A world champion athlete shouldn’t have to fight for the right diagnosis—yet Kelly Palace did, for years. What began as a swimmer’s quick fix for itchy, chlorine-dry skin became a descent into topical steroid addiction and withdrawal: spreading rashes, burning, oozing skin, misdiagnoses, and the long, lonely road of recovery. Kelly lays out the unvarnished truth about a “miracle cream” millions use and why the industry’s strongest selling points—fast relief and flawless skin—can mask a deeper pr...
Oct 21, 2025•40 min•Ep. 229
What if you could enjoy all the powerful health benefits of fasting without actually going hungry? Dr. Chris Rhodes, a biochemist with a PhD from UC Davis, has discovered a revolutionary approach that might make this possible. During this fascinating conversation, Dr. Rhodes explains how fasting triggers a remarkable survival response in our cells. After about 24 hours without food, our bodies deplete glycogen stores and enter "true fasting metabolism," activating anti-inflammatory pathways, cel...
Oct 14, 2025•43 min•Ep. 228
What if the clothes you wear and the sheets you sleep on could actively improve your health without you doing a thing? In this fascinating conversation, Seth Casden introduces us to a truly passive biohacking tool that's hiding in plain sight. Technology transforms ordinary fabrics into wellness tools by embedding them with micron-sized minerals that capture body heat and convert it into beneficial infrared light. This light penetrates the skin and increases local circulation, delivering more ox...
Oct 07, 2025•37 min•Ep. 227
What if the secret to treating age-related diseases and extending healthy lifespan lies within tiny cellular structures that evolved from ancient bacteria? In this mind-expanding conversation, biochemist Dr. Natalie Yivgi-Ohana reveals how mitochondria—far more than mere cellular powerhouses—control everything from hormone production to programmed cell death. Dr. Yivgi-Ohana, founder of Minovia Therapeutics, takes us on a fascinating journey through mitochondrial science, explaining how these or...
Sep 30, 2025•49 min•Ep. 226
Ever wondered how a single molecule can regulate blood flow, support neurotransmission, and boost immune defense? Dr. Bryan unravels these mysteries and cuts through the confusion with nitrous oxide, sharing invaluable insights from his collaborations with Nobel Prize winners. Join us as we explore why nitric oxide is pivotal to our health and longevity, and why it deserves more attention in medical circles. We also probe into the darker side of proton pump inhibitors (PPIs) and their detrimenta...
Sep 23, 2025•48 min•Ep. 225
GLP-1 agonists are transforming medicine in ways few could have predicted. In this captivating conversation, naturopathic physician Dr. Tina Moore challenges the conventional narrative around these medications, revealing their potential beyond weight loss and diabetes management. When Dr. Tina first began researching GLP-1s, she discovered a wealth of overlooked studies showing profound effects on inflammation, autoimmunity, and regenerative healing. Despite facing significant pushback from coll...
Sep 16, 2025•47 min•Ep. 224
Ready to revolutionize your understanding of metabolism? Dr. Dominic D'Agostino takes us deep into the science of ketosis, revealing why this evolutionary metabolic state might be the missing link in our modern health crisis. The keto revolution isn't just about weight loss. As Dr. Dom explains, ketosis fundamentally changes our physiology in ways that impact every major system in our body. While our ancestors regularly shifted in and out of this fat-burning state, most modern humans never exper...
Sep 09, 2025•47 min•Ep. 223
Guest: Forrest Smith — serial founder bringing clinic-grade photobiomodulation to a safe, wearable form factor. Theme: Why dose and delivery matter more than raw wattage for red light therapy. Key takeaways Wavelengths that work: Deep red 660 nm (blood flow, NO release, shallow penetration) + 808 nm near-IR (deeper tissues/joints). Mechanisms: Hemoglobin photodissociates NO → vasodilation + better O₂ delivery; mitochondria’s cytochrome c oxidase bottleneck relieved → higher ATP output; downstrea...
Sep 02, 2025•41 min•Ep. 222
Cancer isn’t just random genetic mutations. It doesn’t “just happen.” In this episode, Dr. Connealy pulls back the curtain on what really drives cancer — from mitochondrial breakdown and hidden toxins to stress, parasites, and even low voltage inside your cells. You’ll learn how to hack your environment, strengthen your biology, and prevent disease years before a tumor ever shows up on a scan. Dr. Leigh Erin Connealy, MD, is one of the most sought-after integrative oncologists in the world. She ...
Aug 26, 2025•48 min•Ep. 221
What if one natural molecule could reverse key signs of aging, repair your immune system, grow your hair, and even help you sleep better? In this episode, Robert Lufkin, MD, sits down with Leslie Kenny , a patient advocate with a remarkable story. At 39, she was told she had only 5 years to live with lupus and rheumatoid arthritis. Instead, through lifestyle changes and a breakthrough discovery about spermidine , she now enjoys extraordinary health — with a biological age of just 21 at age 60. �...
Aug 19, 2025•43 min•Ep. 220
Dive into the fascinating world of longevity research as we explore rapamycin, potentially the most powerful anti-aging pharmaceutical currently known. Dr. Rick Cohen, longevity physician with over 25 years of experience, reveals how this natural molecule discovered on Easter Island targets a fundamental cellular pathway called mTOR that acts as our body's metabolic switch between growth and repair. This episode is sponsored by Gatlan who makes rapamycin that we will be discussing available in t...
Aug 12, 2025•42 min•Ep. 219
What if the key to feeling better at 45 than you did at 25 isn't about accepting "normal" lab values, but about optimizing your hormones to their ideal levels? In this eye-opening conversation, Dr. Lauren Fitzgerald—a board-certified anesthesiologist who now specializes in bioidentical hormone replacement therapy—challenges conventional medical wisdom about hormone health. Dr. Fitzgerald breaks down the critical difference between bioidentical hormones and non-bioidentical versions. This distinc...
Aug 05, 2025•41 min•Ep. 218
Unlock the secrets of male well-being with Christos Konstantinidis, the pioneering founder and CEO of Adam Health, as we unveil the profound link between erectile health and holistic male wellness. Discover how your body's signals, often overlooked, could be the earliest indicators of serious health concerns like cardiovascular disease. Christos provides enlightening insights into how erectile function serves as a critical health barometer, cutting across cardiovascular, neurological, and hormon...
Jul 29, 2025•33 min•Ep. 217
What if we could reset our cellular batteries? In this fascinating deep dive into cutting-edge longevity science, Tom Benson from Mitrix Bio reveals how mitochondrial transplantation could revolutionize how we treat age-related diseases and potentially add decades of healthy living to our lives. The conversation begins by exploring the extraordinary nature of mitochondria – those tiny power plants within our cells that generate 95% of our body's energy through molecular rotors functioning like m...
Jul 22, 2025•54 min•Ep. 216
Curious about the real power of testosterone beyond the realm of bodybuilding? Join us as we sit down with Dr Andrew Sun, a fellowship-trained andrology specialist, who unpacks the diverse roles this crucial hormone plays in men's health. Discover the surprising factors, like poor sleep and metabolic syndrome, that can lower testosterone levels even in younger men. Andrew guides us through the significance of testosterone replacement therapy, not as a vanity metric but as a doorway to enhancing ...
Jul 15, 2025•47 min•Ep. 215
Ever wondered if you can truly turn back the clock on aging? Join us in this compelling episode as Dr. Mark Hyman shares his extraordinary insights on the power of functional medicine to rejuvenate the body and mind at any age. Discover how Dr. Hyman's personal and professional journey led him to uncover the foundational causes of aging and chronic disease, and learn about the vital distinctions between beneficial and harmful stress. We also delve into the fascinating concept of biological versu...
Jul 08, 2025•50 min•Ep. 214
This week we are broadcasting a fascinating presentation from my good friend Dr Vincent Giampapa where he discusses the potential and actual use of stem cell therapy for longevity. I have had the pleasure of visiting his remarkable longevity center in San Jose Costa Rica. We will be having a dedicated upcoming episode about it. This presentation is from the most recent RAADFEST meeting which is set to take place again in Las Vegas on July 10-13. You won't want to miss it! https://www.raadfest.co...
Jul 01, 2025•40 min•Ep. 213
As we near the end of the school year, I'd like to give a shoutout to Mr George Gaskin's 7th grade history class at Harvard-Westlake School who are fans of this program. Have you ever wondered what keeps your cells functioning properly? The answer might be a molecule with a funny name but serious implications for longevity. Spermidine, found in every living cell on Earth, is essential for triggering autophagy—your body's internal cleaning system that recycles damaged cellular components. Biochem...
Jun 24, 2025•1 hr 2 min•Ep. 212
Dr. Christopher Palmer is a friend and regular guest on this program and he never disappoints. This week he takes us on a fascinating journey through the groundbreaking connection between metabolism and mental health, revealing how the foods we eat profoundly impact not just our bodies but our minds. As a Harvard psychiatrist and director of the Metabolic and Mental Health Program at McLean Hospital, Chris shares compelling evidence that many psychiatric conditions may fundamentally be disorders...
Jun 17, 2025•45 min•Ep. 211
This week we are broadcasting a fascinating presentation from my good friend Dr Shelly Jordan where he discusses not only the importance of a central aging clock but also a possible treatment to reset it. He has even offered the procedure to me. Please let me know if you think I should take him up on his offer. This presentation is from the most recent RAADFEST meeting which is set to take place again in Las Vegas on July 10-13. You won't want to miss it! We get to unlock the secrets of aging wi...
Jun 10, 2025•37 min•Ep. 210
This week we are co-broadcasting the premiere episode of a new podcast series entitled Quantum Leadership. It is helmed by Dr Stephen Sideroff, a dear friend and one of my first podcast guests as well as the cohost of several of our episodes. It is a true pleasure to share this episode of his new podcast in its entirely this week. Please let us know how you like it and if you would like to see more of these. Steve interviews Ralph Gonsalves, Prime Minister of St. Vincent and the Grenadines. This...
Jun 03, 2025•1 hr 1 min•Ep. 209
What if everything you thought you knew about weight management was wrong? Dr. Alexandra Sowa, board-certified internist and obesity medicine specialist, challenges conventional wisdom in this eye-opening conversation about the true nature of obesity and the revolutionary medications transforming its treatment. This episode is sponsored by Rio.life who makes GLP-1 agonists available in their programs. I am an advisor to Rio but I only advise companies that I believe in and would use for myself a...
May 27, 2025•53 min•Ep. 208
Amy Alkon's eight-year scientific deep dive into menopause began with a hot flash that felt like being "locked in a trunk in the Everglades." What followed was a shocking discovery of the vast gap between medical practice and scientific evidence in women's health care. As a self-described "science mole rat" without medical training but with rigorous research skills, Alkon uncovered critical distinctions between perimenopause and menopause that most doctors overlook. Perimenopause isn't simply "m...
May 20, 2025•54 min•Ep. 207
What if your body wasn't designed to be sick? What if those nagging symptoms you've been fighting aren't problems at all, but messages—your body's desperate attempt to communicate that something deeper needs attention? In this revealing conversation, metabolic health expert and my good friend Ben Azadi introduces his new book "Metabolic Freedom," explaining why an astonishing 93% of Americans are metabolically unhealthy and what we can do about it. Rather than focusing on niche approaches like s...
May 13, 2025•45 min•Ep. 206
The shocking truth about cancer treatment lies in what medical schools aren't teaching doctors. After 20 years as a radiation oncologist, Dr. Katie Deming discovered that cancer might be fundamentally a metabolic condition rather than primarily genetic—an insight that transforms how we approach healing. Cancer cells predominantly use glucose as fuel through fermentation, even when oxygen is present (the Warburg effect). By eliminating this fuel source through ketogenic diets or extended water fa...
May 06, 2025•57 min•Ep. 205
Could a simple molecule be the key to resolving seemingly incurable health conditions? Greg shares his remarkable journey from facing imminent death to complete recovery using molecular hydrogen therapy. After conventional medicine failed to treat his tumors, severe heart condition, and debilitating autoimmune issues, Greg's desperate search led him to discover what he believes to be the profound healing potential of properly administered molecular hydrogen. Unlike conventional antioxidants, mol...
Apr 29, 2025•1 hr 6 min•Ep. 204
Dr. Giles Yeo, Cambridge University Professor, author of "Why Calories Don't Count," and Chief Science Advisor at Rio demolishes weight management myths with scientific precision and personal warmth. This mind-shifting conversation reveals why blaming people for obesity fundamentally misunderstands human biology. Full disclosure: I am also an advisor for Rio but I only work with companies I believe in and would use for myself and my family. Bold scientific insights abound as Dr. Yeo reveals why ...
Apr 22, 2025•39 min•Ep. 203
Dr. Aubrey de Grey reveals why reversing aging may be easier than slowing it down in this mind-expanding conversation that challenges conventional wisdom about human longevity. The renowned biomedical gerontologist outlines his damage repair approach that's gaining mainstream scientific acceptance after initial skepticism. The financial landscape of longevity research has dramatically transformed, with billions flowing into the space. Dr. de Grey provides an insider's assessment of major players...
Apr 15, 2025•41 min•Ep. 202
What if healing isn't the same as curing? Dr. Amita Kalaichandran draws from her unique background in conventional medicine, public health, integrative approaches, and journalism to reshape our understanding of true wellness in ways that might surprise you. At the heart of this conversation lies a powerful distinction: while Western medicine excels at curing (removing disease), healing represents something far more profound—a return to wholeness that integrates illness and challenges into our li...
Apr 08, 2025•30 min•Ep. 201
This week Dr. Eric Gordon returns to our program to draw back the curtain on chronic complex illness, illuminating the profound yet often overlooked connection between interrupted healing cycles and persistent health problems that conventional medicine struggles to address. At the heart of conditions like chronic fatigue syndrome, Lyme disease, and atypical autoimmune disorders lies chronic inflammation—not as a symptom, but as the driving force. Gordon explains that these debilitating condition...
Apr 01, 2025•31 min•Ep. 200
