00:48 A rapid way to identify serious bacterial infections A newly-developed method that can rapidly identify the type of bacteria causing a blood-infection, and the correct antibiotics to treat it, could save clinicians time, and patient lives. Blood infections are serious, and can lead to the life-threatening condition sepsis, but conventional diagnostic methods can take days to identify the causes. This new method does away with some of the time-consuming steps, and the researchers behind it ...
Jul 24, 2024•35 min
01:04 A gel to safely transport proteins A gel that encases proteins could be a new way to safely transport medicines without requiring them to be kept cold, according to new research. To test it, the team behind the work posted themselves a protein suspended in this gel, showing that it was perfectly preserved and retained its activity, despite being dropped in transit and exposed to varying temperatures. The researchers hope this gel will help overcome the need to freeze protein-based medicine...
Jul 17, 2024•28 min
00:45 In situ editing of the gut microbiome Researchers have developed a method to directly edit the genes of specific bacteria in the guts of live mice, something that has previously been difficult to accomplish due to the complexity of this environment. The tool was able to edit over 90% of an E. coli strain colonising mice guts, with other work showing the tool could be used to edit genes in pathogenic bacterial species and strains. It is hoped that with further research this technique could ...
Jul 10, 2024•27 min
00:47 Searching for dark matter in black holes Researchers have been scanning the skies looking for black holes that formed at the very beginning of the Universe — one place where elusive and mysterious dark matter is thought to be located. If these black holes did contain dark matter, they would be especially massive and so researchers would be able to see the bending of light as they pass in front of stars. Such events would be rare, so to find them researchers trawled through a decades-long d...
Jul 03, 2024•37 min
In 2026, NASA aims to send humans back to the Moon's surface, as part of the Artemis III mission. In preparation, astronauts have been performing moonwalking simulations to ensure that they are able to make the most of their precious time on the lunar surface. In one dress rehearsal, a pair of astronauts took part in a training exercise in an Arizona volcanic field, working with a science team to practice doing geology work in difficult conditions designed to mimic some that will be experienced ...
Jun 28, 2024•15 min
00:31 How open are ‘open source’ AI systems? Many of the large language models powering AI systems are described as ‘open source’ but critics say this is a misnomer, with restricted access to code and training data preventing researchers from probing how these systems work. While the definition of open source in AI models is yet to be agreed, advocates say that ‘full’ openness is crucial in efforts to make AI accountable. New research has ranked the openness of different systems, showing that de...
Jun 26, 2024•18 min
00:46 How light touches are sensed during sex 150 years after they were discovered, researchers have identified how specific nerve-cell structures on the penis and clitoris are activated. While these structures, called Krause corpuscles, are similar to touch-activated corpuscles found on people’s fingers and hands, there was little known about how they work, or their role in sex. Working in mice, a team found that Krause corpuscles in both male and females were activated when exposed to low-freq...
Jun 19, 2024•32 min
00:48 Short-haul spaceflight's effect on the human body. A comprehensive suite of biomedical data, collected during the first all-civilian spaceflight, is helping researchers unpick the effects that being in orbit has on the human body. Analysis of data collected from the crew of SpaceX’s Inspiration4 mission reveals that short duration spaceflight can result in physiological changes similar to those seen on longer spaceflights. These changes included things like alterations in immune-cell funct...
Jun 12, 2024•38 min
In this episode: 00:46 Making a molecular Bose-Einstein condensate For the first time, researchers have coaxed molecules into a bizarre form of matter called a Bose-Einstein condensate, in which they all act in a single gigantic quantum state. While condensates have been made using atoms for decades, the complex interactions of molecules have prevented them from being cooled into this state. Now, a team has successfully made a Bose-Einstein condensate using molecules made of caesium and sodium a...
Jun 05, 2024•28 min
In this episode: 00:25 What the rise of AI language models means for robots Companies are melding artificial intelligence with robotics, in an effort to catapult both to new heights. They hope that by incorporating the algorithms that power chatbots it will give robots more common-sense knowledge and let them tackle a wide range of tasks. However, while impressive demonstrations of AI-powered robots exist, many researchers say there is a long road to actual deployment, and that safety and reliab...
May 29, 2024•23 min
Growing up in Alabama in the 1960s, mathematician Freeman Hrabowski was moved to join the civil rights moment after hearing Martin Luther King Jr speak. Even as a child, he saw the desperate need to make change. He would go on to do just that — at the University of Maryland Baltimore County, where he co-founded the Meyerhoff Scholars Program, one of the leading pathways to success for Black students in STEM subjects in the United States. Freeman is the subject of the first in a new series of Q&a...
May 28, 2024•37 min
AIs are often described as 'black boxes' with researchers unable to to figure out how they 'think'. To better understand these often inscrutable systems, some scientists are borrowing from psychology and neuroscience to design tools to reverse-engineer them, which they hope will lead to the design of safer, more efficient AIs. This is an audio version of our Feature: How does ChatGPT ‘think’? Psychology and neuroscience crack open AI large language models Hosted on Acast. See acast.com/privacy f...
May 24, 2024•18 min
00:45 The neuroscience of fentanyl addiction Research in mice has shown that fentanyl addiction is the result of two brain circuits working in tandem, rather than a single neural pathway as had been previously thought. One circuit underlies the positive feelings this powerful drug elicits, which the other was responsible for the intense withdrawal when it is taken away. Opioid addiction leads to tens of thousands of deaths each year, and the team hopes that this work will help in the development...
May 22, 2024•20 min
In this episode: 00:45 A recyclable 3D printing resin from an unusual source Many 3D printers create objects using liquid resins that turn into robust solids when exposed to light. But many of these are derived from petrochemicals that are difficult to recycle. To overcome this a team has developed a new type of resin, which they’ve made using a bodybuilding supplement called lipoic acid. Their resin can be printed, recycled and reused multiple times, which they hope could in future contribute t...
May 15, 2024•31 min
In this episode: 00:45 A nuclear timekeeper that could transform fundamental-physics research. Nuclear clocks — based on tiny shifts in energy in an atomic nucleus — could be even more accurate and stable than other advanced timekeeping systems, but have been difficult to make. Now, a team of researchers have made a breakthrough in the development of these clocks, identifying the correct frequency of laser light required to make this energy transition happen. Ultimately it’s hoped that physicist...
May 08, 2024•22 min
Ever since scientific enquiry began, people have focused mainly on men, or if studies involve animals, on male mice, male rats or whatever it may be. And this has led to gaps in scientists’ understanding of how diseases, and responses to treatment, and many other things might vary between people of different sexes and genders. These days, mainly thanks to big funders like the NIH introducing new guidelines and mandates, a lot more scientists are thinking about sex and, where appropriate, gender....
May 02, 2024•59 min
In this episode: 00:46 Using genomics to explain geographic differences in cancer risk The risk of developing cancer can vary hugely depending on geographic region, but it’s not exactly clear why. To get a better idea, a team has compared the genomes of kidney cancers taken from people around the globe. They reveal a link between geographical locations and specific genetic mutations, suggesting that there are as-yet unknown environmental or chemical exposures in different locations. They hope th...
May 01, 2024•25 min
Many people around the world feel lonely. Chronic loneliness is known to have far-reaching health effects and has been linked to multiple conditions and even early death. But the mechanisms through which feeling alone can lead to poor health is a puzzle. Now, researchers are looking at neurons in the hopes that they may help explain why health issues arise when social needs go unmet. This is an audio version of our Feature Why loneliness is bad for your health Hosted on Acast. See...
Apr 26, 2024•15 min
In this episode: 00:46 Optical clocks at sea Optical atomic clocks are the most precise timekeeping devices on the planet, but these devices are huge and difficult to work with, limiting their use outside of the lab. Now, researchers have developed a portable optical clock and demonstrated its robustness by sending it on a perilous sea journey. The team hope that this work will pave the way to more practical uses of optical clocks, such as on satellites where they could help improve the accuracy...
Apr 24, 2024•29 min
Humans setting up home in outer space has long been the preserve of science fiction. Now, thanks to advances in technology and the backing of billionaires, this dream could actually be realised. But is it more likely to be a nightmare? Kelly and Zach Weinersmith join us to discuss their new book A City on Mars and some of the medical, environmental and legal roadblocks that may prevent humanity from ultimately settling in space. A City on Mars: Can We Settle Space, Should We Settle Space, and Ha...
Apr 19, 2024•38 min
In this episode: 00:46 Mysterious methane emission from a cool brown dwarf The James Webb Space Telescope (JWST) is revealing the makeup of brown dwarfs — strange space objects that blur the line between a planet and a star. And it appears that methane in the atmosphere of one of these objects, named W1935, is emitting infrared radiation. Where the energy comes from is a mystery however, researchers hypothesise that the glow could be caused by an aurora in the object’s atmosphere, perhaps driven...
Apr 17, 2024•34 min
In this episode: 00:46 Mapping ‘ghost roads’ in tropical forests Across the world, huge numbers of illegal roads have been cut into forests. However, due to their illicit nature, the exact numbers of these roads and their impacts on ecosystems is poorly understood. To address this, researchers have undertaken a huge mapping exercise across the tropical Asia-Pacific region. Their findings reveal over a million kilometers of roads that don’t appear on official maps, and that their construction is ...
Apr 10, 2024•23 min
Around the world, rates of cancers that typically affect older adults are increasing in those under 50 years old. Models based on global data predict that the number of early-onset cancer cases like these will increase by around 30% between 2019 and 2030. The most likely contributors — such as rising rates of obesity and early-cancer screening — do not fully account for the increase. To try and understand the reasons behind this trend, many researchers are searching for answers buried in studies...
Apr 05, 2024•16 min
In this episode: 00:35 Pregnancy advances your ‘biological’ age — but giving birth turns it back Growing a baby leads to changes in the distribution of certain chemical markers on a pregnant person’s DNA, but new research suggests that after giving birth, these changes can revert to an earlier state. Nature News: Pregnancy advances your ‘biological’ age — but giving birth turns it back 08:07 Bird gestures to say 'after you' A Japanese tit ( Parus minor ) will flutter its wings to invite their ma...
Apr 03, 2024•25 min
In this episode: 01:28 Inflammation’s role in memory How memories are stored is an ongoing question in neuroscience. Now researchers have found an inflammatory pathway that responds to DNA damage in neurons has a key role in the persistence of memories. How this pathway helps memories persist is unclear, but the researchers suggest that how the DNA damage is repaired may play a role. As inflammation in the brain is often associated with disease, the team were surprised by this finding, which the...
Mar 27, 2024•27 min
This podcast has been corrected: in a previous version at 5:55 we stated that that the team's 200mm devices currently contain only a couple of magnetic tunnelling junctions, in fact they studied 500-1000 devices in this work. 00:48 How mysterious skyrmions could power next-generation computers Skyrmions are tiny whirlpools of magnetic spin that some researchers believe have useful properties that could unlock new kinds of computing. However getting skyrmions to perform useful computational tasks...
Mar 20, 2024•30 min
In this episode: 00:45 Making a map of the human heart The human heart consists of multiple, specialised structures that all work together to enable the organ to beat for a lifetime. But exactly which cells are present in each part of the heart has been difficult to ascertain. Now, a team has combined molecular techniques to create an atlas of the developing human heart at an individual cell level. Their atlas provides insights into how cell communities communicate and form different structures....
Mar 13, 2024•27 min
In this episode: 00:48 Bumblebees can learn new tricks from each other One behaviour thought unique to humans is the ability to learn something from your predecessors that you couldn’t figure out on your own. However, researchers believe they have shown bumblebees are also capable of this ‘standing on the shoulders of giants’ approach to learning. Bees that were taught how to complete a puzzle too difficult to solve on their own, were able to share this knowledge with other bees, raising the pos...
Mar 06, 2024•37 min
In this episode: 00:49 What caused the Universe to become fully transparent? Around 13 billion years ago, the Universe was filled with a dense ‘fog’ of neutral hydrogen that blocked certain wavelengths of light. This fog was lifted when the hydrogen was hit by radiation in a process known as reionisation, but the source of this radiation has been debated. Now, researchers have used the JWST to peer deep into the Universe’s past and found that charged particles pouring out from dwarf galaxies app...
Feb 28, 2024•26 min
The phenomenon of animals catching diseases from humans, called reverse zoonoses, has had a severe impact on great ape populations, often representing a bigger threat than habitat loss or poaching. However, while many scientists and conservationists agree that human diseases pose one of the greatest risks to great apes today there are a few efforts under way to use a research-based approach to mitigate this problem. This is an audio version of our Feature Chimpanzees are dying from our colds — t...
Feb 26, 2024•25 min
