Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay. In this episode, I will be having and audio conference all about descriptions of Endogenous Catecholamines like Nor Adrenaline, Dopamine in different doses, Fenoldopam and Dopexamine . I hope to extend my views about Adrenaline in upcoming episode. I will be covering each of these under head points like receptor action, function, basic route of administration, mechanism, uses and side effects. For all the updates and latest...
Dec 25, 2022•15 min•Season 1Ep. 135
Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay. In today's episode, I will be covering the complete classification of Adrenergic Drugs and brief details of each head of the classification. Along with this confab, I will also be inviting you all and celebrating the second birthday of my podcast virtually. All in all, it would be great fun, hope you all join me in this annual celebration. Expecting your wonderful audio presence today!! For all the updates and latest episod...
Dec 12, 2022•14 min•Season 17Ep. 134
Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay. In today's episode, I will be talking about the variety of mechanisms or pathways or routes of action adopted by catecholamines exerting their effects via alpha and beta receptors. All the details will be covered, especially the most novel/neo Biased Beta Receptor Agonist concept which involves Beta Arrestin and ensures Cardioprotection. After the interesting episodic conversation, I would like all to stay tuned and updated...
Dec 03, 2022•15 min•Season 17Ep. 133
Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay. In today's episode I will be talking about Sympathomimetic agent effects like Metabolic Effects, Ocular Effects, GIT Effects and miscellaneous effects. After the last liner about effects on Splenic capsule in animals, I will be describing the slight lengthier spacing of episodes sometimes on timeline in following way: A tale as old as time Innumerable plans rushing inside Nothing's calling me Nothing's holding me I am the p...
Nov 20, 2022•9 min•Season 17Ep. 132
In today's episode, continuing the legacy of Effects of Sympathomimetic stimulation , I will discuss the effects on Blood vessels and related Blood Pressure. Related to these two talks, It will be perfect to ornament my end notes of the commendable vocals with an account of the crowned,"VASOMOTOR REVERSAL OF DALE". What an auspicious narration for the day! Hope you like this episode, talk to you very soon, sooner than you could think, truly!! For all the updates and latest episodes of my podcast...
Nov 09, 2022•13 min•Season 17Ep. 131
Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay. In today's episode, I will be greeting all those celebrating, "Happy Halloween". First and foremost, I will be summarising adrenergic receptor effects in brief and then I will begin with effects on individual organs or organ systems. I will be describing effects on Salivary glands, Lungs, Heart, Urinary tract, Uterus, etc. Pausing my speech, to ponder and listen to the ticking clock, I declare the wrap for the day, wishing ...
Oct 29, 2022•9 min•Season 17Ep. 130
Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay. In this episode, I will be giving an introductory overview of Adrenergic Receptors, both Alpha and Beta receptors, their classification, subtypes, action of Catecholamines on these receptors and also I will supplement this great information conversation with a chat about Receptor Regulation, topics like Up and Down receptor regulation, Desensitisation and Supersensitivity of Receptors. With the falling curtain words, I will...
Oct 27, 2022•13 min•Season 17Ep. 129
Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay. Today's episode of the day i.e. "le sujet d'aujourd'hui" is a sequel of last episode and the two highlighted processes that I will cover are the Reuptake and the Metabolism of Catecholamines, all in all the termination of action/effect of catecholamines in nutshell! I will be describing reuptake at neuronal (axonal & vesicle) level and also at extraneuronal sites. Next, I will be covering metabolism of catecholamines ao...
Oct 18, 2022•10 min•Season 17Ep. 128
Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay. In this episode, we begin the Adrenergic/Sympathetic system Introductory concepts like overview of the system, the names of endogenous cataecholamines(CAs), their synthesis, storage and release comprehension, all in all will be done in detail "le sujet d'aujourd'hui" I will cover all steps, important catalysing enzymes and their roles, some of their blockers, their unique features, etc. Two more steps will be covered in nex...
Oct 12, 2022•14 min•Season 17Ep. 127
Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay. This is closing episode in the month long celebration series of Podcast Day, and then from next episode We will be again on track of ANS! In today's episode I will converse about thick and thins of all the four phases of Clinical trials! All different terms and important points will be thrown a great light upon. Finally on the wrap moment, I will be stating the following in French & English: "365 jours, montagnes russes...
Oct 03, 2022•13 min•Season 17Ep. 126
Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay. In today's episode, We will gain Pre knowledge before we actually enter the main field of "Clinical trials". What are the intermediate factors or events in between Pre clinical tests and clinical trials in the humans is the whole concept of today's conversation. After knowing the important various factors affecting Clinical Trials, we will have an overview and details of terms like "Informed Consent", "Investigational New D...
Sep 25, 2022•13 min•Season 17Ep. 125
Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay. Today's episode about Pre Clinical testing/Studies is the sequel of last episode about Screening studies. In this episode, all stages of Pre Clinical Testing will be discussed like Acute toxicity testing, Subacute Toxicity testing, Chronic toxicity testing and different tests for carcinogenic , allergic and mutagenic profile of drug along with their pharmacodynamic and pharmacokinetic profile evaluation. It is quite interes...
Sep 18, 2022•19 min•Season 17Ep. 124
Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay. In this episode, I will hallmark the celebration of "INTERNATIONAL PODCAST DAY" (30th September) to make it not only one day but complete month's celebration. This bonus episode will herald the series of around 4 episodes to make this year's podcast day special! And I choose the celebrated topic to be Novel Drug Development. In this episode I will cover all the steps of Discovery of new drug like 1. Target Identification 2....
Sep 11, 2022•20 min•Season 17Ep. 123
Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay. In this episode, I will be doing a RAPID FIRE Question-Answer Round of around 15-17 questions about ANTICHOLINERGIC DRUGS, a sort of Quick Revision or Summary we can say. I am sure this will be a great closing session of this topic and will help you all to listen the overall topic altogether at a time period of around 15 minutes. It was great fun and exercise doing this episode, I am sure you all gonna like it too.. For all...
Sep 01, 2022•15 min•Season 17Ep. 122
Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay. A quick, celebrated poetic August weather update will break the ice today!! In this episode, I will be discussing Atropine poisoning, its diagnosis and cure. But before that I will quickly cover points related to Anticholinergic drug effects on Respiratory tract states and also on the Gut. Hence effect of variety of Atropine congeners like Dicyclomine, propantheline, Ipratropium bromide, Tiotropium bromide, Glycopyrrolate, ...
Aug 20, 2022•17 min•Season 17Ep. 121
Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay. In today's episode, I will be discussing effects and applications of Anticholinergic drugs- Atropine and congener drugs on Sweating and also on Genitourinary system. To begin with, effects on sweating will be discussed, details like mechanism, Atropine fever , etc will be covered. In next step, Anticholinergic drug effects on Genitourinary system will be discussed. Under this head all details will be covered and many congen...
Aug 10, 2022•9 min•Season 17Ep. 120
Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay. In today's eye to eye talk, I show a great concern for your eyes and describe the Effects and Uses of Atropine and Congener drugs/ Substitute drugs on Eyes and associated structures. I will be covering Atropine and Congener drugs, the semisynthetic derivatives like Cyclopentolate, Tropicamide, Homatropine, Eucatropine, etc. I will be detailing the mechanism of Direct/Indirect , in other words, Active/Passive mydriasis and t...
Jul 31, 2022•11 min•Season 17Ep. 119
Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay. In today's episode, I will be talking about Atropine (though not about congener drugs or substitute drugs) effects and applications as far as Cardio Vascular System is concerned! There are plenty of noteworthy features and points and wonderful applications especially amazing memorable mechanisms. It will serve one hunk of knowledge and information for the day, and you have to wait more for the main course to be served and w...
Jul 21, 2022•11 min•Season 17Ep. 118
Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay. In today's episode, I will be commencing my discussions about Atropine Substitutes, it may take up a handful of episodes to complete them though. Today's raison detre (objective) gonna be effects and actions of Atropine and Alternative drugs or Congeners on different states/pathologies of Central Nervous System like Motion Sickness, Parkinson's Disease and diagnosis of Alzheimer's disease. The mentioned new drugs are Scopol...
Jul 11, 2022•11 min•Season 17Ep. 117
Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay. "Il n'y a pas de raccourci pour aller la ou ca vaut la peine daller!" "There's no shortcut to get where it's worth going!" In today's episode, I will be covering details of the drug Atropine, its spectrum, its site of action, receptors and actions in detail! I will be doing that in bullet points. Hope you all like this episode and stay tuned and charged up for upcoming episodes in which I will be covering Comparisons of Atr...
Jun 28, 2022•10 min•Season 17Ep. 116
Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay. In this episode , I will be heralding a new topic namely Anticholinergic/Antimuscarinic drugs. This is introductory episode for these agents. Atropine is hallmark/prototype drug and then I will be giving a long lively list of other drugs too! The main heads are Natural Alkaloids, Semisynthetic derivatives or drugs and Synthetic derivatives and then they have their subheads too! With a quick remark on general Pharmacokinetic...
Jun 20, 2022•11 min•Season 17Ep. 115
Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay. In today's talk, I will talk about both Stimulants and Blockers acting on Autonomic Ganglia. Names, mechanisms, details, indications, uses, etc. for both types will be discussed in detail. Short convo though, I will be hitting it out of the park!! For all the updates and latest episodes of my podcast, please visit www.ispharmacologydifficult.com where you can also sign up for a free monthly newsletter of mine. It actually c...
Jun 13, 2022•13 min•Season 17Ep. 114
Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay. Heading on to JUNE 5, the "World Environment Day," its the best time to take a pause and ponder over the discussions about Ecopharmacology or Environmental Pharmacology. Nothing more relevant than to have this celebrated "talk of the day". I will be covering 360 degree aspect of this topic and a few words about related topics like Pharmacoenvironmentology, Epigenetics, Environmental Toxicology and Pharmacovigilance. It is a...
Jun 03, 2022•23 min•Season 17Ep. 113
Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay. In this episode, I will discussing detail all about Anticholinesterase Poisoning, I will be covering all aspects of Organophosphate poisoning- agents, signs and symptoms, effects, non pharmacological treatment and medicinal therapy. Few small talks about Carbamate agent poisoning, Reversible agent Poisoning and Chronic organophosphate poisoning will also be cherished along. With these important conversations, we together to...
May 26, 2022•14 min•Season 17Ep. 112
Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay. In today's episode, I will be conversing about Uses of Anticholinesterases in general. Actually it gonna be a list, and main uses talked about are - Lambert Eaton Syndrome, Cobra bite, Belladona poisoning, Alzheimer's disease, post operative Paralytic ileus and post operative decurarization and treatment of excessive dosing of certain group of drugs (Antihistamines and Tricyclic antidepressants) It happened to be a nice pre...
May 19, 2022•11 min•Season 17Ep. 111
Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay. In today's episode, our curiosity rocket ship gonna fly high in space and sky of science and Erudition to explore all about Myasthenia Gravis, an Autoimmune disease/ Disorder. I will start with describing Autoimmune disease, then particularly Myasthenia Gravis, its pathogenesis, how it occurs, where it occurs, where are the signs and symptoms occurring. A little light will be thrown on Historical aspect, then therapy of the...
May 05, 2022•16 min•Season 17Ep. 110
Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay. In today's conversation, I will be detailing the Anticholinesterases , the Irreversible agents namely Carbamates, Carbaryl and Propoxur and Organophosphates, Malathion, Parathion, Dyflos, Ecothiophate, Isofluorophate, Tabun, Sarin, Soman. Everything from Classification, then mechanism, site of action, effects, adverse effects and Therapeutic uses will be discussed thoroughly. To begin with I have a brief Summertime poem dep...
Apr 28, 2022•13 min•Season 17Ep. 109
Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay. In today's episode I will be setting up the verbal conference about drug details, all reversible anticholinesterases like Physostigmine, Neostigmine, Pyridostigmine, Rivastigmine, Galantamine, Edrophonium, Ambenonium, Distigmine, Tacrine, Donepezil.... All sea waters gonna be touched and splashed like basic characteristics, derivation, chemical nature, half life, pharmacodynamics, pharmacokinetics, and as the discussion pro...
Apr 21, 2022•13 min•Season 17Ep. 108
Welcome all to IS PHARMACOLOGY DIFFICULT Podcast ! I am Dr Radhika Vijay. In today’s episode, I will be discussing Introductory aspects of Anticholinesterases , these are the inhibitors of Acetylcholine esterase enzyme which hydrolyses Acetylcholine in the synapse! It is all in all a new runway to land our plane of episode today…After discussing structural aspects, slight differences, common features, binding sites, mechanisms.I will be heading over to broadly classify these agents and today wil...
Apr 13, 2022•12 min•Season 17Ep. 107
Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay.In today’s episode, I will be conveying details about Nicotine, its mechanism, etc. Though it is linked to the last episode and dosage forms of Nicotine Replacement Therapy (NRT) will not be repeated, an ample light is thrown on the toxicity, both acute and chronic toxicity of Nicotine. Sign and Symptoms and management is too discussed.Discussion heads too include Vaping, Neonicotinoids and Smoking cessation.Smoking Cessatio...
Apr 06, 2022•13 min•Season 17Ep. 106
