Send us a Text Message (please include your email so we can respond!) Episode 39! In this episode we talk about steroids in septic shock from community acquired pneumonia - a secondary from the APROCCHSS trial. We then dive into our mailbag to talk about a couple of topics we've been asked questions about and address them in a more broad sense. A pseudo-mailbag but with real answers APROCCHSS-CAP: https://pubmed.ncbi.nlm.nih.gov/38310918/ If you enjoy the show be sure to like and subscribe, leav...
Jun 04, 2024•52 min•Season 1Ep. 39
Send us a Text Message (please include your email so we can respond!) We're live from ATS! We decide to format our episode after the NEJM/JAMA/ATS combined session and talk about the articles presented there. Some of them we've talked about before but provide new insights from listeners and questions from the audience. Some of them are new and we provide our thoughts from the presentations (not enough time to fully read the articles) The one article we skip is ASTER that was published in JAMA by...
May 21, 2024•55 min•Season 1Ep. 38
Send us a Text Message (please include your email so we can respond!) Episode 37! In this episode we talk about glycemic control in the ICU. We liked the flipped script and so we're again going old article first. NICE-SUGAR or "Intensive versus conventional glucose control in critically ill patients" was published in NEJM 2009 and then we talk about TGC-Fast or "Tight Blood-Glucose Control without Early Parenteral Nutrition in the ICU" published NEJM September of 2023 NICE SUGAR: https://pubmed....
May 07, 2024•49 min•Season 1Ep. 37
Send us a Text Message (please include your email so we can respond!) Episode 36! In this episode we talk about tranexamic acid in GI bleeds. We flip the script a little bit and talk about our OLD article first, HALT-IT or "Tranexamic acid in upper gastrointestinal bleed in patients with cirrhosis: A randomized controlled trial" published in Lancet in 2020. This sets the stage for our new trial "Tranexamic acid in upper gastrointestinal bleed in patients with cirrhosis" published in Kumar et al ...
Apr 23, 2024•41 min•Season 1Ep. 36
Send us a Text Message (please include your email so we can respond!) Episode 35! In this episode we talk about extubation practices with "Effect of aggressive vs conservative screening and confirmatory test on time to extubation among patients at low or intermediate risk: a randomized clinical trial" published in Intensive Care Medicine by Hernandez et al. We then talk about an observation study by Zarrabian et al published in the Blue Journal "Liberation from Invasive Mechanical Ventilation wi...
Apr 09, 2024•59 min•Season 1Ep. 35
Send us a Text Message (please include your email so we can respond!) Episode 34! In this episode we talk about oxygen targets! Specifically we go over the two oxygen target analyses that were published simultaneously with ISICEM. We spend most of our time with HOT-COVID published by Nielson et al and then dip a little into individualized treatment effects of oxygen targets published by Buell et al - both published in JAMA March 2024. The latter is a complex topic and we hit some of the high poi...
Mar 26, 2024•51 min•Season 1Ep. 34
Send us a Text Message (please include your email so we can respond!) Episode 33! In this episode we are excited to be joined by Eddy Fan and Whitney Gannon, two extraordinary ECMO researchers to talk about VENT-AVOID or " Extracorporeal Carbon Dioxide Removal to Avoid Invasive Ventilation During Exacerbations of Chronic Obstructive Pulmonary Disease" published March 2024 by Duggal et al in the ATS Blue Journal. VENT-AVOID: https://pubmed.ncbi.nlm.nih.gov/38261630/ If you enjoy the show be sure ...
Mar 12, 2024•53 min•Season 1Ep. 33
Send us a Text Message (please include your email so we can respond!) Episode 32! We got a lot of feedback on our last episode so we decided to address it in a full episode! A lot of listeners asked us about vasopressors specifically vasopressin and angiotensin-2 so we talk about VASST, VANISH, and ATHOS-3. It is a full episode but a good one! VASST: https://pubmed.ncbi.nlm.nih.gov/18305265/ VANISH: https://pubmed.ncbi.nlm.nih.gov/27483065/ ATHOS-3: https://pubmed.ncbi.nlm.nih.gov/28528561/ If y...
Feb 27, 2024•1 hr 3 min•Season 1Ep. 32
Send us a Text Message (please include your email so we can respond!) Episode 31! This episode we talk first about invasive vs non-invasive blood pressures from an observational paper titled "Accuracy of Noninvasive Blood Pressure Monitoring in Critically Ill Adults" published in journal of Intensive Care Medicine by Haber et al and then for our old trial we further the discussion of blood pressure by talking about the 65 trial! Non-invasive vs invasive blood pressure: https://pubmed.ncbi.nlm.ni...
Feb 13, 2024•42 min•Season 1Ep. 31
Send us a Text Message (please include your email so we can respond!) Episode 30! This episode is a little different. We recap the SCCM conference first. THEN we go into PROPHY-VAP or "Ceftriaxone to prevent early ventilator-associated pneumonia in patients with acute brain injury" published January 2024 by Professor Dahyot-Fizelier in Lancet Respiratory Medicine. Then we dive into our long neglected mailbag to review listener questions about MINT, intubation timing, ACORN, and all the steroids ...
Jan 30, 2024•55 min•Season 1Ep. 30
Send us a Text Message (please include your email so we can respond!) Episode 29! We stray a little bit from our new and old article structure to talk about two recently published but slightly different ARDS recommendations from ATS and ESCIM. We compare and contrast them and give our takes on the data and evidence. Thanks to everyone who emails in and gives feedback, we will do our mail bag next episode! ATS Guidelines: https://pubmed.ncbi.nlm.nih.gov/38032683/ ESICM guidelines: https://pubmed....
Jan 16, 2024•48 min
Send us a Text Message (please include your email so we can respond!) Episode 28! In this episodes we talk about ECMO! PRONECMO evaluated the effect of prone positioning on patients already on ECMO by Schmidt et al in JAMA December 2023 and then EOLIA by Combes et al in NEJM 2018 which is our old article which randomized patients to ECMO or not. Great discussion here! PRONECMO: https://pubmed.ncbi.nlm.nih.gov/38038395/ EOLIA: https://pubmed.ncbi.nlm.nih.gov/29791822/ If you enjoy the show be sur...
Jan 02, 2024•55 min•Season 1Ep. 28
Send us a Text Message (please include your email so we can respond!) Episode 27! In this episodes we sit down to talk all about the "when" to intubate a patient centered around acute poisoning in the NICO trial or "Effect of Noninvasive Airway Management of Comatose Patients With Acute Poisoning: A Randomized Clinical Trial" published by Freud et al in JAMA November 2023. We ended up talk a lot about that so we cut our old article a little bit short and discuss a couple of JAMA articles about d...
Dec 19, 2023•47 min•Season 1Ep. 27
Send us a Text Message (please include your email so we can respond!) This was easily our most requested article to discuss and for good reason - Eddie and Todd recently published the ACORN trial or "Cefepime vs Piperacillin-Tazobactam in Adults Hospitalized With Acute Infection" in JAMA October 2023. We recognize our bias as the first and last authors on the paper so we wanted to get some other smart people in the studio to balance us out so we partnered with Furf and Monty of PulmPEEPs for thi...
Dec 12, 2023•50 min•Season 1Ep. 26
Send us a Text Message (please include your email so we can respond!) Episode 25! In this episode we talk about the MINT trial or "Restrictive or Liberal Transfusion Strategy in Myocardial Infarction and Anemia" published in NEJM November 2023 by Carson et al. We supplement this with a recent observational cohort study that gives Todd anxiety titled "Intracerebral Hemorrhage Among Blood Donors and Their Transfusion Recipients" by Zhao et al in JAMA September 2023. MINT: https://pubmed.ncbi.nlm.n...
Dec 05, 2023•45 min•Season 1Ep. 25
Send us a Text Message (please include your email so we can respond!) Episode 24! Three trials about COVID were published with ESICM which we talk about all three here. COVID has been decreasing in prevalence in our ICU at least so we anchor our discussion around what we can learn from these trials about ARDS in general or what we can carry forward to future pandemics compared to our typical "Are we using this in our practice". Simvastatin: https://pubmed.ncbi.nlm.nih.gov/37888913/ Vitamin C: ht...
Nov 21, 2023•56 min
Send us a Text Message (please include your email so we can respond!) Episode 23! We spend a little bit of time talking about our recent conference related travel and food experience but dive into our coverage of the trials that released with ESICM including "Inhaled Amikacin to Prevent Ventilator-Associated Pneumonia" by Ehrmann et al published in NEJM and "Landiolol and Organ Failure in Patients With Septic Shock" by Whitehouse et al in JAMA, both October 2023 AMIKINHAL: https://pubmed.ncbi.nl...
Nov 07, 2023•53 min•Season 1Ep. 23
Send us a Text Message (please include your email so we can respond!) Episode 22! In this episode we talk about "Peripheral Administration of Norepinephrine: A Prospective Observational Study" published August 2023 by Yerke et al in CHEST. For our old article we talk about "Effect of midodrine versus placebo on time to vasopressor discontinuation in patients with persistent hypotension in the intensive care unit (MIDAS)" by Santer et al published October 2020 by Santer et al. No mailbag this tim...
Oct 24, 2023•38 min
Send us a Text Message (please include your email so we can respond!) Live show? Thank you so much to the organizers of the ACNP/PA Critical Care Bootcamp who invited us to do a live episode of the show! We talked about the AKIKI2 trial "Comparison of two delayed strategies for renal replacement therapy initiation for severe acute kidney injury" by Gaudry et al in Lancet 2021. AKIKI2: https://pubmed.ncbi.nlm.nih.gov/33812488/ If you enjoy the show be sure to like and subscribe, leave that 5 star...
Oct 17, 2023•26 min
Send us a Text Message (please include your email so we can respond!) Episode 21! In this episode we talk about "Extracorporeal Life Support in Infarct-Related Cardiogenic Shock" published August 2023 by Thiele et al in NEJM. Then we dive into our neglected mail bad to try to answer some listener questions. ECLS-SHOCK: https://pubmed.ncbi.nlm.nih.gov/37634145/ If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associ...
Oct 10, 2023•46 min•Season 1Ep. 21
Send us a Text Message (please include your email so we can respond!) Episode 20! In this episode we talk about "Effect of Selective Decontamination of the Digestive Tract on Hospital Mortality in Critically Ill Patients Receiving Mechanical Ventilation" published October 2022 by the ANZICS group in JAMA. We have the first author and senior authors on the accompanying systematic review and meta-analysis, Naomi Hammond and Anthony Delany, all the way from Australia (!) on with us to talk to us ab...
Sep 26, 2023•46 min•Season 1Ep. 20
Send us a Text Message (please include your email so we can respond!) Episode 19! In this episode we talk about "Oxygen-Saturation Targets for Critically Ill Adults Receiving Mechanical Ventilation" published November 2022 by Semler et al in the New England Journal of Medicine. We have the first author, Matt Semler, on with us to talk to us about the trial and his improv comedy claim to fame. PILOT: https://pubmed.ncbi.nlm.nih.gov/36278971/ If you enjoy the show be sure to like and subscribe, le...
Sep 12, 2023•52 min•Season 1Ep. 19
Send us a Text Message (please include your email so we can respond!) Episode 18! In this episode we talk about "Early adjunctive methylene blue in patients with septic shock: a randomized controlled trial" published March 2023 by Ibarra-Estrada et al in Critical Care. We made a planning mistake so no old article today so we left it short! Methylene blue: https://pubmed.ncbi.nlm.nih.gov/36915146/ If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us ...
Aug 29, 2023•26 min
Send us a Text Message (please include your email so we can respond!) Episode 17! In this episode we talk about "Aggressive of Moderate Fluid Resuscitation in Acute Pancreatitis" published September 2022 by de-Madaria et al in the New England Journal of Medicine and then talk about the landmark study "Early Goal-Directed Therapy in the Treatment of Severe Sepsis and Septic Shock" by Rivers et al also NEJM but November 2001 WATERFALL: https://pubmed.ncbi.nlm.nih.gov/36103415/ EGDT: https://pubmed...
Aug 15, 2023•40 min•Season 1Ep. 17
Send us a Text Message (please include your email so we can respond!) Episode 16! In this episode we talk about "Phenobarbital-Based Protocol for Alcohol Withdrawal Syndrome in a Medical ICU: Pre-Post Implementation Study" published April 2023 by Alwakeel et al and then talk about the landmark study TRICC or "A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care" We also explore car donation jingles (1-877 KARS 4 KIDS Phenobarbital: https://pubmed.ncbi...
Aug 01, 2023•48 min•Season 1Ep. 16
Send us a Text Message (please include your email so we can respond!) Episode 15! In this episode we talk about "Blood-Pressure Targets in Comatose Survivors of Cardiac Arrest" published October 2022 by Kjaergaard (apologies in advance for the pronounciation...) et al and then talk about the prospective observational cohort "Weaning from mechanical ventilation in intensive care units across 50 countries (WEAN SAFE)" BOX-BP: https://pubmed.ncbi.nlm.nih.gov/36027564/ WEAN SAFE: https://pubmed.ncbi...
Jul 18, 2023•40 min
Send us a Text Message (please include your email so we can respond!) Summer is here and we're getting a chance to catch our breath! Unless there is a surprise article drop we anticipate that our next few episodes are going to be a little bit different as we catch up on non-RCT happenings in the critical care world. This episode is the same, our discussion on ARDS is a fascinating history lesson blended in with current insights. ARDS Guidelines: https://pubmed.ncbi.nlm.nih.gov/37326646/ ARMA: ht...
Jul 04, 2023•41 min•Season 1Ep. 14
Send us a Text Message (please include your email so we can respond!) Episode 13! We made it this far! Instead of keying in on one major article from the Critical Care Reviews Conference 2023 we decided to do a pot pourri of the entire conference. It was quite the whirlwind, if there is any point or trial you want us to elaborate please contact us and let us know! Otherwise we discuss EXIT-SEP in our "short" discussion section. This was published in JAMA Internal Medicine by Liu et al evaluating...
Jun 20, 2023•42 min•Season 1Ep. 13
Send us a Text Message (please include your email so we can respond!) This is a little off schedule (and a little long!) but we were SO EXCITED to have the opportunity to sit down and talk with Matt Prekker, the lead author on the DEVICE trial evaluating video versus direct laryngoscopy for tracheal intubation which was published TODAY, June 2023, in the New England Journal of Medicine and presented TODAY at CCR Meeting 2023. DEVICE: https://www.nejm.org/doi/full/10.1056/NEJMoa2301601?query=feat...
Jun 16, 2023•54 min•Season 1Ep. 13
Send us a Text Message (please include your email so we can respond!) Episode 11/12 (depending on how you count the ATS episode)! This time we discuss "Platelet Transfusion before CVC Placement in Patients with Thrombocytopenia" published in NEJM May 2023. Apologies for the lack of old articles, with summer travel plans we've prepped for a couple but ran out of recording time. When things slow down a bit, we'll get back into our normal flow. PACER: https://pubmed.ncbi.nlm.nih.gov/37224197/ If yo...
Jun 06, 2023•35 min•Season 1Ep. 12
