Loyal Listeners! Free yourselves from this outdated language! Emancipate your hospitals from 'Escalation antibiotics'! In today's episode, Callum and Jame rant for 35 minutes about how we talk about changing therapy, and how talk of escalating antibiotics leads to desire for 'big gun' antibiotics. Apologies for Callum's audio quality on this episode. We'd apologise for Callum in general, but you chose to listen, really you've only yourself to blame. Links: Tunnocks Tea Cakes Ledaig whisky ID:IOT...
Jun 26, 2023•36 min•Season 1Ep. 52
The title says it all. We're going back to the lab for this discussion. Join Jame and Callum as they have an in depth discussion about the nature of urine culture. Prep notes for this episode available here . Support the show Support us on: Patreon: https://www.patreon.com/cw/IDIOTS_pod BuyMeACoffee: https://www.buymeacoffee.com/idiotspod Prep notes for completed episodes can be found here (Not all episodes have prep notes). If you are enjoying the podcast please leave a review on your preferred...
Jun 13, 2023•55 min•Season 1Ep. 51
Ever wondered what a clinical scientist is or how to become one? Are you a clinical scientist and looking to sit the FRCPath exams? Join Jame and Callum as they talk to Phillipa Burns and Vicki Fleming about their experiences in preparing for their FRCPath exams in microbiology. Here are some of the resources mentioned during this episode: Colour atlas of bacteriology UK Reference laboratory manuals Tropical Medicine Notebook Bailey & Scott's Diagnostic Microbiology, 15th Edition Review agar...
May 30, 2023•41 min•Season 1Ep. 50
Welcome to the party pal! The penicillin allergy assessment and delabelling party, that is. Callum takes Jame through the latest evidence base in antibiotic allergy in general, and beta lactam allergy assessment and management in particular. Links: PENFAST Score paper: Trubiano JA et al. Development and Validation of a Penicillin Allergy Clinical Decision Rule. doi: 10.1001/jamainternmed.2020.0403. Sulfonamide allergy paper here (couldn't find anything published more recently): Urbancic KF et al...
May 06, 2023•32 min•Season 1Ep. 49
Join Callum with guests Morgan Evans, Olivia Hawkes and Katy Hill for the final(?) part of the ECCMID 2023 highlights ECCMID sessions discussed: - Antimicrobial stewardship poster session - Ethical dilemmas with antimicrobial therapy - The value of diagnostic information for antimicrobial stewardship - Tick borne diseases and prevention Music: https://pixabay.com/music/acoustic-group-outrigger-144123/ Support the show Support us on: Patreon: https://www.patreon.com/cw/IDIOTS_pod BuyMeACoffee: ht...
May 01, 2023•33 min•Season 1Ep. 48
Join Callum with guests Andrew Seaton, Marianna Avellar, Hannah Pymont, Eva Garmendia, Sanjay Patel and Dave Hettle live from ECCMID 2023. ECCMID sessions discussed: - Fairytales or reality, checking some eminence paradigms for treatment of severe infections - Neglected tropical skin diseases - Non-canonical approaches to treatment of infections - Paediatric interactive cases: dilemmas for the microbiologist and infection specialist - Clinical grand round For the AMR studio podcast: https://www....
Apr 28, 2023•34 min•Season 1Ep. 47
Join Callum with Guests Robert Ball, Kelly Bicknell & Rob Read live from ECCMID 2023. ECCMID sessions discussed: Antibiotic stewardship for urinary tract infections: challenges and opportunities Viral Infection in immunosuppressed patients: what is new? Responsible publishing in CM/ID Secondary haemophagocytic lymphohistiocytosis and infectious diseases Review article on HLH: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8094004/ Music: https://pixabay.com/music/acoustic-group-outrigger-14412...
Apr 26, 2023•26 min•Season 1Ep. 46
Callum is reunited with Jame following their separation at ECCMID 2023. Callum shares some highlights including Archaea and their role in human health, Digitalisation within the microbiology lab and the ESCMID/IDSA interview Links to publications on Archaea: https://www.moissleichingerlab.com/projects/ https://twitter.com/chmoei?lang=en Digitalisation and machine learning in microbiology presentation link: https://appliedmicrobiologyresearch.net/en/blog/keynote-by https://twitter.com/AppliedMicr...
Apr 24, 2023•33 min•Season 1Ep. 45
Jame rides solo today, going over the beta-lactamase inhibitors, old and new, how to think about them and when to use them in anger. New Show notes format! Available at https://idiots.notion.site/Beta-Lactamase-Inhibitors-f9999b6a4867470996a31c53e661b5ac NB: For now all old show notes are available in the usual Onedrive folder. Support the show Support us on: Patreon: https://www.patreon.com/cw/IDIOTS_pod BuyMeACoffee: https://www.buymeacoffee.com/idiotspod Prep notes for completed episodes can ...
Apr 03, 2023•31 min•Season 1Ep. 44
Jame and Callum are joined by the one and only Sara Dong of Febrile fame to look at the American Board of Internal Medicine's Infectious Disease Certification Exam. Support the show Support us on: Patreon: https://www.patreon.com/cw/IDIOTS_pod BuyMeACoffee: https://www.buymeacoffee.com/idiotspod Prep notes for completed episodes can be found here (Not all episodes have prep notes). If you are enjoying the podcast please leave a review on your preferred podcast app!...
Mar 20, 2023•49 min•Season 1Ep. 43
Jame and Callum are joined by semi-recent FRCPath Microbiology part 1 exam passers Callum and Jame to discuss how best to prepare for this exam. This exam is sat by all infection trainees in the UK, as well as other health care professionals working in infection such as clinical scientists. Full revision resources notes available in the linked OneDrive folder below (if you can't access it let us know). Let us know once you pass! (Disclaimer: previous sentence for engagement purposes only, please...
Mar 06, 2023•44 min•Season 1Ep. 42
Jame and Callum are joined by Vin from Microbe Mail to discuss the management of Difficult to Treat Resistance (DTR) Gram negative infections in South Africa. If you haven't already check out Microbe mail for a high quality infection podcast linking the lab and clinical management.... wait that sounds familiar! Vin is a associate Professor in Clinical Microbiology at the University of the Witwatersrand, Johannesburg, South Africa and a practising clinical microbiologist with the National Health ...
Feb 20, 2023•54 min•Season 1Ep. 41
Jame and Callum are joined by recent FRCPath Microbiology part 2 exam passers Olly and Rob to discuss how best to prepare for the exam. This is the final exam required to qualify as a medical/clinical microbiologist in the UK. Full revision resources notes available on this notion page: https://idiots.notion.site/40-FRCPath-part-2-microbiology-78288c756979431fa82c6191ab3622f3 Support the show Support us on: Patreon: https://www.patreon.com/cw/IDIOTS_pod BuyMeACoffee: https://www.buymeacoffee.com...
Feb 06, 2023•1 hr 4 min•Season 1Ep. 40
It's time for journal club! Jame and Callum discuss community acquired pneumonia treatment and a paper from 2021 which examines shorter duration therapy for patients responding to therapy. Paper discussed: Dinh, Aurélien et al. “Discontinuing β-lactam treatment after 3 days for patients with community-acquired pneumonia in non-critical care wards (PTC): a double-blind, randomised, placebo-controlled, non-inferiority trial.” Lancet 2021;397: 1195-1203. doi:10.1016/S0140-6736(21)00313-5 Shorter is...
Jan 23, 2023•43 min•Season 1Ep. 39
In this episode as requested on twitter (sort of), Callum & Jame compare and contrast Gram positive & negative bacteraemia. Happy new year! Please also see our older episode on bloodstream infection: www.buzzsprout.com/1782416/9162105-5-back-to-bacteraemia SABATO trial details here: https://twitter.com/sebpoule/status/1518496524552056833?s=46&t=Dre0YLRm_gwnKQ8OakDarw Support the show Support us on: Patreon: https://www.patreon.com/cw/IDIOTS_pod BuyMeACoffee: https://www.buymeacoffee....
Jan 09, 2023•31 min•Season 1Ep. 38
This Christmas, Jame shares a tale of woe: the rise and fall of Plazomicin, a hapless victim of antibiotic market forces. The conversation then proceeds/degenerates into a discussion of the economics of Antimicrobials in general, with a focus on the ‘Netflix’ model being piloted in the UK. WE’LL BE BACK NEXT YEAR SEE YOU THEN Support the show Support us on: Patreon: https://www.patreon.com/cw/IDIOTS_pod BuyMeACoffee: https://www.buymeacoffee.com/idiotspod Prep notes for completed episodes can be...
Dec 25, 2022•24 min•Season 1Ep. 37
Join Jame and Callum as they take a deep dive into urinalysis, a commonly (mis)used test for UTI (and other conditions). This test put you into murky waters when used clinically and we hope to give some information to avoid being a pisse prophet. Some sources referred to in this episode: NICE Clinical knowledge summary SMI 41: Investigation of urine Summary article of PPV and NPV for urinalysis: - Diagnosis and treatment of urinary tract infections across age groups, AJOG, 2018 Performance of LE...
Dec 12, 2022•42 min•Season 1Ep. 36
Callum and Jame discuss the HACEK organisms (apart from Haemophilus which we discussed in episode 32). Support the show Support us on: Patreon: https://www.patreon.com/cw/IDIOTS_pod BuyMeACoffee: https://www.buymeacoffee.com/idiotspod Prep notes for completed episodes can be found here (Not all episodes have prep notes). If you are enjoying the podcast please leave a review on your preferred podcast app!...
Nov 28, 2022•35 min•Season 1Ep. 35
An atypical episode about pneumonia. Callum and Jame discuss their pet peeves. Support the show Support us on: Patreon: https://www.patreon.com/cw/IDIOTS_pod BuyMeACoffee: https://www.buymeacoffee.com/idiotspod Prep notes for completed episodes can be found here (Not all episodes have prep notes). If you are enjoying the podcast please leave a review on your preferred podcast app!...
Nov 14, 2022•18 min•Season 1Ep. 34
Callum and Jame talk about everyone's favourite antibiotic class that covers Staph, Pseudomonas and Gram negatives, is predominantly renally excreted and isn't a quinolone, the aminoglycosides. We go over classification, mechanism of action, spectrum, resistance mechanisms, PK/PD, penetrance to various tissues, toxicity, and dosing. This is a companion piece to our star appearance on Febrile in August: https://player.captivate.fm/episode/0777091c-0991-42d4-89a9-4032d77b4fa5 Support the show Supp...
Oct 25, 2022•56 min•Season 1Ep. 33
Join Jame and Callum as they talk you through Haemophilus spp. Turns out that Haemophilus influenzae isn't the cause of Influenza. We answer some questions such as: What are X and V? Suggestions and comments to idiotspodcasting@gmail.com or @IDiots_pod If you are enjoying the podcast please leave a review on your preferred podcast app! Feel like giving back? Donations of caffeine gratefully received! https://www.buymeacoffee.com/idiotspod Useful resources: -SMI on HACEK organisms https://www.gov...
Oct 10, 2022•41 min•Season 1Ep. 32
Join Jame and Callum as they discuss the two titans of diarrhoea, Salmonella and Shigella. Who knew Salmonella species were so complex? Jame explains something that will SHOCK you about Shigella (maybe). Suggestions and comments to idiotspodcasting@gmail.com or @IDiots_pod If you are enjoying the podcast please leave a review on your preferred podcast app! Feel like giving back? Donations of caffeine gratefully received! https://www.buymeacoffee.com/idiotspod Useful resources: Review of Salmonel...
Sep 26, 2022•50 min•Season 1Ep. 31
Yersinia. Not very important today, very very important in the past! Callum and Jame talk through the medically important Yersinia species, and how to treat them. Links: CDC page for treatment of plague: https://www.cdc.gov/plague/healthcare/clinicians.html UK HSA SMI 21: ID of Yersinia Species https://www.gov.uk/government/publications/smi-id-21-identification-of-yersinia-species-from-faeces The 'Jump' test for mesenteric adenitis Jame mentioned has a name (the J-up test), and it works! Sensiti...
Sep 12, 2022•36 min•Season 1Ep. 30
Join Jame and Callum and they discuss some of the other Enterobacterales Gram negatives. Particularly breaking down them into their families and into Lactose fermenters and non-fermenters. Jame has a small breakdown around our Twitter handle near the end. Comments suggestions and criticisms to idiotspodcasting@gmail.com or @IDiots_pod Some lists: Chromosomal AmpC Carriers (high-risk): HECK YES · Hafnia alvei, Enterobacter cloacae, Citrobacter freundii, Klebsiella aerogenes , Yersinia enterocolit...
Aug 29, 2022•35 min•Season 1Ep. 29
Join Jame as he continues to talks through the ESCMID and IDSA treatment of Multi Drug Resistant Gram negative guidelines/guidance. Callum listens and occasionally asks a question! Jame is so passionate on this subject that we have split the episode into two parts. ECDC guidelines · https://onlinelibrary.wiley.com/doi/full/10.1111/j.1469-0691.2011.03570.x · https://www.ecdc.europa.eu/en/news-events/multidrug-resistant-extensively-drug-resistant-and-pandrug-resistant-bacteria-0 Canadian guideline...
Aug 15, 2022•20 min•Season 1Ep. 28
Join Jame as he talks through the ESCMID and IDSA treatment of Multi Drug Resistant Gram negative guidelines/guidance. Callum listens and occasionally asks a question! Jame is so passionate on this subject that we have split the episode into two parts. ECDC guidelines · https://onlinelibrary.wiley.com/doi/full/10.1111/j.1469-0691.2011.03570.x · https://www.ecdc.europa.eu/en/news-events/multidrug-resistant-extensively-drug-resistant-and-pandrug-resistant-bacteria-0 Canadian guidelines · https://w...
Aug 08, 2022•44 min•Season 1Ep. 27
ID:IOTS is 1 year old today! Jame and Callum have a short chat about the the podcast, why we started and where we’re going. Of course, the real ID:IOTS are the friends we made along the way… If you want to send us cake email idiotspodcasting@gmail.com Support the show Support us on: Patreon: https://www.patreon.com/cw/IDIOTS_pod BuyMeACoffee: https://www.buymeacoffee.com/idiotspod Prep notes for completed episodes can be found here (Not all episodes have prep notes). If you are enjoying the podc...
Jul 28, 2022•10 min•Season 1Ep. 26
Back after a summer break, Jame and Callum discuss the fascinating machine that is the MALDI-TOF. Matrix Assisted Laser Desorption Ionisation Time Of Flight mass spectrometry. We discuss the basics of how it functions, its application in the lab and some pros and cons of its use along with what the future may hold. Here are some relevant videos and papers: - Exciting video of MALDI-TOF https://www.youtube.com/watch?v=0jeFpXHZ8W0&ab_channel=BrukerDaltonics - MALDI-TOF to detect MRSA https://w...
Jul 25, 2022•26 min•Season 1Ep. 25
Join Jame and Callum as they discussion all things beta lactamase including ESBL, AmpC and Carbapenemases. We talk through classification systems, patterns of resistance and some methods of detection. Some resources we found helpful: Summary of beta lactamase classification: https://microbeonline.com/betalactamase-classification/ Summary of AmpC: https://www.idstewardship.com/heck-yes-get-amped-updates-ampc-harboring-bacteria/ EUCAST detection of resistance: https://www.eucast.org/fileadmin/src/...
Jun 24, 2022•1 hr 5 min•Season 1Ep. 24
Callum and Jame provide an overview of the Carbapenem class of antibiotics discussing: what they are; their spectrum of action (looking in particular at what they don't cover); resistance; how to use them; and side effects. This site has a useful summary of the new formulation of carbapenems and their spectra: http://www.microbiologynutsandbolts.co.uk/the-bug-blog/new-sweets-on-the-market-but-will-these-new-flavours-live-up-to-their-vibrant-colours Here is the NEJM paper on Tebipenem Jame mentio...
Jun 01, 2022•33 min•Season 1Ep. 23
