Medizin - Open Access LMU - Teil 04/22

Risikofaktoren bei Epileptikern

Distribution of chromaffin secretory vesicles, acetylcholinesterase, and lysosomal enzymes in sucrose and percoll gradients

Crude chromaffin secretory vesicles, obtained by differential centrifugation, were further purified on isotonic (Percoll) gradients. The chromaffin vesicle fractions recovered from the gradients contain acetylcholinesterase as well as lysosomal enzymes. With the aid of a subsequent sucrose gradient lysosomal enzymes could be removed from chromaffin vesicle fractions, but not acetylcholinesterase. This suggests that lysosomal enzymes do not pass through the chromaffin vesicles during the biogenes...

The cytolytic T lymphocyte response to the murine cytomegalovirus

During the acute cytolytic T lymphocyte (CTL) response of mice to infection with the murine cytomegalovirus two independent populations of activated interleukin-receptive CTL precursors can be demonstrated. One population is specific for cell membrane-incorporated viral structural antigens, whereas the second population detects an antigen, whose appearance is correlated with the synthesis of viral immediate early proteins. Since this new type of antigen is only defined by lymphocyte recognition,...

Kriterien der Behandlungsfehler in der Erfahrung des rechtsmedizinischen Gutachters

Untersuchungen zur Funktionsfähigkeit des Gehörs, speziell der Frequenzauflösung, unter Alkoholeinfluß

The cytolytic T lymphocyte response to the murine cytomegalovirus

Limiting dilution (LD) analysis with two modifications, the expansion and the restimulation LD assay, led to the detection and quantification of two distinct in vivo maturation stages within the lineage of virus- specific self-restricted CTL after infection of mice with the murine cytomegalovirus (MCMV). A low frequency set, representing an average of 15% of the specifically activated CTL-P in a draining lymph node, generated virus-specific lytic activity in the absence of antigen, solely under ...

Monoclonal antibodies reactive with swine lymphocytes

A panel of monoclonal antibodies (mAb) with specificity for swine leukocytes was prepared by somatic cell hybridization with the use of spleen cells from mice immunized with swine thymocytes. The reactivity of two mAb (295/33 and 122/28), which both immunoprecipitated from the surface of swine leukocytes an antigen termed S-L2 with an apparent m.w. of 33 to 35 kilodaltons under reducing and 65 to 70 kilodaltons under nonreducing conditions, was investigated in detail. These mAb were reactive in ...

Frequency analysis of cytolytic T lymphocyte precursors (CTL-P) generated in vivo during lethal rabies infection of mice. II. Rabies virus genus specificity of CTL-P

Cytolytic T lymphocyte precursors (CTL-P) were sensitized in vivo by intraplantar infection of C57BL/6 mice with a lethal dose of rabies virus, strain ERA (ERA). As a result of sensitization CTL-P matured to interleukin-receptive CTL-P (IL-CTL-P) that could be expanded in vitro to Thy-1+, Lyt-2+ CTL clones in the presence of IL without subjection to antigen-driven selection. After infection with ERA, IL-CTL-P-derived CTL lysed fibroblasts infected with rabies virus but not those infected with an...

Significance of herpesvirus immediate early gene expression in cellular immunity to cytomegalovirus infection

Interstitial pneumonia linked with reactivation of latent human cytomegalovirus due to iatrogenic immunosuppression can be a serious complication of bone marrow transplantation therapy of aplastic anaemia and acute leukaemia1. Cellular immunity plays a critical role in the immune surveillance of inapparent cytomegalovirus infections in man and the mouse1−7. The molecular basis of latency, however, and the interaction between latently or recurrently infected cells and the immune system of the hos...

Temporal regulation of murine cytomegalovirus transcription and mapping of viral RNA synthesized at immediate early times after infection

The replication of murine cytomegalovirus strain Smith in murine embryonic fibroblasts was investigated at immediate early, early, and late times after infection. Cloned subgenomic HindIII fragments of murine cytomegalovirus DNA served to define the regions of transcription. At immediate early times viral RNA classes ranging in size from 5.1 to 1.05 kilobases (kb) were transcribed mainly from the fragments HindIII-K and -L, whereas low levels of transcription were detected from the two termini H...

Urincholesterinbestimmung im Rahmen der Früherkennung und Verlaufskontrolle von Harnblasentumoren

Die Androgenüberproduktion

Urinary cholesterol: its association with a macromolecular protein- lipid complex

The cholesterol-containing complexes in the urine of normal subjects and patients with diseases accompanied by hyperexcretion of urinary cholesterol were characterized. In normal subjects, the major portion of the recovered urinary cholesterol was eluted in the void volume fractions after gel chromatography on Bio-Gel A-5m; this suggested an association with a macromolecular complex above 5 X 10(6) daltons. A comparable elution pattern was seen in most of the urines of the patients with benign o...

Das Phänomen des "plötzlichen Kindstodes" aus sozialer und psychologischer Sicht

Anwendungsmöglichkeiten des porösen Polyäthylens in der rekonstruktiven Chirurgie des Kopf-Hals-Bereiches

Original-Prüfungsfragen mit Kommentar GK 3: Hals-Nasen-Ohren-Heilkunde

Porous polyethylene and proplast

A comparative animal study showed that, after implantation in skull defects in guinea pigs, porous high-density polyethylene (PHDPE) was substantially better anchored in the bone than Proplast, and had greater stability of form and structure. In Proplast, ingrowth of fibrous tissue caused partial structural dilatation and fragmentation, which could limit its suitability for use in reconstructive surgery.

Unser Konzept bei Anlage und Verschluß eines Tracheostoma

Chronobioassay of radiation injury in mice with and without timeshift

Ersatz knorpeliger Strukturen durch Kunststoffendoprothesen

Actions of D-Ala2-D-Leu5-enkephalin and dynorphin A (1–17) on neocortical neurons in vitro

Intracellular recordings were made from neocortical neurons in vitro. Application of D-Ala2-D-Leu5-enkephalin (DADL) by different methods produced a decrease in EPSP amplitude and in the amplitude of L-glutamate-induced depolarizations without changes in membrane potential or membrane input resistance. The DADL effects were blocked by naloxone and persisted when synaptic transmission was depressed, suggesting DADL acts on postsynaptically located opiate receptors. With dynorphin A (1–17), depola...

The influence of timeshift on ciradian rhythm of sensitivity to X-irradiation in mice

For two groups of male C3H mice an eastbound transmeridional flight was simulated by inducing a time shift of the L:D schedule of 8 hr. The assumed flight brought about a maxima) reduction of the daily light and dark span, respectively. A third group remained unshifted. At seven different times during the following day, subgroups of the time shifted mice as well as of the group with unchange schedule were exposed to whole body X-irradiation. Mortality and body temperature of each animal were reg...

Acute radiation unjury of mice and the influence of sudden time shift

Different types of potassium transport linked to carbachol and γ-aminobutyric acid actions in rat sympathetic neurons

Carbachol and γ-aminobutyric acid depolarize mammalian sympathetic neurons and increase the free extracellular K+-concentration. We have used double-barrelled ion-sensitive microelectrodes to determine changes of the membrane potential and of the free intracellular Na+-, K+- and Cl−-concentrations ([Na+]i, [K+]iand [Cl−]i) during neurotransmitter application. Experiments were performed on isolated, desheathed superior cervical ganglia of the rat, maintained in Krebs solution at 30°C. Application...

Molecular Analysis of the Envelope Gene and Long Terminal Repeat of Friend Mink Cell Focus-Inducing Virus: Implications for the Functions of These Sequences

The chronobiology of the EEG and methods for analysis in health and convulsive disorder

Circadian dysrythmia in the behavior of epileptic children with clonazepam and/or phenobarbital treatment.

Ciradian dysrhythmias in the EEG of children with clonazepam treatment

The effects of different anticonvulsants on the system of cir-cadian and ultradian rhythms in the EEG of children was investigated in ten 24*-h recordings of children with different forms of epilepsy. Circadian dysrhythmias could be found in children with Clonazepam treatment.

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