You could be one metabolic bottleneck away from feeling amazing. Mitome is the first at-home test that measures your cellular energy directly and gives you a personalized roadmap to optimize energy, slow aging, and protect against disease. Find it at mito.me This is not medical advice and is for educational purposes only. Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome .
Aging is best explained by declining mitochondrial function over time. This answers its own "why." Mitochondria produce the energy needed for repair so if any of it gets lost it sets up a vicious cycle. And some *always* gets lost. But how much is under your control. From Joe Rogan Experience JRE 2420. https://www.youtube.com/watch?v=QBn54YNnKD0 It's a vicious cycle initiated by the second law of thermodynamics which requires a constant input of energy to prevent the collapse of order. Hence, th...
This is a clip from Joe Rogan Experience JRE 2420. Watch the full interview here: https://www.youtube.com/watch?v=QBn54YNnKD0 Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome .
This is a clip from Joe Rogan Experience JRE 2420. Watch the full interview here: https://www.youtube.com/watch?v=QBn54YNnKD0
This is a clip from Joe Rogan Experience Episode 2420. You can watch the full interview here: https://www.youtube.com/watch?v=QBn54YNnKD0
Mitochondria govern everything. Watch this with the slides here: https://www.youtube.com/watch?v=mED1_L3wZbc Mitochondria convert your food to usable energy in the form of ATP, which is used to produce, maintain, repair, distribute, and organize everything in your body. Abundant health right now, and preserving your health throughout the lifespan toward your longevity, all depends on your mitochondria. In fact the best explanation for aging is that its a vicious cycle of declining mitochondrial ...
Chris Masterjohn, PhD, Founder and Scientific Director of mito.me, explains why SSRI withdrawal is mitochondrial dysfunction and what to do about it. This is not medical advice, diagnosis, or treatment. 29 million Americans and about 5-10% of the world's population are on SSRIs, which have become the first-line treatment of depression. These can cause sexual dysfunction and emotional blunting in up to half of people, an unclear incidence of sleep disruption, and a rare risk of suicidality, self-...
For a long time, most people believed that when we exercise, our muscles make lactic acid, this acidifies the muscles, and the acidity contributes to contractile failure, fatigue, and delayed-onset muscle soreness. Some people still believe this. You may have heard the argument against it from well-known figures like Andy Galpin, or, if you're deep into the science, you may have read the work of George Brooks. In this lesson, we are going to cover the biochemistry of lactate production. We will ...
D-lactate is commonly stated to be exclusively a microbial metabolite. This is found in assumptions within the medical literature for decades even when it was long-known to be false. While D-lactate is indeed made by bacteria, D-lactate is also inarguably and irrefutably produced by human enzymes. In this podcast, moreover, I will argue the following: Microbial contribution to D-lactate in humans under normal circumstances is negligible. I coin the term "the D-lactate shuttle" to describe a role...
In this podcast we cover elevated creatinine, insomnia, cramps constipation, water retention, hair loss, irritation and anger, lightheadedness during lifting, bloating, aggravation of restless leg syndrome, irritation of asthma, bloody noses, anxiety, headaches, heart palpitations, twitching, and fast or slow heartbeat. The full podcast and article can be found here: https://chrismasterjohnphd.substack.com/p/handling-creatine-side-effects Chris Masterjohn, PhD, is the Founder and Scientific Dire...
Creatine is like your second mitochondria. Or, the mitochondria's chief of staff. Or its co-pilot. Your mitochondria make ATP so you can see clearly, hear accurately, digest your food, power your brain, show off your your shiny skin, lift heavy things, and perform your best at the challenges you face. They do that all with the help of creatine. Creatine is responsible for spreading the impact of mitochondrial ATP production into the general area of the cell known as the cytosol, and into every o...
Question: Is whole food vitamin C superior to natural because it is part of a tyrosinase complex? Short Answer: Vitamin C is nearly ubiquitously distributed in plant tissues, and is never bound to any enzyme as a structural complex. Vitamin C promotes absorption of iron from plant foods, inhibits copper absorption, and de-loads copper from ceruloplasmin, which may play a role in distributing copper to tissues. Vitamin C is not capable of destroying ceruloplasmin. These functions follow directly ...
Question: What Is the Real Issue With Seed Oils? Short Answer: The main issue with seed oils is that they present an oxidative liability. They do not acutely cause oxidative stress, but their polyunsaturated fatty acids (PUFAs) are more vulnerable than any other macronutrient to oxidative damage. Oxidative stress can increase because of nutrient deficiencies, toxins, infections, other sources of inflammation, alcohol, or smoking, and it will inevitably increase as a function of aging. As oxidati...
Question: How useful is hair trace mineral analysis (HTMA) for nutritional testing? Short Answer: Hair trace mineral analysis is included as an optional add-on in the comprehensive nutritional screening from Testing Nutritional Status: The Ultimate Cheat Sheet, because it can capture data for some ultra-trace minerals for which there are no better-validated tests, and it might capture a pattern that might not be picked up as quickly with blood work, such as a mineral transport issue. However, it...
Nutrition is far more powerful than drugs to improve cognitive performance. We start by looking at cocaine, Adderall, and Ritalin, and show why these drugs cannot possibly hold a candle to nutrition. Optimal nutrition can definitely optimize the function of dopamine, norepinephrine, acetylcholine, histamine, creatine, and the methylation system, and in doing so can simultaneously optimize focus, motivation, sustained attention, and mental flexibility, and methylation, all while eliminating anxie...
Debunking the myth that vitamin C in plants is found in a special "tyrosinase complex." For the written article with references, see here: https://chrismasterjohnphd.substack.com/p/vitamin-c-whole-food-vs-synthetic For issues of vitamin C dosing and balancing with other nutrients, see these two links: https://chrismasterjohnphd.substack.com/p/the-powerful-duo-how-glutathione https://chrismasterjohnphd.substack.com/p/balancing-vitamin-c-and-glutathione-d6f Chris Masterjohn, PhD, is the Founder an...
Watch or listen to the full critique here: https://www.youtube.com/watch?v=kMPvCiOkEtQ Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome .
Is high-dose vitamin C good for you? High-dose intravenous vitamin C can selectively kill cancer cells in live patients and can save sepsis patients from dying, but it acts as a pro-oxidant in cancer and an antioxidant in sepsis. So what does it do in the rest of us? Oral doses of 2000 milligrams raise oxalate levels in most people, and as little as 400 milligrams raises oxalate in some people. This seems to be the most sensitive indicator of a delicate imbalance with glutathione and other facto...
Question: How to Find the Root Cause of Autoimmunity? Short Answer: Autoimmune conditions are likely driven by deficiencies of vitamins A and D, which contribute to post-infectious autoimmunity by compromising the rhythmic rise and fall of myeloid-derived suppressor cells (MDSCs), and to autoimmunity regardless of infections through impaired suppression of Th17 helper T cells. More broadly, infections and tissue damage are the most likely drivers of autoimmunity onset. However, energy metabolism...
High-dose intravenous (IV) vitamin C has the potential to kill cancer cells and prolong the survival of terminal cancer patients. This podcast is a preview, the full video is available only to Masterpass members. See the written article with links to references here: https://chrismasterjohnphd.substack.com/p/the-powerful-duo-how-glutathione Subscribe to the Masterpass here: https://chrismasterjohnphd.substack.com/subscribe I am not a medical doctor and this is not medical advice. Please do not m...
The ability to become startled is an adaptive behavior that protects us from being injured by a sudden threat, and prepares us for the fight-or-flight response when necessary. Nevertheless, getting startled too easily can be a sign that something is wrong. Here's what to do about it. For the written version with links to references and links to testing, see here: https://chrismasterjohnphd.substack.com/p/startled-try-glycine Chris Masterjohn, PhD, is the Founder and Scientific Director of the mi...
Hormones matter, but they are never in charge. Their abnormalities are never the root cause of anything. All hormones do is communicate the biochemistry of one tissue to the biochemistry of another tissue. In this episode: Three Reasons For Hormones to Be Messed Up Exceptions to the Rule Leptin, Insulin, and Thyroid Hormone As an Example How to Approach Hormones For the written version, the links to references, and the links to testing, see here: https://chrismasterjohnphd.substack.com/p/hormone...
Most people who take biotin take it for their hair and nails. Yet biotin does much more than this. Learn what to use it for, how much to take, and how to avoid adverse effects in less than ten minutes. Read the written and fully referenced version here: https://chrismasterjohnphd.substack.com/p/biotins-health-benefits-way-beyond Get my short and sweet tips on each nutrient in the Cliff Notes here: https://chris-masterjohn-phd.myshopify.com/products/the-vitamins-and-minerals-101-cliff-notes It's ...
This is how to use a simple home measurement to expose the harmful effects of a supplement before they even happen. Read the article here: https://chrismasterjohnphd.substack.com/p/the-dark-side-of-biotin Subscribe to my newsletter to get my series on improving respiratory chain function as soon as new articles come out: https://chrismasterjohnphd.substack.com/subscribe See the "super unlock" article here: https://chrismasterjohnphd.substack.com/p/unlocking-performance-and-longevity Chris Master...
Question: Why Would Vitamin C cause muscle pain, joint pain, and brain fog? Short Answer: Acutely, vitamin C would likely cause these effects by generating oxalate, which could cause crystals that lead to muscle and joint pain, and could cut energy metabolism in half, leading to brain fog. This vulnerability could result from deficiencies of any of the B vitamins, any of the electrolytes, or of iron, copper, or sulfur; from diabetes, low adrenals, or hypothyroidism; or from any of the hundreds o...
If you are eating a high-protein diet, you probably aren't getting enough biotin. This is especially true if you are a protein-fueled athlete and find your skin too oily, too itchy, or too red; if your blood sugar is getting out of control; or if you simply feel down in the dumps. And it's especially true if you find your hands or feet tingling or get subtle sensations of something crawling on your skin. Alternatively, if you're pregnant or looking to conceive, this is something you really need ...
The use of high-dose biotin supplements has increased almost 30-fold over the last twenty years for such problems as diabetes, smell and taste disorders, disorders of the hair, skin, and nails, and multiple sclerosis. Studies show it can improve diabetes, and case reports show it can miraculously recover lost smell and taste even when smell and taste were lost as a result of surgery or the side effects of medications or other supplements. Yet, some studies show multiple sclerosis gets worse on h...
The most useful tests are the ones no one ever orders. This podcast is available for free for 48 hours, and then will only be available to Masterpass members. The written and fully referenced article, the podcast, and the permanently available video can be found here: https://chrismasterjohnphd.substack.com/p/how-to-interpret-ketone-ratios-and Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome ....
Question: Can NAC hurt your gut health? Short Answer: N-acetylcysteine or NAC can be used at a dose of 600 to 2,400 milligrams per day for 5-10 days to disrupt biofilms and make it easier for antimicrobials to kill bacteria. Animal studies suggest that acute doses up to 6 grams do not deplete mucus or cause ulceration, but that an acute dose of 17.5 grams can deplete mucus and cause ulcers within two hours. Human studies suggest that 10 grams per day can be used for 24 weeks with fewer than 1 in...
Each person has one to six highly unique unlocks that will only work for them, and this is how to find them. This podcast is only available here for the next 48 hours. This video is a free preview of a full-length 69-minute podcast. You can access the full video, full podcast, and the written and fully referenced article here: https://chrismasterjohnphd.substack.com/p/unlocking-performance-and-longevity Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome...
