In this episode, the ID:IOTS Podcast Microbiome Correspondent Dr Anastasia "Tash" Theodosiou, finishes educating Callum and Jame (mostly Callum) on the concept of Microbiotoxicity! This episode is part 2 of 2. Here we discuss: - What is microbiotoxicity? - Risk factors for microbiotoxicity - Which antibiotics are associated with microbiotoxicity? - Mitigating microbiotoxicity https://www.researchgate.net/profile/Anastasia-Theodosiou https://x.com/doctoranastasia Support the show Support us on: P...
Jun 17, 2024•46 min•Season 1Ep. 82
In this episode, the ID:IOTS Podcast Microbiome Correspondent Dr Anastasia "Tash" Theodosiou, returns to talk about her favourite subject! This episode is part 1 of 2. Here we discuss: - What is the microbiome - Viewing the microbiome as an organ system - The microbiome's association with disease - How we study the microbiome Stay tuned for part 2 (in 1-2 weeks depending on editing), when we talk about the effect of medicine on the microbiome, microbiotoxicity, and what you can do to keep your p...
Jun 03, 2024•30 min•Season 1Ep. 81
Join us for this special 80th episode celebrating Jame's favourite trial. https://www.nejm.org/doi/full/10.1056/NEJMoa1808312 Prep notes (including the images referred to in the poem) here . Special thanks to the Wikiguidelines Endocarditis crew for their work summarising the evidence this poem was based on. Support the show Support us on: Patreon: https://www.patreon.com/cw/IDIOTS_pod BuyMeACoffee: https://www.buymeacoffee.com/idiotspod Prep notes for completed episodes can be found here (Not a...
May 20, 2024•6 min•Season 1Ep. 80
Presenting: More on Penicillin-Binding-Proteins than you realistically ever need to know! What is the difference between Gram positive and negative bacteria's cell walls? What is a Penicillin Binding Protein (PBP)? Why are they called PBPs? What do PBPs do? What makes MRSA resistant to (most) beta-lactams? These any many more questions answered! Notion page here - you'll need it for this one, check it out! Support the show Support us on: Patreon: https://www.patreon.com/cw/IDIOTS_pod BuyMeACoffe...
May 06, 2024•32 min•Season 1Ep. 79
One PK table to rule them all One table to find them One table to bring them all And in the darkness blind them… …with awesome antibiotic PK facts you can use to bedazzle your friends and enemies alike! Prep notes here . Support the show Support us on: Patreon: https://www.patreon.com/cw/IDIOTS_pod BuyMeACoffee: https://www.buymeacoffee.com/idiotspod Prep notes for completed episodes can be found here (Not all episodes have prep notes). If you are enjoying the podcast please leave a review on yo...
Apr 21, 2024•27 min•Season 1Ep. 78
The last Pharmacokinetics episode had finally been …Excreted! This episode covers the ‘drug out’ bit of pharmacokinetics, including things such as: -What is clearance? -how to calculate half life and -doesn’t everything leave through the kidneys anyway? (That is sort of true, also shut up). Check out our prep notes (including for this episode) here . Support the show Support us on: Patreon: https://www.patreon.com/cw/IDIOTS_pod BuyMeACoffee: https://www.buymeacoffee.com/idiotspod Prep notes for ...
Apr 08, 2024•43 min•Season 1Ep. 77
It's the second Pharmacokinetics episode you never knew you wanted! Let’s talk about how antibiotics are distributed around the body once absorbed, using the examples of Amoxicillin and CallumShutUpicillin (listen to episode for clarification). What exactly is the volume of distribution? Want a handy reference for the plasma protein binding of various antimicrobials? Then this is the episode for you! Check out our prep notes (including for this episode) here . Support the show Support us on: Pat...
Mar 24, 2024•41 min•Season 1Ep. 76
It's the Pharmacokinetics episode you never knew you wanted! Callum didn't know either, but never mind that let's talk about how antibiotics are absorbed, and how we can use that to improve our use of them in clinical practice. Want ammunition for that oral switch? Got someone who's doubting oral antibiotics' effectiveness? Then this is the episode for you! Check out our prep notes (including for this episode) here . Support the show Support us on: Patreon: https://www.patreon.com/cw/IDIOTS_pod ...
Mar 11, 2024•41 min•Season 1Ep. 75
In this final episode of the Nobbling the Nonfermentors mini-series, Jame and Callum discuss the (mostly historical) pathogen Burkholderia mallei, causative agent of Glanders. We did it. We got to the end. Nonfermentors... Nobbled. Support the show Support us on: Patreon: https://www.patreon.com/cw/IDIOTS_pod BuyMeACoffee: https://www.buymeacoffee.com/idiotspod Prep notes for completed episodes can be found here (Not all episodes have prep notes). If you are enjoying the podcast please leave a r...
Feb 25, 2024•25 min•Season 1Ep. 74
Post-publication, Callum and Jame give a little extra information on the SABATO trial in its final form compared to it's pre-publication state. Final article here: Efficacy and safety of an early oral switch in low-risk Staphylococcus aureus bloodstream infection (SABATO): an international, open-label, parallel-group, randomised, controlled, non-inferiority trial , Kaasch, Achim J Valiente, Adoración et al. Lancet Infect Dis. 2024 Jan 17:S1473-3099(23)00756-9. PMID: 38244557. https://doi.org/10....
Feb 13, 2024•7 min•Season 1Ep. 73
JOURNAL CLUB, YO, IT’S A SABATO!!! Join Jame and Callum as we travel back in time to when we recorded this deep dive into the SABATO trial pre-print, now peer-reviewed and published in the Lancet ID! In the next episode we'll give a little update as to how the final article differs from the preprint (not much). We also talked about in our FIS Highlights Episode 3 . We loved this trial and we hope you’ll all give it a read, it’s well worth it! Article here: Efficacy and safety of an early oral sw...
Feb 12, 2024•39 min•Season 1Ep. 72
In this penultimate episode in the Nobbling the Nonfermentors mini-series, Jame and Callum discuss the regionally important neglected tropical disease Melioidosis, caused by Burkholderia pseudomallei. This episode was based disproportionately on the following article, and we extend our thanks to the authors for thoughfully publishing it so close to us wanting to do a podcast episode on Melioid! Meumann, E.M., Limmathurotsakul, D., Dunachie, S.J. et al. Burkholderia pseudomallei and melioidosis. ...
Jan 29, 2024•40 min•Season 1Ep. 71
In this Episode, Callum reflect on his recent runaway success passing the FRCPath Part 2, passes on some tips and tricks for the exam, and then we talk about what 3 antibiotics we would take with us to a Desert Island (that has all pathogens and environments where you would find said pathogens, so not just a desert apparently). 'Prepping to Pass' episodes mentioned: 40, 42, 43 & 50. The Table and Links mentioned in this episode can be found here: https://idiots.notion.site/70-Reflections-on-...
Jan 08, 2024•53 min•Season 1Ep. 70
How do you think about antibiotics? This Christmas we give the best gift of all: no puns in an episode. Join Jame and Callum as they talk about a method for thinking about and explaining antibiotics. Here are the show notes for this episode: https://idiots.notion.site/69-Choosing-an-antimicrobial-4e7446a91ff6413aa14924a2ba905ffa Support the show Support us on: Patreon: https://www.patreon.com/cw/IDIOTS_pod BuyMeACoffee: https://www.buymeacoffee.com/idiotspod Prep notes for completed episodes can...
Dec 25, 2023•22 min•Season 1Ep. 69
Did you think the evidence base for Stenotrophomonas was bad? Well allow us to introduce you to Burkholderia cepacia complex! BCC is pretty niche but a key pathogen in people living with cystic fibrosis. We talk through the (very) limited treatment options and evidence base for this difficult bug. Prep notes for this episode here: https://idiots.notion.site/68-Burkholderia-cepacia-complex-7bba8a7c74df490cb2e91d087a3cdb2a Support the show Support us on: Patreon: https://www.patreon.com/cw/IDIOTS_...
Dec 18, 2023•53 min•Season 1Ep. 68
Callum and Jame wrap up their thoughts on the recent FIS conference. Support the show Support us on: Patreon: https://www.patreon.com/cw/IDIOTS_pod BuyMeACoffee: https://www.buymeacoffee.com/idiotspod Prep notes for completed episodes can be found here (Not all episodes have prep notes). If you are enjoying the podcast please leave a review on your preferred podcast app!...
Dec 04, 2023•32 min•Season 1Ep. 67
Join Jame, Callum and Pals for a discussion on some highlights from FIS 2023: https://microbiologysociety.org/event/full-events-listing/federation-of-infection-societies-fis-conference.html Mentioned in episode: ESCMID brain abscess guidelines: https://www.sciencedirect.com/science/article/pii/S1198743X23003993# ORAL study protocol: https://trialsjournal.biomedcentral.com/articles/10.1186/s13063-021-05783-8 ACBLM/ALM: https://www.acb.org.uk/ Pathology networks: https://www.england.nhs.uk/patholo...
Nov 27, 2023•36 min•Season 1Ep. 66
Join Jame, Callum and Pals for a discussion on some highlights from FIS 2023: https://microbiologysociety.org/event/full-events-listing/federation-of-infection-societies-fis-conference.html Mentioned in episode: UCHL HLH protocol and referral details: https://www.uclh.nhs.uk/our-services/find-service/medical-specialties-1/hlh-service SNAP trial: https://www.snaptrial.com.au/ SNAP trial email: snap-trial@unimelb.edu.au SABATO (pre-print) https://www.medrxiv.org/content/10.1101/2023.07.03.23291932...
Nov 20, 2023•28 min•Season 1Ep. 65
In this episode Jame and Callum are joined by Louis, host of the let's talk micro podcast. Listen in for a discussion on what a Biomedical Scientist is and how to become one. We explore the key details that clinicians need to add to their specimen request details; and ponder how laboratory managers can make this easier for clinicians. How to request a test: https://global.oup.com/academic/product/how-to-request-a-test-a-clinicians-guide-to-the-interpretation-and-evaluation-of-medical-tests-97801...
Nov 06, 2023•43 min•Season 1Ep. 64
Ready for some startling Steno statistics? In this big 1-parter, Callum & Jame go through Stenotrophomonas maltophilia, from start to finish. Unlike Pseudomonas & Acinetobacter, Steno is much less commonly seen outside of ITU & the immunocompromised; but when it shows up you have to know what you’re doing. Luckily for you, there’s basically only 2 treatments! (In Europe: you’ll see what I mean). 2 crap puns in this one, so… get ready for that. Support the show Support us on: Patreon:...
Oct 23, 2023•54 min•Season 1Ep. 63
In Part 2 of our episodes on Acinetobacter we talk abouit resistance, and then do a deep dive into the evidence base for the management of CRAB: Carbapenem-Resistant Acinetobacter Baumanii-calcoaceticus complex. Do have a look at the prep notes for this episode if you want more information on Acinetobacter. Links to podcasts mentioned in this episode ID:IOTS Episode 41: Bugs Without Borders Febrile episodes 76 & 77: Piece de (Gram-negative) Resistance Episode 76 Episode 77 For links to the p...
Oct 09, 2023•44 min•Season 1Ep. 62
In this episode, Callum and Jame go over the second big family of nonfermentors, Acinetobacter. In part 1 we talk about the organisms themselves, risk factors, clinical syndromes and diagnostics before talking a little about treatment. In Part 2 (released next week) we’ll talk about Carbapenem-Resistant Acinetobacter Baumanii-calcoaceticus (CRAB), and resistance mechanisms in general. Support the show Support us on: Patreon: https://www.patreon.com/cw/IDIOTS_pod BuyMeACoffee: https://www.buymeac...
Oct 02, 2023•28 min•Season 1Ep. 61
In part 2, we discuss the limited treatment options for pseudomonas infection, some wildcard options and the resistance mechanisms that make Pseudomonas such a tricky bugger to treat! Support the show Support us on: Patreon: https://www.patreon.com/cw/IDIOTS_pod BuyMeACoffee: https://www.buymeacoffee.com/idiotspod Prep notes for completed episodes can be found here (Not all episodes have prep notes). If you are enjoying the podcast please leave a review on your preferred podcast app!...
Sep 11, 2023•46 min•Season 1Ep. 60
It was a long time coming, but it’s here. Jame and Callum set off on our mini-series, Nobbling the Nonfermentors, starting with an introduction to glucose-nonfermenting organisms before moving on to the biggie: Pseudomonas aeruginosa! Part 2 next week covers treatment of Pseudomonas, including a deep dive into Pseudomonas resistance mechanisms. Stay tuned! Support the show Support us on: Patreon: https://www.patreon.com/cw/IDIOTS_pod BuyMeACoffee: https://www.buymeacoffee.com/idiotspod Prep note...
Sep 04, 2023•33 min•Season 1Ep. 59
Jame and Callum were delighted to be invited as guests to the podcast Microbe Mail by host Vindana (Vin) Chibabhai. Check out the Microbe Mail podcast: https://microbemail.captivate.fm/ @microbemail We discuss how bactericidal and bacteriostatic are defined, what the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) are and why this isn't as simple as it first seems. We then discuss specific clinical situations and where bactercidal vs static have been compared....
Aug 29, 2023•43 min•Season 1Ep. 58
Jame and Callum are together in person to talk about the importance of keeping your house in order. Being an infection specialist does not automatically make you an antimicrobial steward. We reflect on some challenges to being an antimicrobial steward when practising infection medicine The choosing wisely campaign mentioned by Jame: https://www.choosingwisely.org/ A course on Antimicrobial Stewardship which is a good starting point: https://www.futurelearn.com/courses/antimicrobial-stewardship T...
Aug 22, 2023•24 min•Season 1Ep. 57
We were delighted to be joined by Dr Anastasia "Tash" Theodosiou to talk about breastfeeding, antibiotics and the risks of antibiotic harm to mum and baby. Tash is an infectious diseases/medical microbiology trainee, host of the HelloMicro blog and has volunteered as a Breastfeeding Peer Supporter. *Note the NICE guidelines have been updated and do not recommend trimethoprim in any stage of pregnancy Support the show Support us on: Patreon: https://www.patreon.com/cw/IDIOTS_pod BuyMeACoffee: htt...
Aug 07, 2023•1 hr 9 min•Season 1Ep. 56
2 years. It’s been a hell of a ride. Here’s to 2 more. Links from this episode: KASIC 1-page evidence-summary on aminopenicillins for resistant enterococcal UTIs: https://bit.ly/44CtNnq AUDIENCE SURVEY!!! Please do fill this out, it would mean a lot to us: https://forms.gle/aCq2djmfKPjA6tkMA . Support the show Support us on: Patreon: https://www.patreon.com/cw/IDIOTS_pod BuyMeACoffee: https://www.buymeacoffee.com/idiotspod Prep notes for completed episodes can be found here (Not all episodes hav...
Jul 28, 2023•22 min•Season 1Ep. 55
This is the urine antibiotic drug penetrance you never knew you wanted. Jame might be prouder of this than his own children. Callum, as you will be able to tell, remains indifferent*. Figure out which antibiotics you can trust, and which you can't. Use the table in the prep notes and links to win arguments, justify treating 'resistant' organisms in the urine, BREAK HEARTS - you name it! Enjoy! Prep notes for this episode: https://idiots.notion.site/UTI-Drug-Choice-5deb611895254444a040bf78d2003cd...
Jul 24, 2023•59 min•Season 1Ep. 54
Catheter-associated UTI: Callum’s nemesis. His white whale. His Sauron. His favourite rant. Want to know how favourite? Listen on! Show notes for this episode here Useful links (see show notes for more) RICAT study Chlorhexidine meatal cleaning Support the show Support us on: Patreon: https://www.patreon.com/cw/IDIOTS_pod BuyMeACoffee: https://www.buymeacoffee.com/idiotspod Prep notes for completed episodes can be found here (Not all episodes have prep notes). If you are enjoying the podcast ple...
Jul 10, 2023•1 hr 15 min•Season 1Ep. 53
