Original Report: https://www.nejm.org/doi/abs/10.1056/NEJMc2500231 References:Syphilis – Its early history and Treatment until Penicillin and the Debate on its Origins. https://jmvh.org/article/syphilis-its-early-history-and-treatment-until-penicillin-and-the-debate-on-its-origins/Establishment of the Nichols strain as the type strain of Treponema pallidum. https://pmc.ncbi.nlm.nih.gov/articles/PMC11868658/In vitro assay to demonstrate high-level erythromycin resistance of a clinical isolate of ...
May 19, 2025•23 min•Season 1Ep. 31
Chubbyemu video: https://open.spotify.com/episode/5BXEnVu8h0UWvlfmkwy3Xv?si=1XFT34Q9Q06okvMB2UgNKg Selected References: Intravenous mushroom poisoning . https://pubmed.ncbi.nlm.nih.gov/4025991/ The inhibition of mitochondrial cytochrome oxidase by the gases carbon monoxide, nitric oxide, hydrogen cyanide and hydrogen sulfide: chemical mechanism and physiological significance. https://pubmed.ncbi.nlm.nih.gov/18839291/ Clinical toxicology of cyanide. https://pubmed.ncbi.nlm.nih.gov/3526995/ Probin...
Apr 07, 2025•16 min•Season 1Ep. 30
Chubbyemu is on Spotify now! Chubbyemu Licorice Video: https://open.spotify.com/episode/77z8mZGbmBI4E2JtA8GXsh?si=k_qV_IkrQiqTGpn8EXK61Q References: A bradykinin-potentiating factor (bpf) present in the venom of bothrops jararaca. https://pmc.ncbi.nlm.nih.gov/articles/PMC1704050/ UpToDate, Choice of drug therapy in primary (essential) hypertension. Primary Hyperaldosteronism. https://www.ncbi.nlm.nih.gov/books/NBK539779/ NEJM Case 24-1992....
Mar 29, 2025•21 min•Season 1Ep. 29
Dr Pavlos Msaouel: https://faculty.mdanderson.org/profiles/pavlos_msaouel.html 0:00 Pretext and context MD Anderson Cancer Center 1:42 The Early Experiences That Shaped Dr Msaouel 3:39 The System of Cancer Research In the United States 5:25 FDA Drug Approvals and Special Designations For Oncology 11:09 A trade-off in our current system 12:35 Whoops 😞 I misspoke 14:35 Randomized trials are not supposed to be representative of a population 18:10 Inference for the treatment of Katie Coleman (metas...
May 16, 2023•1 hr 10 min•Season 1Ep. 28
Mug is here 😳 ► https://crowdmade.com/collections/chubbyemu @chubbyemu energy drink video ► https://youtu.be/tAtaIZD0Ebs A Student Ate Only Chips And Fries For 10 Years ► https://youtu.be/VINtwoyaF_8 A Mom Ate 5 Day Old Sushi 🍣 ► https://youtu.be/R0d6Dpx2li4 Vitamin B12 deficiency can cause neurologic problems. It's stored in the liver and isn't made in humans. It needs to be sourced via diet....
Jan 09, 2023•12 min•Season 1Ep. 27
@chubbyemu video: https://youtu.be/xtVvtsPgfew Heme Review Podcast: https://anchor.fm/chubbyemu Behind the scenes channel: @BigEmus Music by @Lifeformed ► https://lifeformed.bandcamp.com All Heme Review videos (playlist) ► https://www.youtube.com/playlist?list=PLAHeV2H_YiGUYhHOF4wRMCuqBIJvrnWqS Daddy Longlegs by Vengolis Loxosceles gaucho by Halies Some images by Getty Images References: CMS Malaque, RS Vetter, M Entres. Loxosceles spiders. Critical Care toxicology. https://link.springer.com/r...
Dec 26, 2022•11 min•Season 1Ep. 26
Caffeine Dry Scoop: https://youtu.be/sylqJ0NEVJw Happened while filming this video: https://youtu.be/LKNfFm0QDXQ Music by Lifeformed: https://lifeformed.bandcamp.com References: The Signaling Pathways Involved in the Anticonvulsive Effects of the Adenosine A1 Receptor. https://www.mdpi.com/1422-0067/22/1/320 Caffeine Withdrawal. https://www.ncbi.nlm.nih.gov/books/NBK430790/ A critical review of caffeine withdrawal: empirical validation of symptoms and signs, incidence, severity, and associated f...
Dec 20, 2022•14 min•Season 1Ep. 25
In 2015, a boy rubbed an entire tube of minty pain relief cream in-between his legs, and it caused his organs to shut down. Majority of modern men I believe are familiar with this action-- you may have accidentally applied it to the area yourself, or to the eyes, where it will hurt for a time that feels like an eternity. Chubbyemu video: https://open.spotify.com/episode/2ul5F6qQn8KoHlqfFFsXDz?si=u72E79cMSGaaSQIlaDEWEw Boy Drinking his mom's essential oils: https://open.spotify.com/episode/4dmWDz...
May 13, 2022•21 min•Season 1Ep. 24
Fasting can be an effective tool for weight loss. However if used inappropriately, can result in some not good situations. The patient's situation in this case isn't quite like the intermittent fasting schedules that are popular today. Chubbyemu video: https://open.spotify.com/episode/7zeoihTgEj0pEWIkRvDKIt?si=8YBaRCtkT1m6j9aJZeen2A Music by Lifeformed Tweet me: https://twitter.com/hemereview IG me: https://instagram.com/hemereview References: Mechanism of hypokalemia in magnesium deficiency. Hu...
Apr 25, 2022•18 min•Season 1Ep. 23
Video version of this podcast: https://youtu.be/bq1kwlGhPyE Original Chubbyemu video: https://youtu.be/5ujTYLV2Qo4 Tweet me: https://twitter.com/hemereview IG me: https://instagram.com/hemereview Music by Lifeformed References: Fulminant Liver Failure in Association with the Emetic Toxin of Bacillus cereus. https://www.nejm.org/doi/full/10.1056/NEJM199704173361604 Sudden Death of a Young Adult Associated with Bacillus cereus Food Poisoning. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3232990/ A...
Apr 18, 2022•20 min•Season 1Ep. 22
Chubbyemu video: https://youtu.be/3E75UvmY9GA Heme Review video on Renal Medullary Carcinoma: https://youtu.be/j7WGP6sJBLk Herman Connor Contact Cora Connor (Herman's sister): https://www.twitter.com/RMCAwareness Cora Facebook: https://www.facebook.com/RMCSupport IG me: https://www.instagram.com/hemereview Tweet me: https://www.twitter.com/hemereview...
Aug 21, 2021•24 min•Season 1Ep. 21
Video version of this podcast: https://youtu.be/j7WGP6sJBLk Chubbyemu video A Man Felt Pain In His Back. This Is What Happened To His Kidney. https://youtu.be/3E75UvmY9GA References: Renal medullary carcinoma. The seventh sickle cell nephropathy. Am J Surg Pathol. 1995 Jan;19(1):1-11. https://pubmed.ncbi.nlm.nih.gov/7528470/ A Model Linking Sickle Cell Hemoglobinopathies and SMARCB1 Loss in Renal Medullary Carcinoma. Clin Cancer Res. 2018 May 1;24(9):2044-2049. https://pubmed.ncbi.nlm.nih.gov/29...
Aug 18, 2021•19 min•Season 1Ep. 20
Video version of this podcast: https://youtu.be/B8LLf7DkR5U Chubbyemu video of KT: https://youtu.be/LKNfFm0QDXQ Dr Bora Lim can be reached at https://www.twitter.com/naborala Burn pits are a waste management tool for armed forces overseas. However, the nature of waste today is different than half a century ago. The smoke, fumes, and particulate matter that have been observed emanating from these pits contain a heterogeneous variety of materials. Exact exposure levels are not known in veterans, h...
Jun 21, 2021•31 min•Season 1Ep. 19
Video version of this podcast: https://youtu.be/oP_mJmWrfTQ Chubbyemu video of this case: https://www.youtube.com/watch?v=WPxb2IG9MOk Featuring: Dr Sonal Jagasia, MD, MPH. Psychiatrist in private practice. Tweet me: https://www.twitter.com/hemereview IG me: https://www.instagram.com/hemereview FB me: https://www.facebook.com/hemereview Dextromethorphan is an over the counter cough medicine. It is for coughs. Misuse of it can cause life threatening side effects. References: Dextromethorphan, chlo...
May 24, 2021•16 min•Season 1Ep. 18
This episode is up to date as of 11 April 2021 Statement from water company CEO: https://www.youtube.com/watch?v=faCsru9Ctgk Inside Edition video about this case: https://www.youtube.com/watch?v=lmEpmyc7g9Y Local News talking about the water: https://www.youtube.com/watch?v=oGQJcnlk5ag On March 13, the FDA was alerted to five cases of acute non-viral hepatitis (resulting in acute liver failure) in infants and children that occurred in November 2020 with an unknown cause reported to the Southern ...
Apr 12, 2021•11 min•Season 1Ep. 17
Chubbyemu video: https://www.youtube.com/watch?v=1MggKIfEld4 Heme Review video: https://www.youtube.com/watch?v=mPHXldh4_H4 Tweet me: https://www.twitter.com/hemereview IG me: https://www.instagram.com/hemereview FB me: https://www.facebook.com/hemereview Chubbyemu YouTube channel: https://www.youtube.com/channel/UCKOvOaJv4GK-oDqx-sj7VVg Heme Review YouTube channel: https://www.youtube.com/channel/UCNSoNc9s67nfOGlCXSu5VsA References: Potential Benefits of Dietary Fibre Intervention in Inflammato...
Apr 05, 2021•13 min•Season 1Ep. 16
Video version of this interview: https://youtu.be/oLe9UdL-qIk Jill's Blog: https://throughthevalley.ca White Ribbon Project: https://twitter.com/TheWRP4LC LUNGevity Foundation: https://lungevity.org GO2 Foundation: https://go2foundation.org Lung Cancer Canada: https://www.lungcancercanada.ca Lung Foundation Australia: https://lungfoundation.com.au Lung Cancer Europe (LUCe): https://www.lungcancereurope.eu Tweet me: https://www.twitter.com/hemereview IG me: https://www.instagram.com/hemereview FB...
Mar 30, 2021•26 min•Season 1Ep. 15
Please note the CONTENT WARNING at the beginning-- there's a reason I can't make the videos as described in this episode. They may surface in a different form at some time in the future. Heme Review YouTube: https://www.youtube.com/channel/UCNSoNc9s67nfOGlCXSu5VsA Tweet me: https://www.twitter.com/hemereview IG me: https://www.instagram.com/hemereview FB me: https://www.facebook.com/hemereview
Mar 20, 2021•15 min•Season 1Ep. 14
Video of this interview: https://youtu.be/o15HCjtSkug Chubbyemu video https://youtu.be/ChPeG19qKUo Christopher's recount of his case: https://youtu.be/7BpymtR2vpA Tweet me: https://www.twitter.com/hemereview IG me: https://www.instagram.com/hemereview FB me: https://www.facebook.com/hemereview 2,4-Dinitrophenol (DNP) is a chemical that is not approved for weight loss. It is a classic case of efficacy, but without safety in the setting of weight loss. This setting of weight loss can be prone to c...
Mar 03, 2021•1 hr 3 min•Season 1Ep. 13
Patient CE's personal recount of case: https://youtu.be/7BpymtR2vpA Patient CE's Interview: https://youtu.be/o15HCjtSkug Chubbyemu video on this case: https://youtu.be/ChPeG19qKUo Heme Review video version: https://youtu.be/jgDUMNaVqHg 2,4-Dinitrophenol (DNP) is a chemical that is not approved for weight loss in the United States. It is a classic case of efficacy, but without safety in the setting of weight loss. This setting of weight loss can be prone to chemical misuse, further exacerbating u...
Mar 03, 2021•20 min•Season 1Ep. 12
Based on N Engl J Med 2020; 383:1263-1275. https://www.nejm.org/doi/full/10.1056/NEJMcpc2002420 Chubbyemu video of this case: https://open.spotify.com/episode/77z8mZGbmBI4E2JtA8GXsh?si=k_qV_IkrQiqTGpn8EXK61Q Tweet me: https://twitter.com/hemereview IG me: https://instagram.com/hemereview FB me: https://facebook.com/hemereview Licorice candy has glycyrrhizin which increases cortisol (stress hormone) levels in the body. This causes hypokalemia. Hypo- low. Kal- kalium (potassium). emia- presence in...
Oct 05, 2020•19 min•Season 1Ep. 11
YouTube Video Version: https://youtu.be/ZNA_NtcutYY Chubbyemu Video: https://youtu.be/NaAFOrudj0g References: The Pharmacology and Use of H1-Receptor-Antagonist. N Engl J Med 1994; 330:1663-1670 Advances in H1-Antihistamines. N Engl J Med 2004; 351:2203-2217 Cardiac arrest caused by diphenhydramine overdose. Acute Med Surg. 2018 Oct; 5(4): 380–383. IV Lipid Emulsion Infusion in the Treatment of Severe Diphenhydramine. Am J Case Rep. 2019 May 29;20:758-763. Diphenhydramine with Intraventricular C...
Sep 15, 2020•10 min
YouTube Video Version: https://youtu.be/QSXzRWiuvxE Chubbyemu video of this case ▶️ https://youtu.be/fr8bp8a2QS4 The Body After Drinking A Snowglobe ▶️ https://youtu.be/elzijduKNS8 The Body After 2 Gallons Coffee In 3 Hours ▶️ https://youtu.be/rn-WLpa_nyQ Tweet me: https://www.twitter.com/hemereview FB me: https://www.facebook.com/hemereview IG me: https://www.instagram.com/hemereview Music by @Lifeformed Heatstroke is a serious problem and the heatwaves that cause it, claim more lives on averag...
Aug 15, 2020•19 min
Methanol-contaminated hand sanitizer has been on sale in the USA during COVID-19 pandemic. The FDA has issued a warning against this, and have listed the brands. Most stores that are selling these brands have pulled them from shelves. Methanol is a toxic alcohol that can cause blindness. Its antidote is ethanol, which is the alcohol that people drink casually, however management needs to be done by a healthcare professional, as methanol hangs around in the body for several days. The case present...
Aug 01, 2020•15 min•Season 1Ep. 8
This episode is about the pathophysiology on crystallopathies. The cellular pathways involved unify multiple concepts and multiple branches of medicine, from toxicology to cardiology to rheumatology and oncology. Heme Review YouTube Channel: https://www.youtube.com/channel/UCNSoNc9s67nfOGlCXSu5VsA References: [0] Crystallopathies. N Engl J Med 2016; 374:2465-2476. https://www.nejm.org/doi/full/10.1056/NEJMra1601611 [1] Recent advances in the mechanisms of NLRP3 inflammasome activation and its in...
Jul 27, 2020•14 min•Season 1Ep. 7
Chubbyemu case: https://youtu.be/UrbylXMU8Mw Most snowglobes are just made of water, but some can contain ethylene glycol. Most of those usually don't contain enough ethylene glycol to cause damage, but keep the word "usually" in mind. A homemade snowglobe can contain concentrations of anything, which is what happened in this case. Ethylene glycol can cause a profound high anion gap metabolic acidosis, and we'll explain the science, chemistry and physiology behind that in this episode. Reference...
Jul 21, 2020•17 min•Season 1Ep. 6
Max recommended amount of caffeine per day is 400mg. @Chubbyemu case report video ► https://youtu.be/wj_AOzSSDMM Instagram me: https://www.instagram.com/hemereview Facebook me: https://www.facebook.com/hemereview Tweet me: https://www.twitter.com/hemereview Music by @Lifeformed Some caffeine is OK. 1-2 cups of coffee can generally be ok. Unreasonably large amounts of caffeine NOT OK. References: [0] Hensher C, Vogel J. Insulin Euglycemic Therapy in the Treatment of Caffeine. Chest. 2020 May;157(...
May 19, 2020•13 min•Season 1Ep. 5
Support this podcast! https://anchor.fm/chubbyemu/support Video version of this video: https://youtu.be/iVt5BpoTHYg Tweet me: https://twitter.com/HemeReview IG me: https://instagram.com/HemeReview Music by Lifeformed: http://lifeformed.bandcamp.com/ References: [0] Chapman PB et. al. Vemurafenib in patients with BRAFV600 mutation-positive metastatic melanoma: final overall survival results of the randomized BRIM-3 study.Ann Oncol. 2017 Oct 1;28(10):2581-2587. https://www.ncbi.nlm.nih.gov/pubmed/...
May 04, 2020•33 min•Season 1Ep. 4
Support this podcast! https://anchor.fm/chubbyemu/support Video version of this podcast: https://www.youtube.com/watch?v=bxGS07U-B98 Video by Chubbyemu: A Farmer Removed His Own Skin Cancer With A Pocket Knife. This Is What Happened To His Brain. https://www.youtube.com/watch?v=KKaJhQBusH8 References: - Melanoma brain metastases: current areas of investigation and future directions. Cancer J. 2017 Jan-Feb; 23(1): 68–74. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5300745/ - The metastatic cycle...
Apr 13, 2020•30 min•Season 1Ep. 3
This episode was recorded on and is current up to Friday March 27 2020. Support this podcast! https://anchor.fm/chubbyemu/support Video version of this podcast: https://youtu.be/smI60BngTns Papers described in show: - Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open- label non-randomized clinical trial. Gautret et. al. (Google Doc: https://drive.google.com/file/d/186Bel9RqfsmEx55FDum4xY_IlWSHnGbj/view , version as preprint submission: https://www.sciencedirect.c...
Mar 28, 2020•39 min•Season 1Ep. 2
