of early preparation for biotech startups. Learn why biomanufact...
Oct 17, 2024•18 min•Ep. 98
Send us a text In this captivating episode, host David Brühlmann welcomes James Ryall, a strategic consultant with over two decades of experience in cell biology and regenerative medicine. From his groundbreaking work in skeletal muscle research to revolutionizing cultured meat production, James shares his fascinating journey through academia and industry. Discover how he's now helping biotech startups align their technical strategies with commercial outcomes, accelerating their path to mar...
Oct 15, 2024•24 min•Ep. 97
Send us a text Are you ready to revolutionize your bioprocess development? Join David Brühlmann as he interviews Belma Alispahic, Chief Scientific Officer and Co-Founder of AnalysisMode, who unveils the game-changing potential of AI in biopharma. Discover how AI is transforming the industry, from drug discovery to manufacturing, and learn why it's no longer optional but essential for success. Key takeaways: Leverage AI to streamline experiments, reduce costs, and accelerate your path to mar...
Oct 10, 2024•20 min•Ep. 96
Send us a text Is AI the secret weapon biotech scientists have been waiting for? In this eye-opening episode, we dive deep into the world of AI-driven bioprocess development with Belma Alispahic, Chief Scientific Officer and Co-Founder of AnalysisMode. Discover how AI is transforming the biotech landscape, from reducing downtime by 50% to unlocking unprecedented levels of precision in process optimization. Key takeaways: Learn how AI can slash experiment time by up to 80%, saving you valuable re...
Oct 08, 2024•21 min•Ep. 95
Send us a text In this electrifying episode, we dive deep into the future of biotech with biotech influencer Benjamin McLeod. From quantum AI mapping cellular interactions to the game-changing potential of process analytical technology, Ben, who is also a Cell & Gene Therapy Segment Lead at NanoMosaic, unveils how artificial intelligence is set to transform the cell and gene therapy landscape. Discover why LinkedIn is becoming the new frontier for biotech networking and career advancement. L...
Oct 03, 2024•20 min•Ep. 94
Send us a text Discover how a failed optometry dream led Benjamin McLeod to become a leading voice in cell and gene therapy. In this eye-opening episode, Ben, who is a Cell & Gene Therapy Segment Lead at NanoMosaic, shares his unconventional path from lab work to LinkedIn stardom, revealing how he bridges the gap between R&D and marketing in biotech. Learn how Ben's weekly science memes evolved into valuable content that attracts both lab techs and CEOs alike. Key takeaways: Gain in...
Oct 01, 2024•24 min•Ep. 93
Send us a text Ever wondered why your perfectly optimized lab process falls apart at industrial scale? Mass transfer experts Lars Puiman and Rik Volger from the University of Delft reveal the hidden world of oxygen transfer and aeration that can make or break your production. Dive into the crucial differences between lab-scale and industrial-scale bioreactors, and discover why your DO sensor might be fooling you. Learn how CFD simulations and innovative downscaling techniques can revolutionize y...
Sep 26, 2024•16 min•Ep. 92
Send us a text Unlock the mysteries of oxygen transfer in bioreactors with mass transfer experts Lars Puiman and Rik Volger from the University of Delft. In this eye-opening episode, dive deep into the crucial world of kLa (oxygen mass transfer coefficient) and its impact on bioprocess scale-up. Discover why understanding kLa is essential for optimizing cell growth and product formation in bioreactors. Learn practical strategies to enhance oxygen transfer, from manipulating bubble size to levera...
Sep 24, 2024•17 min•Ep. 91
Send us a text Dive into the cutting-edge world of gene therapy as we unravel the complexities of AAV production. In this insightful episode, Ahmed Youssef, a seasoned AAV expert and Senior Process Development Manager at Ascend, explains how you can navigate the complex world of AAV scale-up and learn why thinking outside the box is crucial for success. Key takeaways: Leverage early expert advice to ensure your therapeutic's long-term viability Explore innovative technologies like doggy bon...
Sep 19, 2024•25 min•Ep. 90
Send us a text Unlock the mysteries of AAV manufacturing in this eye-opening episode! Ahmed, a seasoned AAV expert and Senior Process Development Manager at Ascend, reveals insider strategies for biotech scientists navigating the complex world of gene therapy production. Discover why quality is the cornerstone of successful AAV development and how to avoid costly missteps in the journey from lab to clinic. Key takeaways: Learn to design a robust AAV manufacturing process that stands up to regula...
Sep 17, 2024•20 min•Ep. 88
Send us a text Unlock the secret weapon of biotech success! In this eye-opening episode, host David Brühlmann reveals how fractional CTOs are revolutionizing drug development, inspired by Michael Jordan's approach to greatness. Learn how this innovative strategy can slash timelines, mitigate risks, and give your biotech company a competitive edge. Discover the game-changing benefits of fractional expertise: Gain rapid access to broad biotech knowledge, navigating complex challenges with eas...
Sep 12, 2024•17 min•Ep. 88
Send us a text Unlock the secrets of successful bioprocess development with host David Brühlmann as he shares hard-won lessons from his 15+ years of experience leading technology transfers and technology innovation projects. Discover why prioritizing process development is crucial for transforming groundbreaking science into life-changing therapies. In this eye-opening episode, you'll learn: How to avoid costly mistakes in technology transfer and scale-up, saving you time and resources Stra...
Sep 10, 2024•17 min•Ep. 87
Send us a text What if your biomanufacturing facility could run itself, optimize its own processes, and operate non-stop? This isn't science fiction – it's the cutting-edge reality Professor Massimo Morbidelli is helping to create. In this captivating episode, the bioprocessing pioneer unveils how AI, continuous manufacturing, and revolutionary machine learning techniques are transforming the industry landscape. As a Professor Emeritus at ETH Zurich and Politecnico di Milano, and a co-...
Sep 05, 2024•23 min•Ep. 86
Send us a text Imagine a world where biologic drugs are produced faster, cheaper, and with unprecedented precision. In this episode, we dive into that future with Professor Massimo Morbidelli, a trailblazer in bioprocessing innovation. As a Professor Emeritus at ETH Zurich and Politecnico di Milano, and a co-founder of ChromaCon (now YMC) and DataHow, Massimo Morbidelli has been at the forefront of bioprocess innovation. He is currently the recipient of the ERC Advanced Grant Continuous Digitali...
Sep 03, 2024•24 min•Ep. 85
Send us a text Are your shake flasks holding back your bioprocess development? Discover how to transform them into smart bioreactors! In this game-changing episode, we talk with Jens Bayer about the groundbreaking DOTS platform. He is a deep tech entrepreneur and seasoned commercial leader, currently serving as Chief Commercial Officer at Scientific Bioprocessing. Jens reveals how this cutting-edge technology is bridging the gap between simple shake flasks and complex bioreactors, offering scien...
Aug 29, 2024•23 min•Ep. 84
Send us a text Are shake flasks outdated relics or untapped goldmines of bioprocess development? In this eye-opening episode, we dive deep with Jens Bayer, a deep tech entrepreneur and seasoned commercial leader, currently serving as Chief Commercial Officer at Scientific Bioprocessing. Jens shatters common misconceptions about shake flasks, revealing why they remain indispensable tools in both industry and research settings. Discover: Why shake flasks are irreplaceable for rapid, cost-effective...
Aug 27, 2024•18 min•Ep. 83
Send us a text Dive into the cutting-edge world of autologous cell-based therapy with Deana Mohr, CEO and co-founder of MUVON Therapeutics, spin-off from the University of Zurich. In this eye-opening episode, discover how MUVON Therapeutics’ innovative approach to muscle regeneration is revolutionizing treatments for stress urinary incontinence and beyond. Learn how her team is tackling the challenges of bringing personalized medicine to market at scale, from navigating complex regulations to au...
Aug 22, 2024•18 min•Ep. 82
Send us a text Discover how scientists are transforming lives through innovative muscle regeneration therapy. In this captivating episode, Deana Mohr, CEO and co-founder of MUVON Therapeutics, spin-off from the University of Zurich, unveils her groundbreaking autologous muscle regeneration technology for treating stress urinary incontinence. Learn how this minimally invasive treatment harnesses the power of a patient's own cells to restore muscle function, offering hope to millions. Diana s...
Aug 20, 2024•23 min•Ep. 81
Send us a text Ever wondered why some biotech facilities thrive while others struggle Alfredo Martínez Mogarra, a Bioprocess Engineer with over 30 years of experience and Chief Operations Manager at VIVEbiotech, reveals the secrets to successful biotech manufacturing. In this eye-opening episode, Alfredo shares critical insights on bridging the gap between lab-scale processes and industrial production. You will get: Strategies for seamless scale-up and risk mitigation in bioprocess development T...
Aug 15, 2024•20 min•Ep. 80
Send us a text Ever wondered what it takes to build a large-scale biotech manufacturing facility? Alfredo Martínez Mogarra, a seasoned Bioprocess Engineer with over 30 years of experience and Chief Operations Manager at VIVEbiotech, reveals the secrets behind successful biotech facility design and scale-up. He has been at the forefront of transforming bench processes into industrial realities. In this eye-opening episode, Alfredo shares critical insights on navigating the complex world of biotec...
Aug 13, 2024•24 min•Ep. 79
Send us a text Unlock the secrets of cell factories and discover how cutting-edge technologies are revolutionizing biopharmaceutical production. In this episode, we welcome Mauro Torres, a postdoctoral researcher at the University of Manchester, who takes us on a fascinating journey through the complex world of protein manufacturing. Mauro Torres explains the intricate steps involved in the secretory pathway, from gene expression to protein export, likening it to a sophisticated car manufacturin...
Aug 08, 2024•18 min•Ep. 78
Send us a text Unlock the secrets of cell factories with Mauro Torres, a postdoctoral researcher at the University of Manchester who brings cutting-edge insights into protein production. Discover how the concept of cell factories has evolved from basic insulin extraction to groundbreaking treatments for genetic disorders and cancer. We reveal the challenges faced by biotech scientists in bioprocess development and offers a fascinating analogy between car manufacturing and cellular protein assemb...
Aug 06, 2024•23 min•Ep. 77
Send us a text Curious about the latest innovations in cell analysis technology? Join us in this episode with Furkan Gökçe, New Business Development Manager at Amphasys, as we delve into the fascinating world of Impedance Flow Cytometry (IFC). Furkan shares how IFC is revolutionizing single-cell analysis by providing faster, more precise, and high-resolution data. Key Takeaways: Real-Time Precision: Discover how IFC allows for real-time, label-free assessments of cells, providing detailed insigh...
Aug 01, 2024•23 min•Ep. 76
