Send us a Text Message (please include your email so we can respond!) Episode 69! We start talking about the articles from the CCR25 conference with RESCUE-3 or "Temporary Transvenous Diaphragm Neurostimulation for Weaning from Mechanical Ventilation" published in AJRCCM by Dres et al and PROMIZING or "Proportional-Assist Ventilation for Minimizing the Duration of Mechanical Ventilation" by Bosma et al in NEJM. RESCUE-3 (pubmed): https://pubmed.ncbi.nlm.nih.gov/40498082/ PROMIZING (pubmed): http...
Jul 15, 2025•45 min•Season 1Ep. 69
Send us a Text Message (please include your email so we can respond!) Episode 68! Today we talk about modes of mechanical ventilation with the first author Dr. Kevin Seitz. This was published in CHEST April of 2025 as "Effect of Ventilator Mode on Ventilator-Free Days in Critically Ill Adults: A Randomized Clinical Trial". Disclaimer, this is stated in the episode but Todd and I are authors on this paper. Please keep that in mind as you enjoy the episode! Pubmed: https://pubmed.ncbi.nlm.nih.gov/...
Jul 01, 2025•50 min•Season 1Ep. 68
Send us a Text Message (please include your email so we can respond!) Episode 67! Today we do a quick overview of the presentations from the Critical Care Reviews 2025 (CCR25) Conference! If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon fo...
Jun 17, 2025•43 min•Season 1Ep. 67
Send us a Text Message (please include your email so we can respond!) Episode 66! Today we talk about Acute Chest Syndrome in Sickle Cell Disease with one of our favorite hematologists, Benjamin Tillman! We base our discussion around the TASC trial or "Comparison of Prophylactic and Therapeutic Doses of Anticoagulation for Acute Chest Syndrome in Sickle Cell Disease" published by Dessap et al in AJRCCM April of 2025. Pubmed: https://pubmed.ncbi.nlm.nih.gov/40209087/ AJRCCM: https://www.atsjourna...
Jun 03, 2025•46 min•Season 1Ep. 66
Send us a Text Message (please include your email so we can respond!) Episode 65! Though this is during ATS, this episode was pre-recorded so you will get some reactions to the conference in the coming episodes. Instead we have a short episode where we talk about risk factors for stress ulcers and transfusion threshold in upper GI bleeding! Risk factors: https://pubmed.ncbi.nlm.nih.gov/40315134/ Transfusion threshold: https://pubmed.ncbi.nlm.nih.gov/23281973/ Transfusion threshold (NEJM): https:...
May 20, 2025•35 min•Season 1Ep. 65
Send us a Text Message (please include your email so we can respond!) Episode 64! We talk more about steroids in severe community acquired pneumonia with "Effect of hydrocortisone on mortality in patients with severe community-acquired pneumonia : The REMAP-CAP Corticosteroid Domain Randomized Clinical Trial" published in Intensive Care Medicine April of 2025. Pubmed: https://pubmed.ncbi.nlm.nih.gov/40261382/ If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure ...
May 06, 2025•40 min•Season 1Ep. 64
Send us a Text Message (please include your email so we can respond!) Episode 63! We talk about intermediate risk PE in "Large-Bore Mechanical Thrombectomy Versus Catheter-Directed Thrombolysis in the Management of Intermediate-Risk Pulmonary Embolism" by Jaber et al published in Circulation in February 2025. Then we talk about "Fibrinolysis for patients with intermediate-risk pulmonary embolism" by Meter et al in NEJM 2014. PEERLESS: https://pubmed.ncbi.nlm.nih.gov/39470698/ PEITHO: https://pub...
Apr 22, 2025•50 min•Season 1Ep. 63
Send us a Text Message (please include your email so we can respond!) Episode 62! We talk briefly about two of the analyses that dropped with the ISICEM conference and then talk in depth about SESAR or "Inhaled Sedation in Acute Respiratory Distress Syndrome" by Jabudon et al in JAMA 2025. Then was answer a question on sleep in the ICU. Eddie did misspeak when he said one of the dexmedetomidine articles was in Lancet Respiratory medicine, rather, it was published in eClinical Medicine part of th...
Apr 08, 2025•49 min•Season 1Ep. 62
Send us a Text Message (please include your email so we can respond!) Episode 61! We talk about HFNC including extubation to HFNC in "Early weaning from invasive mechanical ventilation via high-flow nasal oxygen versus conventional weaning in patients with hypoxemic respiratory failure" by Ayyawar et al published in Critical Care Science. Then we talk about weaning HFNC from the "How I do it" series from CHEST. Auto-PEEP (NEJM): https://www.nejm.org/doi/full/10.1056/NEJM199307153290322 Extubate ...
Mar 25, 2025•47 min•Season 1Ep. 61
Send us a Text Message (please include your email so we can respond!) Episode 60! We jump to SCCM where we talk about 2 late breakers - PROACTIVE or "Propranolol As an Anxiolytic to Reduce the Use of Sedatives for Critically Ill Adults Receiving Mechanical Ventilation" by Downar et al and "Acetylsalicylic Acid Treatment in Patients With Sepsis and Septic Shock" by Almeida et al both published in CCM in 2025. PROACTIVE (pubmed): https://pubmed.ncbi.nlm.nih.gov/39982178/ PROACTIVE (CCM): https://p...
Mar 11, 2025•45 min•Season 1Ep. 60
Send us a Text Message (please include your email so we can respond!) Episode 59! We finish our CCR down under coverage with TRAUMOX2 or "Early Restrictive vs Liberal Oxygen for Trauma Patients" published in JAMA by Arleth et al and then switch to SAHARA or "Liberal or Restrictive Transfusion Strategy in Aneurysmal Subarachnoid Hemorrhage" by English et al published in NEJM. We then frustrate Todd with questions from our mailbag, a good episode! TRAUMOX2 (pubmed): https://pubmed.ncbi.nlm.nih.gov...
Feb 25, 2025•57 min•Season 1Ep. 59
Send us a Text Message (please include your email so we can respond!) Episode 58! We talk about non-invasive oxygen support and RENOVATE or "High-Flow Nasal Oxygen vs Noninvasive Ventilation in Patients With Acute Respiratory Failure" published in JAMA December 2024 and presented at the CCR Down Under Conference. We supplement this by first talking about FLORALI or "High-flow oxygen through nasal cannula in acute hypoxemic respiratory failure" published in NEJM May 2015 RENOVATE (pubmed): https:...
Feb 11, 2025•57 min•Season 1Ep. 58
Send us a Text Message (please include your email so we can respond!) Episode 57! We were excited to have on this episode Dr. Adam Wright who is a PhD in Bioinformatics to discuss SCREEN or "Electronic Sepsis Screening Among Patients Admitted to Hospital Wards: A Stepped-Wedge Cluster Randomized Trial" published by Arabi et al in JAMA 2024 and presented at the CCR Down Under Conference. A long episode but a lot of good discussion SCREEN (pubmed): https://pubmed.ncbi.nlm.nih.gov/39658862/ SCREEN ...
Jan 28, 2025•1 hr 6 min•Season 1Ep. 57
Send us a Text Message (please include your email so we can respond!) Episode 56! In this episode we spend a few minutes talking about making decisions on ECMO initiation but spend most of the episode talking about ADAPT-Sepsis or "Biomarker-Guided Antibiotic Duration for Hospitalized Patients With Suspected Sepsis" published by Dark et al in JAMA 2024 and presented at the CCR Down Under Conference. ADAPT-Sepsis (pubmed): https://pubmed.ncbi.nlm.nih.gov/39652885/ ADAPT-Sepsis (JAMA): https://jam...
Jan 14, 2025•46 min•Season 1Ep. 56
Send us a Text Message (please include your email so we can respond!) Episode 55 and Happy New Year! In this episode we talk broad strokes about the CCR Down Under Conference and the trials that were presented, then Todd and Eddie go over a bunch of articles from the year 2024 that they didn't have time to go over or want to re-emphasize for whatever reason. Big show and we hope you enjoy! TIGHT K: https://pubmed.ncbi.nlm.nih.gov/39215972/ PROPHY VAP: https://pubmed.ncbi.nlm.nih.gov/38262428/ RE...
Dec 31, 2024•1 hr•Season 1Ep. 55
Send us a Text Message (please include your email so we can respond!) Episode 54! In this episode we talk about antibiotic duration in bacteremia (BALANCE) and also antibiotic duration in Pseudomonas Ventilator associated pneumonia (iDIAPASON). BALANCE (NEJM): https://www.nejm.org/doi/full/10.1056/NEJMoa2404991 BALANCE (pubmed): https://pubmed.ncbi.nlm.nih.gov/39565030/ iDIAPASON (ICM): https://link.springer.com/article/10.1007/s00134-022-06690-5 iDIAPASON (pubmed): https://pubmed.ncbi.nlm.nih.g...
Dec 17, 2024•52 min•Season 1Ep. 54
Send us a Text Message (please include your email so we can respond!) Episode 53! In this episode we talk about access in patients with out of hospital cardiac arrest. Both articles are similar so we talk in depth about IVIO and then bringing PARAMEDIC-3 to round out our discussion. A good acronym discussion too, don't miss it! IVIO (NEJM): https://www.nejm.org/doi/10.1056/NEJMoa2407616 IVIO (pubmed): https://pubmed.ncbi.nlm.nih.gov/39480221/ PARAMEDIC-3 (NEJM): https://www.nejm.org/doi/full/10....
Dec 03, 2024•34 min•Season 1Ep. 53
Send us a Text Message (please include your email so we can respond!) Episode 52! In this episode we talk about fevers in acute neurologic injury and double that up with talking about low tidal volume ventilation in patients with neurologic injury INTREPID (JAMA): https://jamanetwork.com/journals/jama/fullarticle/2824088 INTREPID (pubmed): https://pubmed.ncbi.nlm.nih.gov/39320879/ PROLABI (Blue): https://www.atsjournals.org/doi/full/10.1164/rccm.202402-0375OC PROLABI (pubmed): https://pubmed.ncb...
Nov 19, 2024•41 min•Season 1Ep. 52
Send us a Text Message (please include your email so we can respond!) We are (were) LIVE at ACNP Critical Care Bootcamp 2024! Thank you to the organizers of the conference for inviting us do a live show and thank you to everyone who came out to listen! We talk about the NONSEDA trial or "Nonsedation or Light Sedation in Critically Ill, Mechanically Ventilated Patients" by Olsen et al published in the New England Journal of Medicine February 2020 NONSEDA (pubmed): https://pubmed.ncbi.nlm.nih.gov/...
Nov 05, 2024•23 min•Season 1Ep. 51
Send us a Text Message (please include your email so we can respond!) Episode 50! In this episode we talk about SBT frequency and "Frequency of Screening and Spontaneous Breathing Trial Techniques" by Burns et al from JAMA 2024 that was released with the ESICM conference. In our second segment, instead of another trial we talk a little bit about the IV fluid shortage happening in the United States. FAST (JAMA): https://jamanetwork.com/journals/jama/fullarticle/2824928 FAST (pubmed): https://pubm...
Oct 22, 2024•56 min•Season 1Ep. 50
Send us a Text Message (please include your email so we can respond!) We are LIVE at CHEST2024! Thank you to the organizers of the conference for inviting us do a live show and thank you to everyone who came out to listen! We talk about a few articles that were recently published in CHEST - "Prophylactic Minocycline for Delirium in Critically Ill Patients: A Randomized Controlled Trial" published by Dal-Pizzol et al and then "Comparative Effectiveness of Amiodarone and Lidocaine for the Treatmen...
Oct 07, 2024•52 min•Season 1Ep. 49
Send us a Text Message (please include your email so we can respond!) Episode 48! In this episode we talk about the long term effects of ICU visitation policies on families. Long Term Outcomes of Visitation (pubmed): https://pubmed.ncbi.nlm.nih.gov/39172240/ Long Term Outcomes of Visitation (ICM): https://link.springer.com/article/10.1007/s00134-024-07577-3 Outcomes of Visitation (pubmed): https://pubmed.ncbi.nlm.nih.gov/31310297/ Outcomes of Visitation (JAMA): https://jamanetwork.com/journals/j...
Sep 24, 2024•35 min•Season 1Ep. 48
Send us a Text Message (please include your email so we can respond!) Episode 47! In this episode we talk about a prospective observational study examining cognitive motor dissociation by Bodien et al published in the New England Journal of Medicine and then we pair that talking about the guidelines for death by neurologic criteria published in SCCM! An episode of somber but important topics! Cognitive Motor Dissociation (pubmed): https://pubmed.ncbi.nlm.nih.gov/39141852/ Cognitive Motor Dissoci...
Sep 10, 2024•43 min•Season 1Ep. 47
Send us a Text Message (please include your email so we can respond!) Episode 46! In this episode we talk about thrombolytic windows in acute ischemic stroke from TIMELESS published by Albers et al published in the New England Journal of Medicine and then we talk about ANDROMEDA shock and serial lactates published by Hernandez et al! TIMELESS (pubmed): https://pubmed.ncbi.nlm.nih.gov/38329148/ TIMELESS (NEJM): https://www.nejm.org/doi/10.1056/NEJMoa2310392 ANDROMEDA-Shock (pubmed):https://pubmed...
Aug 27, 2024•50 min•Season 1Ep. 46
Send us a Text Message (please include your email so we can respond!) Episode 45! In this episode we talk about sepsis bundles and the 1-BED trial by Fruend et al and discuss the stress ulcer prophylaxis guidelines just published in SCCM! 1-BED (pubmed): https://pubmed.ncbi.nlm.nih.gov/38913098/ SUP Guidelines: https://www.sccm.org/Clinical-Resources/Guidelines/Guidelines/SCCM-ASHP-Guideline-Prevention-of-UGIB If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure...
Aug 13, 2024•52 min•Season 1Ep. 45
Send us a Text Message (please include your email so we can respond!) We were honored to be joined by Joanna Stollings (and honestly we needed someone to keep us grounded) to talk about BLING3 or "Continuous vs Intermittent β-Lactam Antibiotic Infusions in Critically Ill Patients With Sepsis" published in JAMA by Dulhunty et al and also released with the CCR24 conference. pubmed: https://pubmed.ncbi.nlm.nih.gov/38864155/ JAMA: https://jamanetwork.com/journals/jama/fullarticle/2819971 If you enjo...
Jul 30, 2024•52 min•Season 1Ep. 44
Send us a Text Message (please include your email so we can respond!) Episode 43! In this episode come close to finishing our dedicated discussion of the CCR24 trials talking about transfusion targets in TBI (HEMOTION) and dapagliflozin in critical illness (DEFENDER)! HEMOTION: https://www.nejm.org/doi/full/10.1056/NEJMoa2404360 HEMOTION (pubmed): https://pubmed.ncbi.nlm.nih.gov/38869931/ DEFENDER: https://jamanetwork.com/journals/jama/fullarticle/2820242 DEFENDER (pubmed): https://pubmed.ncbi.n...
Jul 16, 2024•45 min•Season 1Ep. 43
Send us a Text Message (please include your email so we can respond!) Episode 42! In this episode we foray into weight lifting and body building as we talked about amino acids for kidney protection after cardiac surgery (PROTECTION) and cycling in addition to PT in mechanically ventilated adults (CYCLE). We also feature our first real ad for the Critical Care ACNP/PA Bootcamp! Details below! Bagging vs Ventilator During Cardiac Arrest: https://journal.chestnet.org/article/S0012-3692(24)00248-4/a...
Jul 02, 2024•1 hr•Season 1Ep. 42
Send us a Text Message (please include your email so we can respond!) Episode 41! We continue our CCR24 recap with a brief overview and thoughts on the conference as a whole and then dive into REVISE or "Stress Ulcer Prophylaxis during Invasive Mechanical Ventilation" published by Cook et al in NEJM June 2024. Not the sexiest of all the topics but important nonetheless (and we will get to the others soon!) REVISE: https://pubmed.ncbi.nlm.nih.gov/38875111/ If you enjoy the show be sure to like an...
Jun 18, 2024•44 min•Season 1Ep. 41
Send us a Text Message (please include your email so we can respond!) Episode 40! In this special episode releasing at the conclusion of the PREOXI presentation at the Critical Care Reviews 2024 conference in Belfast, Ireland - we discuss the recently published PREOXI trial evaluating NIV vs facemask as pre-oxygenation for emergent endotracheal intubation. Kevin Gibbs, the first author and presenter at the conference, is our special guest. Stay tuned for our review of some of the other results f...
Jun 13, 2024•1 hr 6 min•Season 1Ep. 40
