Here Professor Gorbunova about the naked mole rat and bowhead whale and what adaptions they have to enable them to live longer. From this she discusses how these adaptions might be translated into interventions for humans. Dr Vera Gorbunova is a biologist. As the Doris Johns Cherry Professor at the University of Rochester, she identified high molecular weight hyaluronan as the key mediator of cancer resistance in the naked mole rat 🌐Links in this video Dr Gorbunova's website https://www.sas.roc...
Oct 31, 2023•18 min•Season 41Ep. 4
Here Professor Gorbunova talks about hyaluronic acid, what it is and why it is different in naked mole rats. She also talks about a trial that she performed where the gene for HA was placed in mice. Finally we talk about how this could be translated into clinical usage. Dr Vera Gorbunova is a biologist. As the Doris Johns Cherry Professor at the University of Rochester, she identified high molecular weight hyaluronan as the key mediator of cancer resistance in the naked mole rat 🌐Links in this ...
Oct 29, 2023•11 min•Season 41Ep. 3
Here Professor Gorbunova talks about the two functions of SIRT6, deacetylation and ribosylation, the importance of them and how they can be activated. She also touches on chromatin remodeling and Yamanaka factors. Dr Vera Gorbunova is a biologist. As the Doris Johns Cherry Professor at the University of Rochester, she identified high molecular weight hyaluronan as the key mediator of cancer resistance in the naked mole rat 🌐Links in this video Dr Gorbunova's website https://www.sas.rochester.ed...
Oct 25, 2023•15 min•Season 41Ep. 2
Here Professor Gorbunova talks about the key activities of SIRT6 that are involved with longevity, particularly DNA repair and the suppression of transposons. Dr Vera Gorbunova is a biologist. As the Doris Johns Cherry Professor at the University of Rochester, she identified high molecular weight hyaluronan as the key mediator of cancer resistance in the naked mole rat 🌐Links in this video Dr Gorbunova's website https://www.sas.rochester.edu/bio/people/faculty/gorbunova_vera/ Sirtuin 6: linking...
Oct 24, 2023•14 min•Season 41Ep. 1
In this video Dr Wang talks about the current state of trials and how the therapy might eventually look. Stan Wang is Founder and CEO of Thymmune Therapeutics, a cell therapy company working to address high unmet needs across immunology. Previously, Stan was Founding Chief Scientific Officer at Cellino Biotech, where he led R&D and application of its technology to rapidly engineer cells. Stan received his Ph.D. from the University of Cambridge and his M.D. from Columbia University. He was a ...
Oct 22, 2023•13 min•Season 40Ep. 2
In this episode Dr Wang explains about the thymus gland and his technology for not only restoring the thymus but building new thymuses from iPCSs at scale. Stan Wang is Founder and CEO of Thymmune Therapeutics, a cell therapy company working to address high unmet needs across immunology. Previously, Stan was Founding Chief Scientific Officer at Cellino Biotech, where he led R&D and application of its technology to rapidly engineer cells. Stan received his Ph.D. from the University of Cambrid...
Oct 19, 2023•23 min•Season 40Ep. 1
Here Dr Tan talks about tocotrienols in bone health, what an appropriate dosage is and it is better not to take alpha tocopherol with the tocotrienols. Dr. Barrie Tan was formerly an assistant professor at the University of Massachusetts in Amherst (Chemistry, Food Science & Nutrition). His mission at American River Nutrition is to deliver the highest quality nutritional products based on sound scientific research. Today, his research focuses on lipid-soluble nutrients that have the potentia...
Oct 17, 2023•12 min•Season 39Ep. 3
Here Dr Tan talks about the trails that have been run on tocotrienols and the results that have been seen. They have beneficial effects on a number of the markers of metabolic syndrome, such as the lipid panel and liver fat. Dr. Barrie Tan was formerly an assistant professor at the University of Massachusetts in Amherst (Chemistry, Food Science & Nutrition). His mission at American River Nutrition is to deliver the highest quality nutritional products based on sound scientific research. Toda...
Oct 15, 2023•19 min•Season 39Ep. 2
Here Dr Tan introduces the forms of vitamin E, how they are different and why this matters. He also discusses why a fat based anti-oxidant is required and where alpha tocotrienol is found in nature. Dr. Barrie Tan was formerly an assistant professor at the University of Massachusetts in Amherst (Chemistry, Food Science & Nutrition). His mission at American River Nutrition is to deliver the highest quality nutritional products based on sound scientific research. Today, his research focuses on...
Oct 12, 2023•20 min•Season 39Ep. 1
Dr. Nathan Price is the Chief Scientific Officer of Thorne HealthTech. He is co-author with Lee Hood of The Age of Scientific Wellness, and has written articles for The Wall Street Journal, LA Times, and Scientific American. In 2019, he was named one of 10 Emerging Leaders in Health and Medicine by the National Academy of Medicine, and in 2021 he was appointed to the Board on Life Sciences of the National Academies of Sciences, Engineering, and Medicine. 🌐Links in this video Thorne https://www....
Oct 10, 2023•28 min•Season 38Ep. 3
Here Dr Price talks about some of the things that they learned during the pilot exercises, about biomarkers and the gut microbiome. Dr. Nathan Price is the Chief Scientific Officer of Thorne HealthTech. He is co-author with Lee Hood of The Age of Scientific Wellness, and has written articles for The Wall Street Journal, LA Times, and Scientific American. In 2019, he was named one of 10 Emerging Leaders in Health and Medicine by the National Academy of Medicine, and in 2021 he was appointed to th...
Oct 08, 2023•27 min•Season 38Ep. 2
Here Dr Price talks about the concepts of Scientific Wellness and the pilot projects that he and his team ran to try this out. Dr. Nathan Price is the Chief Scientific Officer of Thorne HealthTech. He is co-author with Lee Hood of The Age of Scientific Wellness, and has written articles for The Wall Street Journal, LA Times, and Scientific American. In 2019, he was named one of 10 Emerging Leaders in Health and Medicine by the National Academy of Medicine, and in 2021 he was appointed to the Boa...
Oct 05, 2023•11 min•Season 38Ep. 1
Here Prof Kaeberlein talks about where he sees longevity going in the near future. We also talk about personalized medicine and whether it is ready for general use. Dr. Kaeberlein’s research interests are focused on biological mechanisms of aging in order to facilitate translational interventions that promote healthspan and improve quality of life. He has published more than 200 scientific papers, has been recognized by several prestigious awards, and has Fellow status in the American Associatio...
Oct 03, 2023•10 min•Season 37Ep. 6
Here Prof Kaeberlein discusses his thoughts on exercise and diet. In particular he goes into detail on intermittent fasting, time restricted feeding and calorie restriction. Dr. Kaeberlein’s research interests are focused on biological mechanisms of aging in order to facilitate translational interventions that promote healthspan and improve quality of life. He has published more than 200 scientific papers, has been recognized by several prestigious awards, and has Fellow status in the American A...
Sep 30, 2023•19 min•Season 37Ep. 5
Here Prof Kaeberlein talks about the million molecule challenge and why he thought that it was necessary. Dr. Kaeberlein’s research interests are focused on biological mechanisms of aging in order to facilitate translational interventions that promote healthspan and improve quality of life. He has published more than 200 scientific papers, has been recognized by several prestigious awards, and has Fellow status in the American Association for the Advancement of Science (AAAS), the American Aging...
Sep 28, 2023•7 min•Season 37Ep. 3
Here Prof Kaeberlein talks about the Dog Aging Project a study which is following 100,000's of dogs to understand aging better and includes a RTC of rapamycin related to lifespan. Dr. Kaeberlein’s research interests are focused on biological mechanisms of aging in order to facilitate translational interventions that promote healthspan and improve quality of life. He has published more than 200 scientific papers, has been recognized by several prestigious awards, and has Fellow status in the Amer...
Sep 26, 2023•7 min•Season 37Ep. 3
Here Prof Kaeberlein talks about the recent paper on taurine deficiency as a driver of aging and makes some comparisons between taurine and rapamycin. Dr. Kaeberlein’s research interests are focused on biological mechanisms of aging in order to facilitate translational interventions that promote healthspan and improve quality of life. He has published more than 200 scientific papers, has been recognized by several prestigious awards, and has Fellow status in the American Association for the Adva...
Sep 24, 2023•7 min•Season 37Ep. 2
Here Prof Kaeberlein provides some updates on rapamycin, in particular the results from the survey based trial that his team ran and thoughts on next steps for the supplement. Dr. Kaeberlein’s research interests are focused on biological mechanisms of aging in order to facilitate translational interventions that promote healthspan and improve quality of life. He has published more than 200 scientific papers, has been recognized by several prestigious awards, and has Fellow status in the American...
Sep 21, 2023•22 min•Season 37Ep. 1
Here we discuss how to measure your gut microbiome, what the future of probiotic and gut microbiome research may hold and what Dr Cutcliffe's personal regimen is. 🌐Links in this video Colleen Cutcliffe is the Chief Executive Officer and co-founder of Pendulum. She has more than 15 years of experience leading and managing biology teams in academia, pharmaceuticals, and biotechnology. Prior to starting Pendulum, Colleen was the senior manager of biology at Pacific Biosciences and a scientist at E...
Sep 17, 2023•17 min•Season 36Ep. 4
Metabolic Daily is a less potent but more available form of the Glucose Control probiotic used in the clinical trial. Dr Colleen Cutcliffe discusses the differences in the formulations, the best time to take and what effects people have seen 🌐Links in this video Colleen Cutcliffe is the Chief Executive Officer and co-founder of Pendulum. She has more than 15 years of experience leading and managing biology teams in academia, pharmaceuticals, and biotechnology. Prior to starting Pendulum, Collee...
Sep 14, 2023•13 min•Season 36Ep. 3
We talk to Dr Colleen Cutcliffe about a clinical trial that they ran with 5 strains of probiotic. We also talk about whether the strains remained resident and what are the best prebiotics for akkermansia. 🌐Links in this video Colleen Cutcliffe is the Chief Executive Officer and co-founder of Pendulum. She has more than 15 years of experience leading and managing biology teams in academia, pharmaceuticals, and biotechnology. Prior to starting Pendulum, Colleen was the senior manager of biology a...
Sep 12, 2023•12 min•Season 36Ep. 2
We talk to Dr Colleen Cutcliffe about akkermansia muciniphila a probiotic that is involved in Some links are affiliate links so we will earn a commission when they are used to purchase products. 🌐Links in this video Colleen Cutcliffe is the Chief Executive Officer and co-founder of Pendulum. She has more than 15 years of experience leading and managing biology teams in academia, pharmaceuticals, and biotechnology. Prior to starting Pendulum, Colleen was the senior manager of biology at Pacific ...
Sep 10, 2023•12 min•Season 36Ep. 1
This is a bonus extra where we asked Dr Baur for his view on the recent taurine longevity paper as he had written a perspective piece in the same publication - Taurine linked with healthy aging https://www.science.org/doi/10.1126/science.adi3025 🌐Links in this video The Baur Lab website https://www.med.upenn.edu/baurlab/ Catch us on YouTube 10% Discount on Renue By Science products with code MHS https://renuebyscience.com/ Use SUBMHS for 15% on subscriptions NOVOS Core & NOVOS Boost https...
Sep 07, 2023•21 min•Season 35Ep. 6
We talk to Dr Joseph Baur about NMNH and NRH and some of the ways that his lab is working on optimizing NAD boosters by trying to get more of the NAD into the mitochondria and testing on larger animals and in humans. 🌐Links in this video The Baur Lab website https://www.med.upenn.edu/baurlab/ Catch us on YouTube: https://www.youtube.com/c/modernhealthspan 10% Discount on Renue By Science products with code MHS https://renuebyscience.com/ Use SUBMHS for 15% on subscriptions NOVOS Core & NOVO...
Sep 05, 2023•10 min•Season 35Ep. 5
We talk to Dr Joseph Baur about how the NAD precursors are absorbed when administered in different formats and what is seen in the biochemistry after that. And some really weird interaction between mammals and bacteria with nicotinamide/nicotinic acid in the gut. 🌐Links in this video The Baur Lab website https://www.med.upenn.edu/baurlab/ Catch us on YouTube: https://www.youtube.com/c/modernhealthspan 10% Discount on Renue By Science products with code MHS https://renuebyscience.com/ Use SUBMHS...
Sep 02, 2023•17 min•Season 35Ep. 4
We talk to Dr Joseph Baur about results from trials of NAD boosters in mice and human trials and possible reasons for why the positive results in mice have not translated to humans. 🌐Links in this video The Baur Lab website https://www.med.upenn.edu/baurlab/ Catch us on YouTube: https://www.youtube.com/c/modernhealthspan 10% Discount on Renue By Science products with code MHS https://renuebyscience.com/ Use SUBMHS for 15% on subscriptions NOVOS Core & NOVOS Boost https://novoslabs.com/?ref=...
Aug 31, 2023•12 min•Season 35Ep. 3
We talk to Dr Joseph Baur about how NAD metabolism changes with age, especially the role of NAMPT, the consuming enzymes and NAD boosters. 🌐Links in this video The Baur Lab website https://www.med.upenn.edu/baurlab/ Catch us on YouTube: https://www.youtube.com/c/modernhealthspan 10% Discount on Renue By Science products with code MHS https://renuebyscience.com/ Use SUBMHS for 15% on subscriptions NOVOS Core & NOVOS Boost https://novoslabs.com/?ref=3957 $5 off any purchase if users use code ...
Aug 28, 2023•13 min•Season 35Ep. 2
We talk to Dr Joseph Baur about the evidence of NAD decline with age and how it can be restored with exercise. We also touch on NAD/NADH ratio. Some links are affiliate links so we will earn a commission when they are used to purchase products. 🌐Links in this video The Baur Lab website https://www.med.upenn.edu/baurlab/ Catch us on YouTube: https://www.youtube.com/c/modernhealthspan 10% Discount on Renue By Science products with code MHS https://renuebyscience.com/ Use SUBMHS for 15% on subscri...
Aug 27, 2023•10 min•Season 35Ep. 1
We talk to Dr Vijay Yadav about his planned next steps for interventional human trials and what doses he will try. Dr Yadav leads the Systems Biology of Aging Laboratory, which aims to identify novel functional connections between organs and to unravel factors that underlie human metabolism and its disorders. The lab's expertise is in the development of a variety of technologies including mouse genetic (CRISPR/Cas, homologous recombination in embryonic stem cells, iPS cells), genomic (Nucleic ac...
Aug 24, 2023•9 min•Season 34Ep. 4
We talk to Dr Vijay Yadav about the human results from the trial and how the dosage might translate into humans. Dr Yadav leads the Systems Biology of Aging Laboratory, which aims to identify novel functional connections between organs and to unravel factors that underlie human metabolism and its disorders. The lab's expertise is in the development of a variety of technologies including mouse genetic (CRISPR/Cas, homologous recombination in embryonic stem cells, iPS cells), genomic (Nucleic acid...
Aug 22, 2023•17 min•Season 34Ep. 3
