Scientific integrity is a crucial component of scholarly publishing. In order to consistently publish high-quality science, it is integral to have strong ethical standards for scientific and academic integrity. At Impact Journals, a growing industry of digital technologies, tools, and ideas are constantly being added to our robust scientific integrity process. Impact Journals (based out of Buffalo, New York) is an international open-access publisher of journals in the field of biomedical science...
May 18, 2021•3 min
In the cover paper of this week's issue of Oncotarget (Volume 12, Issue 10), titled, "Inhibitory effects of Tomivosertib in acute myeloid leukemia," researchers based out of Chicago, Illinois, U.S., from Northwestern University’s Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, and Jesse Brown Veterans Affairs Medical Center conducted a new study to assess the efficacy of Tomivosertib to regulate the eIF4E binding protein in AML. In this study, th...
May 13, 2021•6 min
Listen to the latest oncology-focused research published in this week’s issue of Oncotarget, Volume 12, Issue 10. View the complete issue: https://www.oncotarget.com/archive/v12/i10/ COVER PAPER: “Inhibitory effects of Tomivosertib in acute myeloid leukemia” https://doi.org/10.18632/oncotarget.27952 EDITORIAL: “Raman spectroscopy determination of the mineral characteristics of microcalcifications in breast cancer, a way towards an improved screening approach” https://doi.org/10.18632/oncotarget....
May 11, 2021•6 min
Oncotarget published this trending research paper on April 13, 2021, entitled, “Insulin-like growth factor 1/Child-Turcotte-Pugh composite score as a predictor of treatment outcomes in patients with advanced hepatocellular carcinoma treated with sorafenib,” by researchers from the University of Texas MD Anderson Cancer Center, Massachusetts General Hospital, and Harvard Medical School. The majority of circulating insulin–like growth factor (IGF) is synthesized and secreted by the liver, and leve...
May 08, 2021•6 min
In the cover paper of this week's issue of Oncotarget (Volume 12, Issue 9), titled, "Creation of a new class of radiosensitizers for glioblastoma based on the mibefradil pharmacophore," researchers conducted a study to create mibefradil analogs as superior radiosensitizers for glioblastomas. In the current study, based on their previous findings, the researchers from Yale University used structure activity relationship analysis and EJ-DR assays to create, synthesize, and profile a series of 140 ...
Apr 29, 2021•5 min
Listen to the latest oncology-focused research published in this week’s issue of Oncotarget, Volume 12, Issue 9. View the complete issue: https://www.oncotarget.com/archive/v12/i9/ Oncotarget Volume 12, Issue 9 features: COVER PAPER: “Creation of a new class of radiosensitizers for glioblastoma based on the mibefradil pharmacophore” https://doi.org/10.18632/oncotarget.27933 EDITORIAL: “Is there a role for CDK 4/6 inhibitors in breast cancer brain metastases?” https://doi.org/10.18632/oncotarget....
Apr 28, 2021•7 min
Oncotarget published this trending paper on July 21, 2020, entitled, “Genomic markers of midostaurin drug sensitivity in FLT3 mutated and FLT3 wild-type acute myeloid leukemia patients,” by researchers from Knight Cancer Institute, Oregon Health and Science University; Division of Hematology and Medical Oncology, Oregon Health and Science University; Howard Hughes Medical Institute; Department of Cell, Developmental, and Cancer Biology, Oregon Health and Science University. The researchers condu...
Apr 27, 2021•6 min
In the cover paper of this week's issue of Oncotarget (Volume 12, Issue 8), titled, "Prognostic and therapeutic value of the Hippo pathway, RABL6A, and p53-MDM2 axes in sarcomas," researchers examined five potential biomarkers across 18 different histologic subtypes of sarcoma in 163 tissue samples. Immunohistochemical staining, statistical analysis, and correlation-based network analysis revealed promising results. Researchers from the University of Iowa, University of Alabama at Birmingham, an...
Apr 15, 2021•8 min
Listen to short summaries of the latest oncology-focused research published in this week's issue of Oncotarget. https://www.oncotarget.com/archive/v12/i8/ Oncotarget Volume 12, Issue 8 features: COVER PAPER: “Prognostic and therapeutic value of the Hippo pathway, RABL6A, and p53-MDM2 axes in sarcomas” https://doi.org/10.18632/oncotarget.27928 NEWS: “Immunotherapy and fatigue: what we know and what we don’t know” https://doi.org/10.18632/oncotarget.27946 (PDF Download) EDITORIAL: “Drug exposure: ...
Apr 14, 2021•10 min
Oncotarget published this trending paper on March 30, 2021, entitled, “Differential expression of Vitamin D binding protein in thyroid cancer health disparities,” researchers from Harbor-UCLA Medical Center, Loma Linda University School of Medicine, and Riverside University Health System compared the expression of DBP in patients with thyroid cancer from Filipino Americans and European Americans. Filipino Americans are disproportionately affected by thyroid cancer, and the goal of this research ...
Apr 09, 2021•6 min
In this top-performing paper published in Oncotarget on July 17, 2018, entitled, “A diagnostic autoantibody signature for primary cutaneous melanoma,” Australian researchers developed the first blood test to detect melanoma in early stages. The researchers from Australia’s Edith Cowan University, Hollywood Private Hospital, Level 1 Melanoma, St. John of God Hospital, Dermatology Specialist Group, Skin Check WA, and The University of Western Australia collected blood sera (plural of serum, which ...
Apr 07, 2021•5 min
In Oncotarget Volume 12, Issue 7 cover paper, titled, "Caloric restriction creates a metabolic pattern of chronological aging delay that in budding yeast differs from the metabolic design established by two other geroprotectors," the researchers conducted a study which compared the metabolic effects of three geroprotectors in budding yeast: calorie restriction, the tor1Δ mutation, and lithocholic acid. In this study, the researchers from the Department of Biology at Concordia University in Montr...
Apr 02, 2021•6 min
The American Association for Cancer Research (AACR) organizes an annual meeting program covering some of the most recent discoveries in cancer research. The conference aims to highlight work from the best minds in research and medicine from institutions all over the world. Oncotarget, exhibited by its publisher Impact Journals, will be participating virtually at the AACR Annual Meeting this year. Visit the Oncotarget website: www.oncotarget.com Visit the Impact Journals website: www.impactjourna...
Apr 02, 2021•3 min
Listen to short summaries of the latest oncology-focused research published in this week's issue of Oncotarget. https://www.oncotarget.com/archive/v12/i7/ Oncotarget Volume 12, Issue 7 features: COVER PAPER: "Caloric restriction creates a metabolic pattern of chronological aging delay that in budding yeast differs from the metabolic design established by two other geroprotectors" https://doi.org/10.18632/oncotarget.27926 EDITORIAL: "The long road to TRAIL therapy: a TRAILshort detour" https://do...
Apr 02, 2021•10 min
In a trending paper published by Oncotarget on March 2, 2021, titled, “Quantitative proteome profiling stratifies fibroepithelial lesions of the breast,” researchers from India conducted a study to better characterize phyllodes tumors and other breast fibroepithelial lesions in order to improve diagnosis and treatment for patients. To begin identifying the differentially expressed genes and proteins among FAD and PTs in benign, borderline, and malignant states, the researchers conducted quantita...
Mar 19, 2021•5 min
Oncotarget published "Quantitative proteome profiling stratifies fibroepithelial lesions of the breast" which reported that the current grading system remains unreliable in differentiating these tumors due to histological heterogeneity and lack of appropriate markers to monitor the sudden and unpredictable malignant transformation of PTs. The high- throughput quantitative proteomic analysis suggested that FAD and PTs form distinct clusters away from borderline and malignant though there exist ma...
Mar 18, 2021•4 min
In the cover paper of this week's issue of Oncotarget, titled: "Genomic and neoantigen evolution from primary tumor to first metastases in head and neck squamous cell carcinoma," the aim of the researchers in this exploratory study was to characterize the genomic and neoantigen changes in 23 paired primary and recurrent HNSCC tumors. Of the 23 patients in this study, 17 were male and 14 were tobacco smokers. The distribution of primary tumor location was nine in the oral cavity, seven in the oro...
Mar 17, 2021•7 min
Listen to short summaries of the latest oncology-focused research literature published in this week's issue of Oncotarget. https://www.oncotarget.com/archive/v12/i6/ Oncotarget Volume 12, Issue 6 features: COVER PAPER: "Genomic and neoantigen evolution from primary tumor to first metastases in head and neck squamous cell carcinoma." Institutions: Washington University in St. Louis, Columbia University, St. Louis Children’s Hospital, Siteman Cancer Center Quote: “We characterized genomic and neoa...
Mar 16, 2021•4 min
In a trending paper published by Oncotarget on March 2, 2021, researchers conducted a study to better understand why young Andean people are disproportionately affected by hepatocellular carcinoma (HCC) than others around the world. Hepatocellular carcinoma (HCC) is one of the most heterogeneous forms of cancer, and affects older patients commonly after they have had prolonged liver disease. However, among Andean people, half of the total patients who develop HCC are adolescents and young adults...
Mar 11, 2021•6 min
Oncotarget published this top-performing paper in 2018, when researchers compared the overall survival, average total healthcare costs, and resource utilization among patients with advanced cancers who received either standard care or precision, targeted oncology. The researchers, from Intermountain Healthcare facilities (located in Utah and California, U.S.) and California’s Stanford University School of Medicine, conducted a well-read study published in 2018, titled: “Precision oncology in adv...
Mar 10, 2021•5 min
In February, 2021, researchers from Spain conducted a study published in Oncotarget, titled: “Head to head evaluation of second generation ALK inhibitors brigatinib and alectinib as first-line treatment for ALK+ NSCLC using an in silico systems biology-based approach.” This trending paper was authored by researchers practicing at the Hospital Germans Trias i Pujol, Takeda Farmacéutica España, Anaxomics Biotech, and Universitat Pompeu Fabra. The researchers used a computer simulated modeling syst...
Mar 05, 2021•7 min
In the cover paper of this week's issue of Oncotarget, titled: "The cancer testis antigens CABYR-a/b and CABYR-c are expressed in a subset of colorectal cancers and hold promise as targets for specific immunotherapy," researchers evaluate CABYR isoforms a/b and c mRNA expression in colorectal cancer in hopes of determining whether or not these proteins may be promising vaccine targets. Read the full study here: https://doi.org/10.18632/oncotarget.27897 Oncotarget Volume 12, Issue 5: https://www....
Mar 05, 2021•6 min
Listen to short summaries of the latest oncology-focused research literature published in this week's issue of Oncotarget Volume 12, Issue 5. Click here for the complete issue: https://www.oncotarget.com/archive/v12/i5/ Oncotarget Volume 12, Issue 5 features: Cover Paper: "The cancer testis antigens CABYR-a/b and CABYR-c are expressed in a subset of colorectal cancers and hold promise as targets for specific immunotherapy." https://doi.org/10.18632/oncotarget.27897 Research Perspective: "Tumor m...
Mar 03, 2021•8 min
A review paper published this month in Oncotarget by researchers from the University of Modena and Reggio Emilia in Italy and the Sulaiman AlRajhi Medical School in Saudi Arabia is trending, and titled, “Cancer stem cells and macrophages: molecular connections and future perspectives against cancer.” (Read the paper here: https://www.oncotarget.com/article/27870/text/) Two authors of this review paper, Dr. Beatrice Aramini and Dr. Valentina Masciale, provide an overview of their research on the ...
Feb 26, 2021•9 min
Hundreds of scientific studies, reviews, and analyses are being published from around the world at any given time. This can make reading the latest research literature a time consuming task—depending, of course, on the quantity of papers one hopes to consume. As a tool to help alleviate this important undertaking, many researchers have taken to listening to one of the top open-access podcasts of 2020 and 2021: The Oncotarget Podcast. After a paper is published, it is added to an enhanced post-pu...
Feb 24, 2021•2 min
Dr. Mikhail V. Blagosklonny, M.D., Ph.D., Editor-in-Chief of Oncotarget, and Professor, at Roswell Park Cancer Institute, published "The goal of geroscience is life extension" which was selected as the Featured Cover Paper for Volume 12 Issue 3 and reported that although numerous drugs seemingly extend healthspan in mice, only a few extend lifespan in mice and only one does it consistently. Some of them, alone or in combination, can be used in humans, without further clinical trials. Dr. Mikhail...
Feb 03, 2021•3 min
The cover for issue 2 of Oncotarget features Figure 4, "Combination therapy TA99/ICB reduced the lung tumor burden in the B16 model of metastases," published in "Improved therapeutic efficacy of unmodified anti-tumor antibodies by immune checkpoint blockade and kinase targeted therapy in mouse models of melanoma" by Pérez-Lorenzo, et al. which reported that here, the authors showed that removing immune suppression and enhancing stimulatory signals increased the anti-tumor activity of unmodified ...
Jan 21, 2021•4 min
The cover for issue 28 of Oncotarget features Figure 5, "TMEM165 expression levels alters N-linked glycosylation," by Murali, et al., and reported that the TMEM165 protein was not detected in non-malignant matched breast tissues and was detected in invasive ductal breast carcinoma tissues by mass spectrometry. The hypothesis is that the TMEM165 protein confers a growth advantage to breast cancer. The authors created a CRISPR/Cas9 knockout of TMEM165 in the human invasive breast cancer cell line ...
Jan 11, 2021•5 min
Volume 11, Issue 28 of Oncotarget features "Genetic analysis of the cooperative tumorigenic effects of targeted deletions of tumor suppressors Rb1, Trp53, Men1, and Pten in neuroendocrine tumors in mice" by Xu et, al. which reported that the authors examined whether the TSGs Rb1, Trp53, Pten, and Men1 have cooperative effects in suppressing neuroendocrine tumors in mice. By monitoring growth and examining the histopathology of the pituitary and pancreas in these mice, the authors demonstrated th...
Jan 11, 2021•4 min
Volume 11, Issue 28 of Oncotarget features "Rapid onset type 1 diabetes with anti-PD-1 directed therapy", by Yun et al. and reported that Type 1 diabetes is a rare immune-related adverse event caused by checkpoint inhibitors with serious risk for diabetic ketoacidosis. Of the patients who received immunotherapy, 5 patients were found to have type 1 diabetes, all of whom presented with DKA requiring insulin at 20 to 972 days from their first anti-PD- 1 dose. Four patients had new-onset diabetes w...
Jan 11, 2021•4 min
