The 120 Year Diet

The crossroads of food, science, and longevity are pushing the forefront of current thinking.  The science of Epigenetics and Nutrigenomics deals with how what we put in our bodies impacts our DNA, the chance of disease and the likelihood of living a long life.

This week's podcast dives into the flavors around the art and science of food as medicine.

Let me know what you think after listening.  I’ve posted the show notes/ outline below for further contemplation.

Intermittent Fasting

• • Nutrient dense
  • Vital and essential nutritional cofactors

• The 120 year diet

• • Not new – 80yrs + of data
  • Dr. Walford – 1950s pioneer of concept
    • Under-nutrition without malnutrition
    • Restrict calories to 40% of 2,000 cal diet
    • Our daily intake has ballooned along with waistline
  • Vitamins
  • Minerals
  • Phytonutrients
  • **Notice I didn’t say anything about eating a cow sandwhich

• Experiements showing benefit of up to 70% reduction in calorie intake

Beneficial Mechanisms of Caloric Restriction

1. CV effects
   1. Decrease HR, BP, LDL & triglycerides
2. Improved insulin sensitivity – normalization of glucose levels
3. Increase protein synthesis
   1. elimination of abnormal proteins
   2. Enhanced actions of chaperone molecules
      1. Synthesis & maintenance of essentialproteins
4. Modulation of apoptosis (orderly cell death)
   1. Improvement in repair & maintenance of DNA integrity
   2. Benefits transcription
5. Reduce oxidative stress
   1. Qualitative and quantitative decrease in free radicals
6. Decrease body temperature
7. Reduction in body fat mass
   1. Decrease visceral fat mass
   2. Increase muscle mass
8. Beneficial effects on age related decreases in hormone secretion
   1. DHEA
   2. Growth hormone
9. Improved brain function
   1. Memory
   2. Cognition
   3. Mood
10. Enhanced engagement in physical activity
11. Growth factor stimulation
    1. Brain derived neurotrophic factor (BDNF)
12. Weight loss

Calorie Restriction Mimetics

• Metformin
• Resveratrol
• Carnosine
• Avocado
• Gymnema
• 2-deoxyglucose
• Aminoguanidine
• Hydroxycitrate
• Adiponectin
• Thiazolidinodiones
• Iodoacetate
• Modulators of NPY
• Exandin
• PYY3-36
• Leptin
• Alpha Lipoic Acid
• Cinnamon
• Acetyl-L-Carnitine
• Mixed Antioxidants
• Oxaloacetate (not approved for supplement use)

Positive lifestyle change and multiple interventions promote longevity in a synergistic manner.

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