Dr. Peter Attia Peter is the founder of Attia Medical, a medical practice with offices in San Diego and New York City, focusing on the applied science of longevity and optimal performance. In addition to being a medical doctor, Dr. Attia has done research on the role of regulatory T cells in cancer regression and other immune-based therapies for cancer. Regulatory T cells have also been, in the past, referred to as suppressor T cells because of their role in actually attenuating or reducing the ...
Mar 13, 2016•1 hr 9 min
Dr. Rhonda Patrick explains how cold shock is a type of hormesis, which is a description of a type of stress that, in the right doses, is enough to shock the body and kick off adaptive processes and response mechanisms that are hardwired into our genes, and, once on, are able to create a resilience that actually exceeds what was needed to counter the initial stimuli. In this episode, you'll discover: (00:00) Introduction (03:09) Cold exposure is good stress for the brain (15:42) Cryotherapy redu...
Feb 12, 2016•1 hr 2 min
Rich Roll This podcast features Rich Roll. Rich is an author, a podcaster ("Rich Roll Podcast" on iTunes) , as well as founder and first person to complete the EPIC5 Challenge. The EPIC5 challenge involves completing 5 Full Iron Distance triathlons on 5 Hawaiian islands in under a week. Rich has also been a repeated top finisher in the Ultraman World Championships in Hawaii, which is a three-day, 515km (320 mile) annual endurance race held on the Big Island of Hawaii. You can read about Rich's j...
Jan 23, 2016•1 hr 40 min
In this episode, Dr. Rhonda Patrick chats with Dr. Darya and Kevin Rose. Dr. Darya Rose, PhD is a neuroscientist, author of "Foodist: Using Real Food and Real Science to Lose Weight Without Dieting," and creator of Summer Tomato, which was featured in TIME magazine's list of the web's 50 best websites in 2011. Kevin you may know from TV, the investing world, or any of a wide variety of things he's well known for (founding digg.com, just for starters). More recently, Kevin hosts a podcast where h...
Dec 25, 2015•54 min
Dr. Pierre Capel Dr. Pierre Capel is a professor emeritus in experimental immunology at the Utrecht University in the Netherlands where he researched a wide range of topics from genetic modification to cancer immunotherapy. Pierre also works with Wim Hof, otherwise known as the iceman (guest on the last podcast ) who is especially well-known for some of his amazing physical feats, like staying in a tub with direct contact to ice for over an hour and fifty three minutes. Pierre explains some of t...
Nov 06, 2015•1 hr 16 min
Wim Hof Wim Hof, also known as "the Iceman", holds the world record for the longest ice bath (1 hour and 53 minutes and 12 seconds), just to name one of his many impressive feats. Dr. Patrick and Wim talk a bit about Wim's back story that culminated in him trying out cold water immersion, the relatively recent 2014 scientific publication of the "Wim Hof Method" which includes cold exposure during training, exposure to bacterial endotoxin, Wim's breathing techniques, and meditation. In this episo...
Oct 22, 2015•50 min
Dr. Rhonda Patrick delivers the keynote lecture at the Orthomolecular Medicine Congress in Bussum, Netherlands (MBOG Congres 2015). In this talk, you'll learn about: (00:00) Introduction (04:52) Micronutrient inadequacies and triage theory (10:42) Role of DNA damage in cancer and aging (21:10) Vitamin D, serotonin, and the development of autism (41:39) Omega-3s also regulate serotonin If you're interested in learning more, you can read the full show notes here . Join over 300,000 people and get ...
Oct 15, 2015•58 min
In this podcast, I discuss some of the mechanisms by which chronic stress (and rumination) affect health and aging and how meditation can reduce rumination and buffer stress. In this episode, you'll discover: (00:00) Introduction (02:41) Eustress such as exercise vs distress such as fear (06:15) Effects of stress on the brain (07:30) Effects of stress on the gut and microbiome (10:21) Stress accelerates biological aging (15:04) Meditation reduces rumination and promotes empathy (19:53) Effects o...
Sep 25, 2015•41 min
In this episode Rhonda talks about: (00:00) Introduction (03:00) Heat stress makes the body more resilient to the stresses of aging (14:45) Possible mechanisms why sauna use reduces heart disease risk (16:45) Sauna enhances athletic endurance and muscle growth (28:16) Sauna use stimulates neurogenesis and improves cognitive function and mood (37:34) Sauna use detoxifies BPA, PCBs, phthalates, and other metals (51:10) Practical applications sauna use and other heat stressors like hot yoga If you'...
Sep 11, 2015•1 hr 5 min
Dr. Justin Sonnenburg Dr. Justin Sonnenburg is an associate professor of microbiology and immunology at Stanford and Dr. Erica Sonnenburg is a senior research scientist in the Sonnenburg lab where they research many aspects the interaction between diet with the 100 trillion or so bacteria in the gut (specifically the colon) and how this impacts the health of the host (which in this case is a laboratory research mouse). In this episode, we discuss... (00:00) Introduction (02:50) What is the gut m...
Sep 03, 2015•47 min
Dr. Ronald Krauss Dr. Ronald Krauss, M.D. is the director of atherosclerosis research at Children's Hospital Oakland Research Institute, Adjunct Professor at UCSF and UC Berkeley. Dr. Krauss is really one of the pioneering scientists that changed the way we all think about cholesterol and saturated fat. He developed an assay that allows the quantification of low density lipoprotein particle size and concentration (known to the wider world as LDL cholesterol) based on a technique which determines...
Aug 27, 2015•1 hr 24 min
CHORI Bar Team Meet some of the CHORI bar team: Dr. Bruce Ames, Dr. Joyce McCann, and Dr. Mark Shigenaga. On this podcast we talk about the different types of HDL and LDL cholesterol and what they do in the body. We discuss a low-calorie, micronutrient- and fiber-dense nutrition bar (referred to as the CHORI bar) that Bruce and I briefly touched on in a previous conversation, how each of the components of the bar from the vitamins and minerals to the fiber and polyphenols are all really importan...
Aug 20, 2015•1 hr 1 min
Dr. Aubrey de Grey Dr. Aubrey de Grey is a biomedical gerontologist and the founder of the SENS research foundation which aims to find technologies that can repair the various types of damage that occur during the aging process. In this episode, we discuss... 00:00:00 - Introduction 00:02:27 - How to understand aging 00:08:14 - Epigenetic modifications accommodate cellular aging 00:18:24 - Inflammation is a double-edged sword 00:24:00 - Parabiosis has the potential to slow aging 00:31:35 - Lifes...
Aug 13, 2015•48 min
Dr. Rhonda Patrick answers some of the most popular questions regarding vitamin D including: (00:00) Introduction (02:22) How do you decide how much vitamin D to supplement with? (12:51) Is it possible to get too much vitamin D? (20:52) Is there a difference between vitamin D made from the sun versus a supplement? (24:43) What form of vitamin D is more bioavailable or absorbed better? Join over 300,000 people and get the latest distilled information straight to your inbox weekly: https://www.fou...
Aug 06, 2015•30 min
Dan Pardi Dr. Dan Pardi researches sleep neurobiology and is a co-founder of Dan's Plan, an online wellness and technology company. In this episode, we discuss... (00:00) Introduction (03:27) Circadian rhythms are key to health (07:07) Artificial lights suppress melatonin production (12:04) Sleep clears toxins from the brain (16:14) Sleep deprivation increases appetite and decreases energy expenditure (24:09) Sleep is critical for creating long-term memories (31:29) Blue light can reset circadia...
Jul 28, 2015•1 hr 6 min
Tim Ferriss Tim Ferris is a notorious self-experimenter, three-time New York Times bestselling author, angel investor, startup advisor, and much, much, much more. In this episode, we discuss... (00:00) Introduction (02:29) Oxytocin, vasopressin, and the neuroendocrine basis of pair bond formation (05:54) Tim's self-experimentation with the ketogenic diet and the biomarkers he measures daily (14:55) Can a ketogenic diet reduce Alzheimer's disease risk? (22:14) Inflammation accelerates aging, but ...
Jul 20, 2015•1 hr 15 min
Jim Kean Jim Kean is the CEO of National Pro Grid League (NPGL) and founder of WellnessFX. In this podcast Rhonda and Jim discuss the quantified self movement and the importance of measuring biomarkers more than once, the gut's role in cholesterol and serotonin in the gut versus in the brain, about the role of exercise in preventing neuroinflammation and the effects of overtraining on sex hormones. We also chat a bit about the psychology of constructing a new, non-gender segregated, team spectat...
Jul 02, 2015•33 min
Dr. Bruce Ames Dr. Rhonda Patrick speaks with Dr. Bruce Ames, about a micronutrient- and fiber-dense nutrition bar (referred to as the CHORI bar) that was developed in the Ames laboratory. The bar was formulated to be moderate in calories (107 kcal/≈25 g bar), but nutrient dense, with a polyphenolic-rich matrix of fruit, walnuts, and non-alkali-processed dark chocolate, supplemental vitamins, minerals, docosahexaenoic acid (DHA), a blend of insoluble and soluble fibers, protein, and glutamine. M...
Jun 22, 2015•10 min
Dr. Bruce Ames In this podcast, Dr. Rhonda Patrick interviews her mentor, Dr. Bruce Ames, about his triage theory and other nutrition topics. Dr. Ames was the 23rd most-cited scientist between 1973 and 1984, which is evidence of his long and productive career investigating human health and disease. Dr. Ames continues his research expanding our knowledge of nutrients such as vitamin D and its role in Autism spectrum disorder. In this episode, we discuss... (00:00) Introduction (04:18) Dr. Ames di...
Feb 12, 2015•43 min
In this interview, Dr. Rhonda Patrick talks to Dr. Frans Kuypers about his lab's discovery on how the human placenta is a rich source of pluripotent stem cells, and yet the placenta is thrown away after delivery. In this episode, we discuss... (00:00) Introduction (04:39) The human placenta as a source of hematopoietic cells (11:30) Pluripotent cells can differentiate into any cell in the human body (13:03) Public banking of abundant pluripotent placental stem cells (18:06) Therapeutic applicati...
Dec 17, 2014•1 hr 2 min
Dr. George A Brooks Dr. George A Brooks, an expert in exercise physiology and lactate metabolism. Lactate, a once demonized molecule thought to form lactic acid and become a dead-end toxic metabolite, has been vindicated by the work of Dr. Brooks, his colleagues, and others. In this episode, we discuss... (00:00) Introduction (01:40) Dr. Brooks' experience as an athlete inspired his research on lactate (06:50) Lactate and its relationship to muscle fatigue is misunderstood (09:10) Adaptations to...
Dec 02, 2014•1 hr
In this episode Dr. Rhonda Patrick interviews Dr. Terry Wahls about how she reversed her secondary-progressive multiple sclerosis with a micronutrient-dense diet and Paleo principles. She identified vitamins/minerals and other compounds present in vegetables/fruits that are essential for mitochondrial health, which is critical for brain function. In this episode, we discuss... (00:00) Introduction (00:48) Dysfunctional mitochondria contribute to disease development (04:03) Suboptimal magnesium s...
Jul 22, 2014•20 min
