27: Yamanaka Factors - Can Aging Be Reversed?
Aug 23, 2023•8 min
Listen to this episode in Metacast mobile app
Don't just listen to podcasts. Learn from them with transcripts, summaries, and chapters for every episode. Skim, search, and bookmark insights. Learn more
Episode description
Buck discusses Yamanaka Factors and recent experiments where a team led by David Sinclair was successful in reversing cellular age applying the concepts in an experiment.
- 00:00:02 - Is it possible to stop or even reverse the aging process?
- 00:01:48 - 2012 research by Shinya Yamanaka - Yamanaka Factors
- 00:02:50 - Pluripotent stem cells
- 00:03:08 - Revolutionary discovery for the world of regenerative medicine
- 00:03:28 - Salk Institute study using mice with progeria
- 00:03:55 - Doxycycline and improvements in signs of aging
- 00:04:26 - David Sinclair's research to regenerate optic nerves in mice to restore vision
- 00:04:49 - David Sinclair's book on aging research called Lifespan
- 00:05:20 - Epigenome and the aging process
- 00:06:15 - Horvath lab and using Yamanaka factors to reset epigenetic clocks in rats
For the best experience, listen in Metacast app for iOS or Android