Mind & Matter - podcast cover

Mind & Matter

Whether food, drugs or ideas, what you consume influences who you become. Learn directly from the best scientists & thinkers alive today about how your mind-body reacts to what you feed it.

The weekly M&M podcast features conversations with the most interesting scientists, thinkers, and technology entrepreneurs alive today.


Not medical advice.

At M&M, we are interested in trying to figure out how things work, not affirming our existing beliefs. We prefer consulting primary rather than secondary sources and independent rather than institutional voices. If we encounter uncomfortable truths or the evidence suggests unfashionable ideas may be valid, so be it.


As the host, my aim is to help you better understand how the body & mind work by curating & synthesizing information in a way that yields science-based insights that you can choose to use or disregard in your own life. Taking ownership of your health starts with taking ownership of your information diet.


I am motivated to connect the dots and distill general principles from what I learn, preferring to ask questions and play devil’s advocate to debating or incessantly pushing my own viewpoint.


My beliefs:


Sometimes modern discoveries teach us we must unlearn received wisdom. Other times, modern information overload & historical chauvinism cause us to forget ancient wisdom which stills applies. The framework for learning that I embody is inspired by three Ancient Greek maxims inscribed in the Temple of Apollo at Delphi:

  • “Γνῶθι σεαυτόν” (Know thyself)
  • “Μηδὲν ἄγαν” (Nothing in excess)
  • “Ἐγγύα πάρα δ Ἄτα” (Certainty brings insanity)

Episodes

Aging, Biological Clocks, Proteomics, Longevity & Healthspan | Austin Argentieri | 175

Send us a text About the guest: Austin Argentieri, PhD is a researcher in the Analytic & Translational Genetics Unit at the Massachusetts General Hospital with academic appointments at Harvard & the Broad Institute. His research focuses on large-scale analyses to to understand human aging. Episode summary: Nick and Dr. Argentieri discuss: chronological vs. biological age; DNA methylation and aging clocks; proteomics and protein measurements in aging research; health, longevity, and human...

Sep 03, 20241 hr 33 minSeason 4Ep. 175

Adipose Tissue & Body Fat: Obesity, Insulin, Leptin, Fertility, Weight Loss & GLP-1 Drugs | Sean Hartig | 174

Send us a text About the guest: Sean Hartig, PhD is an associate professor at the Baylor College of Medicine, where is lab studies adipose (fat) tissue, metabolic regulation, and obesity & energy balance disorders. Episode summary: Nick and Dr. Hartig discuss: visceral vs. subcutaneous fat; white, brown, and beige adipose tissue; physiology of fat cells; obesity, insulin resistance, and leptin resistance; hormones & fertility; GLP-1 drugs for weight loss; and more. Related episodes: Obes...

Aug 29, 20241 hr 44 minSeason 4Ep. 174

Psychedelics, Consciousness, Mental Health & the Entropic Brain | Robin Carhart-Harris | 173

Send us a text About the guest: Robin Carhart-Harris, PhD is a neuroscientist & psychopharmacologist. His lab at the University of California-San Francisco studies the effects of psychedelics and other drugs on the human brain, using neuroimaging and other approaches. Episode summary: Nick and Dr. Carhart-Harris discuss: psychedelics & the human brain; functional connectivity & entropy in brain patterns; the “entropic brain” hypothesis of psychedelic drug action; psychiatry & dep...

Aug 24, 20241 hr 58 minSeason 4Ep. 173

Immune System, Gut Microbiome, Vitamin D, Cancer, Innate Immunity, Inflammation & Gut-Immune Interactions | Caetano Reis e Sousa | 172

Send us a text About the guest: Caetano Reis e Sousa, DPhil is an immunologist and Principal Group Leader at the Francis Crick Institute in London. His lab studies immune system function, including its ability to fight infection and cancer. Episode summary: Nick and Dr. Reis e Sousa discuss: dendritic cells & innate immunity; how the immune system recognizes pathogens, damaged cells, and cancer cells; gut microbiome & non-pathogenic bacteria; inflammation; vitamin D & gut-immune inte...

Aug 21, 20241 hr 12 minSeason 4Ep. 172

Comparative Brain Evolution: Mammals, Primates & Humans | Robert Barton | 171

Send us a text About the guest: Robert Barton, PhD is an evolutionary anthropologist and Professor at Durham University. He studies the evolution of the brain and behavior across species, including humans. Episode summary: Nick and Dr. Barton discuss: mammalian brain evolution; how brain and body size scale across mammals; how metabolism relates to brain size and function; the evolution of the neocortex & cerebellum in primates & humans; the concept of “intelligence” and whether it relat...

Aug 18, 20241 hr 39 minSeason 4Ep. 171

Sex Differences, Drugs & the Brain: Psychedelics, Psilocybin, Alcohol & Nicotine | Melissa Herman | 170

Send us a text About the guest: Melissa Herman, PhD is a neuroscientist and associate professor at the University of North Carolina. Her lab studies the effects of drugs on the brain and behavior in rodents. Episode summary: Nick and Dr. Herman discuss: sex differences in the brain between males and females; behavioral variability among individuals; the effects of psychedelics like psilocybin on the amygdala and hypothalamus; effects of alcohol and vaporized nicotine; and more. Related episode: ...

Aug 14, 20241 hr 15 minSeason 4Ep. 170

Epigenetics, Chromatin Plasticity & the Neural Basis of Memory | Giulia Santoni | 169

Send us a text About the guest: Giulia Santoni, PhD is a neuroscientist who obtained her PhD at the EPFL in Switzerland, where she studied epigenetic influences on memory formation. Episode summary: Nick and Dr. Santoni discuss: transcription & gene regulation; synaptic plasticity; learning & associative memory; epigenetics, histones, DNA methylation, and mechanisms of gene regulation; chromatin plasticity & the neural basis of memory formation; and more. Related episodes: Emotion, C...

Aug 09, 20241 hr 24 minSeason 4Ep. 169

Sleep: Neural Circuits, Orexin/Hypocretin, Hypothalamus, Neuromodulators, Stress & Cortisol, Sleep Drugs & Ultrasound Technology | Luis de Lecea | 168

Send us a text About the guest: Luis de Lecea, PhD is a neurobiologist whose lab at Stanford University studies the neural basis of sleep & wakefulness in animals. Episode summary: Nick and Dr. de Lecea discuss: the neural basis of sleep; sleep architecture & sleep phases (NREM vs. REM sleep); orexin/hypocretin neurons & the lateral hypothalamus; cortisol & stress; circadian rhythms; neuromodulators (norepinephrine, dopamine, etc); sleep across animal species; sleep drugs; ultras...

Aug 05, 20241 hr 40 minSeason 4Ep. 168

Plant Chemistry & the Chemical Basis of Marijuana Aroma | Iain Oswald | 167

Send us a text About the guest: Iain Oswald, PhD is an organic chemist and Director of Research & Development at Abstrax Tech. Episode summary: Nick and Dr. Oswald discuss: plant chemistry; marijuana strains and their aroma; the chemical basis of cannabis aroma; terpenes vs. non-terpene volatile organic compounds; and more. Related episodes: Marijuana, Plant Chemistry, Terpenes, Volatile Sulfur Compounds, Cannabis Industry, What Pungent Weed Smells Like & Why | Iain Oswald | #114 Endocan...

Jul 26, 202451 minSeason 4Ep. 167

History of Diet & Food, Population Size & Social Stability, Psychological Pandemics, Physical & Mental Health in Civilization Cycles | Rudyard Lynch | 193

Send us a text About the guest: Rudyard Lynch is a history and anthropology scholar and host of the popular YouTube channel, whatifalthist. Episode summary: Nick and Rudyard discuss: history of agriculture, diet & food; population density, social structure, and social behavior; the rise and fall of civilizations; history and future of religion & spirituality; and more. Independent Scholars Series: Episodes in this podcast sub-series are freely available in partial form to all listeners. ...

Jul 19, 202436 minSeason 4Ep. 193

Evolution: Natural Selection, Genetic Drift, Origin of Life, Cellular Complexity, Epigenetics | Michael Lynch | 166

Send us a text About the guest: Michael Lynch, PhD is an evolutionary biologist at Arizona State University who studies the origins of genomic and cellular complexity. Episode summary: Nick and Dr. Lynch discuss: natural selection vs. genetic drift; genetic mutations & the speed of evolution; origin of life; the evolution of cellular complexity; epigenetics & the inheritance of acquired characteristics; and more. Related episodes: Evolution & Animal Development: How Nature Builds &am...

Jul 14, 20241 hr 29 minSeason 4Ep. 166

PUFAs in Brain Health & Disease, Dietary Fats, Brain Lipids, Nutrition | Richard Bazinet | 165

Send us a text About the guest: Richard Bazinet, PhD is neurochemist and nutritional scientist at the University of Toronto. His lab studies brain lipid metabolism in health and disease. Episode summary: Nick and Dr. Bazinet discuss: lipid metabolism in the liver and brain; dietary fatty acids (saturated, monounsaturated, polyunsaturated); fatty acids in brain health & disease; endocannabinoids; omega-3 PUFAs, seed oils & diet; and more. *This content is never meant to serve as medical a...

Jul 10, 20241 hr 41 minSeason 4Ep. 165

Seed Oils, Chronic Disease, Diet & Religious Cults, Mainstream Medicine vs. Independent Research | Tucker Goodrich | 192

Send us a text About the guest: Tucker Goodrich is an independent researcher and self-described “seed oil zealot” who credits many of his own health improvements with minimizing his consumption of industrial seed oils. He runs a Substack page, and provides interesting commentary about scientific research on seed oils, metabolic health, and related topics. Episode summary: Nick and Tucker discuss: what seed oils are and their history; differences between omega-6 and omega-3 polyunsaturated fatty ...

Jun 30, 202421 minSeason 4Ep. 192

Dopamine, Reward, Motivation, Lateral Hypothalamus, Feeding Behavior & Eating Disorders | Melissa Sharpe | 164

Send us a text About the guest: Melissa Sharpe, PhD is a neuroscientist. Her lab at the University of Sydney studies reinforcement and reward learning in rodents. Episode summary: Nick and Dr. Sharpe discuss: dopamine and its association with reward learning and motivation; reinforcement learning & the brain; the lateral hypothalamus and feeding behavior; and more. Related episodes: Drugs, Addiction & Neuroplasticity: Psychedelics, MDMA, Opioids, Cocaine, Amphetamine (Adderall), Nicotine...

Jun 26, 20241 hr 9 minSeason 4Ep. 164

Anesthesia, Placebo Effects, Consciousness, Subjectivity, MDMA, Ketamine, Opioids, Psychedelics | Boris Heifets | 163

Send us a text About the guest: Boris Heifets, MD, PhD is an anesthesiologist and researcher at Stanford University. His lab studies non-ordinary states of consciousness and psychoactive drugs like MDMA, ketamine, and psychedelics. Episode summary: Nick and Dr. Heifets discuss: anesthesia and how anesthetics work; placebo effects & expectations in clinical research; ketamine as an antidepressant, anesthetic, and recreational drug; the subjective effects of psychedelics and other drugs; MDMA ...

Jun 22, 20241 hr 45 minSeason 4Ep. 163

Drugs, Addiction & Neuroplasticity: Psychedelics, MDMA, Opioids, Cocaine, Amphetamine (Adderall), Nicotine, Marijuana & Alcohol | Robert Malenka | 162

Send us a text About the guest: Robert Malenka, MD, PhD is psychiatrist & neuroscientist. He has spent most of his career at Stanford University, where his lab studies synaptic plasticity, mechanisms of drug action in the brain, and the neural basis of behavior. Episode summary: Nick and Dr. Malenka discuss: mechanisms of synaptic plasticity in the brain, such as LTP & LTD; addiction & the dopamine reward circuitry of the brain; psychoactive drugs ranging from stimulants (cocaine, ni...

Jun 16, 20241 hr 35 minSeason 4Ep. 162

GLP-1, Weight Loss Drugs, Ozempic, Obesity, NMDA Receptors, Metabolism & Brain Health | Christoffer Clemmensen | 161

Send us a text About the guest: Christoffer Clemmensen, PhD is scientist running the Metabolism & Molecular Pharmacology group at the University of Copenhagen in Denmark. His lab studies the biological basis of obesity & other metabolic disorders. Episode summary: Nick and Dr. Clemmensen discuss: GLP-1 & gut hormones; obesity & metabolic disease; GLP-1 agonists and weight loss drugs (e.g. Ozempic); novel, dual-action weight loss drugs his lab has created; and more. Previous discu...

Jun 12, 20241 hr 33 minSeason 4Ep. 161

Diet, Hunting, Culture and Evolution of Paleolithic Humans & Hunter Gatherers | Eugene Morin | 160

Send us a text About the guest: Eugene Morin, PhD is a Professor of Anthropology at the University of Trent who studies Paleolithic humans and animals. Episode summary: Nick and Dr. Morin discuss evolution of Paleolithic humans; Neanderthal diet & cultural capacity; key human adaptations related to endurance and stamina; hunter gatherer hunting strategies; evolution of human digestion; and more. *This content is never meant to serve as medical advice. Support the show All episodes, show note...

Jun 01, 20241 hr 24 minSeason 4Ep. 160

Neuroscience of Social Behavior, Pain, Empathy, Emotion, Brain Mechanisms of MDMA | Monique Smith | 159

Send us a text About the guest: Monique Smith, PhD is an assistant professor of neurobiology at the University of California-San Diego, where her lab studies the neuroscience of social behavior, pain, and emotion. Episode summary: Nick and Dr. Smith discuss: the neurobiology of pain perception; social & empathy-like behavior in animals; emotion; brain mechanisms of MDMA; serotonin; and more. *This content is never meant to serve as medical advice. Support the show All episodes, show notes, t...

May 23, 20241 hr 27 minSeason 4Ep. 159

Ketosis & Ketogenic Diet: Brain & Mental Health, Metabolism, Diet & Exercise, Cancer, Diabetes | Dominic D'Agostino | 158

Send us a text About the guest: Dominic D'Agostino, PhD is a researcher and professor at the University of South Florida, where his lab studies metabolism, human biology, and related subjects. Episode summary: Nick and Dr. D'Agostino discuss: ketosis and the ketogenic diet; effects of ketosis on diabetes, insulin resistance & metabolic health; effects on brain & mental health; relationship with exercise performance; cholesterol, LDL, triglycerides & other biomarkers; cancer; and more...

May 16, 20241 hr 42 minSeason 4Ep. 158

Preventative Medicine & Lies Taught in Medical Schools | Robert Lufkin | 157

Send us a text About the guest: Robert Lufkin, MD is a radiologist and professor at UCLA. His new book is called, " Lies I Taught in Medical School ." Episode summary: Nick and Dr. Lufkin talk about: the history of medicine in the United States; diet & lifestyle vs. pharmaceuticals in acute vs. chronic disease; diabetes, metabolic syndrome & insulin resistance; health institutions like the American Diabetes Association & American Heart Association, including their financial influence...

May 09, 20241 hr 45 minSeason 4Ep. 157

Psychology of Stress, Resilience, Emotion & Child Development | Stephen Sideroff | 156

Send us a text About the guest: Stephen Sideroff, PhD is a clinical psychologist and Associate Professor of Psychiatry and Behavioral Sciences at UCLA. His new book is, " The 9 Pillars of Resilience ." Episode summary: Nick and Dr. Sideroff discuss: childhood & developmental psychology; clinical & Gestalt psychology; stress & resilience; pharmaceuticals, talk therapy, and plant medicines; emotions & psychopathology; and more. *This content is never meant to serve as medical advic...

May 03, 20241 hr 40 minSeason 4Ep. 156

Cell Biology of Aging, Mitochondria, Metabolism, Autophagy & Stress | Andrew Dillin | 155

Send us a text About the guest: Andrew Dillin, PhD is Professoer of Molecular & Cell Biology at UC-Berkeley and Howard Hughes Medical Institute investigator. His lab studies mechanisms of aging, mitochondrial biology, and related subjects. Episode summary: Nick and Dr. Dillin discuss: cell biology; mitochondria & the endoplasmic reticulum; aging & autophagy; mitochondrial biology in neurons; diet, exercise, and oxygen effects on mitochondrial health; and more. *This content is never ...

Apr 29, 20241 hr 40 minSeason 4Ep. 155

Evolution & Genetics of Human Diet, Disease Risk, Skin Color & Origins of Modern Europeans | Eske Willerslev | 154

Send us a text About the guest: Eske Willerslev, PhD is an evolutionary biologist and Professor of evolution at both the University of Copenhagen and University of Cambridge. Episode summary: Nick and Dr. Willerslev discuss: human evolution out of Africa; the origins of modern Europeans; hunter gatherers, early farmers, and pastoralists; genetics of human disease risk; evolution of diet & metabolism; evolution of light skin color; and more. *This content is never meant to serve as medical ad...

Apr 24, 20241 hr 52 minSeason 4Ep. 154

Diet, Nutrition, Metabolic Psychiatry, Brain & Mental Health | Georgia Ede | 153

Send us a text About the guest: Georgia Ede, MD is a psychiatrist and author of, "Change Your Diet, Change Your Mind: A Powerful Plan to Improve Mood, Overcome Anxiety, And Protect Memory for a Lifetime of Optimal Mental Health." Episode summary: Nick and Dr. Ede discuss: glucose vs. ketones for brain energy; metabolic health & insulin resistance; animal vs. plant-based foods; nutrients, anti-nutrients & plant toxins; ketogenic, carnivore & plant-based diets; carbohydrates & proc...

Apr 19, 20241 hr 51 minSeason 4Ep. 153

Plant Chemistry, Cannabinoids, Cannabis Terpenes & the Entourage Effect | Ryan Vandrey | 152

Send us a text About the guest: Ryan Vandrey, PhD is a Professor of Psychiatry & Behavioral Sciences at Johns Hopkins University, where his lab studies the behavioral pharmacology of cannabis (marijuana), nicotine/tobacco, and other substances. Episode summary: Nick and Dr. Vandrey discuss: marijuana; cannabinoids like THC; terpenes like limonene, myrcene, and pinene; the entourage effect; anxiety and other side effects of cannabis consumption; and more. *This content is never meant to serve...

Apr 12, 20241 hr 31 minSeason 4Ep. 152

Aging, mTOR, Sirtuins, Rapamycin, Metformin, the Truth of Resveratrol & Longevity Supplements, David Sinclair & Anti-Aging Myths | Matt Kaeberlein | 151

Send us a text About the guest: Matt Kaeberlein, PhD is a Professor of at the University of Washington and CEO of OptiSpan. His research focuses on the biology of aging and longevity. Episode summary: Nick and Dr. Kaeberlein discuss: the biology of aging; mTOR, FGF1, growth & metabolism; sirtuins, NAD & NMN; longevity drugs like metformin & rapamycin; facts & myths about longevity molecules like resveratrol & taurine; controversies in aging research related to prominent Harva...

Apr 07, 20242 hr 29 minSeason 4Ep. 151

Visual System, Visual Impairments & Cures, Amblyopia, Neuroplasticity, Critical Periods & Metaplasticity, Ketamine & Psychedelics | Mark Bear | 150

Send us a text About the guest: Mark Bear, PhD is a Professor of Neuroscience at MIT, where his lab studies the visual system, neuroplasticity, and the pathophysiology of amblyopia and visual impairments. Episode summary: Nick and Dr. Bear discuss: the visual system in the brain, from the retina to visual cortex; critical periods of brain development; mechanisms of neuroplasticity; metaplasticity; amblyopia and visual impairments; ketamine & psychedelics; and more. *This content is never mea...

Apr 03, 20241 hr 16 minSeason 4Ep. 150

DNA & RNA Biology, mRNA Vaccines, Vaccine Contamination & Side Effects, Spike Protein, Ivermectin, Hop Latent Viroid | Kevin McKernan | 149

Send us a text About the guest: Kevin McKernan is the Chief Science Officer at Medicinal genomics and has been working the the biotechnology sector and conducting genomics research going back to his involvement in the Human Genome Project. Episode summary: Nick and Kevin discuss: basics of DNA and RNA biology; mRNA vaccines and how they work compared to traditional vaccines; the mRNA vaccine manufacturing process; DNA contamination in the Pfizer and Modern mRNA vaccines for COVID; the SARS-CoV-2...

Mar 30, 20241 hr 51 minSeason 4Ep. 149

Dietary Protein, Muscle Growth, Resistance Training, Amino Acids, Plant vs. Animal Protein Sources, Anabolic Growth | Luc van Loon | 148

Send us a text About the guest: Luc van Loon, PhD is a Professor of Physiology of Exercise and Nutrition and Head of the M3-research group at the Department of Human Biology at Maastricht University. His lab focuses on the skeletal muscle adaptive response to physical (in)activity, the impact of nutrition on metabolism, and related topics. Episode summary: Nick and Dr. van Loon discuss: amino acid biology; branched chain amino acids like leucine; atypical amino acids like taurine; muscle growth ...

Mar 27, 20241 hr 23 minSeason 4Ep. 148
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