The fifth MWM Energy Metabolism lesson explores the third and fourth steps of the citric acid cycle and explains how the rate of ATP production is regulated according to the cell's need for ATP. Together with lesson four, it explains how cells regulate their ATP production according to their needs and abilities. In the course of exploring this theme, we look at the role of AMP kinase (AMPK) in promoting energy uptake when ATP levels are low. Watch the full lesson at chrismasterjohnphd.com/mwm/2/...
Aug 29, 2017•8 min
This lesson explores the first two steps of the citric acid cycle and explains how the rate of ATP production is regulated according to the abilities of the electron transport chain. Together with lesson five, it explains how cells regulate their ATP production according to their needs and abilities. In the course of exploring this theme, we examine the role of reactive oxygen species in diabetes. Watch the full lesson at chrismasterjohnphd.com/mwm/2/4 Sign up for MWM Pro for early access to con...
Aug 28, 2017•7 min
This lesson provides an overview of the basic objectives of using the citric acid cycle and the electron transport chain to make ATP. We start here because, no matter whether we burn protein, carbs, or fat, these two interrelated systems are what is shared in common. Watch the full lesson at chrismasterjohnphd.com/mwm/2/3 Sign up for MWM Pro for early access to content, enhanced keyword searching, self-pacing tools, downloadable audio and transcripts, a rich array of hyperlinked further reading ...
Aug 27, 2017•10 min
The second MWM energy metabolism looks at how we use enzymes to exert exquisite control over what happens inside our bodies. If the second law of thermodynamics holds that entropy is always increasing, why don't we reach maximum entropy right away? Why do we observe any order at all? The activation energy represents the resistance to change that can be found in any substance. We exploit the concept biologically by maintaining a body temperature that provides insufficient energy for most relevant...
Aug 26, 2017•8 min
The first MWM Energy Metabolism lesson answers the question, why do we have to eat such an enormous amount of food? The answer is to comply with the second law of thermodynamics. If you have a chemistry background, you should recognize this as a light review of the thermodynamics unit from a general chemistry class, with its most essential concepts teased out and packed into a half hour lesson. If you don't, you can use this as a basic foundation for understanding the biochemistry to follow. The...
Aug 25, 2017•8 min
Masterclass With Masterjohn Energy Metabolism is a structured course that begins with foundational principles and progresses to advanced topics to give you everything you need to know about the biochemistry of how we break down food for energy, use the energy, and store the excess. It broadcasts FREE on YouTube and Facebook twice a week and is now in its 31st lesson. As a subscriber to the Mastering Nutrition podcast, you will now get the cliff notes of these lessons in audio format. This gives ...
Aug 25, 2017•6 min
MTHFR is an enzyme that allows folate (vitamin B9) to support the cellular process of methylation, which is important for the synthesis of creatine and phosphatidylcholine, the regulation of gene expression, neurotransmitter metabolism, and dozens of other processes. There are two common polymorphisms that decrease its activity, A1298C and C677T, with C677T having the stronger effect. Genetic decreases in MTHFR activity are associated with cardiovascular disease, neurologic and psychiatric disor...
Aug 12, 2017•2 hr 2 min
Insulin is almost universally considered a hormone whose primary purpose is to regulate blood glucose levels. Indeed, it does this. But is that the whole picture? When we look at what governs pancreatic insulin secretion inside the beta-cell, it's about total energy and the versatility of the short-term energy supply, not about glucose. When we look at what insulin does to energy metabolism, it does far more than regulate blood glucose: it governs how we use energy and what we do with it. What i...
Jul 30, 2017•1 hr 39 min
Do carbs and insulin make you fat? The argument centers on the ability of insulin to promote the conversion of carbohydrate to fat and lock fat in adipose tissue, as well as the necessity of glucose to provide the backbone to fat molecules within adipose tissue. But the argument ignores that all of these pathways are fundamentally regulated at a biochemical level by how much energy you need and how much you have. In episode 44 of Mastering Nutrition, we take a deep dive into the details of the b...
Jul 22, 2017•1 hr 47 min
Our consciousness is like a net. We want the net to be fluid enough to let thoughts that bother us pass through without grabbing our attention, but strong enough to grab on to the ideas and motivations that will drive us to achieve what we value in life. Nutrition has a big impact on this net. In this episode, learn how foods like liver, egg yolks, meat, leafy greens, legumes, collagen, bone broth, spinach, wheat, and beets can impact how fluid or stable your mind is by impacting the methylation...
Jul 17, 2017•1 hr 38 min
In this episode, we look at whether fat can fuel the athlete. We begin with the physiological principles involved, then take a look at the evidence from studies swapping fat for carbs to see how it impacts athletic performance. This episode is brought to you by US Wellness Meats . I use their liverwurst as a convenient way to make a sustainable habit of eating a diversity of organ meats. They also have a milder braunschweiger and an even milder head cheese that gives you similar benefits, as wel...
Jul 08, 2017•1 hr 22 min
In this episode, I weigh in on the American Heart Association's new Presidential Advisory and Dietary Fats and Cardiovascular Disease, and all the headlines that have been spinning on the supposed risks of coconut oil. This episode is brought to you by US Wellness Meats . I use their liverwurst as a convenient way to make a sustainable habit of eating a diversity of organ meats. They also have a milder braunschweiger and an even milder head cheese that gives you similar benefits, as well as a wi...
Jun 24, 2017•1 hr 34 min
Analia Camarasa asked this question on Facebook: Ever since you've mentioned PTH on your podcast we've been measuring it in the office. It's nice to see that when patients come in on high doses of D supplementation their PTH is maximally suppressed, as it should be. I wish you could talk about the outliers briefly, normal D at 31 ng/mL and PTH outside of the range eating a healthy WAP diet, for example. Watch the video for my response. Access the show notes, transcript, and comments here . Chris...
May 18, 2017•4 min
Vitamin D deficiency and calcium deficiency look very similar, and poorly interpreted blood tests can easily mislead us into taking the wrong supplements. Here's how to tell them apart. Access the show notes, transcript, and comments here . Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome .
May 16, 2017•5 min
Glutamate is the most abundant amino acid in the diet, but is usually bound up in proteins. In its free form, it contributes to the umami taste, which is the savory flavor associated with meat and mushrooms. Long, slow cooking and fermenting can both bring out this flavor.⠀ Unfortunately, some people don't tolerate glutamate well. Glutamate sensitivity is controversial, but some of the symptoms people say they experience are headaches, sweating, flushing, or sets of symptoms that mimic allergies...
May 11, 2017•4 min
If you've got high cholesterol then this video is for you. Access the show notes, transcript, and comments here . Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome .
May 09, 2017•7 min
In episode 31, I explain why glutathione survives digestion and can be absorbed intact, and why supplementing with it or eating it in foods helps support your health. My recommended supplements: Jarrow Reduced Glutathione and Core Med Science Optimized Liposomal Glutathione . In most cases, save money by trying Jarrow first. Use the discount code from this episode to sign up for Masterclass With Masterjohn Pro with a $20/year lifetime discount, offer ending May 13. This episode is a companion to...
May 07, 2017•1 hr 19 min
Tracking calories can be really hard, but here's how to make it easy. Like, easy easy? Easy easy easy easy? Well, no, not easier than not tracking calories. But far easier than you would expect if you haven't tried it. And thousands of times easier than some other methods of tracking calories. Access the show notes, transcript, and comments here . Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome ....
May 04, 2017•8 min
This is how I recommend losing weight if you want a method that is reliable and easy to optimize over time. Access the show notes, transcript, and comments here. Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome .
May 02, 2017•9 min
The effect of sprouting on the folate concentration of legumes is incredible . It peaks on the fourth day of sprouting, though, according to a recent study. But is it always the fourth day in every legume under any condition sprouted in a home kitchen? Are the sprouted legumes on the store shelf four-day sprouts? Right now there are more questions than answers, but I believe that opting for sprouted legumes is a good way to supercharge your folate status as long as you still make an effort to ge...
Apr 28, 2017•7 min
Did you realize even washing vegetables causes loss of folate? Learn everything you need to know to get enough folate from picking the right foods to avoiding loss in the kitchen in this five-minute video. Access the show notes, transcript, and comments here . Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome ....
Apr 25, 2017•5 min
You absolutely cannot trust frozen veggies as a source of folate. Remarkably, though, folate is stunningly stable in liver during frozen storage, and even cooking. Access the show notes, transcript, and comments here . Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome .
Apr 21, 2017•4 min
Episode 39 is a panel discussion between me and three panel members who are either finishing medical school now or are recent graduates of medical school. We discuss the current state of nutrition in medical school, whether and how it should change, what doctors and future doctors should do to obtain a deep understanding of nutrition, and what patients should do to obtain high-quality, nutritionally focused medical care. The panel: Clayton Dalton received his MD from Columbia Medical School and ...
Apr 09, 2017•2 hr 10 min
If you feel better when you eat refined grains or when you take a multivitamin or B complex with synthetic folic acid, this video is for you. Access the show notes, transcript, and comments here . Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome .
Mar 24, 2017•6 min
Spend eight minutes to know whether you need to manage your iron status and how to do it by watching this video. There's a 30% chance it could make a big difference in your health, and a 3% chance it could be life-changing. Access the show notes, transcript, and comments here . Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome ....
Mar 22, 2017•8 min
If you're concerned about your cholesterol, or confused about what to do, this episode is for you. In this episode, I list the four key factors that control blood cholesterol levels and outline the simplest dietary or lifestyle changes we can make to have the biggest impact. This episode is brought to you by US Wellness Meats . Head to grasslandbeef.com and enter "Chris" at checkout to get 15% off your order as long as the final price is over $75 and you order fewer than 40 pounds of meat. You c...
Mar 19, 2017•59 min
This is a really important update to the video I put out on Tuesday about millet. There are millets on the market that can wreck your thyroid gland and others that are harmless. It's important to know the difference. Access the show notes, transcript, and comments here . Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome ....
Mar 16, 2017•7 min
If you eat millet or eat gluten-free bread, you should watch this video, because you could be hurting your thyroid. Access the show notes, transcript, and comments here . Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome .
Mar 14, 2017•7 min
In this episode, I explain how to come up with a good question, obtain the background information you need, find research, obtain full texts, organize them, read the different sections of a paper to get the right kind of value out of it, and critically analyze the study design. If you're a beginner, this is really designed for you. If you're more advanced, you'll enjoy the specific examples I give of problems interpreting research studies. This episode is brought to you by US Wellness Meats . He...
Mar 11, 2017•2 hr 5 min
Last time we talked about supporting zinc nutritional status. Today we talk about how to kill a cold with zinc. Believe it or not, the principles are completely different. Your oysters can help you get sick lest often. But knowing how to find the right zinc lozenge and use it correctly is your secret weapon to stop a cold dead in its tracks when it eventually comes. Access the show notes, transcript, and comments here . Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitocho...
Mar 09, 2017•6 min
