Table of Contents: Oncotarget Volume 12, Issue #6

Listen to short summaries of the latest oncology-focused research literature published in this week's issue of Oncotarget. https://www.oncotarget.com/archive/v12/i6/ Oncotarget Volume 12, Issue 6 features: COVER PAPER: "Genomic and neoantigen evolution from primary tumor to first metastases in head and neck squamous cell carcinoma." Institutions: Washington University in St. Louis, Columbia University, St. Louis Children’s Hospital, Siteman Cancer Center Quote: “We characterized genomic and neoantigen changes between 23 paired primary and recurrent HNSCC tumors. Twenty-three biopsies from patients originally diagnosed with locally advanced disease were identified from the Washington University tumor bank.” doi.org/10.18632/oncotarget.27907 EDITORIAL: "Innovating and expanding weight loss strategies for breast cancer survivors." Institution: Johns Hopkins Sidney Kimmel Comprehensive Cancer Center Quote: “Compared to those with ideal body weight, women who have excess weight experience inferior outcomes once diagnosed with breast cancer, despite standard local and adjuvant therapy [6].” https://doi.org/10.18632/oncotarget.27898 RESEARCH PERSPECTIVE: "Pancreatic cancer driver mutations are targetable through distant alternative RNA splicing dependencies." Institutions: The Johns Hopkins University School of Medicine, Dartmouth Geisel School of Medicine and Norris Cotton Cancer Center, Yale University, Stony Brook University Renaissance School of Medicine Quote: “Here, we review PDAC pathogenesis as it relates to fundamental ARS [Alternative RNA splicing] biology, with an extension to implications for PDAC patient clinical management.” doi.org/10.18632/oncotarget.27901 RESEARCH PAPER: "A high-content AlphaScreen™ identifies E6-specific small molecule inhibitors as potential therapeutics for HPV+ head and neck squamous cell carcinomas." Institutions: Loma Linda University, University of Kansas Quote: “Herein we describe our search for small molecule inhibitors that disrupt binding of E6 to caspase 8 using AlphaScreen technology™ (Perkin Elmer, Waltham, MA). This technology is a proximity-based platform for identifying hit compounds that perturb a specific interaction between two beaded proteins. Using this approach, we interrogated a library of over 5000 small molecules for compounds that antagonize E6 binding to caspase 8.” doi.org/10.18632/oncotarget.27908 RESEARCH PAPER: "Characterization of the inflammatory microenvironment and hepatic macrophage subsets in experimental hepatocellular carcinoma models." Institution: Ghent University Quote: “Here, we characterized the tumor microenvironment and the proportion and transcriptional profile of hepatic macrophages (Mφ) in two commonly used HCC mouse models.” doi.org/10.18632/oncotarget.27906 RESEARCH PAPER: "Molecular characterization of lung squamous cell carcinoma tumors reveals therapeutically relevant alterations." Institutions: Tata Memorial Centre, Homi Bhabha National Institute Quote: “We performed survival analyses of lung squamous cell carcinoma patients harboring therapeutically relevant alterations identified by whole exome sequencing and mass spectrometry-based validation across 430 lung squamous tumors.” doi.org/10.18632/oncotarget.27905 About Oncotarget: Oncotarget is a bi-weekly, peer-reviewed, open access biomedical journal covering research on all aspects of oncology. To learn more about Oncotarget, please visit www.oncotarget.com or follow us: SoundCloud - @oncotarget Facebook - www.facebook.com/Oncotarget/ Twitter - twitter.com/oncotarget LinkedIn - www.linkedin.com/company/oncotarget Instagram - www.instagram.com/oncotargetjrnl/ YouTube - www.youtube.com/OncotargetYouTube Pinterest - www.pinterest.com/oncotarget/ Reddit - www.reddit.com/user/Oncotarget/ Oncotarget is published by Impact Journals, LLC please visit www.ImpactJournals.com or connect with @ImpactJrnls Media Contact MEDIA@IMPACTJOURNALS.COM 18009220957x105