Here Dr Joffrey discusses his view on future of aging and the most promising technology that he sees which will make a difference. He also talks about Longevity Escape Velocity. 🌐Links in this episode Dr Joffrey's podcast on aging - free copy of his book, Longevity for Busy People is available for download from there. https://sapiopodcast.com/ Consumer Labs https://www.consumerlab.com/ Renue by Science all 10% discount with code MHS https://renuebyscience.com/ Use SUBMHS for 15% on subscription...
Mar 10, 2024•18 min•Season 48Ep. 1
Here Matt & Wade discuss lifestyle, nutrition and supplement strategies to support cognitive performance as we get older. The Ultimate Nutrition Bible can be found here https://ultimatenutritionsystem.com/modern Our code of Modern10 will already be applied. The code will also work for all BiOptimizer products. 🌐Links in this episode Renue by Science all 10% discount with code MHS https://renuebyscience.com/ Use SUBMHS for 15% on subscriptions 10% off DoNotAge all products with discount code...
Mar 07, 2024•13 min•Season 47Ep. 4
Here Matt & Wade discuss saturated fats and proteins as part of the diet. The Ultimate Nutrition Bible can be found here https://ultimatenutritionsystem.com/modern Our code of Modern10 will already be applied. The code will also work for all BiOptimizer products. 🌐Links in this episode Renue by Science all 10% discount with code MHS https://renuebyscience.com/ Use SUBMHS for 15% on subscriptions 10% off DoNotAge all products with discount code MHS https://donotage.org/products/ ProHealth 15...
Mar 05, 2024•15 min•Season 47Ep. 3
The Ultimate Nutrition Bible can be found here https://ultimatenutritionsystem.com/modern Our code of Modern10 will already be applied. The code will also work for all BiOptimizer products. 🌐Links in this episode Renue by Science all 10% discount with code MHS https://renuebyscience.com/ Use SUBMHS for 15% on subscriptions 10% off DoNotAge all products with discount code MHS https://donotage.org/products/ ProHealth 15% of all products Code MODERN: https://www.prohealth.com/ Here Matt & Wade...
Mar 03, 2024•16 min•Season 47Ep. 2
Here Matt & Wade discuss how to structure a diet and some of the pitfalls that can happen in implementation. The Ultimate Nutrition Bible can be found here https://ultimatenutritionsystem.com/modern Our code of Modern10 will already be applied. The code will also work for all BiOptimizer products. 🌐Links in this episode Renue by Science all 10% discount with code MHS https://renuebyscience.com/ Use SUBMHS for 15% on subscriptions 10% off DoNotAge all products with discount code MHS https://...
Feb 29, 2024•19 min•Season 47Ep. 1
Here Dr Sorrentino discusses his personal longevity protocol and also some of his current work and how this is targeted at moving discoveries into the clinic. Vincenzo Sorrentino is an Italian-born scientist in the fields of aging, mitochondrial biology and neuromuscular degeneration. He obtained his PhD Cum Laude at the University of Amsterdam on LDL-cholesterol regulation by the ubiquitin-proteasome system. Subsequently, he moved to Lausanne, Switzerland, for his postdoctoral research in Prof....
Feb 03, 2024•12 min•Season 46Ep. 4
Here Dr Sorrentino discusses mitochondria and muscle aging and results from trials of Urolithin A and NR in countering some of the ill effects. Vincenzo Sorrentino is an Italian-born scientist in the fields of aging, mitochondrial biology and neuromuscular degeneration. He obtained his PhD Cum Laude at the University of Amsterdam on LDL-cholesterol regulation by the ubiquitin-proteasome system. Subsequently, he moved to Lausanne, Switzerland, for his postdoctoral research in Prof. Johan Auwerx’s...
Jan 23, 2024•14 min•Season 46Ep. 3
Here Dr Sorrentino discusses proteostasis, how it goes wrong with age and how raising NAD levels can help. Vincenzo Sorrentino is an Italian-born scientist in the fields of aging, mitochondrial biology and neuromuscular degeneration. He obtained his PhD Cum Laude at the University of Amsterdam on LDL-cholesterol regulation by the ubiquitin-proteasome system. Subsequently, he moved to Lausanne, Switzerland, for his postdoctoral research in Prof. Johan Auwerx’s lab at the EPFL. His work there focu...
Jan 18, 2024•12 min•Season 46Ep. 2
Apologies for missing the last two release dates. Hopefully back on track now! Here Dr Sorrentino introduces trigonelline a methylated form of nicotinic acid which can boost NAD levels. He also talks about his work at Singapore and the translation of longevity science into the clinic. Vincenzo Sorrentino is an Italian-born scientist in the fields of aging, mitochondrial biology and neuromuscular degeneration. He obtained his PhD Cum Laude at the University of Amsterdam on LDL-cholesterol regulat...
Jan 16, 2024•20 min•Season 46Ep. 1
Here Dr Maroon, talks about some of the latest work that they are doing at Pittsburgh University on direct stimulation of the brain with magnetic pulses, light and ultra-sound. Dr Joseph Maroon is an American neurosurgeon, author, and triathlon athlete. He is the professor and vice chairman of the Department of Neurological Surgery at the University of Pittsburgh Medical Center and has been the team neuroscientist for the Pittsburg Stealers since 1980. After starting to compete in triathlons in ...
Jan 08, 2024•9 min•Season 46Ep. 6
Here Dr Maroon, talks about the supplements that he takes to help him with his exercise protocol. Dr Joseph Maroon is an American neurosurgeon, author, and triathlon athlete. He is the professor and vice chairman of the Department of Neurological Surgery at the University of Pittsburgh Medical Center and has been the team neuroscientist for the Pittsburg Stealers since 1980. After starting to compete in triathlons in his 40’s he has completed more than 70 Olympic distance events including 8 inte...
Jan 06, 2024•5 min•Season 46Ep. 5
Here Dr Maroon, talks about stress, including eustress and distress and his way of handling stress (exercise!) Dr Joseph Maroon is an American neurosurgeon, author, and triathlon athlete. He is the professor and vice chairman of the Department of Neurological Surgery at the University of Pittsburgh Medical Center and has been the team neuroscientist for the Pittsburg Stealers since 1980. After starting to compete in triathlons in his 40’s he has completed more than 70 Olympic distance events inc...
Jan 01, 2024•7 min•Season 46Ep. 4
Here Dr Maroon, talks his personal diet and his thoughts on protein intake, sarcopenia, the ketogenic diet and omega-3 fatty acids. Dr Joseph Maroon is an American neurosurgeon, author, and triathlon athlete. He is the professor and vice chairman of the Department of Neurological Surgery at the University of Pittsburgh Medical Center and has been the team neuroscientist for the Pittsburg Stealers since 1980. After starting to compete in triathlons in his 40’s he has completed more than 70 Olympi...
Dec 31, 2023•10 min•Season 46Ep. 3
Here Dr Maroon, talks about research that he is working on with a colleague in India, Dr Pravat Mandal looking at ROS as a cause of Alzheimer's and glutathione as a possible preventative measure. Dr Joseph Maroon is an American neurosurgeon, author, and triathlon athlete. He is the professor and vice chairman of the Department of Neurological Surgery at the University of Pittsburgh Medical Center and has been the team neuroscientist for the Pittsburg Stealers since 1980. After starting to compet...
Dec 28, 2023•7 min•Season 46Ep. 2
Here Dr Maroon, discusses his path to becoming a triathlete, his exercise protocol and his experience with hyperbaric oxygen therapy. Dr Joseph Maroon is an American neurosurgeon, author, and triathlon athlete. He is the professor and vice chairman of the Department of Neurological Surgery at the University of Pittsburgh Medical Center and has been the team neuroscientist for the Pittsburg Stealers since 1980. After starting to compete in triathlons in his 40’s he has completed more than 70 Olym...
Dec 24, 2023•19 min•Season 46Ep. 1
Here Dr Seranova talks about the supplements she takes, and a couple that she does not. Also sleeping and a hack for getting better deep sleep. The new brain supplement that Dr Seranova talks about is now available. Dr. Seranova is a serial entrepreneur, holds an MSc in Translational Neuroscience from the University of Sheffield and a PhD in Stem Cell Biology and Autophagy from the University of Birmingham, UK. 🌐Links in this episode NMN Bio website: https://nmnbio.co.uk/ NAD depletion mediates...
Dec 19, 2023•26 min•Season 45Ep. 5
Here Dr Seranova talks about her diet and exercise and how she thinks about these. Some links are affiliate links so we will earn a commission when they are used to purchase products. Dr. Seranova is a serial entrepreneur, holds an MSc in Translational Neuroscience from the University of Sheffield and a PhD in Stem Cell Biology and Autophagy from the University of Birmingham, UK. 🌐Links in this episode NMN Bio website: https://nmnbio.co.uk/ NAD depletion mediates cytotoxicity in human neurons w...
Dec 16, 2023•18 min•Season 45Ep. 4
Dr. Seranova is a serial entrepreneur, holds an MSc in Translational Neuroscience from the University of Sheffield and a PhD in Stem Cell Biology and Autophagy from the University of Birmingham, UK. 🌐Links in this episode NMN Bio website: https://nmnbio.co.uk/ NAD depletion mediates cytotoxicity in human neurons with autophagy deficiency https://www.sciencedirect.com/science/article/pii/S2211124723003832 Autophagy promotes cell survival by maintaining NAD levels https://pubmed.ncbi.nlm.nih.gov/...
Dec 11, 2023•14 min•Season 45Ep. 3
Here Dr Seranova answers some questions on the paper from the first interview (https://youtu.be/fsuhtgKUZRg). Particular topics we discuss, mitochondria fragmentation, de novo pathway in neurons, difference between NR & NMN. Dr. Seranova is a serial entrepreneur, holds an MSc in Translational Neuroscience from the University of Sheffield and a PhD in Stem Cell Biology and Autophagy from the University of Birmingham, UK. 🌐Links in this episode NMN Bio website: https://nmnbio.co.uk/ NAD deple...
Dec 09, 2023•15 min•Season 45Ep. 2
Here Dr Seranova talks through her latest paper on the impact of NAD precursors (NR & NMN) on autophagy in human neuron Dr. Seranova is a serial entrepreneur, holds an MSc in Translational Neuroscience from the University of Sheffield and a PhD in Stem Cell Biology and Autophagy from the University of Birmingham, UK. 🌐Links in this episode NMN Bio website: https://nmnbio.co.uk/ NAD depletion mediates cytotoxicity in human neurons with autophagy deficiency https://www.sciencedirect.com/scien...
Dec 03, 2023•27 min•Season 45Ep. 1
Here Dr Gibala talks how to think about exercise routines and nutrition as well as sharing his own protocol and the current work of his lab Dr Martin Gibala is a Professor at McMaster University where his research examines the effects of exercise at the molecular to whole body level in both healthy individuals and people with chronic diseases. In addition to basic, mechanistic studies on the regulation of skeletal muscle energy metabolism, his laboratory conducts applied research that examines t...
Nov 30, 2023•22 min•Season 44Ep. 3
Here Dr Gibala talks about what is VO2max, why it is important, how to measure and improve it. Dr Martin Gibala is a Professor at McMaster University where his research examines the effects of exercise at the molecular to whole body level in both healthy individuals and people with chronic diseases. In addition to basic, mechanistic studies on the regulation of skeletal muscle energy metabolism, his laboratory conducts applied research that examines the impact of physical training and nutrition ...
Nov 25, 2023•18 min•Season 43Ep. 2
Here Dr Gibala introduces interval training and discusses the various styles, and the benefits. Dr Martin Gibala is a Professor at McMaster University where his research examines the effects of exercise at the molecular to whole body level in both healthy individuals and people with chronic diseases. In addition to basic, mechanistic studies on the regulation of skeletal muscle energy metabolism, his laboratory conducts applied research that examines the impact of physical training and nutrition...
Nov 21, 2023•22 min•Season 44Ep. 1
Here Dr Patel talks about his topical glutathione treatment Glutaryl and the recent trial that was conducted at McGill University. Dr. Nayan Patel is an alumnus of the University Of Southern California School Of Pharmacy, where he now serves as adjunct faculty. A pharmacist for over three decades, Patel is an internationally recognized expert, consultant, and lecturer on the Master Antioxidant Glutathione. Dr. Patel founded Auro Wellness in 2011 to create products to help the body function at an...
Nov 19, 2023•14 min•Season 43Ep. 3
Here Dr Patel talks about the changes that happen with glutathione as we age, why it is important and what we can do to restore the levels. Dr. Nayan Patel is an alumnus of the University Of Southern California School Of Pharmacy, where he now serves as adjunct faculty. A pharmacist for over three decades, Patel is an internationally recognized expert, consultant, and lecturer on the Master Antioxidant Glutathione. Dr. Patel founded Auro Wellness in 2011 to create products to help the body funct...
Nov 16, 2023•12 min•Season 43Ep. 2
Here Dr Patel talks about glutathione's major two functions in the body, as an antioxidant and a detoxifier. He also discusses measuring our glutathione levels and what would be a good value to aim for. Dr. Nayan Patel is an alumnus of the University Of Southern California School Of Pharmacy, where he now serves as adjunct faculty. A pharmacist for over three decades, Patel is an internationally recognized expert, consultant, and lecturer on the Master Antioxidant Glutathione. Dr. Patel founded ...
Nov 14, 2023•21 min•Season 43Ep. 1
Here Dr Conlon talks about her personal protocol, that she has decided on as a data driven scientist. We also discuss the next steps for Nuchido as a longevity company. Dr Nichola Conlon is a molecular biologist specialising in the study of cellular aging. After a career in drug development, she founded Nuchido Laboratories to deliver disruptive innovation in the field of aging, rejuvenation and healthspan. Dr Conlon has a passion for sharing the latest science and is an accomplished speaker, wi...
Nov 11, 2023•10 min•Season 42Ep. 4
Here Dr Conlon talks about the human trial that she sponsored to evaluate the benefits of Time+ on humans. Dr Nichola Conlon is a molecular biologist specialising in the study of cellular aging. After a career in drug development, she founded Nuchido Laboratories to deliver disruptive innovation in the field of aging, rejuvenation and healthspan. Dr Conlon has a passion for sharing the latest science and is an accomplished speaker, with a skill for translating advanced science to help educate an...
Nov 09, 2023•16 min•Season 42Ep. 3
Here Dr Conlon talks through all the components of Nuchido Time+ and how they fit into the strategy of restoring NAD by activating the cell's natural mechanisms. Dr Nichola Conlon is a molecular biologist specialising in the study of cellular aging. After a career in drug development, she founded Nuchido Laboratories to deliver disruptive innovation in the field of aging, rejuvenation and healthspan. Dr Conlon has a passion for sharing the latest science and is an accomplished speaker, with a sk...
Nov 07, 2023•10 min•Season 42Ep. 2
Here Dr Conlon explains the biochemistry behind Nuchido Time+ and how it activates the salvage pathway through NAMPT to replenish cellular NAD in sustainable way. Dr Nichola Conlon is a molecular biologist specialising in the study of cellular aging. After a career in drug development, she founded Nuchido Laboratories to deliver disruptive innovation in the field of aging, rejuvenation and healthspan. Dr Conlon has a passion for sharing the latest science and is an accomplished speaker, with a s...
Nov 04, 2023•28 min•Season 42Ep. 1
