Mind & Matter - podcast cover

Mind & Matter

Whether food, drugs or ideas, what you consume influences who you become. Learn directly from the best scientists & thinkers alive today about how your mind-body reacts to what you feed it.

The weekly M&M podcast features conversations with the most interesting scientists, thinkers, and technology entrepreneurs alive today.


Not medical advice.

At M&M, we are interested in trying to figure out how things work, not affirming our existing beliefs. We prefer consulting primary rather than secondary sources and independent rather than institutional voices. If we encounter uncomfortable truths or the evidence suggests unfashionable ideas may be valid, so be it.


As the host, my aim is to help you better understand how the body & mind work by curating & synthesizing information in a way that yields science-based insights that you can choose to use or disregard in your own life. Taking ownership of your health starts with taking ownership of your information diet.


I am motivated to connect the dots and distill general principles from what I learn, preferring to ask questions and play devil’s advocate to debating or incessantly pushing my own viewpoint.


My beliefs:


Sometimes modern discoveries teach us we must unlearn received wisdom. Other times, modern information overload & historical chauvinism cause us to forget ancient wisdom which stills applies. The framework for learning that I embody is inspired by three Ancient Greek maxims inscribed in the Temple of Apollo at Delphi:

  • “Γνῶθι σεαυτόν” (Know thyself)
  • “Μηδὲν ἄγαν” (Nothing in excess)
  • “Ἐγγύα πάρα δ Ἄτα” (Certainty brings insanity)
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Episodes

Ketamine: Opioid System, Sex Differences, S- vs. R- Isomers, Depression & Ultrasound Imaging Technology | Tommaso Di Ianni | 147

Send us a text About the guest: Tommaso Di Ianni, PhD is an Assistant Professor in the Departments of Psychiatry & Behavioral Sciences and Radiology & Biomedical Imaging at the University of California, San Francisco. His lab uses ultrasound technology and deep learning to study the brain. Episode summary: Nick and Dr. Di Ianni discuss: the current state of scientific understanding of ketamine; S-ketamine vs. R-ketamine isomers; the antidepressant effects of ketamine; ketamine's known me...

Mar 22, 20241 hr 21 minSeason 4Ep. 147

Photobiology, Sunlight, Firelight, Incandescent Bulbs vs. LEDs, Mitochondria, Melatonin, Sunscreen & the Optics of the Body | Scott Zimmerman | 146

Send us a text About the guest: Scott Zimmerman is an optical engineer and photobiology expert Episode summary: Nick and Scott talk about: how light interacts with the body and affects our cells; melatonin as an antioxidant; how red & near-infrared light affect mitochondria; sunlight, fire light, and artificial light; incandescent light bulbs vs. LEDs; negative health effects of artificial light; sunscreen & makeup; red & near-infrared light therapy; the optical properties of the hum...

Mar 19, 20241 hr 17 minSeason 4Ep. 146

Epigenetics, Hormones, Endocrine Disruptors, Microplastics, Xenoestrogens, Obesity, Inheritance of Acquired Characteristics | Bruce Blumberg | 145

Send us a text About the Guest: Bruce Blumberg, PhD is a Professor of Cell & Developmental Biology at UC-Irvine. HIs lab studies epigenetics, gene x environment interactions, hormones & endocrine disruptors, obesogens & environmental toxins, and more. Episode Summary: Nick and Dr. Blumberg discuss: Embryonic development; hormones and hormone receptors; estrogen & xenoestrogens; environmental toxins, obesogens, pesticides & contaminants; environmental causes of obesity; microp...

Mar 14, 20241 hr 31 minSeason 4Ep. 145

Inflammation, Innate Immunity, Allergies & Allergens, Immune System Evolution, Fasting & Metabolism | Clare Bryant | 144

Send us a text About the Guest: Clare Bryant, DVM is a Professor of Innate Immunity at Cambridge University. Her lab studies the innate immune system, pathogen detection, inflammation, and chronic disease. Episode Summary: Nick and Dr. Bryant discuss: mechanisms of inflammation; inflammasomes & fatty acids; infection & disease; innate vs. adaptive immunity; chronic inflammation; allergies & allergens; the evolution of the immune system; anti-inflammatory effects of fasting; and more....

Mar 10, 20241 hr 32 minSeason 4Ep. 144

Gut-Brain Communication, Vagus Nerve, Fats & Sugars, Food Addiction, Gut Hormones & Weight Loss Drugs | Will de Lartigue | 143

Send us a text Dr. Guillaume (Will) de Lartigue is a neuroscientist at the Monell Chemical Senses Center. His lab studies the neurobiology of eating, including how the vagus nerve senses internal stimuli in the gut. They discuss: gut-brain communication; the vagus nerve; gut hormones like leptin & GLP-1; weight loss drugs like Ozempic; glucose vs. fructose vs. non-caloric sweeteners; how the vagus nerve connects the gut to the dopamine reward system in the brain; the sensation of fats and su...

Mar 05, 20241 hr 27 minSeason 4Ep. 143

Endogenous DMT in the Mammalian Brain | Nicolas Glynos | 142

Send us a text Dr. Nicolas Glynos received his PhD in Molecular & Integrative Physiology from the University of Michigan, where he studied the psychedelic drug DMT in the mammalian brain. They discuss: the history of DMT research; the use of DMT in ayahuasca; whether DMT is found endogenously in animals; why plants produce DMT; pineal gland, DMT & melatonin; the latest research looking at the presence and effects of DMT in the brain; and more. *Not medical advice. Support the show All ep...

Feb 29, 20241 hr 37 minSeason 4Ep. 142

Evolution, Language, Domestication, Symbolic Cognition, AI & Large Language Models | Terrence Deacon | 141

Send us a text About the Guest: Terrence Deacon, PhD is a Professor in the department of Anthropology at UC-Berkeley. He has written many papers and multiple books about the evolution of human language, origins of consciousness, and related topics. Episode Summary: Nick and Dr. Deacon discuss various aspects of biological evolution, from natural vs. sexual selection to gene duplication and the consequences of domestication; the domestication of dogs and songbirds; human vs. non-human forms of vo...

Feb 24, 20242 hr 14 minSeason 4Ep. 141

Obesogens, Oxidative Stress, Dietary Sugars & Fats, Statins, Diabetes & Causes of Metabolic Dysfunction & Chronic Disease | Robert Lustig | 140

Send us a text About the guest: Robert Lustig, MD is a physician-researcher and expert of metabolic health. He is Professor emeritus of Pediatrics, Division of Endocrinology at the University of California, San Francisco (UCSF), specializing in neuroendocrinology with an emphasis on the regulation of energy balance by the central nervous system. His research and clinical practice has focused on childhood obesity and diabetes. Episode summary: Nick and Dr. Lustig discuss the true causes of obesit...

Feb 17, 20242 hrSeason 4Ep. 140

Metabolic Switching, Fasting, Ketosis, Neuroplasticity, Diet & Neurodegenerative Disease | Mark Mattson | 139

Send us a text About the Guest: Mark Mattson, PhD is a semi-retired neuroscientist at Johns Hopkins who ran a research lab at the NIH for many years. He wrote the book, "The Intermittent Fasting Revolution." Episode Summary: Nick and Dr. Mattson discuss: intermittent fasting & diet; ketosis & metabolic switching; aging & neurodegenerative disease; exercise, stress, and neuroplasticity; and more. *This content is never meant to serve as medical advice. Support the show All episodes, s...

Feb 14, 20241 hr 41 minSeason 4Ep. 139

Evolution & Animal Development: How Nature Builds & Changes Bodies | Sean B. Carroll | 138

Send us a text Sean B. Carroll, PhD is an evolutionary developmental biologist at the University of Maryland, who recently stepped down as VP of Education at the Howard Hughes Medical Institute. He is the author of many popular science books, such as "Endless Forms Most Beautiful." They discuss: developmental biology & genetics; evolutionary biology; genetics, genome size & genetic mutation; animal diversity; snake venom; human brain evolution; and more. *Not medical advice. Support the ...

Feb 09, 20241 hr 53 minSeason 4Ep. 138

DMT, Serotonin, Inflammation, Psychedelics, and Past, Present & Future of Psychedelic Medicine | David & Charles Nichols | 137

Send us a text Dr. David Nichols is a retired chemist and father of Dr. Charles Nichols, a researcher studying psychedelics at Louisiana State University. They discussed: the history of psychedelics science from the 1970s to the present; DMT & 5-MeO-DMT; serotonin, inflammation, and psychedelics & anti-inflammatory drugs; psilocybin, ketamine, and other psychoactive drugs; and more More M&M content about psychedelic science . *Not medical advice. Support the show All episodes, show n...

Feb 06, 20241 hr 38 minSeason 4Ep. 137

Seed Oils, Omega-6 Fats, Inflammation, Obesity, Diabetes, Chronic Disease & Metabolic Dysfunction | Chris Knobbe | 136

Send us a text Dr. Chris Knobbe is a physician, diet & nutrition researchers, and author of, "The Ancestral Diet Revolution." He discusses: seed oils & their health consequences; different types of seed oils (soybean, corn, sunflower, etc.); omega-6 fats like linoleic acid; fatty acid metabolism and oxidation; obesity, diabetes & metabolic health; processed foods vs. whole foods; mitochondria & oxidative stress; and more. *Not medical advice. Support the show All episodes, show n...

Jan 23, 20241 hr 34 minSeason 4Ep. 136

History of Diet Trends & Medical Advice in the US, Fat & Cholesterol, Seed Oils, Processed Food, Ketogenic Diet, Trust in Public Health Institutions | Orrin Devinsky | 135

Send us a text Dr. Orrin Devinsky is a neurologist and Professor at the New York University School of Medicine. They discuss: dietary consumption trends in the US; processed vs. whole foods; vegetable oils & polyunsaturated fats; relationship between saturated fat, dietary cholesterol & heart disease; history of medicine in the US; obesity & diabetes; sugars, fructose, and metabolic health; ketogenic diet & ketosis; whether or not we can trust our public health institutions; and ...

Jan 10, 20241 hr 41 minSeason 4Ep. 135

Omega-6-9 Fats, Vegetable & Seed Oils, Sugar, Processed Food, Metabolic Health & Dietary Origins of Chronic Inflammatory Disease | Artemis Simopoulos | 134

Send us a text Dr. Artemis Simopoulos is a physician and researcher specializing in endocrinology, nutrition, and metabolic health. They discuss: traditional hunter-gatherer diets vs. modern Western diets; dietary fats; omega-6 and omega-3 polyunsaturated fats; sucrose & sugar; chronic inflammatory diseases, obesity & diabetes; vegetable & seed oils vs. other cooking oils; processed foods; fish oil supplements; and more. More content on the science of diet & metabolic health. *No...

Jan 03, 20241 hr 27 minSeason 4Ep. 134

Infant Microbiome & Breast Milk, Oral Microbiome & Cavities, Gut Health, Fiber, Probiotics, Diet, Sex Hormones, Soy Foods & Estrogens | Carolina Tropini | 133

Send us a text Dr. Carolina Tropini is an assistant professor of Microbiology & Immunology at the University of British Columbia, where her lab studies the microbiome in health & disease. Topics covered: infant & vaginal microbiome, breast milk nutrients & C-sections vs. natural births; oral microbiome & cavities; gut microbiome & irritable bowel disease (IBD); fiber, short-chain fatty acids & probiotics; how gut bacteria influence sex hormones (estrogen, testosterone...

Dec 20, 20231 hr 37 minSeason 3Ep. 133

Obesity Epidemic, Metabolism, Saturated Fat vs. PUFAs, Energy Expenditure, Weight Gain & Feeding Behavior | John Speakman | 132

Send us a text Dr. John Speakman is a biologist whose research focuses on energy balance, energy expenditure, genetic and environmental drivers of obesity and the energetic contribution to aging. They discuss: the history of the obesity epidemic in the US vs. China; changes in patterns of physical activity, diet, and energy expenditure in humans over time; how saturated fats vs. PUFAs affect basal metabolism; the relative contributions of fats, carbs, and protein to fat & weight gain; and mo...

Dec 05, 20231 hr 13 minSeason 3Ep. 132

Dietary Fat, Cholesterol, Cardiovascular Health & Disease, Carbohydrates, Dietary Guidelines, Food Industry & Diet Research | Ronald Krauss | 131

Send us a text Nick talks to Dr. Ronald Krauss, a physician and researcher at UCSF who studies the relationship between diet & cardiometabolic health. They discuss: saturated vs. unsaturated fats; carbohydrates & fat synthesis; "good" vs. "bad" cholesterol; official US dietary guidelines and how they're established; funding of research by the food industry; and more. *Not medical advice. Support the show All episodes, show notes, transcripts, and more at the M&M Substack Affiliates: ...

Dec 04, 20231 hr 55 minSeason 3Ep. 131

Cognitive Neuroscience, Cognitive Flexibility & Control, Attention, Working Memory, Multitasking & Behavior | Tobias Egner | 130

Send us a text Dr. Tobias Egner is a Professor of Psychology & Neuroscience at Duke University, where his lab studies cognition, working memory, and cognitive control & flexibility. They discuss: what cognition is and how it's studied experimentally; working memory & attention; cognitive flexibility, cognitive control & multitasking; memory, perception, and predictive coding; and more. *Not medical advice. Support the show All episodes, show notes, transcripts, and more at the M&...

Nov 05, 20231 hr 13 minSeason 3Ep. 130

Biological Sex, Sexual Selection, Sex Behavior, Mating Strategies, Sexual Orientation, Monogamy & Polygyny | David Puts | 129

Send us a text Dr. David Puts is a biological anthropologist at the Penn State University. His research focuses on the evolution and development of human sexuality and sex differences. They discuss: the biological basis of sex; gametes, sex chromosomes & sex hormones; the development of sexual orientation; the evolution of sexual dimorphism & behavior in primates; monogamy & polygyny; and more. *Not medical advice. Support the show All episodes, show notes, transcripts, and more at t...

Oct 22, 20231 hr 48 minSeason 3Ep. 129

Peripheral Nervous System in Health & Disease, Gut Health & Enteric Nervous System, Exercise & Neuroplasticity | Moses Chao | 128

Send us a text Dr. Moses Chao is a professor at the New York University School of Medicine. His lab studies how the environment, neuronal activity, inflammation, injury and disease affect the nervous system. They discuss topics related to his new book, "Peripheral: How Your Nervous System Predicts and Protects Against Disease." Topics include: how the peripheral nervous system differs from the central nervous system; the enteric nervous system & gut health; pain sensation; exercise & neu...

Oct 16, 20231 hr 13 minSeason 3Ep. 128

Psychedelics, Microdosing Psilocybin, Stress Resilience, Anxiety & Obsessive Compulsive Disorder | Mikael Palner | 127

Send us a text Mikael Palner, PhD is a neuroscientist at the University of Souther Denmark. His lab studies the neuronal circuits involved in obsessive compulsive disorder and anxiety . They investigate the effects of serotonergic psychedelic and non-psychedelic drugs that increase neuronal plasticity. They discuss: psychedelics & the brain; the neuroscience of stress, anxiety & compulsive behavior; microdosing psilocybin; and more. More psychedelic science content . *Not medical advice....

Oct 11, 202359 minSeason 3Ep. 127

Evolution of Human Behavior, Anatomy & Diet, Homo naledi & the Cave of Bones | John Hawks | 126

Send us a text Dr. John Hawks is a paleoanthropologist and professor of anthropology at the University of Wisconsin-Madison. They discuss: the evolution of human behavior, diet, anatomy, and culture; Neanderthals, Denisovans, Homo erectus , and other species; the latest discoveries related to Homo naledi , which was the subject of the Netflix documentary, "Cave of Bones." To learn more about evolution, check out these episodes . *Not medical advice. Support the show All episodes, show notes, tra...

Aug 28, 20232 hr 4 minSeason 3Ep. 126

Anxiety, Obsessive Compulsive Disorder, Microglia, From Being a WWII Orphan to the Nobel Prize | Mario Capecchi | 125

Send us a text Dr. Mario Capecchi is a professor of genetics at the University of Utah & Nobel laureate. He discussed: his latest work in neurobiology, looking at the role of microglia in anxiety & Obsessive Compulsive Disorder (OCD); his Nobel Prize-winning work in molecular genetics; molecular biology & genetics; his childhood experiences as an orphan in Italy during World War II; immigrating to the US; his education & scientific career; his exercise & diet; advice for aspi...

Aug 21, 20231 hr 42 minSeason 3Ep. 125

Hormonal Contraception, Sex Hormones, Menstruation, Pregnancy, Puberty, Estrogens, Androgens, Effects of Birth Control on Cognition | Adriene Beltz | 124

Send us a text Dr. Adriene Beltz is an associated professor of psychology at the University of Michigan who studies the effects of sex hormones & hormonal contraception on human cognition and the brain. They discuss: sex hormones (androgens & estrogens); hormonal regulation of menstruation, puberty, and pregnancy; common forms of hormonal birth control & how they work; effects of sex hormones & hormonal birth control on cognition & the brain; and more. *Not medical advice. Su...

Aug 15, 20231 hr 29 minSeason 3Ep. 124

Endocannabinoids, Stress, Exercise, Cortisol, Anxiety, Cannabis & Effects of Marijuana on Brain Development | Matthew Hill | 123

Send us a text Nick talks to Dr. Matthew Hill, a neuroscientist at the University of Calgary whose lab studies how the endocannabinoid system and cannabis (marijuana) influence the brain & behavior. They discuss: endocannabinoid biology; endocannabinoid regulation of stress & anxiety; endocannabinoids & exercise; how marijuana & THC influence brain development; and more. See previous episode with Dr. Matthew Hill: https://mindandmatter.substack.com/p/matthew-hill-endocannabinoid-...

Aug 10, 20231 hr 30 minSeason 3Ep. 123

Cellular Aging, Taurine, Nutrition, Senescence, Longevity, Mitochondria, Metabolism | Vijay Yadav | 122

Send us a text Nick talks to molecular physiologist Dr. Vijay Yadav, an assistant professor at Columbia University whose lab studies the molecular & cell biology of aging, nutrition, and longevity. They discuss: the cell biology of aging; how nutrients affect aging & disease; the atypical amino acid taurine & its effects on aging; taurine clinical trials & supplementation; diet, nutrition & anti-aging effects; and more. *Not medical advice. Support the show All episodes, show...

Aug 02, 20231 hr 16 minSeason 3Ep. 122

Psychedelics, Metaplasticity, Critical Periods, Social Learning, Psilocybin, LSD, MDMA, Ketamine, Ibogaine & Neuroscience | Gül Dölen | 121

Send us a text Nick talks to Gül Dölen, MD, PhD, a neuroscientist at Johns Hopkins University whose lab studies social behavior, synaptic plasticity, psychedelics & evolution. They discuss: What drugs like LSD, psilocybin, ketamine, MDMA, and ibogaine have in common in terms of their molecular effects in the brain; why Dr. Gül Dölen believes all of these drugs can be described as "psychedelics"; the relationship between psychedelics and neuroplasticity vs. metaplasticity; how addictive drugs...

Jul 19, 20231 hr 43 minSeason 3Ep. 121

Psychedelics, Depression, Psychotherapy, SSRIs, Human Clinical Experience of Psychedelic Medicine | Alan Davis | 120

Send us a text Nick talks to Dr. Alan Davis, a clinical psychologist and Director of the Center for Psychedelic Drug Research & Education at Ohio State University. They discuss: the effectiveness of mainstream forms of psychotherapy and antidepressant medications (SSRIs) for depression; psychedelic medicine & psilocybin-assisted psychotherapy; the relevance of the subjective effects of psychedelics for their therapeutic effects; FDA approval for MDMA- and psilocybin-assisted psychotherap...

Jul 11, 20231 hr 7 minSeason 3Ep. 120

Psychedelics, Neuroplasticity, LSD, Psilocybin, Ketamine, MDMA, Latest Psychedelic Science | Bryan Roth | 119

Send us a text Nick talks to Bryan Roth, MD, PhD, a Professor of Pharmacology at the University of North Carolina. Dr. Roth has been studying the molecular mechanisms of psychedelics since the 1980s. They discuss: serotonin 2A receptors in the mammalian brain; psychedelics & neuroplasticity; classic psychedelics (e.g. LSD, psilocybin, DMT) compared to drugs like ketamine & MDMA; TrkB receptors & BDNF; engineering novel drugs & psychiatric treatment methods; latest findings in psy...

Jul 06, 20231 hr 17 minSeason 3Ep. 119

Psychedelics, Terence McKenna, Magic Mushrooms, DMT, Carl Jung, Culture | Dennis McKenna | M&M 118

Send us a text Nick talks to ethnopharmacologist Dr. Dennis McKenna, who is the brother of psychonaut Terence McKenna and author of the book, "The Brotherhood of the Screaming Abyss." They discuss: the lives and psychedelic adventures of Dennis & Terence McKenna; experiences with psilocybin mushrooms & DMT; Carl Jung & psychology; the medical relevance of subjective psychedelic experiences; drugs, culture & society; and more. *Not medical advice Support the show All episodes, sho...

Jun 28, 20231 hr 1 minSeason 3Ep. 118
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